A\u011f\u0131z bo\u015flu\u011fu i\u00e7inde bakteriler, mantarlar ve vir\u00fcsler\nbulunabilir. Birbirleriyle ve konak\u00e7\u0131 ile hastal\u0131kta veya sa\u011fl\u0131kta g\u00fc\u00e7l\u00fc bir\n\u015fekilde etkile\u015fime girerler. Bununla birlikte, mikrobik floran\u0131n dengesizli\u011fi\noral hastal\u0131klara ve sistemik hastal\u0131klara neden olurlar. A\u011f\u0131z bo\u015flu\u011fu yanak\nmukozas\u0131,dil ve damak , orofarinks ile ba\u011flant\u0131l\u0131d\u0131r.<\/p>\n\n\n\n
Bakteriler; en \u00e7ok bulunan taksonomik oral mikrobiyota\ngrubunu temsil eder. \u00c7o\u011funlukla en yayg\u0131n olan Streptococcus, Proteobacteria,\nActinobacteria, Bacteroidetes, Fusobacteria ve Spirochaetes t\u00fcrlerine ait\nbakterilerden olu\u015fur. Oral mikrobiyomun karma\u015f\u0131k ekosistemi dengeye ula\u015fana\nkadar zamanla \u00e7e\u015fitlilikte b\u00fcy\u00fcmeye devam eder. En \u00e7ok g\u00f6r\u00fclen bakteri cinsleri ise ;\nFirmicutes, Bacteroidetes, Proteobacteria, Actinobacteria ve Fusobacteria\nlard\u0131r.<\/p>\n\n\n\n
Fungal; Mantarlar oral mikrobiyomda k\u00fc\u00e7\u00fck bir az\u0131nl\u0131\u011f\u0131\ntemsil eder. Yak\u0131n zamana kadar, oral mikrobiyal pop\u00fclasyonun normal bir\npar\u00e7as\u0131 olarak tan\u0131nan tek mantar grubu Candida cinsine ait t\u00fcrlerdi. Candida\ncinsi en yayg\u0131n olmas\u0131 ile birlikte Cladosporium, Aureobasidium,\nSaccharomycetales, Fusarium, Cryptococcus ve Aspergillus cinsleri tespit\nedilmi\u015ftir.<\/p>\n\n\n\n
Vir\u00fcsler; hem aktif hem de latent formlarda bulunarak oral\nkavite ve orofasiyal b\u00f6lgede geni\u015f hastal\u0131klardan sorumludur. Herpes Simplex 1\nveya 2, ap\u00f6z stomatit ile Sitomegalovir\u00fcs ve Epstein-Barr vir\u00fcs ise periodontal\nhastal\u0131klarda ile ili\u015fkilidir.<\/p>\n\n\n\n
A\u011f\u0131z bo\u015flu\u011funda\nrahats\u0131zl\u0131klara yol a\u00e7an bakteri,vir\u00fcs ve mantar olu\u015fumunu engelleyerek a\u011f\u0131z\nsa\u011fl\u0131\u011f\u0131n\u0131 koruma alt\u0131na almak amac\u0131yla \u00e7e\u015fitli fitoterap\u00f6tik ve aromaterap\u00f6tik\nbile\u015fenler kullan\u0131labilir. Bu \u00e7e\u015fitli bile\u015fenlerin literat\u00fcre kay\u0131tl\u0131 olarak\na\u011f\u0131z bo\u015flu\u011funda rahats\u0131zl\u0131klara yol a\u00e7an kolonilere kar\u015f\u0131 antiviral, antifungal\nve antibakyeriyel etkili olduklar\u0131na dair \u00e7al\u0131\u015fmalar vard\u0131r. A\u011f\u0131z ve di\u015f\nsa\u011fl\u0131\u011f\u0131n\u0131n korunmas\u0131 i\u00e7in g\u00fcnl\u00fck olarak rit\u00fcel haline gelmi\u015f a\u011f\u0131z temizli\u011finden\nsonra bakteri ve mantar olu\u015fumunu \u00f6nlemek ve taze bir nefese sahip olmak i\u00e7in\ndestekleyici olarak kullan\u0131labilir. Oral kullan\u0131ma uygun literat\u00fcre ge\u00e7mi\u015f bu bile\u015fenleri\nayr\u0131 ayr\u0131 inceledi\u011fimizde ;<\/strong><\/p>\n\n\n\n Laden hidrosol\u00fcn\u00fcn ;<\/strong><\/p>\n\n\n\n Yap\u0131lan bir\u00e7ok \u00e7al\u0131\u015fmas\u0131nda Staphylococcus aureus,\nStaphylococcus epidermidis, Pseudomonas aeruginosae, Enterobacter cloacae’den,\nEscherichia coli, Klebsiella pn\u00f6moni, Torulopsis glabrata, Saccharomyces\ncerevisiae ve Candida albicans t\u00fcrlerine kar\u015f\u0131 antibakteriyel ve antifungal\netkisi oldu\u011fu g\u00f6zlenmi\u015ftir. (1)<\/strong><\/p>\n\n\n\n