{"id":37,"date":"2020-04-02T23:48:16","date_gmt":"2020-04-02T20:48:16","guid":{"rendered":"https:\/\/blog.drozberk.com\/?p=37"},"modified":"2020-07-07T00:37:30","modified_gmt":"2020-07-06T21:37:30","slug":"nigella-sativa","status":"publish","type":"post","link":"http:\/\/blog.drozberk.com\/index.php\/2020\/04\/02\/nigella-sativa\/","title":{"rendered":"\u00c7\u00d6REK OTU (N\u0130GELLA SAT\u0130VA)"},"content":{"rendered":"\n<p><strong> <\/strong><\/p>\n\n\n\n<h1 class=\"wp-block-heading\">1-) Thymoquinone and Its Therapeutic Potentials<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;10.1016\/j.phrs.2015.03.011<\/li><\/ul>\n\n\n\n<p><br>\nBitkisel ila\u00e7 son y\u0131llarda b\u00fcy\u00fck ilgi g\u00f6rd\u00fc ve giderek artan \u015fekilde kimyasal\nila\u00e7lara alternatif olarak kullan\u0131lmaktad\u0131r.&nbsp;Birka\u00e7 kan\u0131t hatt\u0131, \u015fifal\u0131\nbitkilerin \u00e7ok \u00e7e\u015fitli hastal\u0131klar\u0131n \u00f6nlenmesi ve iyile\u015ftirilmesindeki olumlu\netkisini desteklemektedir.&nbsp;Timokinon (TQ), Nigella sativa tohumlar\u0131n\u0131n\nu\u00e7ucu ya\u011f\u0131n\u0131n en bol bile\u015fenidir ve N sativa&#8217;n\u0131n \u00e7o\u011fu \u00f6zelli\u011fi esas olarak\nTQ&#8217;ya atfedilir.&nbsp;Anti-oksidan, anti-enflamatuar, imm\u00fcnomod\u00fclat\u00f6r,\nanti-histaminik, anti-mikrobiyal ve anti-t\u00fcm\u00f6r etkileri dahil olmak \u00fczere bir\ndizi TQ&#8217;nun farmakolojik etkisi ara\u015ft\u0131r\u0131lm\u0131\u015ft\u0131r.&nbsp;Ayn\u0131 zamanda\ngastroprotektif, hepatoprotektif, nefroprotektif ve n\u00f6roprotektif aktivitelere\nsahiptir.&nbsp;Ek olarak, kardiyovask\u00fcler bozukluklar, diyabet, \u00fcreme\nbozukluklar\u0131 ve solunum rahats\u0131zl\u0131klar\u0131nda TQ&#8217;nun olumlu etkileri,&nbsp;kemik komplikasyonlar\u0131n\u0131n\nyan\u0131 s\u0131ra fibrozisin tedavisinde de g\u00f6sterilmi\u015ftir.&nbsp;B\u00fcy\u00fck bir veri\ng\u00f6vdesi, TQ&#8217;nun \u00e7ok d\u00fc\u015f\u00fck yan etkilere sahip oldu\u011funu ve ciddi toksisite\nolmad\u0131\u011f\u0131n\u0131 g\u00f6stermektedir.&nbsp;Son zamanlarda, bu diyet fitokimyasal\u0131na,\nsa\u011fl\u0131k yararlar\u0131n\u0131 de\u011ferlendirmek i\u00e7in klinik \u00f6ncesi ve klinik ara\u015ft\u0131rmalarda\nara\u015ft\u0131rmaya y\u00f6nelik artan bir ilgi ile \u00e7ok dikkat edilmi\u015ftir.&nbsp;Burada, N.\nsativa tohumlar\u0131n\u0131n (TQ) aktif bile\u015feninin say\u0131s\u0131z \u00f6zelli\u011fini, \u00e7ok \u00e7e\u015fitli\nhastal\u0131klar i\u00e7in terap\u00f6tik potansiyelleri ba\u011flam\u0131nda rapor edip analiz\nediyoruz.&nbsp;Ayr\u0131ca ilac\u0131n olas\u0131 etki mekanizmalar\u0131n\u0131 da\n\u00f6zetliyoruz.&nbsp;Bildirilen kan\u0131tlar, TQ&#8217;nun klinik \u00e7al\u0131\u015fmalarda yeni bir ila\u00e7\nolarak geli\u015ftirilmesi gerekti\u011fini ileri s\u00fcrmektedir<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">2-)A Review of the Effects of Nigella\nSativa L. And Its Constituent, Thymoquinone, in Metabolic Syndrome<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;10.1007\n\/ s40618-014-0150-1<\/li><\/ul>\n\n\n\n<p><strong>Ama\u00e7:&nbsp;<\/strong>Metabolik sendrom, kardiyovask\u00fcler hastal\u0131k (KVH) olu\u015fumu ve mortalitesi i\u00e7in\n\u00f6nemli bir risk fakt\u00f6r\u00fcd\u00fcr.&nbsp;CVD&#8217;ler d\u00fcnya \u00e7ap\u0131nda \u00f6nde gelen \u00f6l\u00fcm\nnedenidir.&nbsp;Son zamanlarda, CVD dahil olmak \u00fczere \u00e7e\u015fitli bozukluklar i\u00e7in\nkimyasal ila\u00e7lardan daha fazla verimlilik ve minimum istenmeyen etki ile\nbitkisel ila\u00e7lar\u0131n kullan\u0131m\u0131na artan bir ilgi olmu\u015ftur.&nbsp;\u00c7\u00f6rek otu sativa\nve aktif bile\u015feni olan timokinon, antidiyabetik, antiobezite, hipotansif ve\nhipolipidemik \u00f6zellikler sergiledi\u011fi belgelenmi\u015ftir.(CVD:KARD\u0130YOVASK\u00dcLER\nHASTALIKLAR)<\/p>\n\n\n\n<p><strong>Ama\u00e7:&nbsp;<\/strong>Bu derlemede, y\u00fcksek tansiyon, obezite, dislipidemi ve y\u00fcksek kan \u015fekeri\ndahil olmak \u00fczere metabolik sendrom ve CVD risk fakt\u00f6rlerinin farkl\u0131\nbile\u015fenlerinde N. sativa&#8217;n\u0131n rol\u00fcn\u00fc bulmak i\u00e7in en alakal\u0131 makaleleri\ntart\u0131\u015ft\u0131k.<\/p>\n\n\n\n<p><strong>Sonu\u00e7lar:&nbsp;<\/strong>Bu derleme, N. sativa ve TQ&#8217;nun metabolik sendrom tedavisinde potansiyel\nbir rol oynad\u0131\u011f\u0131n\u0131 d\u00fc\u015f\u00fcnd\u00fcrmektedir, ancak bunlar\u0131n etkinli\u011fini de\u011ferlendirmek\ni\u00e7in daha fazla \u00e7al\u0131\u015fma yap\u0131lmal\u0131d\u0131r.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">3-)Effects of Oral Nigella Sativa Oil on the\nExpression Levels and Serum Concentrations of Adiponectin, PPAR-\u03b3, and TNF-\u03b1 in\nOverweight and Obese Women: A Study Protocol for a Crossover-Designed,\nDouble-Blind, Placebo-Controlled Randomized Clinical Trial<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;10.1186\/s13063-019-3568-0<\/li><\/ul>\n\n\n\n<p><strong>Arka Plan:&nbsp;<\/strong>Obezite son y\u0131llarda \u00f6nemli bir halk sa\u011fl\u0131\u011f\u0131 sorunudur.&nbsp;A\u015f\u0131r\u0131 ya\u011f\nbirikmesi enflamatuar durumu te\u015fvik eder.&nbsp;Bu arada, bitkisel \u00fcr\u00fcnler\ny\u00fczy\u0131llard\u0131r romatoid artrit, diyabet ve ast\u0131m\u0131 tedavi etmek i\u00e7in kullan\u0131lan\nNigella sativa (N. Sativa) gibi kilo kayb\u0131 \u00f6zellikleri nedeniyle\npazarlanmaktad\u0131r;&nbsp;son zamanlarda, N. sativa&#8217;n\u0131n anti-obezite \u00f6zellikleri\nde g\u00f6sterilmi\u015ftir.&nbsp;Bununla birlikte, kesin mekanizmalar ve h\u00fccresel ili\u015fkili\nyollar hala belirsizdir.&nbsp;Bu nedenle, oral N. sativa&#8217;n\u0131n TNF-\u03b1, PPAR-y ve\nadiponektin dahil enflamatuar ve adipogenez ile ili\u015fkili fakt\u00f6rlerin gen\nekspresyonu \u00fczerindeki etkilerini de\u011ferlendirmenin yan\u0131 s\u0131ra obez ve a\u015f\u0131r\u0131\nkilolu ki\u015filer aras\u0131ndaki serum konsantrasyonlar\u0131n\u0131 de\u011ferlendirmeyi\nama\u00e7layaca\u011f\u0131z.