{"id":217,"date":"2020-05-15T04:22:25","date_gmt":"2020-05-15T01:22:25","guid":{"rendered":"https:\/\/blog.drozberk.com\/?p=217"},"modified":"2020-07-07T00:37:35","modified_gmt":"2020-07-06T21:37:35","slug":"hayit-vitex-agnus-castus","status":"publish","type":"post","link":"http:\/\/blog.drozberk.com\/index.php\/2020\/05\/15\/hayit-vitex-agnus-castus\/","title":{"rendered":"HAYIT (V\u0130TEX AGNUS CASTUS)"},"content":{"rendered":"\n<h1 class=\"wp-block-heading\">1-)Vitex\nAgnus Castus for Premenstrual Syndrome and Premenstrual Dysphoric Disorder: A\nSystematic Revie&nbsp;<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;<a href=\"https:\/\/doi.org\/10.1007\/s00737-017-0791-0\" target=\"_blank\" rel=\"noreferrer noopener\">10.1007\/s00737-017-0791-0<\/a><\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Bu \u00e7al\u0131\u015fman\u0131n amac\u0131 Vitex agnus castus&#8217;un PMS ve adet \u00f6ncesi\ndisforik bozukluk (PMDD) i\u00e7in g\u00fcvenli ve etkili bir tedavi olup olmad\u0131\u011f\u0131n\u0131\nde\u011ferlendirmek ve bu bulgular\u0131n klinik uygulama i\u00e7in etkilerini\ntart\u0131\u015fmakt\u0131.&nbsp;PubMed ve Scielo veritabanlar\u0131 kullan\u0131larak literat\u00fcr\u00fcn\nsistematik bir incelemesi yap\u0131ld\u0131.&nbsp;Kapsama kriterleri, bu m\u00fcdahaleyi\nplasebo veya aktif bir kar\u015f\u0131la\u015ft\u0131r\u0131c\u0131 ile kar\u015f\u0131la\u015ft\u0131ran ve k\u00f6rle\u015ftirme ve\nb\u0131rakma \/ yoksunluklar\u0131n bir tan\u0131m\u0131n\u0131 i\u00e7eren PMS veya PMDD&#8217;li bireylerde V.\nagnus castus kullan\u0131larak randomize kontroll\u00fc \u00e7al\u0131\u015fmalar (RCT)\nidi.&nbsp;Ara\u015ft\u0131rma, dahil edilen \u00e7al\u0131\u015fmalarda fikir birli\u011fine ula\u015fan iki\nba\u011f\u0131ms\u0131z ara\u015ft\u0131rmac\u0131 taraf\u0131ndan y\u00fcr\u00fct\u00fclm\u00fc\u015ft\u00fcr.&nbsp;Toplam sekiz RK\u00c7 \u00e7al\u0131\u015fmaya\ndahil edildi.&nbsp;\u00c7o\u011fu \u00e7al\u0131\u015fma PMS \u00fczerine odaklanm\u0131\u015ft\u0131r ve PMS ve PMDD&#8217;nin tan\u0131\nkriterleri y\u0131llar i\u00e7inde de\u011fi\u015fmi\u015ftir.&nbsp;\u00dc\u00e7 farkl\u0131 V. agnus castus (VAC)\npreparasyonu test edildi ve \u00e7al\u0131\u015fmalar aras\u0131nda tedavi sonu\u00e7lar\u0131n\u0131n\n\u00f6l\u00e7\u00fclmesinde anlaml\u0131 de\u011fi\u015fkenlik vard\u0131.&nbsp;Bununla birlikte, sekiz \u00e7al\u0131\u015fman\u0131n\nhepsi PMS veya PMDD tedavisinde VAC i\u00e7in pozitifti ve VAC genel olarak iyi\ntolere edildi.&nbsp;Temel k\u0131s\u0131tlamalar, tan\u0131 \u00f6l\u00e7\u00fctlerinin tan\u0131m\u0131ndaki\nfarkl\u0131l\u0131klar, ana sonu\u00e7 \u00f6l\u00e7\u00fctleri olarak kullan\u0131lan ara\u00e7lar ve VAC\nekstraktlar\u0131n\u0131n farkl\u0131 preparatlar\u0131, \u00e7al\u0131\u015fmalar aras\u0131ndaki sonu\u00e7lar\u0131n\nkar\u015f\u0131la\u015ft\u0131r\u0131lmas\u0131n\u0131 s\u0131n\u0131rland\u0131rm\u0131\u015ft\u0131r.&nbsp;Sonu\u00e7 olarak, PMS \/ PMDD tedavisi\ni\u00e7in VAC kullanan RCT&#8217;ler, VAC ekstrakt\u0131n\u0131n PMS \/ PMDD semptomlar\u0131n\u0131n tedavisi\ni\u00e7in dikkate al\u0131nacak g\u00fcvenli ve etkili bir alternatif oldu\u011funu ileri\ns\u00fcrd\u00fc.&nbsp;<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">2-)Medicinal\nPlants for the Treatment of Acne Vulgaris: A Review of Recent Evidences<\/h1>\n\n\n\n<h1 class=\"wp-block-heading\">&nbsp;doi:&nbsp;<a href=\"https:\/\/dx.doi.org\/10.5812%2Fjjm.25580\">10.5812\/jjm.25580<\/a><\/h1>\n\n\n\n<h4 class=\"wp-block-heading\"><em>Vitex agnus-castus<\/em>&nbsp;menstr\u00fcasyondan\n\u00f6nce sivilce i\u00e7in kullan\u0131l\u0131r.&nbsp;Hipofiz bezinde folik\u00fcl uyar\u0131c\u0131 ve\nl\u00fcteinizan hormon seviyelerine etki eden t\u00fcm meyve \u00f6z\u00fct\u00fc, dopaminerjik\nmekanizma yoluyla progesteronda bir art\u0131\u015fa ve \u00f6strojen seviyelerinde azalmaya\nneden olarak, adet \u00f6ncesi prolaktin seviyesini d\u00fc\u015f\u00fcrd\u00fc.&nbsp;Alman Komisyonu\nE,&nbsp;akne tedavisi i\u00e7in&nbsp;g\u00fcnl\u00fck 40 mg&nbsp;<em>Vitex agnus-castus<\/em>&nbsp;ekstresi&nbsp;al\u0131m\u0131n\u0131\n\u00f6nerdi&nbsp;.&nbsp;Hamile ve emziren kad\u0131nlar bu bitkiyi\nkullanmamal\u0131d\u0131r.&nbsp;Gastrointestinal rahats\u0131zl\u0131klar ve deri d\u00f6k\u00fcnt\u00fcleri gibi\nolumsuz yan etkiler bildirilmi\u015ftir (&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4740760\/#A25580R63\">63<\/a>&nbsp;,&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4740760\/#A25580R64\">64<\/a>).&nbsp;Geleneksel\nbitkisel ila\u00e7lar\u0131n anti-akne olarak kullan\u0131lmas\u0131na ek olarak, baz\u0131 bitkilerin\nakne bitkisel tedavisi olarak potansiyellerini belirlemek i\u00e7in antibakteriyel\naktiviteleri ara\u015ft\u0131r\u0131lm\u0131\u015ft\u0131r (&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4740760\/#A25580R65\">65<\/a>&nbsp;).&nbsp;Anaerobik\nbir patojen olan&nbsp;<em>P. acnes<\/em>&nbsp;, akne patogenezinde \u00f6nemli bir\nrol oynar ve reaktif oksijen t\u00fcrlerinin (ROS) \u00fcretimini uyararak ve enflamatuar\nve proinflamatuar sitokinlerin sal\u0131nmas\u0131n\u0131 sa\u011flayarak enflamatuar s\u00fcrece\nba\u015flam\u0131\u015f gibi g\u00f6r\u00fcnmektedir&nbsp;<\/h4>\n\n\n\n<h1 class=\"wp-block-heading\">3-)Therapeutic\nEffect of Vitex Agnus Castus in Patients With Premenstrual Syndrome<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">PMID:&nbsp;22359078<br>\nT\u0131bbi tedaviler adet \u00f6ncesi sendrom (PMS) i\u00e7in yayg\u0131n olarak kullan\u0131lmaktad\u0131r,\nancak hepsinde yan etkiler bask\u0131nd\u0131r.&nbsp;Bitkisel ila\u00e7lar\u0131n nadiren yan\netkileri vard\u0131r ve insanlar bunlara kar\u015f\u0131 kimyasal tedavilere g\u00f6re daha fazla\ne\u011filime sahiptir.&nbsp;Bu \u00e7al\u0131\u015fmada, Vitex agnus castus&#8217;un plasebo ile\nkar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda PMS&#8217;li kad\u0131nlar \u00fczerindeki terap\u00f6tik etkisi\nara\u015ft\u0131r\u0131ld\u0131.&nbsp;Bu randomize, plasebo kontroll\u00fc, \u00e7ift k\u00f6r \u00e7al\u0131\u015fmada 134\nse\u00e7ilmi\u015f hastadan PMS hastal\u0131\u011f\u0131na sahip 128 kad\u0131n de\u011ferlendirildi (aktif 62, plasebo\n66).&nbsp;T\u00fcm hastalar \u00e7al\u0131\u015fma \u00f6ncesi premenstr\u00fcel d\u00f6nemde ba\u015f a\u011fr\u0131s\u0131, \u00f6fke,\nsinirlilik, depresyon, meme dolgunlu\u011fu ve \u015fi\u015fkinlik ve timpani hakk\u0131nda bir \u00f6z\nde\u011ferlendirme anketine cevap vermi\u015ftir.&nbsp;K\u0131rk damla Vitex agnus \u00f6z\u00fct\u00fc veya\ne\u015fle\u015fen plasebo, 6 g\u00fcn boyunca art arda 6 d\u00f6ng\u00fc boyunca\nuygulan\u0131r.&nbsp;Hastalar yine 6 adet d\u00f6ng\u00fcs\u00fcnden sonra \u00f6z de\u011ferlendirme\nanketlerine cevap verdiler.&nbsp;De\u011ferlendirme sonucunda ise Vitex agnus, hafif\nve orta derecede PMS semptomlar\u0131n\u0131n hafifletilmesi i\u00e7in etkili ve iyi tolere\nedilen bir tedavi olarak d\u00fc\u015f\u00fcn\u00fclebilir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">4-)The Effects of Vitex\nAgnus-Castus on Menstrual Bleeding: A Systematic Review and Meta-Analysis<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;<a href=\"https:\/\/doi.org\/10.1515\/jcim-2018-0053\" target=\"_blank\" rel=\"noreferrer noopener\">10.1515\/jcim-2018-0053<\/a><\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Giri\u015f Vitex olarak da adland\u0131r\u0131lan Vitex\nagnus-castus, bir\u00e7ok t\u0131bbi \u00f6zelli\u011fe sahip bir bitkidir.&nbsp;Bu sistematik\n\u00e7al\u0131\u015fma, Vitex&#8217;in menstr\u00fcel kanama (birincil sonu\u00e7) ve yan etkileri (ikincil\nsonu\u00e7lar) \u00fczerindeki etkinli\u011finin ve g\u00fcvenli\u011finin kan\u0131tlar\u0131n\u0131\ninceledi.&nbsp;Gere\u00e7 ve y\u00f6ntem Bu sistematik inceleme \u00e7al\u0131\u015fmas\u0131, PICO\n(pop\u00fclasyon, m\u00fcdahale, kontrol ve sonu\u00e7lar) kriterleri izlenmeden Vitex&#8217;in\nmenstr\u00fcel kanama \u00fczerindeki etkisi \u00fczerine yap\u0131lan randomize kontroll\u00fc \u00e7al\u0131\u015fma,\nyar\u0131 deneysel ve \u00e7apraz ge\u00e7i\u015fli t\u00fcm makaleleri incelemi\u015ftir. Kat\u0131l\u0131mc\u0131lar jinekolojik\nbozuklu\u011fu olmayan \u00fcreme \u00e7a\u011f\u0131ndaki kad\u0131nlard\u0131.&nbsp;M\u00fcdahale, Vitex&#8217;in farkl\u0131\ndozlarda tabletler, kaps\u00fcl veya oral damlalar \u015feklinde kullan\u0131m\u0131n\u0131\ni\u00e7ermi\u015ftir.&nbsp;Kontrol grubu plasebo veya mefenamik asit grubunu i\u00e7ermi\u015ftir.&nbsp;Medline\n(PubMed arac\u0131l\u0131\u011f\u0131yla), Scopus, Embase (Ovid arac\u0131l\u0131\u011f\u0131yla), Cochrane\nK\u00fct\u00fcphanesi, Bilimler A\u011f\u0131, Google Akademik, SID, Magiran, Irandoc ve Iranmedex,\nherhangi bir zaman s\u0131n\u0131r\u0131 olmaks\u0131z\u0131n.&nbsp;\u0130ki yazar, makalelerin kalitesini\nba\u011f\u0131ms\u0131z olarak g\u00f6zden ge\u00e7irdi ve Cochrane el kitab\u0131na dayal\u0131 \u00f6nyarg\u0131 riskini\nde\u011ferlendirdi ve anla\u015fmazl\u0131klar \u00fc\u00e7\u00fcnc\u00fc bir ki\u015fiyle tart\u0131\u015fma ve fikir birli\u011fi\nile \u00e7\u00f6z\u00fcld\u00fc.&nbsp;Meta-analiz s\u00fcrekli veriler (menstr\u00fcel kanaman\u0131n ortalamas\u0131)\n\u00fczerinde yap\u0131ld\u0131.&nbsp;Meta-analizde, kar\u015f\u0131la\u015ft\u0131rma grubu tipine g\u00f6re alt grup\nanalizi yap\u0131lm\u0131\u015ft\u0131r.&nbsp;Sonu\u00e7lar Veritabanlar\u0131nda aranan 8,905 makaleden\n8,905 ba\u015fl\u0131k, 720 \u00f6zet, 85 tam metin ve 20 bildiri incelenmi\u015f ve bunlar\u0131n 5\nbildirisi bu \u00e7al\u0131\u015fmaya girmi\u015ftir.\u00c7al\u0131\u015fmaya dahil edilen \u00e7al\u0131\u015fmalarda Vitex&#8217;in\nyan etkileri olarak sadece bulant\u0131 ve kar\u0131n a\u011fr\u0131s\u0131\nbildirilmi\u015ftir.