Laden bitkisinin i\u00e7eri\u011finde esas olarak ellagic asit i\u00e7eren polifenollere\nba\u011fl\u0131 a\u011f\u0131z bo\u015flu\u011funda bakteriyel yap\u0131\u015fmay\u0131 azaltt\u0131\u011f\u0131n\u0131, di\u015flerde \u00e7\u00fcr\u00fck riskini\nazaltabilece\u011fini g\u00f6sterdi. Ek deneyler, bir C. incanus inf\u00fczyonu (Laden) ile\ndurulama i\u015fleminin, oral s\u0131v\u0131lara maruz kalan mine numunelerinin ba\u015flang\u0131\u00e7taki\nbakteri kolonizasyonunu sekiz saatten fazla azaltt\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. (2)<\/strong><\/p>\n\n\n\n Laden bitkisinin \u00f6zlerinin viral giri\u015f yollar\u0131nda yerel bir\nuygulamas\u0131 ile, grip vir\u00fcs\u00fc (Influenza) enfeksiyonlar\u0131ndan korunmaya yard\u0131mc\u0131\nolabilecek umut verici bir yakla\u015f\u0131m olabilece\u011fi bilimsel \u00e7al\u0131\u015fmalarda\ng\u00f6r\u00fclm\u00fc\u015ft\u00fcr. (3)<\/strong><\/p>\n\n\n\n Laden bitkisinin a\u011f\u0131z mukozas\u0131nda en \u00e7ok rahats\u0131zl\u0131\u011fa yol\na\u00e7an mantar t\u00fcrlerinden olan Candida cinsine ve di\u011fer mantar t\u00fcrleri olan\nFusarium, Cryptococcus ve Aspergillus cinsine kar\u015f\u0131 antifungal etkisi oldu\u011funa\ndair \u00e7al\u0131\u015fmalar mevcuttur.(4,5)<\/strong><\/p>\n\n\n\n Melisa hidrosol\u00fcn\u00fcn;<\/strong><\/p>\n\n\n\n Yap\u0131lan bir\u00e7ok bilimsel \u00e7al\u0131\u015fmada Melisa bitkisinin\ni\u00e7eri\u011findeki fenolik bile\u015fiklerden dolay\u0131 antibakteriyel aktivite g\u00f6sterdi\u011fi\ng\u00f6r\u00fclm\u00fc\u015ft\u00fcr. Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae,\nPseudomonas aeruginosa’ya ve de a\u011f\u0131z bo\u015flu\u011funda bir\u00e7ok soruna yol a\u00e7an gram\npozitif bakterilere kar\u015f\u0131 de\u011fi\u015fen inhibit\u00f6r g\u00fc\u00e7ler g\u00f6stermi\u015ftir. (6,7,11) <\/strong><\/p>\n\n\n\n Melisa bitkisinin ekstrelerinin yap\u0131lan bir\u00e7ok \u00e7al\u0131\u015fmada\n\u00f6zellikle a\u011f\u0131z bo\u015flu\u011funda viral enfeksiyona yol a\u00e7an HSV(Herpes simplex vir\u00fcs)\nvir\u00fcs\u00fcne ve di\u011fer vir\u00fcslere kar\u015f\u0131 antiviral aktivite g\u00f6sterdi\u011fi dikkat\n\u00e7ekmi\u015ftir. (8,9)<\/strong><\/p>\n\n\n\n Melisa \u00f6z\u00fc i\u00e7eren bile\u015fenlerin oral kandidiyaza yol a\u00e7an\nCandida albicans’\u0131n b\u00fcy\u00fcme inhibisyonunda en y\u00fcksek etkinli\u011fe sahip oldu\u011fu ve\nonayland\u0131ktan sonra bitkisel gargara olarak kullan\u0131labilece\u011fine kar\u015f\u0131\n\u00e7al\u0131\u015fmalar mevcuttur. (10,11)<\/strong><\/p>\n\n\n\n Ada\u00e7ay\u0131 hidrosol\u00fc;<\/strong><\/p>\n\n\n\n Ada\u00e7ay\u0131 \u00f6z\u00fct\u00fcn\u00fcn a\u011f\u0131z mukozas\u0131nda rahats\u0131zl\u0131\u011fa yol a\u00e7acak gram\nnegatif ve gram pozitif bakterilere \u00f6zellikle S. aureus ve B. kar\u015f\u0131\nantibakteriyel aktivite sergiledi\u011fi g\u00f6r\u00fclm\u00fc\u015ft\u00fcr. (12)<\/strong><\/p>\n\n\n\n Ada\u00e7ay\u0131 bitkisinin sulu ve etanolik \u00f6zleri, herpes simpleks\nvir\u00fcs\u00fc tip 1 (HSV-1) ve tip 2’ye (HSV-) kar\u015f\u0131 antiviral aktivite g\u00f6stermi\u015ftir. (13)<\/strong><\/p>\n\n\n\n Ada\u00e7ay\u0131 bitkisinin antifungal aktivitesi mayalara(Candida\nt\u00fcrleri), dermatofit ve Aspergillus su\u015flar\u0131na kar\u015f\u0131 g\u00f6zlenmi\u015ftir. (14)<\/strong><\/p>\n\n\n\n Kekik hidrosol\u00fc;<\/strong><\/p>\n\n\n\n Staphylococcus saprophyticus, S. aureus, Micrococcus roseus,\nM. kristinae, M. nishinomiyaensis, M. lylae, M. luteus, M. sedentarius, M.