<\/p>\n\n\n\n<p><strong>Y\u00f6ntemler:&nbsp;<\/strong>V\u00fccut kitle indeksi (VK\u0130) 25-35 kg \/ m&nbsp;<sup>2<\/sup>&nbsp;olan 25-55\nya\u015flar\u0131ndaki obez ve a\u015f\u0131r\u0131 kilolu kad\u0131nlar&nbsp;Shahid Sadoughi T\u0131p Bilimleri\n\u00dcniversitesi Obezite Klini\u011finden al\u0131nacak ve dahil edilme kriterlerine uygunluk\na\u00e7\u0131s\u0131ndan de\u011ferlendirilecektir. .&nbsp;Sekiz hafta boyunca g\u00fcnde iki N. sativa\nkaps\u00fcl\u00fc veya iki plasebo kaps\u00fcl\u00fc almak i\u00e7in rastgele iki gruba atanacaklard\u0131r\n(her kaps\u00fcl 1000 mg N. sativa veya plasebo i\u00e7erir).&nbsp;D\u00f6rt haftal\u0131k bir\ny\u0131kama d\u00f6nemi olacak ve daha sonra kat\u0131l\u0131mc\u0131lar sekiz hafta daha geri\ntakviyeleri alacaklar.&nbsp;Biyokimyasal de\u011ferlendirmeler ve gen ifadeleri\n(ger\u00e7ek zamanl\u0131 polimeraz zincir reaksiyonu kullan\u0131larak) her m\u00fcdahale\nperiyodunun ba\u015f\u0131nda ve sonunda yap\u0131lacakt\u0131r.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">4-)The Effects of Nigella Sativa L. On Obesity: A\nSystematic Review and Meta-Analysis<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;10.1016\/j.jep.2018.03.001<\/li><\/ul>\n\n\n\n<p><strong>Etnofarmakolojik alaka d\u00fczeyi:&nbsp;<\/strong>Nigella sativa L. (N.sativa), y\u00fczy\u0131llard\u0131r romatoid\nartrit, diyabet, ast\u0131m ve di\u011fer metabolik bozukluklar\u0131 tedavi etmek i\u00e7in\nkullan\u0131lan geleneksel bir bitkisel ila\u00e7t\u0131r.&nbsp;Son zamanlarda, N.sativa&#8217;n\u0131n\nanti-obezite \u00f6zellikleri g\u00f6sterilmi\u015ftir.<\/p>\n\n\n\n<p><strong>\u00c7al\u0131\u015fman\u0131n amac\u0131:&nbsp;<\/strong>Obezite tedavisinde tamamlay\u0131c\u0131 bir tedavi olarak N. sativa&#8217;n\u0131n etkileri\ntart\u0131\u015fmal\u0131d\u0131r.&nbsp;Eri\u015fkinlerde N. sativa ile takviyenin baz\u0131 antropometrik\nendeksler \u00fczerindeki etkileri \u00fczerine bir meta-analiz yapmay\u0131 ama\u00e7lad\u0131k.<\/p>\n\n\n\n<p><strong>Gere\u00e7 ve y\u00f6ntem:&nbsp;<\/strong>\u0130lgili plasebo kontroll\u00fc klinik \u00e7al\u0131\u015fmalar\u0131 tan\u0131mlamak i\u00e7in Haziran 2017&#8217;ye\nkadar PubMed \/ Medline, Cochrane K\u00fct\u00fcphanesi, ISI Bilim Web ve Scopus\nveritabanlar\u0131n\u0131 ara\u015ft\u0131rd\u0131k.&nbsp;Veriler, N. sativa&#8217;n\u0131n v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131, v\u00fccut\nkitle indeksi (BMI) ve bel \u00e7evresi (WC) \u00fczerindeki etkilerinin b\u00fcy\u00fckl\u00fc\u011f\u00fcn\u00fc\ng\u00f6stermek i\u00e7in a\u011f\u0131rl\u0131kl\u0131 ortalama farkl\u0131l\u0131klar ve standart sapmalar olarak\nrapor edilmi\u015ftir.<\/p>\n\n\n\n<p><strong>Sonu\u00e7:&nbsp;<\/strong>N. sativa ile takviye, v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131, BMI ve WC&#8217;de azalma \u00fczerinde orta\nderecede etki yapar.&nbsp;Bununla birlikte, v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131 i\u00e7in y\u00fcksek\nheterojenlik ve s\u0131n\u0131rl\u0131 y\u00fcksek kaliteli \u00e7al\u0131\u015fmalar nedeniyle, bulgular dikkatle\nbildirilmelidir.&nbsp;N. sativa takviyesinin ard\u0131ndan ciddi bir yan etki\nbildirilmemi\u015ftir.&nbsp;N. sativa&#8217;n\u0131n di\u011fer antropometrik endeksler \u00fczerindeki\netkilerini a\u00e7\u0131kl\u0131\u011fa kavu\u015fturmak i\u00e7in daha fazla \u00e7al\u0131\u015fmaya ihtiya\u00e7 vard\u0131r.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">5-)Biochemical Effects of Nigella Sativa L Seeds in\nDiabetic Rats<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>PMID:&nbsp;16999030<\/li><\/ul>\n\n\n\n<p>N. sativa tohumlar\u0131n\u0131n (300 mg \/ kg v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131 \/ g\u00fcn)\netanol ekstrakt\u0131n\u0131n streptozotosin ile ind\u00fcklenen diyabetik s\u0131\u00e7anlara 30 g\u00fcn\nboyunca oral olarak uygulanmas\u0131, kan \u015fekeri, lipitler, plazma ins\u00fclin\nseviyelerinin y\u00fckselmesini ve lipit peroksidasyon \u00fcr\u00fcnlerinin artm\u0131\u015f\nseviyelerini \u00f6nemli \u00f6l\u00e7\u00fcde azaltt\u0131 ( TBARS ve hidroperoksitler) ve karaci\u011fer ve\nb\u00f6brekte katalaz, s\u00fcperoksit dismutaz, azalm\u0131\u015f glutatyon ve glutatyon\nperoksidaz gibi antioksidan enzimler.&nbsp;Sonu\u00e7lar, N. sativa tohumlar\u0131\nekstresinin antidiyabetik aktivitesini teyit eder ve antioksidan etkileri\nnedeniyle uygulanmas\u0131n\u0131n, deneysel diyabetik s\u0131\u00e7anlarda diyabetik\nkomplikasyonlar\u0131n kontrol edilmesinde yararl\u0131 olabilece\u011fini d\u00fc\u015f\u00fcnd\u00fcrmektedir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">6-)Effect of Nigella Sativa Seeds on\nthe Glycemic Control of Patients With Type 2 Diabetes Mellitus<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>PMID:&nbsp;21675032<\/li><\/ul>\n\n\n\n<p>Diabetes mellitus, d\u00fcnya \u00e7ap\u0131nda milyonlarca insan\u0131 etkileyen yayg\u0131n bir\nkronik hastal\u0131kt\u0131r.&nbsp;Standart tedavi bir\u00e7ok hastada gerekli kan \u015fekeri\nd\u00fczeltmesini sa\u011flayamamaktad\u0131r.&nbsp;Bu nedenle, diyabetik hastalarda glisemik\nkontrol\u00fc geli\u015ftirmek i\u00e7in potansiyel hipoglisemik ila\u00e7lar\u0131n veya bitkilerin\nara\u015ft\u0131r\u0131lmas\u0131na ihtiya\u00e7 vard\u0131r.&nbsp;Anti-diyabetik ila\u00e7lar\u0131na eklenen tip 2\ndiyabetes mellituslu hastalarda \u00e7\u00f6rek otu sativa tohumlar\u0131 adjuvan tedavi\nolarak kullan\u0131ld\u0131.&nbsp;Toplam 94 hasta \u00e7al\u0131\u015fmaya al\u0131nd\u0131 \u200b\u200bve rastgele \u00fc\u00e7 doz\ngrubuna ayr\u0131ld\u0131.&nbsp;\u00c7\u00f6rek otu sativa i\u00e7eren kaps\u00fcller \u00fc\u00e7 ay boyunca g\u00fcnde 1,\n2 ve 3 gm \/ g\u00fcn dozunda oral yoldan uyguland\u0131.&nbsp;\u00c7\u00f6rek otu sativa&#8217;n\u0131n\nglisemik kontrol \u00fczerindeki etkisi a\u00e7l\u0131k kan glukozu (FBG), kan glukoz seviyesi\n2 saat sonra (2 hPG),&nbsp;ve glikosile hemoglobin (HbA1c).&nbsp;Serum\nC-peptidi ve v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131ndaki de\u011fi\u015fiklikler de \u00f6l\u00e7\u00fcld\u00fc.&nbsp;Homeostatik\nmodel de\u011ferlendirmesinde (HOMA2) ins\u00fclin direnci ve beta h\u00fccre fonksiyonu\nhesapland\u0131.