&nbsp;Sonu\u00e7lar Bu \u00e7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131, m\u00fcdahale grubunda Vitex\nt\u00fcketiminin, adet kanamas\u0131 \u00fczerinde plasebo grubuna g\u00f6re anlaml\u0131 bir etkiye\nsahip olmad\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">5-)Comparison of Vitex\nAgnus-Castus Extracts With Placebo in Reducing Menopausal Symptoms: A\nRandomized Double-Blind Study<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;<a href=\"https:\/\/doi.org\/10.4082\/kjfm.18.0067\" target=\"_blank\" rel=\"noreferrer noopener\">10.4082\/kjfm.18.0067<\/a><\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Ama\u00e7:&nbsp;<\/strong>Menopoz\nsemptomlar\u0131n\u0131n kad\u0131nlar\u0131n ya\u015fam kalitesi \u00fczerinde kayda de\u011fer olumsuz etkileri\nvard\u0131r ve bu da \u00e7e\u015fitli terap\u00f6tik se\u00e7enekleri de\u011ferlendirme ihtiyac\u0131n\u0131 hakl\u0131\n\u00e7\u0131kar\u0131r.&nbsp;Bu ara\u015ft\u0131rma, Vitex agnus-castus ekstraktlar\u0131n\u0131n menopoz\nsemptomlar\u0131n\u0131 hafifletmede plasebo ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda etkinli\u011fini\nbelirlemeyi ama\u00e7lam\u0131\u015ft\u0131r.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Y\u00f6ntemler:&nbsp;<\/strong>Bu\n\u00e7al\u0131\u015fma 2017 y\u0131l\u0131nda Kermanshah&#8217;da bir klini\u011fe sevk edilen 52 kad\u0131ndan olu\u015fan\nbir \u00e7al\u0131\u015fma grubuyla randomize kontroll\u00fc \u00e7ift k\u00f6r klinik bir \u00e7al\u0131\u015fmad\u0131r.\nKat\u0131l\u0131mc\u0131lar rastgele olarak iki gruba ayr\u0131ld\u0131: Vitex grubu (26 denek) ve\nplasebo grubu (26 denek) ).&nbsp;Menopoz semptomlar\u0131, m\u00fcdahaleden \u00f6nce ve 8\nhafta sonra Greene \u00d6l\u00e7e\u011fi kullan\u0131larak de\u011ferlendirildi.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Bulgular:&nbsp;<\/strong>M\u00fcdahalenin\nard\u0131ndan Vitex grubunda total menopozal bozukluk, anksiyete ve vazomotor\ndisfonksiyon i\u00e7in ortalama skorlar plasebo grubuna g\u00f6re anlaml\u0131 olarak daha\nd\u00fc\u015f\u00fckt\u00fc (P &lt;0.05).&nbsp;Somatik komplikasyonlar, depresyon ve cinsel i\u015flev\nbozuklu\u011fu de\u011fi\u015fkenlerinin ortalama skorlar\u0131 Vitex ve plasebo gruplar\u0131 aras\u0131nda anlaml\u0131\nfarkl\u0131l\u0131k g\u00f6stermedi (P&gt; 0.05).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Sonu\u00e7:&nbsp;<\/strong>Vitex\nagnus-castus ekstraktlar\u0131n\u0131n bir fito\u00f6strojenik ila\u00e7 olarak uygulanmas\u0131,\nkad\u0131nlarda menopoz semptomlar\u0131n\u0131 hafifletebilir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">6-)Vitex Agnus-Castus\nSafeguards the Lung Against Lipopolysaccharide-Induced Toxicity in Mice<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;<a href=\"https:\/\/doi.org\/10.1111\/jfbc.12750\" target=\"_blank\" rel=\"noreferrer noopener\">10.1111\/jfbc.12750<\/a> <\/li><li><br>\nVitex agnus-castus (VAC, Verbenaceae), geleneksel \u00c7in t\u0131bb\u0131nda antienflamatuar\nbir ajan olarak yayg\u0131n olarak kullan\u0131lmaktad\u0131r.&nbsp;Bu \u00e7al\u0131\u015fma, VAC\nekstrakt\u0131n\u0131n lipopolisakkarit (LPS) kaynakl\u0131 akut akci\u011fer hasar\u0131na kar\u015f\u0131\nkorunma etkinli\u011fini ara\u015ft\u0131rmay\u0131 ama\u00e7lam\u0131\u015ft\u0131r.&nbsp;Sonu\u00e7lar, VAC&#8217;nin LPS&#8217;nin\nneden oldu\u011fu akut akci\u011fer hasar\u0131na kar\u015f\u0131 g\u00fc\u00e7l\u00fc bir koruyucu aktiviteye sahip\noldu\u011funu g\u00f6stermi\u015ftir.&nbsp;VAC ayr\u0131ca laktat dehidrojenaz\u0131n bronkoalveoler\ns\u0131v\u0131daki aktivitesini azaltt\u0131.&nbsp;VAC, LPS ile ind\u00fcklenen inflamatuar\nh\u00fccrelerin akci\u011fer dokusuna infiltrasyonunu iyile\u015ftirdi ve akci\u011ferin\nhistopatolojik lezyonlar\u0131n\u0131 tersine \u00e7evirdi.&nbsp;Ayr\u0131ca VAC, akci\u011ferdeki lipit\nperoksidasyon markerini (malondialdehit) hafifletti\u011finden LPS&#8217;nin neden oldu\u011fu\noksidatif strese kar\u015f\u0131 koydu.&nbsp;VAC, y\u00fcksek s\u00fcperoksit dismutaz aktivitesi\nve akci\u011fer dokusundaki azalm\u0131\u015f glutatyon i\u00e7eri\u011fini artt\u0131rarak antioksidan\naktiviteyi artt\u0131rd\u0131.&nbsp;Toplu olarak, VAC, antioksidan potansiyeli ile LPS\nkaynakl\u0131 akut akci\u011fer hasar\u0131na kar\u015f\u0131 koruyucu bir aktiviteye sahiptir.&nbsp;<\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">PRAT\u0130K UYGULAMALAR: Vitex agnus-castus, \u00e7e\u015fitli\nrahats\u0131zl\u0131klar\u0131n sindirim \u015fikayetleri, akne, romatizmal a\u011fr\u0131lar, adet\nd\u00fczensizlikleri, adet \u00f6ncesi sendrom, infertilite ve hiperprolaktinemi gibi\n\u00e7e\u015fitli ila\u00e7larda kullan\u0131lmaktad\u0131r.&nbsp;Yapraklar\u0131 baharat olarak kullan\u0131l\u0131r\nve meyveler biber yerine kullan\u0131l\u0131r.&nbsp;VAC g\u0131da takviyeleri kad\u0131nlar\ntaraf\u0131ndan psi\u015fik ve somatik adet \u00f6ncesi semptomlara kar\u015f\u0131 kullan\u0131l\u0131r.&nbsp;Bu\n\u00e7al\u0131\u015fman\u0131n bulgular\u0131, VAC ekstrakt\u0131n\u0131n antioksidatif etkileri nedeniyle LPS&#8217;nin\nneden oldu\u011fu akut akci\u011fer hasar\u0131na kar\u015f\u0131 g\u00fc\u00e7l\u00fc koruyucu aktivitesini\ng\u00f6sterebilir.&nbsp;Bu nedenle VAC, akut akci\u011fer hasar\u0131n\u0131 ve oksidatif hasar\u0131n\nneden oldu\u011fu bir\u00e7ok hastal\u0131\u011f\u0131 iyile\u015ftirmek i\u00e7in sa\u011fl\u0131kl\u0131 bir fonksiyonel g\u0131da\nolarak geli\u015ftirilebilir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">7-)The Genus Vitex: A Review<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;<a href=\"https:\/\/doi.org\/10.4103\/0973-7847.120522\" target=\"_blank\" rel=\"noreferrer noopener\">10.4103\/0973-7847.120522<\/a><\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">G\u00f6zden ge\u00e7irme, Vitex cinsine ili\u015fkin 161\nreferans\u0131 i\u00e7erir ve etnofarmakoloji, morfoloji ve mikroskopi, fitokond\u00fckt\u00f6rler,\nfarmakolojik raporlar, klinik \u00e7al\u0131\u015fmalar ve \u00f6nde gelen Vitex t\u00fcrlerinin\ntoksikolojisini i\u00e7erir.&nbsp;U\u00e7ucu ya\u011flar, flavonoidler, iridoid glikozitler,\nditerpenoidler ve liganlar, cinsin fito-bile\u015fenlerinin ana s\u0131n\u0131flar\u0131n\u0131\nolu\u015fturur.&nbsp;Bu cinsin birka\u00e7 t\u00fcr\u00fcn\u00fcn, bunlar aras\u0131nda V. agnus-castus\nLinn&#8217;nin yapraklar\u0131 ve meyveleri t\u0131bbi de\u011feri vard\u0131r.&nbsp;(Verbenaceae)\ngeleneksel olarak kad\u0131n \u015fikayetlerinin tedavisinde kullan\u0131lmaktad\u0131r.&nbsp;V.\nagnus-castus, adet d\u00f6ng\u00fcs\u00fcn\u00fc d\u00fczenlemek, adet \u00f6ncesi semptom gerginli\u011fini ve\nkayg\u0131s\u0131n\u0131 azaltmak, baz\u0131 menopoz semptomlar\u0131n\u0131 tedavi etmek ve hormonal\nkaynakl\u0131 akneleri tedavi etmek i\u00e7in klinik kullan\u0131mda olan bitkisel ila\u00e7lara da\ndahil edilmi\u015ftir.&nbsp;Baz\u0131 t\u00fcrlerin uzun bir kullan\u0131m gelene\u011fine\nra\u011fmen,&nbsp;cins d\u00fczg\u00fcn ara\u015ft\u0131r\u0131lmam\u0131\u015ft\u0131r.&nbsp;Sonu\u00e7 b\u00f6l\u00fcm\u00fcnde, Vitex\nt\u00fcrlerinin gelecekteki kapsam\u0131, \u00e7ok y\u00f6nl\u00fc biyolojik aktivitelerini ve eylem\ntarzlar\u0131n\u0131 olu\u015fturmak amac\u0131yla vurgulanm\u0131\u015ft\u0131r.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">\ud83d\ude0e&nbsp;Systematic Review of\nPremenstrual, Postmenstrual and Infertility Disorders of Vitex Agnus Castus<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;<a href=\"https:\/\/doi.org\/10.19082\/3685\" target=\"_blank\" rel=\"noreferrer noopener\">10.19082\/3685<\/a><\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Giri\u015f:&nbsp;<\/strong>Vitex olarak da adland\u0131r\u0131lan Vitex agnus-castus, uzun yapraklar\u0131, yumu\u015fak\ng\u00f6vdesi, \u00e7i\u00e7ekleri ve olgunla\u015fma tohumlar\u0131 ile Akdeniz b\u00f6lgesine\n\u00f6zg\u00fcd\u00fcr.&nbsp;Bu \u00e7al\u0131\u015fman\u0131n amac\u0131 Vitex agnus-castus&#8217;un adet \u00f6ncesi, adet\nsonras\u0131 ve infertilite bozuklu\u011funa etkisini g\u00f6zden ge\u00e7irmektir.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Y\u00f6ntemler:&nbsp;<\/strong>Bu derleme makalesi PubMed, Medline, Web of Science ve IranMedex\nveritabanlar\u0131ndaki \u00e7al\u0131\u015fmalar\u0131n ara\u015ft\u0131r\u0131lmas\u0131yla yap\u0131lm\u0131\u015ft\u0131r.&nbsp;\u0130lk arama\nstratejisi yakla\u015f\u0131k 87 referans belirledi.&nbsp;Bu \u00e7al\u0131\u015fmada 43 \u00e7al\u0131\u015fma daha\nileri tarama i\u00e7in kabul edildi ve t\u00fcm dahil edilme kriterlerimizi kar\u015f\u0131lad\u0131\n(\u0130ngilizce, tam metin, Vitex agnus-castus&#8217;un terap\u00f6tik etkileri ve esas olarak\n2009-2016 y\u0131llar\u0131 aras\u0131nda).&nbsp;Arama terimleri Vitex agnus-castus, adet\n\u00f6ncesi, adet sonras\u0131, infertilite bozuklu\u011fu \u00f6zellikleri ve farmakolojik\netkilerdi.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Sonu\u00e7:&nbsp;<\/strong>Vitex agnus-castus&#8217;un adet \u00f6ncesi sendromun (PMS) tedavisine katk\u0131da\nbulundu\u011fu g\u00f6sterilmi\u015ftir.&nbsp;Ayr\u0131ca, bu \u00e7al\u0131\u015fman\u0131n sonucu, bu de\u011ferli\nbitkinin postmenstr\u00fcel hastal\u0131ktan kaynaklanan a\u011fr\u0131y\u0131 hafifletmede yard\u0131mc\u0131\noldu\u011funu g\u00f6stermi\u015ftir.&nbsp;Ayr\u0131ca Vitex agnus-castus&#8217;un infertilite\nbozuklu\u011funda yararl\u0131 oldu\u011fu bulunmu\u015ftur.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Sonu\u00e7:&nbsp;<\/strong>Vitex agnus-castus (AC) bir fitoparmas\u00f6tik bile\u015fiktir ve PMS ve PMDD\ntedavisinde yayg\u0131n olarak kullan\u0131ld\u0131\u011f\u0131 g\u00f6sterilmi\u015ftir.&nbsp;Ek olarak, adet\nsonras\u0131 vakalarda yararl\u0131 oldu\u011fu g\u00f6sterilmi\u015ftir ve hem erkeklerde hem de\nkad\u0131nlarda infertilite vakalar\u0131n\u0131n tedavisine katk\u0131da bulunabilir.