\nvarians, Bacillus megaterium, B. thuringiensis, B’ye kar\u015f\u0131 antibakteriyel\naktivite sergiledi\u011fi \u00e7al\u0131\u015fmalarda g\u00f6r\u00fclm\u00fc\u015ft\u00fcr. (15)<\/strong><\/p>\n\n\n\n Kekik hidrosol\u00fcn\u00fcn Herpes simpleks tip-1 (HSV-1) ve\nparainfluenza tip-3’e (PI-3) kar\u015f\u0131 antiviral aktivite g\u00f6stermi\u015ftir. (16)<\/strong><\/p>\n\n\n\n Kekik hidrosol\u00fcn\u00fcn oral kandidiyaza yol a\u00e7an Candida\nt\u00fcrlerine; Aspergillus flavus, Aspergillus nigar ve Aspergillus pterus\nsu\u015flar\u0131na kar\u015f\u0131 antifungal aktivitesine dair \u00e7al\u0131\u015fmalar mevcuttur. (17)<\/strong><\/p>\n\n\n\n Nane u\u00e7ucu ya\u011f\u0131;<\/strong><\/p>\n\n\n\n Bu ya\u011f\u0131n ana bile\u015fenlerinden olan mentol ve mentonun g\u00fc\u00e7l\u00fc\nantiviral etkisi oldu\u011fu g\u00f6zlenmi\u015ftir. \u00d6zellikle a\u011f\u0131z bak\u0131m \u00fcr\u00fcnlerinde s\u0131kl\u0131kla\nkullan\u0131ld\u0131\u011f\u0131 bilinen nane bitkisinin a\u011f\u0131z mukozas\u0131nda enfeksiyona yol a\u00e7an HSV\nvir\u00fcs\u00fc ve solunum \u015fikayetlerine yol a\u00e7an RSV vir\u00fcs\u00fcne kar\u015f\u0131 g\u00fc\u00e7l\u00fc antiviral\netkisi oldu\u011fu g\u00f6r\u00fclm\u00fc\u015ft\u00fcr. (18,22)<\/strong><\/p>\n\n\n\n Yap\u0131lan bir \u00e7al\u0131\u015fmada nane esansiyel ya\u011f\u0131n\u0131n kullan\u0131m\u0131\nsonucu oral k\u00f6t\u00fc koku seviyesinin anlaml\u0131 olarak de\u011fi\u015fti\u011fi g\u00f6zlenmi\u015ftir.\nFerahlat\u0131c\u0131 ve rahatlat\u0131c\u0131 etkisi ile k\u00f6t\u00fc tad ve kokulara kar\u015f\u0131 sava\u015farak taze\nbir nefese sahip olmay\u0131 sa\u011flar. (19)<\/strong><\/p>\n\n\n\n Nane esansiyel ya\u011f\u0131n\u0131n Candida albicans, C.dubliniensis,\nRhizopus stolonifer, Botrytis cinerea ve Aspergillus niger t\u00fcrlerine kar\u015f\u0131\nantifungal etkisi oldu\u011fu g\u00f6r\u00fclm\u00fc\u015ft\u00fcr. (20)<\/strong><\/p>\n\n\n\n Nane esansiyel ya\u011f\u0131n\u0131n Pseudomonas aeruginosa, Pseudomonas\nfluorescens, Bacillus subtilis ve Staphylococcus aureus ,gram negatif ve\npozitif gibi bir\u00e7ok bakteri t\u00fcr\u00fcne kar\u015f\u0131 antibakteriyel etkisi oldu\u011fu\nbilinmektedir. (21)<\/strong><\/p>\n\n\n\n KAYNAK\u00c7A:<\/strong><\/p>\n\n\n\n A\u011f\u0131z bo\u015flu\u011fu i\u00e7inde bakteriler, mantarlar ve vir\u00fcsler bulunabilir. Birbirleriyle ve konak\u00e7\u0131 ile hastal\u0131kta veya sa\u011fl\u0131kta g\u00fc\u00e7l\u00fc bir \u015fekilde etkile\u015fime girerler. Bununla birlikte, mikrobik floran\u0131n dengesizli\u011fi oral hastal\u0131klara ve sistemik hastal\u0131klara neden olurlar. A\u011f\u0131z bo\u015flu\u011fu yanak mukozas\u0131,dil ve damak , orofarinks ile ba\u011flant\u0131l\u0131d\u0131r. Bakteriler; en \u00e7ok bulunan taksonomik oral mikrobiyota grubunu temsil eder. \u00c7o\u011funlukla en yayg\u0131n […]<\/p>\n","protected":false},"author":1,"featured_media":270,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-265","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-literatur"],"yoast_head":"\n