&nbsp;2 gm \/ g\u00fcn dozunda \u00e7\u00f6rek otu sativa, v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131nda \u00f6nemli\nbir de\u011fi\u015fiklik olmadan FBG, 2hPG ve HbA1&#8217;de \u00f6nemli azalmaya neden\noldu.&nbsp;A\u00e7l\u0131k kan \u015fekeri, 4, 8 ve 12. haftalarda ortalama 45, 62 ve 56 mg \/\ndl azald\u0131.&nbsp;12 haftal\u0131k tedavi sonunda HbAlC% 1.52 azalt\u0131ld\u0131 (P\n&lt;0.0001).&nbsp;HOMA2 ile hesaplanan ins\u00fclin direnci \u00f6nemli \u00f6l\u00e7\u00fcde azald\u0131 (P\n&lt;0.01), 12 haftal\u0131k tedavide B-h\u00fccresi fonksiyonu artt\u0131 (P\n&lt;0.02).&nbsp;Nigella sativa&#8217;n\u0131n 1 g \/ g\u00fcn&#8217;l\u00fck bir dozda kullan\u0131m\u0131 da \u00f6l\u00e7\u00fclen\nt\u00fcm parametrelerde iyile\u015fme e\u011filimleri g\u00f6sterdi, ancak taban \u00e7izgisinden\nistatistiksel olarak anlaml\u0131 de\u011fildi.&nbsp;Ancak,&nbsp;3 gm \/ g\u00fcn doz ile\nfaydal\u0131 yan\u0131tta ba\u015fka bir art\u0131\u015f g\u00f6zlenmemi\u015ftir.&nbsp;\u00c7al\u0131\u015fmada kullan\u0131lan \u00fc\u00e7\nNigella sativa dozu, \u00e7al\u0131\u015fma s\u00fcresi boyunca diyabetik hastalar\u0131n b\u00f6brek\nfonksiyonlar\u0131n\u0131 veya karaci\u011fer fonksiyonlar\u0131n\u0131 olumsuz etkilememi\u015ftir.<\/p>\n\n\n\n<p><strong>Sonu\u00e7:&nbsp;<\/strong>Bu \u00e7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131, tip 2 diyabetik hastalarda g\u00fcnde 2 g \/ g\u00fcn Nigella\nsativa dozunun oral hipoglisemik ajanlara faydal\u0131 bir yard\u0131mc\u0131 olabilece\u011fini\ng\u00f6stermektedir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">7-)Effects of Fenugreek, Nigella, and Termis Seeds\nin Nonalcoholic Fatty Liver in Obese Diabetic Albino Rats<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;10.1016\/j.ajg.2014.12.003<\/li><li><strong><br>\nAma\u00e7 ve \u00e7al\u0131\u015fma amac\u0131:&nbsp;<\/strong>Alkols\u00fcz ya\u011fl\u0131 karaci\u011fer hastal\u0131\u011f\u0131 (NAFLD), tip 2 diabetes mellitus (T2DM)\nvakalar\u0131n\u0131n yakla\u015f\u0131k% 80&#8217;inde g\u00f6r\u00fcl\u00fcr.&nbsp;Bu \u00e7al\u0131\u015fma, Suudi Arabistan&#8217;da\nantidiyabetik ajan olarak kullan\u0131lan baz\u0131 bitkilerin T2DM ve ili\u015fkili ya\u011fl\u0131\nkaraci\u011fer \u00fczerindeki etkilerini ara\u015ft\u0131rm\u0131\u015ft\u0131r.<\/li><\/ul>\n\n\n\n<p><strong>Malzemeler ve y\u00f6ntemler:&nbsp;<\/strong>Toplam 150 yeti\u015fkin erkek albino s\u0131\u00e7an, her biri 25 s\u0131\u00e7andan olu\u015fan alt\u0131\ndeney grubuna ayr\u0131ld\u0131.&nbsp;Yirmi be\u015f s\u0131\u00e7an kontrol grubu olarak kabul\nedildi.&nbsp;Geri kalan s\u0131\u00e7anlarda 120 mg \/ kg taze haz\u0131rlanm\u0131\u015f alloksan\n\u00e7\u00f6zeltisinin deri alt\u0131na enjeksiyonu uygulanarak deneysel diyabet olu\u015fturuldu;&nbsp;bu\ns\u0131\u00e7anlar be\u015f gruba ayr\u0131ld\u0131: bir gruba herhangi bir tedavi\nverilmedi;&nbsp;ikinci grup \u00e7emen otu, \u00c7\u00f6rek otu ve termis tohumlar\u0131 i\u00e7eren bir\nkar\u0131\u015f\u0131m\u0131n sulu bir ekstrakt\u0131 ile muamele edildi;&nbsp;\u00fc\u00e7\u00fcnc\u00fc grup, Nigella\nsativa tohumlar\u0131n\u0131n sulu bir ekstrakt\u0131 ile muamele edildi;&nbsp;d\u00f6rd\u00fcnc\u00fc grup\n\u00e7emen tohumu sulu bir ekstrakt\u0131 ile muamele edildi;&nbsp;ve son olarak be\u015finci\ngrup, v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131n\u0131n 100 mg \/ kg&#8217;l\u0131k bir dozunda sulu bir termis tohumu \u00f6z\u00fc\nile muamele edildi.&nbsp;4 haftal\u0131k tedaviden sonra,&nbsp;kan \u015fekeri ve serum\nins\u00fclin seviyeleri dahil biyokimyasal parametreler hesapland\u0131.&nbsp;Pankreas ve\nkaraci\u011fer \u00f6rnekleri al\u0131nd\u0131 \u200b\u200bve mikroskobik de\u011ferlendirme i\u00e7in i\u015flendi.<\/p>\n\n\n\n<p><strong>Bulgular:&nbsp;<\/strong>Her bitkinin tek ba\u015f\u0131na kullan\u0131lmas\u0131 veya bitkilerin bir kar\u0131\u015f\u0131m\u0131 glikoz ve\nins\u00fclin seviyelerini d\u00fczeltti.&nbsp;Mikroskopik olarak, diyabetik gruptaki\n\u03b2-h\u00fccrelerinin say\u0131s\u0131nda ve \u00e7ap\u0131nda kesin bir iyile\u015fme\ng\u00f6zlenmi\u015ftir.&nbsp;Ayr\u0131ca, deney hayvanlar\u0131n\u0131n karaci\u011ferinde meydana gelen ya\u011f\nde\u011fi\u015fikliklerinde \u00f6nemli bir iyile\u015fme g\u00f6zlenmi\u015ftir.&nbsp;Kar\u0131\u015f\u0131m\u0131n etkinli\u011fi en\netkili olan\u0131yd\u0131.<\/p>\n\n\n\n<p><strong>Sonu\u00e7lar:&nbsp;<\/strong>Kullan\u0131lan bitkilerin tohum kar\u0131\u015f\u0131m\u0131n\u0131n sulu ekstrakt\u0131n\u0131n, ins\u00fclin\nseviyelerinde bir art\u0131\u015f, pankreas\u0131n cells h\u00fccrelerinin yenilenmesi yoluyla\nhiperglisemiyi azaltarak T2DM ile ili\u015fkili karaci\u011fer dokusunda ya\u011f\nde\u011fi\u015fikliklerini iyile\u015ftirmede yararl\u0131 bir ajan oldu\u011fu g\u00f6r\u00fclm\u00fc\u015ft\u00fcr. ili\u015fkili\ndislipideminin iyile\u015fmesi.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">8-)Nigella Sativa Seed Extracts Enhance\nGlucose-Induced Insulin Release From Rat-Isolated Langerhans Islets<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;10.1111\/j.1472-8206.2004.00275.x<\/li><li><br>\nNigella sativa L. &#8216;Siyah kimyon&#8217; (Ranunculaceae), Fas halk t\u0131bb\u0131nda diyabet\nmellitus dahil olmak \u00fczere \u00e7e\u015fitli rahats\u0131zl\u0131klar\u0131n tedavisinde yayg\u0131n olarak\nkullan\u0131lan bitkilerden biridir.&nbsp;Bu \u00e7al\u0131\u015fma, farkl\u0131 N. sativa tohumu\nekstrelerinin ins\u00fclin sekresyonu \u00fczerindeki etkisini ara\u015ft\u0131rmak i\u00e7in\nyap\u0131ld\u0131.&nbsp;Tohumun farkl\u0131 fraksiyonlar\u0131 haz\u0131rland\u0131: iki alt fraksiyona\nb\u00f6l\u00fcnen ya\u011fs\u0131z fraksiyon (HR II): asidik ve n\u00f6tr bile\u015fikler i\u00e7eren birinci (HR\nIII) ve ikinci (HR IV) bazik bile\u015fikler i\u00e7eren.&nbsp;Bu ekstraktlar\u0131n ins\u00fclin\nsalg\u0131lama etkileri, farkl\u0131 konsantrasyonlarda (0.01, 0.1, 1 ve 5 mg \/ mL), in\nvitro olarak izole edilmi\u015f s\u0131\u00e7an pankreatik adac\u0131klar\u0131nda 8.3 mmol \/ L glukoz\nvarl\u0131\u011f\u0131nda de\u011ferlendirildi.