&nbsp;Bu\nbitkide bulunan dopaminerjik bile\u015fikler, adet \u00f6ncesi mastodini ve adet \u00f6ncesi\nsendromun di\u011fer semptomlar\u0131n\u0131 tedavi etmeye yard\u0131mc\u0131 olur.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">9-)Therapeutic Effect of Vitex Agnus Castus in Patients With\nPremenstrual Syndrome<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>PMID:&nbsp;22359078<\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">T\u0131bbi tedaviler adet \u00f6ncesi sendrom (PMS) i\u00e7in\nyayg\u0131n olarak kullan\u0131lmaktad\u0131r, ancak hepsinde yan etkiler\nbask\u0131nd\u0131r.&nbsp;Bitkisel ila\u00e7lar\u0131n nadiren yan etkileri vard\u0131r ve insanlar\nbunlara kar\u015f\u0131 kimyasal tedavilere g\u00f6re daha fazla e\u011filime sahiptir.&nbsp;Bu\n\u00e7al\u0131\u015fmada, Vitex agnus castus&#8217;un plasebo ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda PMS&#8217;li\nkad\u0131nlar \u00fczerindeki terap\u00f6tik etkisi ara\u015ft\u0131r\u0131ld\u0131.&nbsp;Bu randomize, plasebo\nkontroll\u00fc, \u00e7ift k\u00f6r \u00e7al\u0131\u015fmada 134 se\u00e7ilmi\u015f hastadan PMS hastal\u0131\u011f\u0131na sahip 128\nkad\u0131n de\u011ferlendirildi (aktif 62, plasebo 66).&nbsp;T\u00fcm hastalar \u00e7al\u0131\u015fma \u00f6ncesi\npremenstr\u00fcel d\u00f6nemde ba\u015f a\u011fr\u0131s\u0131, \u00f6fke, sinirlilik, depresyon, meme dolgunlu\u011fu\nve \u015fi\u015fkinlik ve timpani hakk\u0131nda bir \u00f6z de\u011ferlendirme anketine cevap vermi\u015ftir.&nbsp;K\u0131rk\ndamla Vitex agnus \u00f6z\u00fct\u00fc veya e\u015fle\u015fen plasebo, 6 g\u00fcn boyunca art arda 6 d\u00f6ng\u00fc\nboyunca uygulan\u0131r.&nbsp;Hastalar yine 6 adet d\u00f6ng\u00fcs\u00fcnden sonra \u00f6z de\u011ferlendirme\nanketlerine cevap verdiler.&nbsp;Her \u00f6\u011fe g\u00f6rsel bir analog \u00f6l\u00e7ek (VAS)\nkullan\u0131larak derecelendirilmi\u015ftir.&nbsp;Hastalar\u0131n ya\u015f ortalamas\u0131 aktif grupta\n30.77 (SD = 4.37) y\u0131l ve plasebo grubunda 30.89 (SD = 4.02) y\u0131l idi. \u00c7al\u0131\u015fma\ngrubunda ve sonras\u0131nda aktif de\u011fi\u015fken ve plasebo grubunda de\u011fi\u015fkenler aras\u0131nda\nanlaml\u0131 fark vard\u0131 (P &lt;0.0001). plasebo ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda Vitex agnus\nkullan\u0131m\u0131nda \u00f6nemli farkl\u0131l\u0131klar oldu\u011funu fark ettik (P &lt;0.0001).&nbsp;Vitex\nagnus, hafif ve orta derecede PMS semptomlar\u0131n\u0131n hafifletilmesi i\u00e7in etkili ve\niyi tolere edilen bir tedavi olarak d\u00fc\u015f\u00fcn\u00fclebilir.&nbsp;De\u011fi\u015fkenler aras\u0131nda\n\u00e7al\u0131\u015fma \u00f6ncesi ve sonras\u0131 aktif ve plasebo grubunda anlaml\u0131 fark vard\u0131 (P\n&lt;0.0001). Ayr\u0131ca Vitex agnus&#8217;un plasebo ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda anlaml\u0131\nfarklar\u0131 saptad\u0131k (P &lt;0.0001).&nbsp;Vitex agnus, hafif ve orta derecede PMS\nsemptomlar\u0131n\u0131n hafifletilmesi i\u00e7in etkili ve iyi tolere edilen bir tedavi\nolarak d\u00fc\u015f\u00fcn\u00fclebilir.&nbsp;De\u011fi\u015fkenler aras\u0131nda \u00e7al\u0131\u015fma \u00f6ncesi ve sonras\u0131 aktif\nve plasebo grubunda anlaml\u0131 fark vard\u0131 (P &lt;0.0001). Ayr\u0131ca Vitex agnus&#8217;un\nplasebo ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda anlaml\u0131 farklar\u0131 saptad\u0131k (P &lt;0.0001).&nbsp;Vitex\nagnus, hafif ve orta derecede PMS semptomlar\u0131n\u0131n hafifletilmesi i\u00e7in etkili ve\niyi tolere edilen bir tedavi olarak d\u00fc\u015f\u00fcn\u00fclebilir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">10-)Vitex Agnus-Castus Extracts\nfor Female Reproductive Disorders: A Systematic Review of Clinical Trials<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;<a href=\"https:\/\/doi.org\/10.1055\/s-0032-1327831\" target=\"_blank\" rel=\"noreferrer noopener\">10.1055\/s-0032-1327831<\/a><\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Vitex agnus-castus L. (iffet a\u011fac\u0131;\nchasteberry), a\u011f\u0131rl\u0131kl\u0131 olarak Anglo-Amerikan ve Avrupa prati\u011finde \u00e7e\u015fitli\nkad\u0131n \u00fcreme ko\u015fullar\u0131 i\u00e7in kullan\u0131lan pop\u00fcler bir bitkisel tedavidir.&nbsp;Bu\nsistematik derlemenin amac\u0131, kad\u0131n sa\u011fl\u0131\u011f\u0131n\u0131 ara\u015ft\u0131ran randomize, kontroll\u00fc\n\u00e7al\u0131\u015fmalardan Vitex ekstraktlar\u0131n\u0131n etkinli\u011fi ve g\u00fcvenilirli\u011fine ili\u015fkin\nkan\u0131tlar\u0131 de\u011ferlendirmekti. randomize, kontroll\u00fc \u00e7al\u0131\u015fmalar veya klinik\n\u00e7al\u0131\u015fmalar i\u00e7in filtrelerle birlikte.&nbsp;Metodolojik kalite Cochrane \u00f6nyarg\u0131\nve Jadad \u00f6l\u00e7ek riskine ve ayr\u0131ca bitkisel m\u00fcdahaleler hakk\u0131ndaki denemelerin\nraporlanmas\u0131 i\u00e7in CONSORT&#8217;un \u00f6nerilen detay\u0131na g\u00f6re\nde\u011ferlendirildi.&nbsp;kontroll\u00fc \u00e7al\u0131\u015fmalar tan\u0131mlanm\u0131\u015f ve bunlardan 12&#8217;si ara\u015ft\u0131rmaya\ndahil edilmi\u015ftir; bunlardan sekizi adet adet \u00f6ncesi adet sendromu, iki adet\nadet \u00f6ncesi disforik bozukluk ve iki adet gizli hiperprolaktinemidir.&nbsp;Adet\n\u00f6ncesi sendrom i\u00e7in, sekiz \u00e7al\u0131\u015fman\u0131n yedisi Vitex ekstraktlar\u0131n\u0131n plasebo (6\n\u00e7al\u0131\u015fman\u0131n 5&#8217;i), piridoksin (1) ve magnezyum oksitten (1) daha \u00fcst\u00fcn oldu\u011funu\nbulmu\u015ftur.&nbsp;Adet \u00f6ncesi disforik bozuklukta, bir \u00e7al\u0131\u015fma Vitex&#8217;in\nfluoksetine e\u015fde\u011fer oldu\u011funu, di\u011ferinde ise fluoksetin Vitex&#8217;ten daha iyi\nperformans g\u00f6sterdi\u011fini bildirdi.&nbsp;Gizli hiperprolaktinemide, bir \u00e7al\u0131\u015fma\nTRH ile uyar\u0131lan prolaktin salg\u0131lanmas\u0131n\u0131 azaltmak i\u00e7in plasebodan \u00fcst\u00fcn\noldu\u011funu, k\u0131salt\u0131lm\u0131\u015f bir luteal faz\u0131 normalle\u015ftirdi\u011fini, orta luteal\nprogesteronu ve 17p-\u00f6stradiol seviyelerini artt\u0131rd\u0131\u011f\u0131n\u0131, di\u011feri Vitex&#8217;in serum\nprolaktini azaltmak i\u00e7in bromokriptin ile kar\u015f\u0131la\u015ft\u0131r\u0131labilir oldu\u011funu buldu.\nd\u00fczeyleri ve iyile\u015ftirici siklik mastalji.&nbsp;Vitex ile advers olaylar\nhafifti ve genellikle seyrekti.&nbsp;Dahil edilen \u00e7al\u0131\u015fmalar\u0131n metodolojik\nkalitesi de\u011fi\u015fmekle birlikte, genellikle orta ila y\u00fcksek d\u00fczeydeydi.&nbsp;S\u0131n\u0131rlamalar,\nbaz\u0131 \u00e7al\u0131\u015fmalarda k\u00fc\u00e7\u00fck \u00f6rnek boyutlar\u0131, tedavi edilen ko\u015fullar\u0131n heterojenli\u011fi\nve bir dizi referans tedaviyi i\u00e7erir.Baz\u0131 metodolojik s\u0131n\u0131rlamalara ra\u011fmen,\nbug\u00fcne kadar randomize, kontroll\u00fc \u00e7al\u0131\u015fmalardan elde edilen sonu\u00e7lar, adet \u00f6ncesi\nsendrom, adet \u00f6ncesi disforik tedavisinde Vitex \u00f6z\u00fctleri i\u00e7in faydalar\n\u00f6nermektedir.&nbsp;Daha fazla ara\u015ft\u0131rma yap\u0131lmas\u0131 ve gelecekteki denemeler i\u00e7in\nraporlamada daha fazla \u015feffafl\u0131k \u00f6nerilmektedir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">11-)Vitex Agnus-Castus in\nPremenstrual Syndrome: A Meta-Analysis of Double-Blind Randomised Controlled\nTrials<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;<a href=\"https:\/\/doi.org\/10.1016\/j.ctim.2019.08.024\" target=\"_blank\" rel=\"noreferrer noopener\">10.1016 \/ j.ctim.2019.08.024<\/a><\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Chasteberry (Vitex agnus-castus, VAC) birka\u00e7\nklinik \u00e7al\u0131\u015fmada incelenmi\u015f ve adet \u00f6ncesi sendrom (PMS) semptomlar\u0131n\u0131n\nhafifletilmesi i\u00e7in ila\u00e7 olarak mevcut olmas\u0131na ra\u011fmen, meta-analizlerde d\u00fczg\u00fcn\nkarakterize edilmi\u015f preparatlar\u0131n etkinli\u011fi\nde\u011ferlendirilmemi\u015ftir.&nbsp;\u00c7al\u0131\u015fmam\u0131z\u0131n amac\u0131 VAC&#8217;nin PMS&#8217;deki etkinli\u011fini\nde\u011ferlendirmekti.&nbsp;Meta-analiz, CONSORT \u00f6nerileri dikkate al\u0131narak PICOS\nformat\u0131 kullan\u0131larak PRISMA y\u00f6nergelerine uygun olarak\nger\u00e7ekle\u015ftirilmi\u015ftir.&nbsp;PubMed, Embase, Cochrane Kontroll\u00fc Ara\u015ft\u0131rmalar\nMerkezi ve Web of Science VAC ile ilgili \u00e7al\u0131\u015fmalar i\u00e7in\nara\u015ft\u0131r\u0131ld\u0131.&nbsp;Analiz, Toplam Belirti Skorunun veya PMS G\u00fcnl\u00fck skorunun\nazalmas\u0131 g\u00f6z \u00f6n\u00fcne al\u0131nd\u0131\u011f\u0131nda, PMS semptomlar\u0131n\u0131n hafifletilmesi i\u00e7in bir\nplaseboya k\u0131yasla d\u00fczg\u00fcn karakterize edilmi\u015f VAC \u00fcr\u00fcnlerinin etkinli\u011fini\nde\u011ferlendirdi.&nbsp;\u00d6zet g\u00f6reli risk (RR) ve% 95 g\u00fcven aral\u0131\u011f\u0131n\u0131 (CI) hesaplamak\ni\u00e7in rasgele etkiler modeli kullan\u0131lm\u0131\u015ft\u0131r.&nbsp;Yaln\u0131zca bitkisel \u00fcr\u00fcnlerin\nuygun \u015fekilde karakterize edilmesini ama\u00e7layan CONSORT tavsiyelerinin\nkriterlerini kar\u015f\u0131layan randomize, \u00e7ift k\u00f6r, plasebo kontroll\u00fc \u00e7al\u0131\u015fmalar dahil\nedilmi\u015ftir.&nbsp;21 klinik \u00e7al\u0131\u015fmadan \u00fc\u00e7 \u00e7al\u0131\u015fma (520 kad\u0131n) dahil etme\nkriterlerini yerine getirmi\u015f, \u00f6zel \u00f6zler Ze 440 ve BNO 1095&#8217;in etkinli\u011fini PMS\ntedavisi i\u00e7in bir plasebo ile kar\u015f\u0131la\u015ft\u0131rm\u0131\u015ft\u0131r.&nbsp;VAC preparatlar\u0131n\u0131n PMS\nsemptomlar\u0131n\u0131n azalt\u0131lmas\u0131nda etkili oldu\u011fu do\u011fruland\u0131: VAC alan kad\u0131nlar\u0131n\nplasebo alanlara g\u00f6re semptomlar\u0131nda bir remisyon ya\u015fama olas\u0131l\u0131\u011f\u0131 2.57 (% 95\nCI 1.52-4.35) daha fazlayd\u0131.&nbsp;VAC ile birka\u00e7 klinik \u00e7al\u0131\u015fma yap\u0131lm\u0131\u015f\nolmas\u0131na ra\u011fmen,&nbsp;\u00e7al\u0131\u015fmalar\u0131n \u00e7o\u011fu, \u00f6zellikle kullan\u0131lan ilac\u0131n tan\u0131m\u0131 ile\nilgili olarak, eksik raporlamaya ba\u011fl\u0131 olarak etkilili\u011fin kan\u0131t\u0131 olarak\nkullan\u0131lamaz.&nbsp;VAC ekstraktlar\u0131n\u0131n etkinli\u011fini de\u011ferlendirmek i\u00e7in CONSORT\n\u00f6nerilerini takip eden daha fazla deneye ihtiya\u00e7 vard\u0131r.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">12-)Efficacy and Safety of Vitex\nAgnus-Castus Extract for Treatment of Premenstrual Syndrome in Japanese\nPatients: A Prospective, Open-Label Study<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;<a href=\"https:\/\/doi.org\/10.1007\/s12325-014-0106-z\" target=\"_blank\" rel=\"noreferrer noopener\">10.1007 \/ s12325-014-0106-z<\/a><\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Giri\u015f:&nbsp;<\/strong>Vitex agnus-castus (VAC) \u00f6z\u00fc i\u00e7eren bitkisel ila\u00e7 Avrupa&#8217;da adet \u00f6ncesi\nsendromu (PMS) olan kad\u0131nlar taraf\u0131ndan yayg\u0131n olarak kullan\u0131lmaktad\u0131r, ancak\nJaponya&#8217;da klinik kan\u0131tlar\u0131n belirlenmesi gerekmektedir.&nbsp;Bu \u00e7al\u0131\u015fma,\nPMS&#8217;li Japon hastalarda VAC ekstrakt\u0131n\u0131n etkinlik ve g\u00fcvenlilik profillerini\nara\u015ft\u0131rmaya \u00e7al\u0131\u015fm\u0131\u015ft\u0131r.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Y\u00f6ntem:&nbsp;<\/strong>PMS&#8217;li ve 18-44 ya\u015flar\u0131ndaki Japon kad\u0131nlarda \u00e7ok merkezli, prospektif,\na\u00e7\u0131k etiketli, tek kollu, faz 3 bir \u00e7al\u0131\u015fma yap\u0131lm\u0131\u015ft\u0131r.&nbsp;Hastalara, \u00fc\u00e7\nadet adet d\u00f6ng\u00fcs\u00fc i\u00e7in g\u00fcnde bir kez 20 mg VAC \u00f6z\u00fc i\u00e7eren Prefemin\u00ae (Max Zeller\nS\u00f6hne AG, Romanshorn, \u0130svi\u00e7re) verildi.&nbsp;Etkinlik profili, g\u00f6rsel bir\nanalog skala (VAS) ile kaydedilen on PMS semptomlar\u0131-sinirlilik, depresif\nduygudurum, \u00f6fke, ba\u015f a\u011fr\u0131s\u0131, \u015fi\u015fkinlik, g\u00f6\u011f\u00fcs dolgunlu\u011fu, cilt bozuklu\u011fu,\nyorgunluk, uyu\u015fukluk ve uykusuzlu\u011fun yo\u011funlu\u011funa g\u00f6re incelendi.&nbsp;Ayr\u0131ca,\nyan\u0131tlay\u0131c\u0131 oran\u0131, yukar\u0131da belirtilen ilk alt\u0131 semptomun VAS skorlar\u0131n\u0131n\ntoplam\u0131 ile tan\u0131mlanan toplam VAS skoruna g\u00f6re hesaplanm\u0131\u015ft\u0131r.&nbsp;Ayr\u0131ca\nhekimin global de\u011ferlendirme (PGA) skorlar\u0131 kaydedildi.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Bulgular:&nbsp;<\/strong>Altm\u0131\u015f dokuz hasta Prefemin\u00ae ald\u0131.&nbsp;\u0130lk adet d\u00f6ng\u00fcs\u00fcnden sonra, toplam\nVAS skorunda istatistiksel olarak anlaml\u0131 bir d\u00fc\u015f\u00fc\u015f g\u00f6zlendi (P &lt;0.001) ve\nsonraki iki d\u00f6ng\u00fc boyunca skor azalmaya devam etti.&nbsp;On semptom skorunun\nher biri bu \u015fekilde \u00f6nemli \u00f6l\u00e7\u00fcde azald\u0131.&nbsp;Ayr\u0131ca, yan\u0131tlama oran\u0131 zamana\nba\u011fl\u0131 bir \u015fekilde artm\u0131\u015ft\u0131r;&nbsp;\u00fc\u00e7\u00fcnc\u00fc menstr\u00fcel siklustaki oran% 91.0 idi ve\nhastalar\u0131n neredeyse tamam\u0131 semptomsuzdu veya PGA&#8217;ya g\u00f6re sadece hafif\nsemptomlar sergiledi.&nbsp;Sekiz hastada ciddi olmayan advers olaylar g\u00f6zlendi;\nbunlardan biri VAC ile nedensel ili\u015fkisi g\u00f6z ard\u0131 edilmeyen alerjik dermatitti.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Sonu\u00e7:&nbsp;<\/strong>VAC ekstresi, Japon hastalarda \u00f6nemli bir yan etki olmaks\u0131z\u0131n PMS\nsemptomlar\u0131n\u0131 iyile\u015ftirdi.&nbsp;Bu, Japon hastalarda VAC ekstrakt\u0131n\u0131n etkisini\nbildiren ilk \u00e7al\u0131\u015fmad\u0131r.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">13-)Dose-dependent Efficacy of the Vitex Agnus Castus Extract Ze\n440 in Patients Suffering From Premenstrual Syndrome<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;<a href=\"https:\/\/doi.org\/10.1016\/j.phymed.2012.08.006\" target=\"_blank\" rel=\"noreferrer noopener\">10.1016\/j.phymed.2012.08.006<\/a><\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Ama\u00e7:&nbsp;<\/strong>Vitex agnus castus L.&#8217;nin (VAC) preparatlar\u0131n\u0131n d\u00fczensiz adet d\u00f6ng\u00fclerini,\nsiklik mastaljiyi ve adet \u00f6ncesi sendromunun (PMS) semptomlar\u0131n\u0131 tedavi etmek\ni\u00e7in etkili oldu\u011fu g\u00f6sterilmi\u015ftir.&nbsp;Bununla birlikte, PMS tedavisi i\u00e7in\ndoz-etki ili\u015fkisi hen\u00fcz olu\u015fturulmam\u0131\u015ft\u0131r.&nbsp;Bu \u00e7al\u0131\u015fmada PMS hastalar\u0131nda\nplaseboya k\u0131yasla \u00fc\u00e7 farkl\u0131 dozda VAC \u00f6z\u00fc Ze 440&#8217;\u0131n klinik etkileri\nara\u015ft\u0131r\u0131ld\u0131.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Y\u00f6ntemler:&nbsp;<\/strong>\u00c7ok merkezli, \u00e7ift k\u00f6r, plasebo kontroll\u00fc, paralel grup \u00e7al\u0131\u015fmas\u0131nda,\nPMS&#8217;li 162 kad\u0131n hasta (18-45 ya\u015f) plasebo veya farkl\u0131 dozlarda Ze 440 (8, 20\nve 30 mg) \u00fczerine randomize edildi. \u00fc\u00e7 adet d\u00f6ng\u00fcs\u00fc.&nbsp;PMS semptomlar\u0131n\u0131n\n\u015fiddeti, sinirlilik, duygudurum de\u011fi\u015fikli\u011fi, \u00f6fke, ba\u015f a\u011fr\u0131s\u0131, \u015fi\u015fkinlik ve\nmeme dolgunlu\u011fu semptomlar\u0131 a\u00e7\u0131s\u0131ndan g\u00f6rsel analog \u00f6l\u00e7ekler (VAS) kullanan\nhastalar taraf\u0131ndan de\u011ferlendirildi.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Sonu\u00e7lar:&nbsp;<\/strong>Tedavilerin her biri iyi tolere edildi.&nbsp;20 mg grubundaki toplam\nsemptom skorundaki (TSS) iyile\u015fme, plasebo ve 8 mg tedavi grubundan anlaml\u0131\nolarak daha y\u00fcksekti.&nbsp;\u00d6te yandan, 30 mg&#8217;l\u0131k daha y\u00fcksek doz, 20mg\ntedavisine k\u0131yasla semptom \u015fiddetini \u00f6nemli \u00f6l\u00e7\u00fcde azaltmad\u0131 ve 20mg kullan\u0131m\u0131\ni\u00e7in rasyonel bir sa\u011flad\u0131.&nbsp;Tek PMS semptom skorlar\u0131 ile ilgili sonu\u00e7lar\ng\u00f6zlendi.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Sonu\u00e7:&nbsp;<\/strong>Bu \u00e7al\u0131\u015fma, VAC ekstrakt\u0131 Ze 440&#8217;\u0131n 20 mg&#8217;l\u0131k bir dozda uyguland\u0131\u011f\u0131nda PMS\nsemptomlar\u0131n\u0131 hafifletmede etkili oldu\u011funu g\u00f6sterdi.&nbsp;Bu nedenle, PMS&#8217;den\nmuzdarip hastalar i\u00e7in g\u00fcnl\u00fck 20 mg Ze 440 tercih edilmelidir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">14-)Treatment for the Premenstrual Syndrome With Agnus Castus\nFruit Extract: Prospective, Randomised, Placebo Controlled Study<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;<a href=\"https:\/\/doi.org\/10.1136\/bmj.322.7279.134\" target=\"_blank\" rel=\"noreferrer noopener\">10.1136 \/ bmj.322.7279.134<\/a><\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Ama\u00e7:&nbsp;<\/strong>Adet \u00f6ncesi sendromlu kad\u0131nlar i\u00e7in agnus castus meyvesinin (Vitex agnus\ncastus L \u00f6z\u00fc Ze 440) plasebo ile etkinli\u011fini ve tolere edilebilirli\u011fini\nkar\u015f\u0131la\u015ft\u0131rmak.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Tasar\u0131m:&nbsp;<\/strong>\u00dc\u00e7 adet d\u00f6ng\u00fcs\u00fcnde randomize, \u00e7ift k\u00f6r, plasebo kontroll\u00fc, paralel grup\nkar\u015f\u0131la\u015ft\u0131rmas\u0131.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Merkez:&nbsp;<\/strong>Genel t\u0131p topluluk klinikleri.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Kat\u0131l\u0131mc\u0131lar:&nbsp;<\/strong>178 kad\u0131n tarand\u0131 ve 170&#8217;i de\u011ferlendirildi (aktif 86; plasebo\n84).&nbsp;Ortalama ya\u015f 36, ortalama d\u00f6ng\u00fc uzunlu\u011fu 28 g\u00fcn, ortalama adet s\u00fcresi\n4.5 g\u00fcn idi.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Giri\u015fimler:&nbsp;<\/strong>Agnus castus (kuru ekstrakt tabletleri) g\u00fcnde bir tablet veya e\u015fle\u015fen\nplasebo, art arda \u00fc\u00e7 d\u00f6ng\u00fc i\u00e7in verilir.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Ana sonu\u00e7 \u00f6l\u00e7\u00fctleri:&nbsp;<\/strong>Ana etkinlik de\u011fi\u015fkeni: kad\u0131nlar\u0131n sinirlilik, duygudurum de\u011fi\u015fikli\u011fi,\n\u00f6fke, ba\u015f a\u011fr\u0131s\u0131, g\u00f6\u011f\u00fcs dolgunlu\u011fu ve \u015fi\u015fkinlik de dahil olmak \u00fczere di\u011fer\nmenstr\u00fcel semptomlar\u0131n kendi de\u011ferlendirmesinde ba\u015flang\u0131\u00e7tan biti\u015f noktas\u0131na\n(\u00fc\u00e7\u00fcnc\u00fc d\u00f6ng\u00fcn\u00fcn sonu) ge\u00e7i\u015f.&nbsp;\u0130kincil etkinlik de\u011fi\u015fkenleri: klinik global\nizlenimdeki de\u011fi\u015fiklikler (durumun \u015fiddeti, k\u00fcresel iyile\u015fme ve risk veya\nfayda) ve yan\u0131tlay\u0131c\u0131 oran\u0131 (semptomlarda% 50 azalma).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Bulgular:&nbsp;<\/strong>Ana de\u011fi\u015fkendeki iyile\u015fme, aktif grupta plasebo grubuna g\u00f6re daha y\u00fcksekti\n(P \u200b\u200b&lt;0.001).&nbsp;\u0130kincil de\u011fi\u015fkenlerin analizi, \u00fc\u00e7 global izlenim \u00f6\u011fesinin\nher birinde aktif tedavinin \u00f6nemli (P &lt;0.001) \u00fcst\u00fcnl\u00fc\u011f\u00fcn\u00fc\ng\u00f6stermi\u015ftir.&nbsp;Yan\u0131tlay\u0131c\u0131 oranlar\u0131 aktif ve plasebo i\u00e7in s\u0131ras\u0131yla% 52 ve%\n24 idi.&nbsp;Yedi kad\u0131n hafif yan etkiler (d\u00f6rd\u00fc aktif, \u00fc\u00e7 plasebo)\nbildirmi\u015ftir, bunlar\u0131n hi\u00e7biri tedavinin kesilmesine neden olmam\u0131\u015ft\u0131r.