&nbsp;Sonu\u00e7lar, ya\u011fdan ar\u0131nd\u0131r\u0131lm\u0131\u015f b\u00fct\u00fcn ekstrakt\u0131n\nveya tohumun kulu\u00e7ka ortam\u0131na temel alt fraksiyonunun eklenmesinin,\nadac\u0131klardan glikoza ba\u011fl\u0131 ins\u00fclin sal\u0131n\u0131m\u0131n\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde artt\u0131rd\u0131\u011f\u0131n\u0131\ng\u00f6stermektedir.&nbsp;Asidik ve n\u00f6tr subfraksiyon durumunda, uyar\u0131c\u0131 etki sadece\ndaha y\u00fcksek konsantrasyonda (5 mg \/ mL) g\u00f6zlendi.&nbsp;Bununla birlikte, bazik\nalt fraksiyon i\u00e7in izole pankreatik adac\u0131klardan ins\u00fclin sal\u0131n\u0131m\u0131nda belirgin\nbir konsantrasyona ba\u011fl\u0131 art\u0131\u015f g\u00f6zlenmi\u015ftir.&nbsp;Verilerimiz, N. sativa\ntohumlar\u0131n\u0131n antidiyabetik \u00f6zelliklerinin, en az\u0131ndan k\u0131smen uyar\u0131lm\u0131\u015f ins\u00fclin\nsal\u0131m\u0131n\u0131n arac\u0131l\u0131k edebilece\u011fini ve temel alt fraksiyonun bu uyar\u0131c\u0131 etkiye\nb\u00fcy\u00fck \u00f6l\u00e7\u00fcde katk\u0131da bulundu\u011funu g\u00f6stermektedir.&nbsp;N. sativa tohumlar\u0131n\u0131n\nins\u00fclinotropik etkisinden sorumlu farmakolojik bile\u015fi\u011fi \/ bile\u015fikleri izole\netmek i\u00e7in ba\u015fka fitokimyasal \u00e7al\u0131\u015fmalar devam etmektedir.&nbsp; <\/li><li><strong>9-)<\/strong><strong>The\nPetroleum Ether Extract of Nigella Sativa Exerts Lipid-Lowering and Insulin-Sensitizing\nActions in the Rat<\/strong><\/li><li>DOI:&nbsp;10.1016\/j.jep.2004.04.030<\/li><\/ul>\n\n\n\n<p>Normal s\u0131\u00e7anlarda Nigella sativa tohumlar\u0131n\u0131n petrol eter\nekstrakt\u0131 ile 4 haftal\u0131k intragastrik gavaj\u0131n kan \u015fekeri, ins\u00fclin ve lipitler\n\u00fczerindeki etkisini inceledik.&nbsp;Petrol eter ekstresi, ge\u00e7ici kilo kayb\u0131na\nd\u00f6n\u00fc\u015fen g\u0131da al\u0131m\u0131nda% 25&#8217;lik bir azalmaya neden oldu.&nbsp;\u0130n vivo veya in\nvitro bitkinin toksisite belirtisi g\u00f6r\u00fclmemi\u015ftir.&nbsp;A\u00e7l\u0131k plazma glikozu,\nNigella sativa tedavisi boyunca stabil kald\u0131.&nbsp;4 haftal\u0131k tedavinin\nsonunda, Nigella sativa ile tedavi edilen s\u0131\u00e7anlarda a\u00e7l\u0131k plazma ins\u00fclin ve\ntrigliserit seviyeleri daha d\u00fc\u015f\u00fckt\u00fc ve \u00e7ift beslemeli kontrollere k\u0131yasla daha\ny\u00fcksek HDL-kolesterol vard\u0131.&nbsp;\u0130ns\u00fcline yan\u0131t, t\u00fcm gruplardan hayvanlardan\nizole edilen hepatositlerde fosforile MAPK p44 \/ 42erk ve PKB&#8217;nin Western blot\nanalizi ile de\u011ferlendirildi.&nbsp;\u0130n vivo Nigella sativa tedavisi, ins\u00fcline\nyan\u0131t olarak MAPK ve PKB&#8217;nin doza ba\u011fl\u0131 daha fazla aktivasyonuyla\nsonu\u00e7land\u0131.&nbsp;Bu sonu\u00e7lar, Nigella sativa&#8217;n\u0131n petrol eter ekstrakt\u0131n\u0131n hafif\nbir anoreksik etkiye sahip oldu\u011funu ve daha \u00f6nce bitki ile elde edilen\nhipolipidemik aktiviteyi i\u00e7erdi\u011fini g\u00f6stermektedir.&nbsp;Daha da \u00f6nemlisi,\nverilerimiz, petrol eter ekstrakt\u0131 ile in vivo tedavinin, hormon resept\u00f6r\u00fcn\u00fcn\niki ana h\u00fccre i\u00e7i sinyal iletim yolunun aktivitesini artt\u0131rarak bir ins\u00fclin\nduyarl\u0131la\u015ft\u0131r\u0131c\u0131 etki yapt\u0131\u011f\u0131n\u0131 g\u00f6stermektedir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">10-)Nigella Sativa Improves Glycemic Control and\nAmeliorates Oxidative Stress in Patients With Type 2 Diabetes Mellitus: Placebo\nControlled Participant Blinded Clinical Trial<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;10.1371\/journal.pone.0113486<\/li><\/ul>\n\n\n\n<p><strong>Giri\u015f ve ama\u00e7:&nbsp;<\/strong>Oksidatif stres, diabetes mellitus patogenezinde ve komplikasyonlar\u0131nda\n\u00f6nemli bir rol oynamaktad\u0131r.&nbsp;\u00d6nceki \u00e7al\u0131\u015fmam\u0131z, tip 2 diyabetliler aras\u0131nda\noral hipoglisemik ila\u00e7larla kombinasyon halinde 3 ayl\u0131k Nigella sativa (NS)\ntakviyesi ile \u00fcretilen glikoz d\u00fc\u015f\u00fcr\u00fcc\u00fc etkiyi g\u00f6stermi\u015ftir.&nbsp;Bu \u00e7al\u0131\u015fma,\noral hipoglisemik ila\u00e7lar \u00fczerinde tip 2 diyabetes mellituslu hastalarda NS&#8217;nin\nuzun s\u00fcreli glikoz d\u00fc\u015f\u00fcr\u00fcc\u00fc etkisini (bir y\u0131ldan fazla) ara\u015ft\u0131rd\u0131 ve bu\nhastalar\u0131n redoks durumu \u00fczerindeki etkisini ara\u015ft\u0131rd\u0131.<\/p>\n\n\n\n<p><strong>Y\u00f6ntemler:&nbsp;<\/strong>Standart oral hipoglisemik ila\u00e7 kullanan 114 tip 2 diyabetik hasta\nrahatl\u0131kla 2 gruba ayr\u0131ld\u0131.&nbsp;Kontrol grubu (n = 57) plasebo olarak aktif\nk\u00f6m\u00fcr ald\u0131 ve NS grubu (n = 57) standart ila\u00e7lar\u0131na ek olarak bir y\u0131l boyunca\ng\u00fcnde 2 g NS ald\u0131.&nbsp;A\u00e7l\u0131k kan \u015fekeri (FBG), glikosillenmi\u015f hemoglobin\n(HbA1c), C-peptid, ba\u015flang\u0131\u00e7taki toplam antioksidan kapasite (TAC), s\u00fcperoksit\ndismutaz (SOD), katalaz (CAT), glutatyon ve tiobarbit\u00fcrik asit reaktif maddeler\n(TBARS) ve her Bundan 3 ay sonra belirlendi.&nbsp;\u0130ns\u00fclin direnci ve cell-h\u00fccre\naktivitesi HOMA2 hesaplay\u0131c\u0131s\u0131 kullan\u0131larak hesapland\u0131.<\/p>\n\n\n\n<p><strong>Bulgular:&nbsp;<\/strong>\u0130ki grup aras\u0131ndaki kar\u015f\u0131la\u015ft\u0131rma FBG&#8217;de anlaml\u0131 bir d\u00fc\u015f\u00fc\u015f g\u00f6sterdi\n(kontrol grubunda 180 \u00b1 5.75 ila 180 \u00b1 5.59 aras\u0131 NS \u00b1 grubunda 195 \u00b1 6.57 ila\n172 \u00b1 5.83), HbA1c (kontrolde 8.2 \u00b1 0.12 ila 8.5 \u00b1 0.14) VS grubunda 8.6 \u00b1 0.13\nila 8.2 \u00b1 0.14) ve TBARS (NS grubunda 54.1 \u00b1 4.64 ila 41.9 \u00b1 3.16 kontrol VS&#8217;de\n48.3 \u00b1 6.89 ila 52.9 \u00b1 5.82), TAC&#8217;de \u00f6nemli bir y\u00fckselmeye ek olarak, NS\nhastalar\u0131nda SOD ve glutatyon kontrollere k\u0131yasla.&nbsp;NS grubunda ins\u00fclin\ndirenci anlaml\u0131 olarak d\u00fc\u015f\u00fckt\u00fc, p-h\u00fccresi aktivitesi t\u00fcm tedavi s\u00fcresi boyunca\ntaban \u00e7izgisi de\u011ferlerinden anlaml\u0131 derecede y\u00fcksekti.