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Sonu\u00e7:&nbsp;<\/strong>Agnus castus meyvesinin kuru ekstresi, adet \u00f6ncesi sendromun semptomlar\u0131n\u0131n\nhafifletilmesi i\u00e7in etkili ve iyi tolere edilen bir tedavidir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">15-)Casticin From Vitex Species: A Short Review on Its\nAnticancer and Anti-Inflammatory Properties<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;<a href=\"https:\/\/doi.org\/10.1016\/j.joim.2018.03.001\" target=\"_blank\" rel=\"noreferrer noopener\">10.1016\/j.joim.2018.03.001<\/a><\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Bu k\u0131sa derleme, Vitex t\u00fcrlerinden kastinin\nantikanser ve antienflamatuar \u00f6zelliklerinin bir g\u00fcncellemesini\nsunmaktad\u0131r.&nbsp;Kastisin, \u00fc\u00e7 halkal\u0131 bir polimetilflavon, bir ortokatil\nk\u0131sm\u0131, bir \u00e7ift ba\u011f, iki hidroksil grubu ve d\u00f6rt metoksil\ngrubudur.&nbsp;Casticin, Vitex cinsindeki \u00e7e\u015fitli bitki dokular\u0131ndan izole\nedilmi\u015ftir: V. trifolia&#8217;n\u0131n meyveleri ve yapraklar\u0131, V. agnus-castus&#8217;un hava\npar\u00e7alar\u0131 ve tohumlar\u0131 ve V. negundo yapraklar\u0131.&nbsp;\u00c7al\u0131\u015fmalar, Vitex\nt\u00fcrlerinden kastinin antiproliferatif ve apoptotik aktivitelerini bildirmi\u015ftir.&nbsp;Bile\u015fik,\nfarkl\u0131 molek\u00fcler mekanizmalar yoluyla bir\u00e7ok kanser h\u00fccresi soyuna kar\u015f\u0131\netkilidir.&nbsp;\u00c7al\u0131\u015fmalar ayr\u0131ca, \u00e7e\u015fitli molek\u00fcler mekanizmalar tan\u0131mlanm\u0131\u015f\nolarak, kastisinin antienflamatuar \u00f6zelliklerini teyit etmi\u015ftir.&nbsp;Di\u011fer\nfarmakolojik \u00f6zellikler aras\u0131nda anti-astmatik, trakeospazmolitik,\nanaljezik,&nbsp;antihiperprolaktinemi, imm\u00fcnomod\u00fclat\u00f6r, opioiderjik,\n\u00f6strojenik, anti-anjiyojenik, antiglioma, akci\u011fer hasar\u0131 korumas\u0131, romatoid\nartrit iyile\u015fmesi ve karaci\u011fer fibrozu zay\u0131flatma faaliyetleri.&nbsp;Premenstr\u00fcel\nsendromlu kad\u0131nlar aras\u0131nda V. agnus-castus&#8217;un kastisin a\u00e7\u0131s\u0131ndan zengin meyve\nekstrakt\u0131n\u0131n klinik \u00e7al\u0131\u015fmalar\u0131 ve ticari kullan\u0131m\u0131 k\u0131saca tart\u0131\u015f\u0131lm\u0131\u015ft\u0131r.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">16-)Vitex Agnus Castus in the\nTreatment of Hyperprolactinemia and Menstrual Disorders &#8211; A Case Report<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>PMID:&nbsp;26277178<\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><br>\nHafif hiperprolaktinemi ve menstr\u00fcel bozukluklar\u0131 (oligomenore) olan bir\nhastay\u0131 tan\u0131mlad\u0131k.&nbsp;Laboratuvar testlerinde nispi hipo\u00f6strojenizmi\nsundu.&nbsp;Manyetik rezonanslar hipofiz adenomunun varl\u0131\u011f\u0131n\u0131\nd\u0131\u015flad\u0131.&nbsp;Hasta bir bromokriptin intolerans\u0131 geli\u015ftirdi\u011finden, Vitex Agnus\nCastus (VAC) \u00f6z\u00fct\u00fc eklenmi\u015ftir.&nbsp;VAC tedavisi, semptomlar\u0131n hafifletilmesi\nve hormonal testlerin iyile\u015ftirilmesi ile etkiliydi.&nbsp;VAC ila\u00e7lar\u0131, adet\n\u00f6ncesi sendromu (PMS), mastalji, adet bozukluklar\u0131 ve hafif hiperprolaktinemi tedavisi\ni\u00e7in endikedir.&nbsp;Etki mekanizmas\u0131 tam olarak anla\u015f\u0131lamam\u0131\u015ft\u0131r, ancak\nVAC&#8217;deki diterpenler ve kastacinin dopanierjik aktivitesi ile\nilgilidir.&nbsp;Randomize klinik \u00e7al\u0131\u015fmalar, VAC ekstrakt\u0131n\u0131n\nhiperprolaktinemi, menstr\u00fcel bozukluklar, PMS ve mastalji tedavisinde\netkinli\u011fini ortaya koydu.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">17-)Treatment\nof Premenstrual Syndrome With a Phytopharmaceutical Formulation Containing\nVitex Agnus Castus<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;<a href=\"https:\/\/doi.org\/10.1089\/152460900318515\" target=\"_blank\" rel=\"noreferrer noopener\">10.1089 \/ 152460900318515<\/a><\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Vitex agnus castus (VAC, Vitex) meyvesinin bir\nekstrakt\u0131ndan yeni bir kat\u0131 preparat i\u00e7in rutin t\u0131bbi ko\u015fullar alt\u0131nda \u00e7ok\nsay\u0131da hastada bir ilac\u0131n etkinli\u011fini ve tolerans\u0131n\u0131 ara\u015ft\u0131rmak i\u00e7in \u00e7ok\nmerkezli bir giri\u015fimsel olmayan \u00e7al\u0131\u015fma (kontrols\u00fcz a\u00e7\u0131k \u00e7al\u0131\u015fma) ger\u00e7ekle\u015ftirildi.\n, adet \u00f6ncesi sendromu (PMS) muzdarip 1634 hastada, iffetli a\u011fa\u00e7,\nChasteberry).&nbsp;Vitex&#8217;in psi\u015fik ve somatik \u015fikayetler, d\u00f6rt karakteristik\nPMS semptom kompleksi depresyon, anksiyete, \u00f6zlem ve hiperhidrasyon (DACH) ve\ntek semptom gruplar\u0131 \u00fczerindeki etkisini belirlemek i\u00e7in spesifik bir anket\ngeli\u015ftirilmi\u015ftir.&nbsp;\u00dc\u00e7 adet d\u00f6ng\u00fcs\u00fcn\u00fcn tedavi d\u00f6neminden sonra hastalar\u0131n%\n93&#8217;\u00fc semptom say\u0131s\u0131nda bir azalma veya PMS \u015fikayetlerinin kesilmesi\nbildirmi\u015ftir.&nbsp;Bir \u00f6l\u00e7\u00fcde,&nbsp;bu etki t\u00fcm semptom komplekslerinde g\u00f6zlendi\nve terap\u00f6tik etkinli\u011fin global de\u011ferlendirmesi ile korele\nedildi.&nbsp;Hekimlerin% 85&#8217;i bunu iyi veya \u00e7ok iyi olarak de\u011ferlendirirken,\nhastalar\u0131n% 81&#8217;i tedaviden sonra durumlar\u0131n\u0131 \u00e7ok veya \u00e7ok daha iyi olarak\nde\u011ferlendirdi.&nbsp;Bask\u0131n semptom olarak mastodinin s\u0131kl\u0131\u011f\u0131n\u0131n ve \u015fiddetinin\nanalizi, 3 ayl\u0131k tedaviden sonra hala \u015fikayetlerin daha az \u015fiddetli oldu\u011funu\nortaya koydu.&nbsp;Hastalar\u0131n y\u00fczde doksan d\u00f6rd\u00fc Vitex tedavisinin tolerans\u0131n\u0131\niyi veya \u00e7ok iyi olarak de\u011ferlendirdi.&nbsp;Hastalar\u0131n% 1.2&#8217;sinde doktorlar\ntaraf\u0131ndan advers ila\u00e7 reaksiyonlar\u0131ndan \u015f\u00fcpheleniliyordu, ancak ciddi advers\nila\u00e7 reaksiyonlar\u0131 yoktu.&nbsp;Bu nedenle, yeni Vitex preparat\u0131n\u0131n risk \/ fayda\noran\u0131 \u00e7ok iyi olarak derecelendirilebilir ve PMS&#8217;nin \u00e7ok y\u00f6nl\u00fc ve homojen\nolmayan klinik tablosunun t\u00fcm y\u00f6nleri i\u00e7in \u00f6nemli etkililik<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">18-)Vitex Agnus-Castus for the Treatment of Cyclic Mastalgia: A\nSystematic Review and Meta-Analysis<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;<a href=\"https:\/\/doi.org\/10.1089\/jwh.2019.7770\" target=\"_blank\" rel=\"noreferrer noopener\">10.1089 \/ jwh.2019.7770<\/a><\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Siklik mastalji (CM), adet \u00f6ncesi ve yayg\u0131n\nolarak \u00fcreme y\u0131llar\u0131nda kad\u0131nlar\u0131 etkileyen, adet \u00f6ncesi ve yayg\u0131n meme\na\u011fr\u0131s\u0131d\u0131r.&nbsp;Dopaminin hipofiz bezi \u00fczerindeki yetersiz inhibit\u00f6r etkisi\nnedeniyle latent hiperprolaktinemi ile ili\u015fkili olabilir.&nbsp;Vitex agnus-castus\n(VAC), dopaminerjik aktivitesi ve CM ve latent hiperprolaktinemi \u00fczerindeki\nolas\u0131 etkileri ile bilinir.&nbsp;Bununla birlikte, VAC&#8217;nin CM \u00fczerindeki tedavi\netkisi belirsizli\u011fini korumaktad\u0131r.&nbsp;<strong><em>Gere\u00e7 ve Y\u00f6ntem:<\/em><\/strong>&nbsp;CM\nhastalar\u0131nda VAC tedavisinin etkinli\u011fini bildiren klinik \u00e7al\u0131\u015fmalar\u0131n\nsistematik bir g\u00f6zden ge\u00e7irme ve meta-analizini yapmak i\u00e7in, b\u00fcy\u00fck ara\u015ft\u0131rma\nveritabanlar\u0131nda literat\u00fcr taramas\u0131 yap\u0131ld\u0131.&nbsp;<strong><em>Sonu\u00e7lar:<\/em><\/strong>Bu\nderleme 25 \u00e7al\u0131\u015fmay\u0131 i\u00e7ermektedir (17 randomize kontrol \u00e7al\u0131\u015fmas\u0131 art\u0131 sekiz\nrandomize olmayan \u00e7al\u0131\u015fma).&nbsp;VAC, adet \u00f6ncesi sendromlar\u0131 olan veya olmayan\n\u00fcreme \u00e7a\u011f\u0131ndaki CM hastalar\u0131nda (18-45 ya\u015f) meme a\u011fr\u0131s\u0131 yo\u011funlu\u011funu\nhafifletmede ve artm\u0131\u015f serum prolaktin d\u00fczeyini d\u00fc\u015f\u00fcrmede etkiliydi.&nbsp;Tipik\ndozaj, 3 ay tedavi s\u00fcresi ile 20-40 mg \/ g\u00fcn idi.&nbsp;Konservatif bir meta-analiz\nsadece alt\u0131 \u00e7al\u0131\u015fmay\u0131 i\u00e7eriyordu&nbsp; ve bir\nplasebo \u00fczerinden VAC lehine orta derecede bir etki b\u00fcy\u00fckl\u00fc\u011f\u00fc ortaya\nkoydu.&nbsp;Yedi \u00e7al\u0131\u015fma, VAC&#8217;\u0131n, dopamin agonistleri, steroidal olmayan\nanti-enflamatuar ila\u00e7lar, serotonin geri al\u0131m inhibit\u00f6rleri ve hormonal\nkontraseptifler de dahil olmak \u00fczere CM i\u00e7in farmas\u00f6tik tedavilere daha d\u00fc\u015f\u00fck\nbir alternatif oldu\u011funu g\u00f6sterdi.&nbsp;VAC g\u00fcvenlidir ve sadece hafif ve geri\nd\u00f6n\u00fc\u015f\u00fcml\u00fc yan etkilerle ili\u015fkilidir.&nbsp;Bununla birlikte, \u00e7o\u011fu \u00e7al\u0131\u015fmada\nyanl\u0131l\u0131k riski, yetersiz bilgi nedeniyle belirsizdir.&nbsp;<strong><em>Sonu\u00e7lar:<\/em><\/strong>&nbsp;VAC,\nCM i\u00e7in g\u00fcvenli ve etkili bir tedavi se\u00e7ene\u011fidir.&nbsp;Kan\u0131t taban\u0131n\u0131\ng\u00fc\u00e7lendirmek i\u00e7in daha y\u00fcksek kaliteli klinik \u00e7al\u0131\u015fmalara ihtiya\u00e7 vard\u0131r.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">18-)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Premenstr\u00fcel sendrom (PMS) \u00e7o\u011fu kad\u0131n\u0131 \u00fcreme\nya\u015famlar\u0131 boyunca etkiler.&nbsp;Ba\u015f a\u011fr\u0131s\u0131, PMS&#8217;nin tipik bir belirtisi olarak\nkabul edilir ve adet d\u00f6nemine yak\u0131n, migrenli kad\u0131nlar en k\u00f6t\u00fc migren\nataklar\u0131n\u0131 ya\u015fayabilir.&nbsp;Vitex agnus-castus (VAC), d\u00fcnya \u00e7ap\u0131nda PMS&#8217;yi\ntedavi etmek i\u00e7in ge\u00e7erli bir ara\u00e7 olarak kabul edilen bir fitoparmas\u00f6tik\nbile\u015fiktir.&nbsp;Bu \u00e7al\u0131\u015fman\u0131n amac\u0131, a\u00e7\u0131k etiketli bir klinik g\u00f6zlemle PMS\ni\u00e7in VAC ile tedavi edilen g\u00f6\u00e7men kad\u0131nlarda ba\u015f a\u011fr\u0131s\u0131n\u0131n d\u00fczelip\nd\u00fczelmedi\u011fini ara\u015ft\u0131rmakt\u0131r.&nbsp;PMS&#8217;li migrenli kad\u0131nlar \u00e7al\u0131\u015fmaya al\u0131nd\u0131\n\u200b\u200bve 3 ayl\u0131k bir s\u00fcre i\u00e7in PMS i\u00e7in VAC (40 mg \/ g\u00fcn) tedavisi almalar\u0131\n\u00f6nerildi.&nbsp;Hem PMS hem de ba\u015f a\u011fr\u0131s\u0131 \u00fczerindeki etkiler\nde\u011ferlendirildi.&nbsp;107 kad\u0131ndan 100&#8217;\u00fc PMS i\u00e7in 3 ayl\u0131k tedaviyi\ntamamlad\u0131.&nbsp;Bunlardan 66 kad\u0131n, PMS semptomlar\u0131nda dramatik bir azalma,\n26&#8217;s\u0131nda hafif bir azalma ve 8&#8217;inin hi\u00e7bir etkisi olmad\u0131\u011f\u0131n\u0131\nbildirdi.&nbsp;Migren ile ilgili olarak, hastalar\u0131n% 42&#8217;si ayl\u0131k atak\ns\u0131kl\u0131\u011f\u0131nda% 50&#8217;den daha fazla azalma ya\u015fad\u0131 ve hastalar\u0131n% 57&#8217;si ba\u015f a\u011fr\u0131s\u0131\nolan ayl\u0131k g\u00fcnlerde% 50&#8217;den daha fazla azalma ya\u015fad\u0131.&nbsp;Hi\u00e7bir hasta dikkate\nde\u011fer yan etkiler bildirmedi.&nbsp;Sonu\u00e7lar\u0131m\u0131z\u0131 do\u011frulamak i\u00e7in plasebo\nkontroll\u00fc bir \u00e7al\u0131\u015fma yap\u0131lmas\u0131n\u0131 beklerken, PMS&#8217;den etkilenen g\u00f6\u00e7men\nkad\u0131nlarda VAC kullan\u0131m\u0131n\u0131n g\u00fcvenli ve iyi tolere edildi\u011fini ve migren ataklar\u0131n\u0131n\ns\u0131kl\u0131\u011f\u0131n\u0131 ve s\u00fcresini olumlu y\u00f6nde etkileyebilece\u011fini g\u00f6zlemledik.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">19-)Treatment of Moderate to\nSevere Premenstrual Syndrome With Vitex Agnus Castus (BNO 1095) in Chinese\nWomen<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;<a href=\"https:\/\/doi.org\/10.3109\/09513591003632126\" target=\"_blank\" rel=\"noreferrer noopener\">10.3109 \/ 09513591003632126<\/a><\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Ama\u00e7:&nbsp;<\/strong>Orta ila \u015fiddetli adet \u00f6ncesi sendromu (PMS) olan \u00c7inli kad\u0131nlar\u0131n\ntedavisinde Vitex agnus castus (VAC, BNO 1095) ekstresinin etkinli\u011fini\nde\u011ferlendirmek.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Y\u00f6ntemler:&nbsp;<\/strong>\u00c7inli kad\u0131nlarda prospektif randomize \u00e7ift k\u00f6r plasebo kontroll\u00fc bir\n\u00e7al\u0131\u015fmad\u0131r.&nbsp;Uygun hastalar rastgele olarak VAC veya plasebo grubuna\nayr\u0131ld\u0131.&nbsp;Semptomlar, d\u00f6rt semptom fakt\u00f6r\u00fcne (negatif etki, su tutma, g\u0131da\nistekleri ve a\u011fr\u0131) sahip g\u00fcnl\u00fck bir derecelendirme skalas\u0131 ile belgelenmi\u015ftir.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Bulgular:&nbsp;<\/strong>Altm\u0131\u015f yedi hasta kaydedildi ve g\u00fcnde bir kez bir tablet VAC veya plasebo\nalmak \u00fczere rastgele atand\u0131.&nbsp;Premenstr\u00fcel sendrom g\u00fcnl\u00fc\u011f\u00fc (PMSD) toplam\nskoru, tedavi grubunda 3. d\u00f6ng\u00fcde ba\u015flang\u0131\u00e7ta 29.38 +\/- 7.63 puandan 4.28 +\/-\n5.76&#8217;ya d\u00fc\u015ferken, 28.76 +\/- 8.23&#8217;den 11.79 +\/- 11.78&#8217;e d\u00fc\u015ft\u00fc plasebo\ngrubunda.&nbsp;D\u00f6rt semptom fakt\u00f6r\u00fc skorunun hepsi 3. tedavi d\u00f6ng\u00fcs\u00fc ile \u00f6nemli\n\u00f6l\u00e7\u00fcde azalm\u0131\u015ft\u0131r.&nbsp;D\u00f6ng\u00fc 3&#8217;te iki grup aras\u0131nda PMSD toplam skoru, negatif\netki skoru ve su tutma a\u00e7\u0131s\u0131ndan anlaml\u0131 fark vard\u0131 (P &lt;0.05).&nbsp;PMSD\ntoplam skorlar\u0131% 60 azalm\u0131\u015f, etkililik olarak tan\u0131mlanm\u0131\u015f ve tedavi grubunda\netkinlik oran\u0131, 3. tedavi d\u00f6ng\u00fcs\u00fcnde plasebo grubundakinden anlaml\u0131 derecede\ny\u00fcksek bulunmu\u015ftur.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Sonu\u00e7:&nbsp;<\/strong>Vitex agnus castus ekstresi BNO 1095, \u00c7inli kad\u0131nlarda orta ila \u015fiddetli\nPMS tedavisinde, \u00f6zellikle olumsuz etki ve su tutma semptomlar\u0131nda etkili\noldu\u011funu g\u00f6stermektedir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">20-)Psychic Aspects of the Premenstrual Dysphoric Disorders. New\nTherapeutic Strategies: Our Experience With Vitex Agnus Castus<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>PMID:&nbsp;21654609<\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Ama\u00e7:&nbsp;<\/strong>Premenstr\u00fcel disforik bozukluk (PMDD), premenstr\u00fcel faz\u0131n ana sorunlar\u0131ndan\nbiridir.&nbsp;Hastalar\u0131n istihdam kapsam\u0131n\u0131, sosyal ve psiko-duygusal a\u00e7\u0131dan\nbazen ge\u00e7ersiz k\u0131lan ve bu nedenle m\u00fcmk\u00fcn oldu\u011funca ayr\u0131nt\u0131l\u0131 ve do\u011fru bir\nte\u015fhis ve tedavi yakla\u015f\u0131m\u0131 gerektiren semptomlardan olu\u015fur.&nbsp;Bu hastal\u0131k\ni\u00e7in mevcut terap\u00f6tik stratejiler \u00e7oktur, ancak son zamanlarda Vitex agnus\ncastus (VAC) \u00fczerinde durulmu\u015ftur;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Y\u00f6ntem ve sonu\u00e7lar:&nbsp;<\/strong>\u00c7al\u0131\u015fmam\u0131z PMDD&#8217;den muzdarip bir grup hastay\u0131 ve VAC ile tedavinin klinik\netkinli\u011fini de\u011ferlendirdi (ve fluoksetin ile tedavi edilen daha homojen bir\nhasta grubunun sonu\u00e7lar\u0131n\u0131n etkinli\u011fini kar\u015f\u0131la\u015ft\u0131rd\u0131).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Sonu\u00e7:&nbsp;<\/strong>Bu \u00e7al\u0131\u015fma literat\u00fcrde VAC tedavisinin hi\u00e7bir yan etkisi olmaks\u0131z\u0131n\netkinli\u011fine ili\u015fkin bildirilen verileri do\u011frulamaktad\u0131r.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">21-)Treatment\nof Premenstrual Tension Syndrome With Vitex Agnus Castus Controlled,\nDouble-Blind Study Versus Pyridoxine<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;<a href=\"https:\/\/doi.org\/10.1016\/s0944-7113(97)80066-9\" target=\"_blank\" rel=\"noreferrer noopener\">10.1016 \/ S0944-7113 (97) 80066-9<\/a><\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Bu \u00e7al\u0131\u015fman\u0131n amac\u0131, \u00fc\u00e7 tedavi d\u00f6ng\u00fcs\u00fc (Vitex\nagnus) d\u00f6nemi boyunca PMTS&#8217;li kad\u0131nlarda piridoksine kar\u015f\u0131 randomize, kontroll\u00fc\nbir \u00e7al\u0131\u015fmada yeni bir kat\u0131 form\u00fclasyonunun (kaps\u00fcller) Agnolyt\u00ae (*)\netkinli\u011fini ve tolere edilebilirli\u011fini belirlemekti.&nbsp;Terap\u00f6tik yan\u0131t, adet\n\u00f6ncesi gerginlik sendromu \u00f6l\u00e7e\u011fi (PMTS \u00f6l\u00e7e\u011fi), sendromun alt\u0131 karakteristik\n\u015fikayetinin kaydedilmesi ve klinik global izlenim \u00f6l\u00e7e\u011fi (CGI \u00f6l\u00e7e\u011fi)\nkullan\u0131larak de\u011ferlendirildi.&nbsp;\u00c7al\u0131\u015fman\u0131n tamamlanmas\u0131n\u0131n ard\u0131ndan,\ntedavinin etkinli\u011fi hem hekim hem de hasta taraf\u0131ndan\nde\u011ferlendirildi.Piridoksin ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, VAC meme hassasiyeti,\n\u00f6dem, i\u00e7 gerginlik, ba\u015f a\u011fr\u0131s\u0131, kab\u0131zl\u0131k ve depresyon gibi tipik PMTS\n\u015fikayetlerinin belirgin \u015fekilde daha belirgin bir \u015fekilde azalmas\u0131na neden\noldu.&nbsp;CGI \u00f6l\u00e7e\u011fi ile benzer sonu\u00e7lar elde edildi.&nbsp;Her iki tedavi\ngrubunda da etkinlik, ara\u015ft\u0131rmac\u0131lar\u0131n% 80&#8217;inden fazlas\u0131 taraf\u0131ndan en az\u0131ndan\nyeterli olarak derecelendirilmi\u015ftir;&nbsp;bununla birlikte VAC tedavisi,\nara\u015ft\u0131rmac\u0131lar\u0131n% 24.5&#8217;i ile m\u00fckemmel ve piridoksin tedavisi% 12.1&#8217;i ile\nderecelendirilmi\u015ftir.&nbsp;Hastalar\u0131n de\u011ferlendirmesine g\u00f6re, VAC grubundaki\nvakalar\u0131n% 36.1&#8217;i ve piridoksin grubundaki% 21.3&#8217;\u00fc \u015fikayeti yoktu.&nbsp;B6\nalt\u0131ndaki 5 hastada ve VAC alt\u0131ndaki 12 hastada advers olaylar\n(gastrointestinal ve alt kar\u0131n \u015fikayetleri, cilt belirtileri ve ge\u00e7ici ba\u015f\na\u011fr\u0131s\u0131) meydana geldi.&nbsp;Ciddi yan etkiler g\u00f6zlenmedi.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">22-)A Vitex Agnus-Castus Extract\nInhibits Cell Growth and Induces Apoptosis in Prostate Epithelial Cell Lines<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;<a href=\"https:\/\/doi.org\/10.1055\/s-2005-871235\" target=\"_blank\" rel=\"noreferrer noopener\">10.1055 \/ s-2005-871235<\/a><\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Vitex agnus-castus meyvelerinin (VACF)\nekstraktlar\u0131n\u0131n hiperprolaktinemi (d\u00f6ng\u00fc bozukluklar\u0131, adet \u00f6ncesi sendromu)\nile ilgili bozukluklar \u00fczerinde yararl\u0131 etkileri oldu\u011fu\na\u00e7\u0131klanmaktad\u0131r.&nbsp;Bir VACF ekstresinin son zamanlarda farkl\u0131 insan kanser\nh\u00fccre dizilerinde antit\u00fcm\u00f6r aktiviteleri sergiledi\u011fi g\u00f6sterilmi\u015ftir.&nbsp;Bu\n\u00e7al\u0131\u015fmada, bir VACF ekstrakt\u0131n\u0131n apoptozu ind\u00fckleyen ve potansiyel sitotoksik\netkilere odaklanan antiproliferatif etkilerini ara\u015ft\u0131rd\u0131k.&nbsp;Farkl\u0131 hastal\u0131k\na\u015famalar\u0131n\u0131 ve androjen duyarl\u0131l\u0131\u011f\u0131n\u0131 temsil eden \u00fc\u00e7 farkl\u0131 insan prostat\nepitel h\u00fccre hatt\u0131 (BPH-1, LNCaP, PC-3) se\u00e7ilmi\u015ftir.&nbsp;VACF&#8217;nin h\u00fccre\ncanl\u0131l\u0131\u011f\u0131 \u00fczerindeki etkisi, WST-8-tetrazolium deneyi kullan\u0131larak\nde\u011ferlendirildi.&nbsp;Tek ba\u015f\u0131na veya bir pan-kaspaz inhibit\u00f6r\u00fc (Z-VAD-fmk) ile\nkombinasyon halinde VACF alan h\u00fccrelerdeki h\u00fccre proliferasyonu, bir Crystal\nViolet deneyi kullan\u0131larak nicelendirildi.&nbsp;Apoptoz ind\u00fcksiyonunu incelemek\ni\u00e7in ak\u0131\u015f sitometrik h\u00fccre d\u00f6ng\u00fcs\u00fc analizi ve bir ELISA y\u00f6ntemi kullan\u0131larak\nDNA fragmantasyonunun \u00f6l\u00e7\u00fclmesi kullan\u0131ld\u0131.