<\/p>\n\n\n\n<p><strong>Sonu\u00e7:&nbsp;<\/strong>Nigella sativa ile uzun s\u00fcreli takviye, oral hipoglisemik ila\u00e7larla tedavi\nedilen tip 2 diyabetik hastalarda glikoz homeostazisini geli\u015ftirir ve\nantioksidan savunma sistemini geli\u015ftirir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">11-)Effects of Thymoquinone on STZ-induced Diabetic\nNephropathy: An Immunohistochemical Study<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;10.3109\/01913123.2013.830166<\/li><\/ul>\n\n\n\n<p><strong>Giri\u015f:&nbsp;<\/strong>Timokinon (TQ), Nigella sativa (NS) tohumlar\u0131n\u0131n en bol ve aktif\nbile\u015fenidir.&nbsp;Karaci\u011fer, b\u00f6brek ve kalp koruyucu etkileri hayvan\nmodellerinde g\u00f6sterilmi\u015ftir.&nbsp;Streptozotosin (STZ), tip I diyabetes\nmellitus (T1DM) olarak da bilinen ins\u00fcline ba\u011f\u0131ml\u0131 diyabet mellitusu (IDDM)\nind\u00fckleyebilen bir ajan olarak deneysel olarak yayg\u0131n olarak kullan\u0131lan bir\nantibiyotiktir.<\/p>\n\n\n\n<p><strong>Ama\u00e7:&nbsp;<\/strong>Bu \u00e7al\u0131\u015fma, s\u0131\u00e7anlarda STZ&#8217;nin neden oldu\u011fu diyabette TQ&#8217;nun olas\u0131 yararl\u0131\netkilerini vurgulamak ve diyabetik nefropatinin TQ&#8217;ya cevab\u0131nda mezenkimal ve\nepitelyal belirte\u00e7lerin prediktif de\u011ferini belirlemek amac\u0131yla yap\u0131ld\u0131.<\/p>\n\n\n\n<p><strong>Gere\u00e7 ve y\u00f6ntem:&nbsp;<\/strong>Altm\u0131\u015f yeti\u015fkin erkek albino s\u0131\u00e7an 3 gruba ayr\u0131ld\u0131: kontrol, tedavi\nedilmeyen diyabetik ve TQ ile tedavi edilen diyabetik.<\/p>\n\n\n\n<p><strong>Bulgular:&nbsp;<\/strong>Diyabetik s\u0131\u00e7anlar, mezen\u015fimal belirte\u00e7ler Fsp1, desmin ve MMP-17&#8217;nin\nimm\u00fcnohistokimyasal ekspresyonu ile hem b\u00f6brek glomerullerinde hem de\nt\u00fcb\u00fcllerde morfolojik de\u011fi\u015fiklikler ve b\u00fcy\u00fck \u00f6l\u00e7\u00fcde diyabetik b\u00f6breklerin\nglomer\u00fcllerinde kaybolmas\u0131 sergiledi.&nbsp;TQ ile tedavi STZ ile ind\u00fcklenen\ndiyabetik s\u0131\u00e7anlarda renal morfolojik ve imm\u00fcnohistokimyasal de\u011fi\u015fiklikleri \u00f6nemli\n\u00f6l\u00e7\u00fcde azaltm\u0131\u015ft\u0131r.<\/p>\n\n\n\n<p><strong>Sonu\u00e7:&nbsp;<\/strong>Timokinonun deneysel diyabetik nefropati \u00fczerinde koruyucu etkileri\nvard\u0131r.&nbsp;Hem mezenkimal hem de epitelyal belirte\u00e7ler erken b\u00f6brek hasar\u0131n\u0131n\nm\u00fckemmel belirleyicileri ve STZ&#8217;nin neden oldu\u011fu diyabetik nefropatide TQ yan\u0131t\nverebilirli\u011finin g\u00f6stergeleri olarak hizmet eder.<\/p>\n\n\n\n<p><strong>12-)Protective\nEffect of Thymoquinone Against High-Fructose Diet-Induced Metabolic Syndrome in\nRats<\/strong><\/p>\n\n\n\n<p><strong>Ama\u00e7:&nbsp;<\/strong>Asya g\u0131dalar\u0131nda yayg\u0131n olarak baharat olarak kullan\u0131lan Nigella sativa\n(Linn.) Tohumunun biyoaktif bir bile\u015feni olan timokinon (TQ) &#8216;nun \u00e7ok \u00e7e\u015fitli\nbiyolojik etkilere sahip oldu\u011fu bildirilmi\u015ftir.&nbsp;Bu \u00e7al\u0131\u015fmada erkek Wistar\ns\u0131\u00e7anlar\u0131nda TQ&#8217;nun y\u00fcksek fruktozlu diyet (HFD) kaynakl\u0131 metabolik sendrom\n(MetS) \u00fczerindeki etkisi de\u011ferlendirildi.<\/p>\n\n\n\n<p><strong>Y\u00f6ntemler:&nbsp;<\/strong>MetS, 42 g\u00fcn boyunca% 60 HFD ile ind\u00fcklendi.&nbsp;TQ (25, 50 ve 100 mg \/\nkg, g\u00fcnde bir kez po) 42 g\u00fcn boyunca HFD ile birlikte uyguland\u0131.&nbsp;Standart\nbir ila\u00e7 olarak pioglitazon (g\u00fcnde bir kez 10 mg \/ kg, po)\nkullan\u0131ld\u0131.&nbsp;Plazma glukozu, trigliseritler, toplam kolesterol ve\nHDL-kolesterol 0 ve 42. g\u00fcnlerde tahmin edildi. Kan bas\u0131nc\u0131ndaki de\u011fi\u015fim, oral\nglukoz tolerans\u0131 ve ins\u00fclin direnci \u00f6l\u00e7\u00fcld\u00fc.&nbsp;Hepatik tiyobarbit\u00fcrik asit\nreaktif maddeler (TBARS), azalt\u0131lm\u0131\u015f glutatyon (GSH), s\u00fcperoksit dismutaz (SOD)\nve katalaz d\u00fczeyleri hepatik oksidatif stresin \u00f6l\u00e7\u00fcs\u00fc olarak\nhesapland\u0131.&nbsp;PPAR-a ve PPAR-y&#8217;nin hepatik mRNA&#8217;s\u0131 da incelenmi\u015ftir.<\/p>\n\n\n\n<p><strong>Bulgular:&nbsp;<\/strong>TQ, hiperglisemi, hipertrigliseridemi, hiperkolesterolemi ve y\u00fcksek\nsistolik kan bas\u0131nc\u0131 gibi HFD ile ind\u00fcklenen MetS&#8217;in karakteristik \u00f6zelliklerini\n\u00f6nledi.&nbsp;TQ ayr\u0131ca bozulmu\u015f glikoz tolerans\u0131n\u0131 ve ins\u00fclin direncini\n\u00f6nledi.&nbsp;Ayn\u0131 zamanda, hepatik TBARS&#8217;ta HFD&#8217;nin neden oldu\u011fu art\u0131\u015f\u0131 ve SOD,\nkatalaz ve GSH&#8217;nin t\u00fckenmesini iyile\u015ftirdi.&nbsp;TQ, HFD s\u0131\u00e7anlar\u0131nda PPAR-a ve\nPPAR-y&#8217;nin hepatik mRNA&#8217;s\u0131nda azalmay\u0131 \u00f6nledi ve etkiler, pioglitazonunkilerle\nkar\u015f\u0131la\u015ft\u0131r\u0131labilirdi.<\/p>\n\n\n\n<p><strong>Sonu\u00e7lar:&nbsp;<\/strong>Bu \u00e7al\u0131\u015fma, TQ&#8217;nun HFD ile ind\u00fcklenen MetS&#8217;e kar\u015f\u0131 PPAR mekanizmas\u0131\narac\u0131l\u0131\u011f\u0131yla arac\u0131l\u0131k edilmi\u015f olabilecek s\u0131\u00e7anlar \u00fczerindeki koruyucu etkisini\ng\u00f6stermektedir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">13-)Protective Effects of the Volatile Oil of\nNigella Sativa Seeds on Beta-Cell Damage in Streptozotocin-Induced Diabetic\nRats: A Light and Electron Microscopic Study<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;10.1007\/s10735-009-9251-0<\/li><\/ul>\n\n\n\n<p>Bu \u00e7al\u0131\u015fman\u0131n amac\u0131, Nigella sativa (NS) tohumlar\u0131n\u0131n u\u00e7ucu\nya\u011f\u0131n\u0131n, STZ ile ind\u00fcklenen diyabetik s\u0131\u00e7anlarda pankreatik beta h\u00fccrelerinin\nins\u00fclin imm\u00fcn reaktivitesi ve ultrastr\u00fckt\u00fcrel de\u011fi\u015fiklikleri \u00fczerindeki olas\u0131\nkoruyucu etkilerini de\u011ferlendirmektir.&nbsp;Diyabet olu\u015fturmak i\u00e7in STZ\nintraperitonal olarak 50 mg \/ kg&#8217;l\u0131k tek bir dozda enjekte edildi.&nbsp;NS ile\ntedavi edilen gruplardaki s\u0131\u00e7anlara, STZ enjeksiyonundan 3 g\u00fcn \u00f6nce ba\u015flayarak\n4 hafta boyunca g\u00fcnde bir kez NS (0.2 ml \/ kg) verildi.&nbsp;Bug\u00fcne kadar, NS\ntedavisi ile STZ&#8217;nin neden oldu\u011fu diyabetik s\u0131\u00e7anlarda pankreatik beta\nh\u00fccrelerinin ultrastr\u00fckt\u00fcrel de\u011fi\u015fiklikleri bildirilmemi\u015ftir.&nbsp;STZ&#8217;nin\nneden oldu\u011fu diyabetli s\u0131\u00e7anlarda adac\u0131k h\u00fccresi dejenerasyonu ve zay\u0131f ins\u00fclin\nimm\u00fcnohistokimyasal boyama g\u00f6zlenmi\u015ftir.&nbsp;\u0130ns\u00fclin i\u00e7in boyama yo\u011funlu\u011funun\nartmas\u0131 ve beta h\u00fccre say\u0131lar\u0131n\u0131n korunmas\u0131 NS ile tedavi edilen diyabetik\ns\u0131\u00e7anlarda belirgindi.&nbsp;NS&#8217;nin STZ-diyabetik s\u0131\u00e7anlar \u00fczerindeki koruyucu\netkisi, gran\u00fcllerle indirgenmi\u015f salg\u0131 vezik\u00fcllerinde \u0131l\u0131ml\u0131 bir art\u0131\u015f ve ayr\u0131ca\nkontrol s\u0131\u00e7anlar\u0131na k\u0131yasla beta h\u00fccresinin mitokondri i\u00e7indeki cristae kayb\u0131\nile hafif bir tahribatla a\u00e7\u0131kt\u0131.&nbsp;Bu bulgular NS tedavisinin, morfolojik\nde\u011fi\u015fiklikleri azaltarak ve pankreatik beta h\u00fccre b\u00fct\u00fcnl\u00fc\u011f\u00fcn\u00fc koruyarak\ndiyabette terap\u00f6tik koruyucu bir etki yapt\u0131\u011f\u0131n\u0131 d\u00fc\u015f\u00fcnd\u00fcrmektedir.&nbsp;Sonu\u00e7\nolarak NS, beta h\u00fccrelerini oksidatif strese kar\u015f\u0131 korumak i\u00e7in klinik olarak\nfaydal\u0131 olabilir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">14-)Ayurvedic Formulation of Liv-Pro-08 Reduces\nNonalcoholic Fatty Liver Disease in Rats Fed With High-Fat Diet<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;10.1016\/j.jams.2011.09.014<\/li><\/ul>\n\n\n\n<p>Alkols\u00fcz ya\u011fl\u0131 karaci\u011fer hastal\u0131\u011f\u0131 (NAFLD) ciddi bir obezite\nile ili\u015fkili bozukluk olarak ortaya \u00e7\u0131km\u0131\u015ft\u0131r ve \u00f6n\u00fcm\u00fczdeki on y\u0131llar boyunca\nd\u00fcnya \u00e7ap\u0131nda \u00f6nemli bir karaci\u011fer sa\u011fl\u0131\u011f\u0131 sorunu olmaya devam\nedecektir.&nbsp;Liv-Pro-08&#8217;in (Nigella sativa, Entada pursaetha ve Ficus\nglomerata) y\u00fcksek ya\u011fl\u0131 diyetle beslenen s\u0131\u00e7anlarda oral ayurveda\nform\u00fclasyonunun etkisini belirlemeyi ama\u00e7lad\u0131k.&nbsp;S\u0131\u00e7anlara 7 g\u00fcnl\u00fck bir\ns\u00fcre i\u00e7in y\u00fcksek ya\u011fl\u0131 bir diyet verildi.&nbsp;Bu s\u00fcrenin sonunda Liv-Pro-08\n(250, 500 ve 750 mg \/ kg. 7 g\u00fcn boyunca v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131na oral yoldan verildi,\ny\u00fcksek ya\u011fl\u0131 diyetin obezite ve ins\u00fclin direnci ile ilgili \u00e7e\u015fitli parametreler\n\u00fczerindeki etkisini inceledik. Liv-Pro-08 ekstrakt\u0131n\u0131 alan deneysel s\u0131\u00e7anlar,\nlipoprotein profilleri, ekstrakt\u0131 almayanlara k\u0131yasla \u00f6nemli \u00f6l\u00e7\u00fcde\ngeli\u015ftirildi.&nbsp;serum aspartat aminotransferaz, alanin aminotransferaz ve\nalkalin fosfataz enzimlerinde hafif bir azalma g\u00f6zlenmi\u015ftir.&nbsp;Ayr\u0131ca\nLiv-Pro-08, a\u00e7l\u0131k serum glikozunu ve a\u00e7l\u0131k ins\u00fclin seviyelerini \u00f6nemli \u00f6l\u00e7\u00fcde\nazaltt\u0131.&nbsp;Bu deneysel \u00e7al\u0131\u015fma Liv-Pro-08&#8217;in NAFLD ilerlemesini \u00f6nlemede\n(yani hepatik lipit birikimini azaltmada) terap\u00f6tik bir ara\u00e7 olarak hareket\nedebilece\u011fini d\u00fc\u015f\u00fcnd\u00fcrmektedir.&nbsp;Daha fazla ara\u015ft\u0131rma ve b\u00fcy\u00fck randomize\n\u00e7al\u0131\u015fmalar\u0131n yap\u0131lmas\u0131 gerekmekle birlikte, ayurveda Liv-Pro-08 oral\nform\u00fclasyon gelecekte NAFLD i\u00e7in potansiyel bir do\u011fal ila\u00e7 olabilir<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">15-)The Possible Protective Effects of Virgin Olive\nOil and Nigella Sativa Seeds on the Biochemical and Histopathological Changes\nin Pancreas of Hyperlipidemic Rats<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;10.5603\/FM.a2019.0017<\/li><\/ul>\n\n\n\n<p><strong>Ama\u00e7:&nbsp;<\/strong>Hiperlipidemi, ateroskleroz geli\u015fimi ve ilerlemesi i\u00e7in bir risk fakt\u00f6r\u00fcd\u00fcr\nve \u00e7e\u015fitli hastal\u0131klarla ba\u011flant\u0131l\u0131d\u0131r.&nbsp;Bu \u00e7al\u0131\u015fma, s\u0131zma zeytinya\u011f\u0131 ve\nNigella sativa tohumlar\u0131n\u0131n s\u0131\u00e7anlar\u0131n pankreas\u0131nda meydana gelen biyokimyasal\nve histopatolojik de\u011fi\u015fiklikler \u00fczerindeki olas\u0131 koruyucu etkilerini\nde\u011ferlendirmek amac\u0131yla yap\u0131lm\u0131\u015ft\u0131r.&nbsp;\u00c7al\u0131\u015fma 8 hafta s\u00fcrer ve d\u00f6rt gruba\n(her biri 6 s\u0131\u00e7an) b\u00f6l\u00fcnm\u00fc\u015f 24 albino s\u0131\u00e7an;&nbsp;grup I, kontrol grubu, normal\nstandart diyetle beslenir, grup II y\u00fcksek ya\u011fl\u0131 diyetle beslenir (HFD), grup\nIII HFD ve s\u0131zma zeytinya\u011f\u0131 ile beslenir, grup IV HFD ve Nigella sativa tohumu\ntozu ile beslenir.<\/p>\n\n\n\n<p><strong>Gere\u00e7 ve y\u00f6ntem:&nbsp;<\/strong>Deney bittikten sonra kan \u00f6rnekleri, a\u00e7l\u0131k kan \u015fekeri, pankreatik amilaz ve\nins\u00fclin d\u00fczeyleri i\u00e7in topland\u0131 ve de\u011ferlendirildi.&nbsp;Daha sonra s\u0131\u00e7anlar\nkurban edildi ve pankreata ekstrakte edildi ve bunlar\u0131n dilimleri, hematoksilin\nboyas\u0131 ve Masson&#8217;un Trikrom boyas\u0131 kullan\u0131larak histolojik inceleme i\u00e7in\ni\u015flendi.&nbsp;Pankreatan\u0131n kuyru\u011fundan k\u00fc\u00e7\u00fck par\u00e7alar \u00e7\u0131kar\u0131ld\u0131 ve elektron\nmikroskobik incelemesi i\u00e7in i\u015flendi.&nbsp;Verilerin uygun istatistiksel testler\nkullan\u0131larak istatistiksel analizi de yap\u0131lm\u0131\u015ft\u0131r.<\/p>\n\n\n\n<p><strong>Bulgular:&nbsp;<\/strong>Bu \u00e7al\u0131\u015fmada, hiperlipidemik s\u0131\u00e7anlarda serum lipit profili, saf zeytinya\u011f\u0131\nveya Nigella sativa tohumu tozu ile y\u00fcksek ya\u011fl\u0131 diyetle beslenen s\u0131\u00e7anlarda\ntoplam kolesterol, LDL-kolesterol ve trigliseritlerde \u00f6nemli bir azalma olarak\niyile\u015ftirilmi\u015ftir.&nbsp;Ayr\u0131ca, Nigella sativa HDL&#8217;yi azalt\u0131rken, s\u0131zma\nzeytinya\u011f\u0131 HDL&#8217;yi \u00f6nemli \u00f6l\u00e7\u00fcde artt\u0131r\u0131r.