&nbsp;Laktat dehidrojenaz (LDH)\naktivitesi, sitotoksisitenin bir belirteci olarak\nbelirlenmi\u015ftir.&nbsp;Ekstrakt, 48 saat boyunca i\u015flemden sonra 10 mikrog \/\nmL&#8217;nin alt\u0131ndaki IC (50) de\u011ferleri ile konsantrasyona ba\u011fl\u0131 bir \u015fekilde \u00fc\u00e7\nh\u00fccre hatt\u0131n\u0131n \u00e7o\u011funun proliferasyonunu inhibe etti.&nbsp;H\u00fccre d\u00f6ng\u00fcs\u00fc analizi\nve DNA par\u00e7alanma deneyleri, h\u00fccrelerin bir k\u0131sm\u0131n\u0131n apoptoz ge\u00e7irdi\u011fini\nd\u00fc\u015f\u00fcnd\u00fcrmektedir.&nbsp;H\u00fccre say\u0131s\u0131nda VACF&#8217;nin neden oldu\u011fu azalma, kaspaza\nba\u011fl\u0131 bir apoptotik h\u00fccre \u00f6l\u00fcm\u00fcn\u00fc g\u00f6steren Z-VAD-fmk taraf\u0131ndan k\u0131smen inhibe\nedildi.&nbsp;Bununla birlikte, VACF ile tedavi edilen h\u00fccrelerin konsantrasyona\nba\u011fl\u0131 LDH aktivitesi sitotoksik etkileri de g\u00f6sterdi.&nbsp;Bu veriler VACF&#8217;nin\ninsan prostat epitel h\u00fccre dizilerinde proliferasyonu inhibe eden ve apoptozu\nind\u00fckleyen bile\u015fenler i\u00e7erdi\u011fini d\u00fc\u015f\u00fcnd\u00fcrmektedir.&nbsp;Ekstrakt sadece iyi\nhuylu prostat hiperplazisinin de\u011fil, ayn\u0131 zamanda insan prostat kanserinin\n\u00f6nlenmesi ve \/ veya tedavisi i\u00e7in de yararl\u0131 olabilir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">23-)Effects of a Combination of\nHypericum Perforatum and Vitex Agnus-Castus on PMS-like Symptoms in\nLate-Perimenopausal Women: Findings From a Subpopulation Analysis<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;<a href=\"https:\/\/doi.org\/10.1089\/acm.2008.0539\" target=\"_blank\" rel=\"noreferrer noopener\">10.1089\/acm.2008.0539<\/a><\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Menopoza tipik olarak atfedilen baz\u0131 semptomlar\u0131n, menopozdan ziyade adet\n\u00f6ncesi sendromla (PMS) daha fazla ili\u015fkili olabilece\u011fi, \u00e7\u00fcnk\u00fc perimenopozal\nkad\u0131nlar\u0131n PMS benzeri semptomlara daha yatk\u0131n oldu\u011fu veya en az\u0131ndan daha az\niyi tolere edildi\u011fi g\u00f6r\u00fclm\u00fc\u015ft\u00fcr. .<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Ama\u00e7:&nbsp;<\/strong>Bu \u00e7al\u0131\u015fman\u0131n amac\u0131, perimenopozal kad\u0131nlarda PMS benzeri semptomlar\u0131n\ntedavisinde Hypericum perforatum (St.John&#8217;s wort) ve Vitex agnus-castus&#8217;un&nbsp; bir kombinasyonunu i\u00e7eren bir fitoterap\u00f6tik\nm\u00fcdahalenin etkinli\u011fini de\u011ferlendirmekti. .<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Tasar\u0131m:&nbsp;<\/strong>Menopoza ba\u011fl\u0131 semptomlar \u00fczerinde 16 hafta boyunca \u00e7ift k\u00f6r, randomize,\nplasebo kontroll\u00fc bir paralel \u00e7al\u0131\u015fma ger\u00e7ekle\u015ftirildi.&nbsp;PMS benzeri\nsemptomlara ili\u015fkin veriler, bu \u00e7al\u0131\u015fmaya kat\u0131lan ge\u00e7 perimenopozal kad\u0131nlar\u0131n\nk\u00fc\u00e7\u00fck bir alt grubundan (n = 14) 4 haftal\u0131k aral\u0131klarla\ntoplanm\u0131\u015ft\u0131r.&nbsp;Birincil sonlan\u0131m noktas\u0131, PMS-A (anksiyete), PMS-D\n(depresyon), PMS-H (hidrasyon) ve PMS-C (istek) alt k\u00fcmelerini i\u00e7eren Abrahams\nMenstr\u00fcel Semptomlar Anketi&#8217;nde \u00f6l\u00e7\u00fclen PMS skorlar\u0131d\u0131r.&nbsp;Bitkisel\nkombinasyon tedavisi veya plasebo tabletleri g\u00fcnde iki kez uyguland\u0131.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Bulgular:&nbsp;<\/strong>16 haftal\u0131k tedavi a\u015famas\u0131n\u0131n sonunda, kovaryans analizleri bitkisel\nkombinasyonun toplam PMS benzeri skorlar (p = 0.02), PMS-D (p = 0.006) ve PMS-C\ni\u00e7in plasebodan \u00fcst\u00fcn oldu\u011funu g\u00f6sterdi.&nbsp;Aktif tedavi grubu, e\u015fle\u015ftirilmi\u015f\nnumuneler t testleri kullan\u0131larak anksiyete (p = 0.003) ve hidrasyon (p =\n0.002) k\u00fcmelerinde \u00f6nemli azalmalar g\u00f6sterdi.&nbsp;Trend analizlerinin\nsonu\u00e7lar\u0131, toplam klinik PMS ve t\u00fcm alt \u00f6l\u00e7ekler i\u00e7in be\u015f a\u015famada t\u00fcm\u00fc klinik\nolarak beklenen y\u00f6nde \u00f6nemli tedavi grubu etkileri g\u00f6stermi\u015ftir.&nbsp;Plasebo\ngrubunda belirgin bir e\u011filim g\u00f6r\u00fclmemi\u015ftir.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Sonu\u00e7lar:&nbsp;<\/strong>Bu sonu\u00e7lar, perimenopozal kad\u0131nlarda PMS benzeri semptomlarda bu\nfitoterap\u00f6tik kombinasyon i\u00e7in potansiyel olarak \u00f6nemli bir klinik uygulama\noldu\u011funu d\u00fc\u015f\u00fcnd\u00fcrmektedir.&nbsp;Bu semptomlar\u0131n ara\u015ft\u0131r\u0131lmas\u0131na y\u00f6nelik\nrandomize, kontroll\u00fc bir \u00e7al\u0131\u015fma ile daha fazla ara\u015ft\u0131rma yap\u0131lmas\u0131 gerekmektedir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">24-)Herbal Medicine for the Management of Polycystic Ovary\nSyndrome (PCOS) and Associated Oligo\/Amenorrhoea and Hyperandrogenism; A Review\nof the Laboratory Evidence for Effects With Corroborative Clinical Findings<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;<a href=\"https:\/\/doi.org\/10.1186\/1472-6882-14-511\" target=\"_blank\" rel=\"noreferrer noopener\">10.1186\/1472-6882-14-511<\/a><\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Polikistik over sendromu (PCOS), d\u00fczensiz adet d\u00f6ng\u00fcs\u00fc, hirsutizm, akne ve\ninfertilite semptomlar\u0131na yol a\u00e7an polikistik yumurtal\u0131klar, kronik anov\u00fclasyon\nve hiperandrojenizm ile karakterize yayg\u0131n, karma\u015f\u0131k bir endokrin\nbozukluktur.&nbsp;Kan\u0131ta dayal\u0131 t\u0131bbi y\u00f6netim, geleneksel farmas\u00f6tik tedavi tek\nsemptomlar\u0131 ele ald\u0131\u011f\u0131ndan, kontrendike olabilece\u011finden, genellikle yan\netkilerle ili\u015fkili oldu\u011fundan ve baz\u0131 durumlarda etkili olmad\u0131\u011f\u0131ndan PCOS i\u00e7in\nmultidisipliner bir yakla\u015f\u0131m\u0131 vurgular.&nbsp;Ayr\u0131ca PKOS&#8217;lu kad\u0131nlar,\nalternatif tedaviler i\u00e7in g\u00fc\u00e7l\u00fc bir istek duyduklar\u0131n\u0131 ifade\netmi\u015flerdir.&nbsp;Bu derlemede alternatif bir tedavi olan bitkisel ila\u00e7 i\u00e7in\nPCOS&#8217;ta \u00fcreme endokrin etkileri incelenmi\u015ftir.&nbsp;Bu derlemenin amac\u0131 hem\nklinik \u00f6ncesi hem de klinik ara\u015ft\u0131rmalardan elde edilen tutarl\u0131 kan\u0131tlar\u0131\ntan\u0131mlamak,<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Y\u00f6ntemler:&nbsp;<\/strong>Bilimsel literat\u00fcrde iki ara\u015ft\u0131rma yapt\u0131k.&nbsp;\u0130lk ara\u015ft\u0131rma oligo \/\namenore, hiperandrojenizm ve PCOS&#8217;taki t\u00fcm bitkisel ekstraktlar\u0131n \u00fcreme\nendokrin etkilerini a\u00e7\u0131klayan klinik \u00f6ncesi ara\u015ft\u0131rmalar\u0131\nara\u015ft\u0131rm\u0131\u015ft\u0131r.&nbsp;\u0130lk aramadan elde edilen bitkisel ila\u00e7lar, ikinci arama\ni\u00e7in anahtar kelimeleri bilgilendirdi.&nbsp;\u0130kinci ara\u015ft\u0131rma, laboratuvar\nbulgular\u0131n\u0131 do\u011frulayan klinik ara\u015ft\u0131rmalar arad\u0131.&nbsp;Hastalar PKOS&#8217;lu\nkad\u0131nlar, adet d\u00fczensizlikleri ve hiperandrojenizmi i\u00e7eriyordu.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Sonu\u00e7lar:&nbsp;<\/strong>Bu \u00e7al\u0131\u015fmaya toplam 33 \u00e7al\u0131\u015fma dahil edilmi\u015ftir.&nbsp;On sekiz klinik\n\u00f6ncesi \u00e7al\u0131\u015fma, etki mekanizmalar\u0131 ve on be\u015f klinik \u00e7al\u0131\u015fma, sekiz randomize\nkontroll\u00fc \u00e7al\u0131\u015fma da dahil olmak \u00fczere klinik \u00f6ncesi bulgular\u0131 ve adet\nd\u00fczensizlikleri, hiperandrojenizmi ve \/ veya PCOS&#8217;u olan 762 kad\u0131n\u0131\ndestekledi.&nbsp;M\u00fcdahaleler aras\u0131nda Vitex agnus-castus, Cimicifuga racemosa,\nTribulus terrestris, Glycyrrhiza spp., Paeonia lactiflora ve Cinnamomum\ncassia&#8217;n\u0131n bitkisel \u00f6zleri vard\u0131.&nbsp;Endokrin sonu\u00e7lar\u0131, azalt\u0131lm\u0131\u015f luteinize\nedici hormon (LH), prolaktin, a\u00e7l\u0131k ins\u00fclin ve testosteronu\ni\u00e7ermi\u015ftir.&nbsp;PKOS&#8217;ta yumurtlaman\u0131n d\u00fczenlenmesi, geli\u015fmi\u015f metabolik hormon\nprofili ve do\u011furganl\u0131k sonu\u00e7lar\u0131n\u0131n iyile\u015fmesi i\u00e7in kan\u0131tlar vard\u0131.&nbsp;\u0130ki\nbitkisel ilac\u0131n ve bromokriptin (ve Vitex agnus-castus) ve klomifen sitrat\u0131n\n(ve Cimicifuga racemosa) farmas\u00f6tik ajanlar\u0131n\u0131n e\u015fde\u011fer bir etkisi oldu\u011funa\ndair kan\u0131tlar vard\u0131.&nbsp;Spirinolakton ve Glycyrrhiza spp&#8217;in tamamlay\u0131c\u0131\nkombinasyonu i\u00e7in daha az sa\u011flam kan\u0131t vard\u0131.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Sonu\u00e7lar:&nbsp;<\/strong>Preklinik ve klinik \u00e7al\u0131\u015fmalar, alt\u0131 bitkisel ilac\u0131n oligo \/ amenore,\nhiperandrojenizm ve PKOS&#8217;lu kad\u0131nlar i\u00e7in faydal\u0131 etkileri olabilece\u011fine dair\nkan\u0131tlar sunmaktad\u0131r.&nbsp;Ancak klinik \u00f6ncesi verilerin miktar\u0131 s\u0131n\u0131rl\u0131yd\u0131 ve\nklinik kan\u0131tlar\u0131n kalitesi de\u011fi\u015fkendi.&nbsp;Bu incelemede yer almayan bitkisel\nila\u00e7lar\u0131n mevcut klinik kan\u0131tlarla ancak klinik \u00f6ncesi verilerin yoklu\u011funda\netkilerini a\u00e7\u0131klamak i\u00e7in daha ileri klinik \u00e7al\u0131\u015fmalara ihtiya\u00e7 vard\u0131r.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">25-)A Comprehensive Review of Clinical Studies With Herbal Medicine\non Polycystic Ovary Syndrome<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;<a href=\"https:\/\/doi.org\/10.1007\/s40199-019-00312-0\" target=\"_blank\" rel=\"noreferrer noopener\">10.1007\/s40199-019-00312-0<\/a><\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Polikistik over sendromu (PCOS), hem metabolik hem de \u00fcreme bozukluklar\u0131\nile karakterize s\u0131k g\u00f6r\u00fclen bir t\u0131bbi durumdur.