&nbsp;Ayr\u0131ca bu gruplarda kan \u015fekeri\nve amilaz\u0131n serum d\u00fczeylerinde \u00f6nemli bir azalma ve ins\u00fclin d\u00fczeylerinde \u00f6nemli\nbir art\u0131\u015f mevcuttur.&nbsp;Histolojik ve ultrastr\u00fckt\u00fcrel sonu\u00e7lar, s\u0131zma\nzeytinya\u011f\u0131 veya Nigella sativa tohumlar\u0131 ile beslenen hiperlipidemik\ns\u0131\u00e7anlardan pankreas dokular\u0131n\u0131n ekzokrin ve endokrin k\u0131s\u0131mlar\u0131n\u0131n\nrejenerasyonunu ortaya \u00e7\u0131karm\u0131\u015ft\u0131r.<\/p>\n\n\n\n<p><strong>Sonu\u00e7 ve \u00f6neriler:&nbsp;<\/strong>Bu \u00e7al\u0131\u015fmadan biyokimyasal sonu\u00e7lar histolojik ve ultrastr\u00fckt\u00fcrel sonu\u00e7lara\nparalel hale geldi, bu y\u00fczden s\u0131zma zeytinya\u011f\u0131 ve Nigella sativa tohumlar\u0131n\u0131n\nantihiperlipidemik ve hipoglisemik etkilere sahip oldu\u011fu ve pankreas\u0131n\nhiperlipidemiye ba\u011fl\u0131 yaralanmalardan koruyabilece\u011fi ve diyetlerde s\u0131zma\nzeytinya\u011f\u0131 ve Nigella sativa tohumlar\u0131n\u0131n g\u00fcnl\u00fck t\u00fcketimi \u015fiddetle tavsiye\nedilir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">16-)<em>Nigella sativa<\/em>&nbsp;Stimulates\nInsulin Secretion From Isolated Rat Islets and Inhibits the Digestion and\nAbsorption of (CH&nbsp;<sub>2<\/sub>&nbsp;O)&nbsp;<sub>n<\/sub>&nbsp;in the Gut<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;10.1042\/BSR20190723<\/li><\/ul>\n\n\n\n<p><em>\u00c7\u00f6rek otu sativa<\/em>&nbsp;tohumlar\u0131\ngeleneksel olarak anti-diyabetik \u00f6zelliklere sahip olarak bilinir.&nbsp;Sonu\u00e7\nolarak, anti-hiperglisemik aktivitesinin mekanizmas\u0131n\u0131 ke\u015ffetmeyi\nama\u00e7l\u0131yoruz.&nbsp;Bu \u00e7al\u0131\u015fmada gastrointestinal (GI) motilite, ba\u011f\u0131rsak\ndisakkaridaz aktivitesi ve ba\u011f\u0131rsakta karbonhidrat sindirimi ve emiliminin\ninhibisyonu gibi \u00e7e\u015fitli deneysel tasar\u0131mlar kullan\u0131lmaktad\u0131r.&nbsp;Tip 2 diyabetik\nmodel olarak kullan\u0131lan hayvanlar, bunlar\u0131 yapmak i\u00e7in streptozotosin ile\nind\u00fcklenmi\u015ftir.&nbsp;Hayvanlar\u0131n ger\u00e7ekten diyabetik oldu\u011funu do\u011frulamak i\u00e7in\noral glukoz tolerans testi yap\u0131ld\u0131.&nbsp;Ekstrakt postprandiyal glikozu d\u00fc\u015f\u00fcrd\u00fc\nve ba\u011f\u0131rsaktaki glikoz emilimine m\u00fcdahale etti\u011fini d\u00fc\u015f\u00fcnd\u00fcrd\u00fc.&nbsp;Ayr\u0131ca\ns\u0131\u00e7anlarda glikoz (2.5 g \/ kg, s \/ b) tolerans\u0131n\u0131\ngeli\u015ftirdi.&nbsp;Ayr\u0131ca,&nbsp;<em>N. sativa<\/em>&nbsp;ile tedavia\u00e7l\u0131k s\u0131\u00e7anlarda\ndisakkaridaz enzim aktivitesini azalt\u0131rken, GI motilitesinde \u00f6nemli bir geli\u015fme\nsa\u011flad\u0131.&nbsp;Ekstrakt bir akut oral s\u00fckroz (2.5 g \/ kg, s \/ b) y\u00fck deneyi\ni\u00e7inde benzer bir etki \u00fcretti.&nbsp;S\u00fckroz uygulamas\u0131n\u0131 takiben, GI yolunun\nalt\u0131 farkl\u0131 b\u00f6l\u00fcm\u00fcnde \u00f6nemli miktarda emilmemi\u015f s\u00fckroz bulundu.&nbsp;Bu,&nbsp;<em>N.\nsativa&#8217;n\u0131n<\/em>&nbsp;GI i\u00e7eri\u011fini serbest b\u0131rakma ve glikoz emilimini azaltma\nveya geciktirme potansiyeline sahip&nbsp;oldu\u011funu g\u00f6sterir&nbsp;.&nbsp;\u0130ns\u00fclin\nsal\u0131m tahlilinde bulunan ekstrakt\u0131n potansiyel bir hipoglisemik aktivitesi,\nburada ekstrakt izole edilmi\u015f s\u0131\u00e7an adac\u0131klar\u0131ndan ins\u00fclin sekresyonunu \u00f6nemli\n\u00f6l\u00e7\u00fcde geli\u015ftirdi.&nbsp;Bu mevcut bulgular,&nbsp;<em>N. sativa&#8217;n\u0131n<\/em>&nbsp;tohumlar,\ntip 2 diyabetik hayvan modelleri i\u00e7inde ba\u011f\u0131rsaktaki karbonhidrat sindirimi ve\nemilimini azaltarak veya geciktirerek ve ayr\u0131ca plazma glikozuna yan\u0131t olarak\nins\u00fclin sekresyonunu iyile\u015ftirerek postprandiyal anti-hiperglisemik aktivite \u00fcretmektedir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">17-)The Effect of&nbsp;<em>Nigella sativa<\/em>&nbsp;Oil\non Serum Levels of Inflammatory Markers, Liver Enzymes, Lipid Profile, Insulin\nand Fasting Blood Sugar in Patients With Non-Alcoholic Fatty Liver<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;10.1007\/s40200-019-00439-6<\/li><\/ul>\n\n\n\n<p><strong>Arkaplan:&nbsp;<\/strong>Alkols\u00fcz ya\u011fl\u0131 karaci\u011fer hastal\u0131\u011f\u0131 (NAFLD), inflamasyonla ili\u015fkili\nmetabolik bozukluklardan biridir.&nbsp;<em>\u00c7\u00f6rek otu sativa<\/em>&nbsp;(NS) tohum\nya\u011f\u0131, Timokinon (TQ), doymam\u0131\u015f ya\u011f asitleri ve flavonoidler gibi farkl\u0131\nkimyasal bile\u015fiklere sahiptir.&nbsp;NS&#8217;ler t\u0131p bilimlerinde anti-enflamatuar ve\nantioksidanlar olarak kullan\u0131l\u0131r.&nbsp;Bu \u00e7al\u0131\u015fmada NAFLD&#8217;li hastalar\u0131n serum\nd\u00fczeylerinde NS ya\u011f\u0131n\u0131n \u00e7e\u015fitli parametreler \u00fczerindeki etkisi ara\u015ft\u0131r\u0131ld\u0131.<\/p>\n\n\n\n<p><strong>Y\u00f6ntemler:&nbsp;<\/strong>NAFLD tan\u0131s\u0131 alan 41 hasta randomize, \u00e7ift k\u00f6r, plasebo kontroll\u00fc bir\nklinik \u00e7al\u0131\u015fmaya kat\u0131ld\u0131.&nbsp;Hastalar rastgele iki gruba ayr\u0131ld\u0131;&nbsp;biri\nNS ya\u011f\u0131 ve di\u011feri 8 hafta boyunca plasebo (parafin ya\u011f\u0131)\nalmaktad\u0131r.&nbsp;\u00c7al\u0131\u015fman\u0131n ba\u015f\u0131nda ve sonunda hastalardan kan \u00f6rnekleri\nal\u0131nd\u0131.&nbsp;Daha sonra, karaci\u011fer enzimleri (ALT, AST ve GGT), enflamatuar\nmarkerler (Hs-CRP, TNF-a ve IL-6), ins\u00fclin, lipit profilleri (toplam\nkolesterol, trigliserit, VLDL, LDL-C ve HDL-C ), FBS ve kan bas\u0131nc\u0131 \u00f6l\u00e7\u00fcld\u00fc.<\/p>\n\n\n\n<p><strong>Bulgular:&nbsp;<\/strong>Ek olarak NS tohum ya\u011f\u0131 t\u00fcketimi FBS seviyesini, lipit profillerini (TG,\nTC, LDL, VLDL), karaci\u011fer enzimlerini (AST ve ALT), hs-CRP inflamatuar markeri,\nIL-6, TNF-\u03b1&#8217;y\u0131 d\u00fc\u015f\u00fcrd\u00fc. plasebo grubuna g\u00f6re HDL-C d\u00fczeylerinde art\u0131\u015f (&nbsp;<em>P<\/em>&nbsp;&lt;0.05).&nbsp;NS\nya\u011f\u0131 alman\u0131n \u00e7al\u0131\u015fman\u0131n ba\u015flang\u0131c\u0131na k\u0131yasla serum ins\u00fclin, kan bas\u0131nc\u0131 ve GGT\nd\u00fczeyleri \u00fczerinde anlaml\u0131 bir etkisi olmam\u0131\u015ft\u0131r (&nbsp;<em>P<\/em>&nbsp;&lt;0.05).