&nbsp;PCOS i\u00e7in farkl\u0131\nfarmas\u00f6tik tedaviler \u00f6nerilmi\u015ftir.&nbsp;Bununla birlikte, uzun s\u00fcreli\ntedavilerin yan etkileri ve olas\u0131 d\u00fc\u015f\u00fck etkinli\u011fi, tamamlay\u0131c\u0131 ve alternatif\ntedavileri de\u011ferli bir se\u00e7enek haline getirmi\u015ftir.&nbsp;Son raporlar,\ntamamlay\u0131c\u0131 tedavilerin kullan\u0131m\u0131n\u0131n artt\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir.&nbsp;Tamamlay\u0131c\u0131\nt\u0131bb\u0131n bir par\u00e7as\u0131 olarak bitkisel ila\u00e7, geleneksel Fars ve \u00c7in t\u0131bb\u0131nda\ntan\u0131t\u0131ld\u0131.&nbsp;\u015eifal\u0131 otlar PCOS hastalar\u0131n\u0131n jinekolojik ve infertilite\nproblemlerinin tedavisinde uzun s\u00fcredir kullan\u0131lmaktad\u0131r.&nbsp;Bu \u00e7al\u0131\u015fmada\nd\u00fcnya \u00e7ap\u0131nda PCOS i\u00e7in kullan\u0131lan bitkisel ila\u00e7lar\u0131 g\u00f6zden ge\u00e7irmeyi\nama\u00e7lad\u0131k.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Y\u00f6ntemler:&nbsp;<\/strong>PubMed, Embase, Cochrane ve Scopus veritabanlar\u0131, ilgili anahtar kelimelere\ng\u00f6re klinik denemeler ve Randomize Kontroll\u00fc Denemeler i\u00e7in\nara\u015ft\u0131r\u0131lm\u0131\u015ft\u0131r.&nbsp;Veriler 1990&#8217;dan 2019&#8217;a kadar topland\u0131.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Sonu\u00e7lar:&nbsp;<\/strong>\u00c7ok say\u0131da \u00e7al\u0131\u015fmaya g\u00f6re, PCOS&#8217;un \u00e7e\u015fitli y\u00f6nlerini iyile\u015ftirmek i\u00e7in\ngeni\u015f bir bitki yelpazesi kullan\u0131labilir.&nbsp;Cinnamomum verum, Trigonella foenum-graecum\nL. ve Vitex agnus-castus gibi otlar, adet ve yumurtlama bozukluklar\u0131, obezite,\nins\u00fclin direnci, lipit-metabolizma disfonksiyonu ve androjen fazlal\u0131\u011f\u0131 ile\nilgili durumlar\u0131 etkileyebilir.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Sonu\u00e7:&nbsp;<\/strong>Do\u011fal ila\u00e7lar olarak baz\u0131 bitkiler PKOS&#8217;un farkl\u0131 y\u00f6nlerini iyile\u015ftirmede\nyararl\u0131 etkilere sahip olabilir;&nbsp;ancak mekanizmalar\u0131n\u0131 ve g\u00fcvenliklerini\nara\u015ft\u0131rmak i\u00e7in daha fazla \u00e7al\u0131\u015fmaya ihtiya\u00e7 vard\u0131r.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">26-)Effects of a Combination of Nigella Sativa and Vitex\nAgnus-Castus With Citalopram on Healthy Menopausal Women With Hot Flashes:\nResults From a Subpopulation Analysis<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;<a href=\"https:\/\/doi.org\/10.1080\/09513590.2018.1499086\" target=\"_blank\" rel=\"noreferrer noopener\">10.1080\/09513590.2018.1499086<\/a><\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Bu \u00e7al\u0131\u015fman\u0131n amac\u0131, sa\u011fl\u0131kl\u0131 menopozal\nkad\u0131nlarda s\u0131cak basmas\u0131 kontrol\u00fcnde Nigella sativa ve Vitex agnus-castus ile\nsitalopram kombinasyonundan olu\u015fan bir fitoterap\u00f6tik m\u00fcdahalenin etkinli\u011fini\nde\u011ferlendirmektir.&nbsp;Temmuz 2016 ile Haziran 2017 aras\u0131nda g\u00fcnde ortalama\nd\u00f6rtten fazla s\u0131cak basmas\u0131 ya\u015fayan 40 ila 60 ya\u015flar\u0131 aras\u0131ndaki 46 kad\u0131n\naras\u0131nda 8 haftal\u0131k, \u00e7ift k\u00f6r, randomize, plasebo kontroll\u00fc bir \u00e7al\u0131\u015fma\nger\u00e7ekle\u015ftirildi. Vazomotor semptomlar\u0131n \u015fiddeti hakk\u0131nda veriler sekizinci\nhaftan\u0131n sonunda topland\u0131.&nbsp;Sabahlar\u0131 g\u00fcnde bir kez bitkisel ila\u00e7 veya\nplasebo kaps\u00fclleri verildi.&nbsp;8 haftal\u0131k tedavi s\u00fcresinin\nsonunda,&nbsp;kovaryans analizleri, vazomotor (p &lt;.001), fiziksel (p =\n.036), psikososyal (p = .001) dahil olmak \u00fczere \u00fc\u00e7 MENQOL alan skoru i\u00e7in\nsitalopram ile bitkisel kombinasyonun plasebo ve sitalopram \u00fczerindeki\n\u00fcst\u00fcnl\u00fc\u011f\u00fcn\u00fc g\u00f6stermi\u015ftir, ancak anlaml\u0131 bir fark g\u00f6zlenmemi\u015ftir.Sonu\u00e7lara\ndayanarak, sitaloprama bir N. sativa ve V. agnus-castus kombinasyonunun\neklenmesi, terap\u00f6tik sonu\u00e7lar\u0131n iyile\u015ftirilmesi i\u00e7in potansiyel bir klinik\nuygulama olabilir.&nbsp;Daha b\u00fcy\u00fck randomize, kontroll\u00fc \u00e7al\u0131\u015fmalar da bu\nsemptomlar\u0131n daha fazla ara\u015ft\u0131r\u0131lmas\u0131 i\u00e7in gereklidir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">27-)Phytopharmacological\nReview on Vitex agnus-castus: A Potential Medicinal Plant<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">Vitex agnus-castus,\nVerbenaceae familyas\u0131na ait k\u00fc\u00e7\u00fck bir a\u011fa\u00e7 veya \u00e7al\u0131d\u0131r.&nbsp;Avrupa, Akdeniz\nve Orta Asya \u00fclkelerine \u00f6zg\u00fc yaprak d\u00f6ken bir \u00e7al\u0131d\u0131r.&nbsp;V. agnus castus,\nbitkisel bir ila\u00e7 olarak uzun bir gelene\u011fe sahiptir ve eski zamanlarda sadece\nanafrodizyak olarak de\u011fil, ayn\u0131 zamanda kad\u0131n genital sisteminin \u00e7e\u015fitli\nrahats\u0131zl\u0131klar\u0131na kar\u015f\u0131 da kullan\u0131lm\u0131\u015ft\u0131r.&nbsp;V. agnus-castus&#8217;taki ana\nbile\u015fenler flavonoidler, u\u00e7ucu ya\u011flar, diterpenler ve\nglikozitlerdir.&nbsp;Flavonoidlerin (kastisin, quercetagetin ve isovitexin) in\nvitro olarak \u00f6strojen resept\u00f6rlerini etkiledi\u011fi g\u00f6sterilmi\u015ftir.&nbsp;V.\nagnus-castus akne, sindirim \u015fikayetleri, adet d\u00fczensizlikleri, adet \u00f6ncesi\nsendromu (PMS), mastalji ve infertiliteyi tedavi etmek ve ayr\u0131ca laktasyon\ndeste\u011fi i\u00e7in kullan\u0131labilir.V.&nbsp;agnus-castus y\u00fczy\u0131llard\u0131r kullan\u0131lmaktad\u0131r\nve bir\u00e7ok jinekolojik \u015fikayet i\u00e7in uygulay\u0131c\u0131lardan ve genel halktan geni\u015f\ndestek almaktad\u0131r, az say\u0131da klinik \u00e7al\u0131\u015fma belgelenmi\u015f kullan\u0131mlar\u0131n\u0131\ndesteklemektedir.&nbsp;Fitokimyasal ve farmakolojik faaliyetlerin varl\u0131\u011f\u0131,\nbitkinin gelecekte yeni iyi etkinlik ilac\u0131n\u0131n geli\u015ftirilmesi i\u00e7in lider bir\nkapasiteye sahip oldu\u011funu kan\u0131tlam\u0131\u015ft\u0131r.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">28-)Safety\nand Efficacy of Chastetree (Vitex Agnus-Castus) During Pregnancy and Lactation<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>PMID:&nbsp;18204102<\/li><\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>&nbsp;<\/strong>Hem klinisyenlerin hem de hastalar\u0131n hamilelik ve emzirme d\u00f6neminde\nkullan\u0131lan bitkilerin kullan\u0131m ve g\u00fcvenli\u011fi endikasyonlar\u0131 hakk\u0131nda temel bilgi\neksikli\u011fi vard\u0131r.&nbsp;Bu, hamilelik ve emzirme d\u00f6neminde yayg\u0131n olarak\nkullan\u0131lan bitkiler i\u00e7in kan\u0131tlar\u0131 sistematik olarak g\u00f6zden ge\u00e7iren bir\nserideki bir makaledir.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Ama\u00e7:&nbsp;<\/strong>Hamilelik ve emzirme ile ilgili konulara odaklanarak, Chastetree&#8217;nin\nkullan\u0131m\u0131, g\u00fcvenli\u011fi ve farmakolojisi hakk\u0131ndaki kan\u0131tlar i\u00e7in literat\u00fcr\u00fc\nsistematik olarak g\u00f6zden ge\u00e7irmek.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Y\u00f6ntemler:&nbsp;<\/strong>Bulunan kan\u0131t derecesine g\u00f6re 7 elektronik veritaban\u0131 ara\u015ft\u0131rd\u0131k ve\nverileri derledik.&nbsp;BULGULAR Gebelikte, teorik ve uzman g\u00f6r\u00fc\u015flere ve in\nvitro \u00e7al\u0131\u015fmalara g\u00f6re chastetree&#8217;nin \u00f6strojenik ve progesteronik aktiviteye,\nuterus uyar\u0131c\u0131 aktiviteye, emmenagog aktivitesine ve d\u00fc\u015f\u00fckleri \u00f6nleyebilece\u011fine\ndair zay\u0131f kan\u0131tlar vard\u0131r.&nbsp;Laktasyonda, laktasyonu artt\u0131r\u0131p azaltmad\u0131\u011f\u0131\nkonusunda teorik ve uzman g\u00f6r\u00fc\u015f\u00fc \u00e7at\u0131\u015fmas\u0131 vard\u0131r.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Sonu\u00e7lar:&nbsp;<\/strong>\u00c7ocuk do\u011furma \u00e7a\u011f\u0131ndaki kad\u0131nlar aras\u0131nda nispeten yayg\u0131n kullan\u0131m\u0131 g\u00f6z\n\u00f6n\u00fcne al\u0131nd\u0131\u011f\u0131nda, baz\u0131 kad\u0131nlar\u0131n bilmeden hamile kal\u0131rken azar azar t\u00fcketmesi\nmuhtemeldir.&nbsp;Tamamlay\u0131c\u0131 ve alternatif t\u0131p, ebelik ve t\u0131p pratisyenleri,\n\u00f6zellikle hasta bir aile planlarken, \u00e7ocuk do\u011furma \u00e7a\u011f\u0131ndaki kad\u0131nlara\nchastetree re\u00e7ete ederken bu ger\u00e7e\u011fin fark\u0131nda olmal\u0131d\u0131r.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>1-)Vitex Agnus Castus for Premenstrual Syndrome and Premenstrual Dysphoric Disorder: A Systematic Revie&nbsp; DOI:&nbsp;10.1007\/s00737-017-0791-0 Bu \u00e7al\u0131\u015fman\u0131n amac\u0131 Vitex agnus castus&#8217;un PMS ve adet \u00f6ncesi disforik bozukluk (PMDD) i\u00e7in g\u00fcvenli ve etkili bir tedavi olup olmad\u0131\u011f\u0131n\u0131 de\u011ferlendirmek ve bu bulgular\u0131n klinik uygulama i\u00e7in etkilerini tart\u0131\u015fmakt\u0131.&nbsp;PubMed ve Scielo veritabanlar\u0131 kullan\u0131larak literat\u00fcr\u00fcn sistematik bir incelemesi yap\u0131ld\u0131.&nbsp;Kapsama kriterleri, bu [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":218,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-217","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-literatur"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>HAYIT (V\u0130TEX AGNUS CASTUS) - Dr. \u00d6zberk Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/blog.drozberk.com\/index.php\/2020\/05\/15\/hayit-vitex-agnus-castus\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"HAYIT (V\u0130TEX AGNUS CASTUS) - Dr. \u00d6zberk Blog\" \/>\n<meta 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