<\/p>\n\n\n\n<p><strong>Sonu\u00e7:&nbsp;<\/strong>NS tohum ya\u011f\u0131 takviyeleri, NAFLD hastalar\u0131nda karaci\u011fer enzimlerini ve\nlipit profillerini azaltabilir ve bu hasta grubundaki iltihab\u0131 azaltarak\nkaraci\u011ferde koruyucu bir rol oynayabilir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">18-)The Effects of Natural Nano-Sized Clinoptilolite\nand&nbsp;<em>Nigella sativa<\/em>&nbsp;Supplementation on Serum Bone Markers in\nDiabetic Rats<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;10.15171\/bi.2019.21<\/li><\/ul>\n\n\n\n<p><strong><em>Giri\u015f:<\/em><\/strong>&nbsp;Bir\u00e7ok \u00e7al\u0131\u015fma,\ndiyabetes mellitusun daha y\u00fcksek kemik k\u0131r\u0131\u011f\u0131 riski ile ili\u015fkili oldu\u011funu\ndo\u011frulamaktad\u0131r.&nbsp;<em>Nigella sativa<\/em>&nbsp;(NS) ve klinoptilolitin\ndiyabetle ili\u015fkili baz\u0131 hastal\u0131klar\u0131n \u00f6nlenmesi \/ azalt\u0131lmas\u0131ndakiyararl\u0131\netkilerig\u00f6sterilmi\u015ftir.&nbsp;Bu \u00e7al\u0131\u015fma, tip 2 diyabetli s\u0131\u00e7anlarda do\u011fal nano\nboyutlu klinoptilolit (NCLN) ve NS&#8217;nin ayr\u0131 ve e\u015fzamanl\u0131 takviyesinin serum\nkemik belirte\u00e7leri \u00fczerindeki etkilerini incelemek i\u00e7in yap\u0131ld\u0131.&nbsp;<strong><em>Y\u00f6ntem:<\/em><\/strong>Toplam\n42 (vaka = 36 ve kontrol = 6) yeti\u015fkin erkek Wistar s\u0131\u00e7an\u0131 diyabetik ve\ndiyabetik olmayan olmak \u00fczere 2 gruba ayr\u0131ld\u0131.&nbsp;Diyabeti do\u011frulamak i\u00e7in\noral glukoz tolerans testi ve ins\u00fclin direncinin homeostatik model\nde\u011ferlendirmesi (HOMA-IR) testi yap\u0131lm\u0131\u015ft\u0131r.&nbsp;Ard\u0131ndan, diyabetik grup 4\nalt gruba ayr\u0131ld\u0131: [1] kontrol (n = 9), [2] NS% 1 \/ g\u0131da (n = 9), [3] NCLN% 2 \/\ng\u0131da (n = 9), [ 4] NS% 1 \/ g\u0131da + NCLN% 2 \/ g\u0131da (n = 9).&nbsp;7 hafta sonra,\nELISA kitleri kullan\u0131larak serum kemik belirte\u00e7 seviyeleri belirlendi.&nbsp;<strong><em>Bulgular:<\/em><\/strong>&nbsp;Analiz,\nNCLN grubundaki (1318.6 \u00b1 217.5 U \/ L) serum alkalin fosfataz (ALP)\nd\u00fczeylerinin,&nbsp;di\u011fer m\u00fcdahale gruplar\u0131ndan&nbsp;\u00f6nemli \u00f6l\u00e7\u00fcde (&nbsp;<em>P<\/em>&nbsp;&lt;0.05)\ndaha y\u00fcksek oldu\u011funu g\u00f6sterdi.&nbsp;\u00d6te yandan, NCLN + NS grubunda (10.8 \u00b1 2.6\nmg \/ dL) serum kalsiyum seviyeleri daha y\u00fcksekti (&nbsp;<em>P<\/em>= 0.027) di\u011fer\nt\u00fcm \u00e7al\u0131\u015fma gruplar\u0131na k\u0131yasla.&nbsp;Bununla birlikte, NS grubundaki\ns\u0131\u00e7anlar&nbsp;di\u011fer takviye gruplar\u0131na k\u0131yasla&nbsp;daha y\u00fcksek (535.8 \u00b1 49.3\npg \/ mL) PTH&#8217;ye (&nbsp;<em>P<\/em>&nbsp;&lt;0.0001)&nbsp;sahipti&nbsp;.&nbsp;D\nvitamini ve osteoprotegerin aras\u0131nda anlaml\u0131 bir fark yoktu.&nbsp;<strong><em>Sonu\u00e7:<\/em><\/strong>&nbsp;Bu\n\u00e7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131, kemik mineralizasyonunun, kalsiyum dola\u015f\u0131m\u0131n\u0131 etkileyerek\nNS ve NCLN&#8217;nin e\u015fzamanl\u0131 kullan\u0131m\u0131ndan etkilenebilece\u011fini\nd\u00fc\u015f\u00fcnd\u00fcrmektedir.&nbsp;Ayr\u0131ca, diyetteki NS uygulamas\u0131, art\u0131r\u0131lm\u0131\u015f bir PTH seviyesi\nile g\u00fc\u00e7l\u00fc bir \u015fekilde ili\u015fkilidir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">19-)Mitigation of Obesity-Promoted\nDiseases by Nigella Sativa and Thymoquinone<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;10.1007\/s11130-012-0279-z<\/li><\/ul>\n\n\n\n<p>Obezite, artm\u0131\u015f kardiyovask\u00fcler hastal\u0131k insidans\u0131, kanser,\nins\u00fclin direnci ve ba\u011f\u0131\u015f\u0131kl\u0131k fonksiyon bozuklu\u011fu ile yak\u0131ndan ili\u015fkilidir ve\nbu nedenle obezite azaltma stratejileri, kilo kayb\u0131n\u0131 te\u015fvik etmenin yan\u0131 s\u0131ra\nbu ikincil patolojileri de dikkate almal\u0131d\u0131r.&nbsp;Son \u00e7al\u0131\u015fmalar siyah\nkimyonun (Nigella sativa) kardiyo-koruyucu, anti-kanser, anti-diyabetik,\nantioksidan ve imm\u00fcn mod\u00fclat\u00f6r \u00f6zelliklere sahip oldu\u011funu g\u00f6stermektedir.&nbsp;Siyah\nkimyon ve \/ veya ana biyoaktif bile\u015feni, timokinon \u00e7e\u015fitli hastal\u0131k\nmodellerinde biyoaktivite g\u00f6stermi\u015ftir, ancak etki mekanizmalar\u0131 b\u00fcy\u00fck \u00f6l\u00e7\u00fcde\nbilinmemektedir.&nbsp;Fonksiyonel g\u0131dalar ve nutras\u00f6tiklere artan ilgi ve\nkullan\u0131m\u0131n yan\u0131 s\u0131ra d\u00fcnya \u00e7ap\u0131nda obezite ve kronik hastal\u0131klar\u0131n artmas\u0131 g\u00f6z\n\u00f6n\u00fcne al\u0131nd\u0131\u011f\u0131nda, siyah kimyonun terap\u00f6tik \/ \u00f6nleyici etkilerine dair daha\nfazla ara\u015ft\u0131rma yararl\u0131 olabilir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">20-)Effects of Black Seed (Nigella Sativa) on\nMetabolic Parameters in Diabetes Mellitus: A Systematic Review<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;10.1016\/j.ctim.2015.01.013<\/li><\/ul>\n\n\n\n<p><strong>Ama\u00e7:&nbsp;<\/strong>G\u00fcncel kan\u0131tlar, baz\u0131 \u015fifal\u0131 bitkilerin metabolik parametreler \u00fczerindeki\nyararl\u0131 etkilerini g\u00f6stermektedir.&nbsp;\u00c7\u00f6rek otu sativa, diabetes mellitusta\nmetabolik fakt\u00f6rleri iyile\u015ftirebilen bitkilere bir \u00f6rnektir.&nbsp;NS&#8217;nin t\u0131bbi\n\u00f6zellikleri \u00fczerine yap\u0131lan birka\u00e7 anlat\u0131 inceleme \u00e7al\u0131\u015fmas\u0131na ra\u011fmen, NS&#8217;nin\ndiyabetes mellitustaki glikoz homoeostaz\u0131 ve lipit profili \u00fczerindeki etkilerini\n\u00f6zetleyen sistematik bir inceleme olmad\u0131\u011f\u0131 g\u00f6r\u00fclmektedir.&nbsp;Bu nedenle, bu\n\u00e7al\u0131\u015fman\u0131n amac\u0131, N. sativa&#8217;n\u0131n diyabetes mellitusta metabolik parametreler\n\u00fczerindeki etkilerini g\u00f6zden ge\u00e7irmektir.<\/p>\n\n\n\n<p><strong>Y\u00f6ntemler:&nbsp;<\/strong>1995&#8217;ten Ocak 2014&#8217;e kadar Pubmed, Science Direct, Google bilim adam\u0131 ve\nSpringer veritabanlar\u0131 arand\u0131. Anahtar kelimeler dahil edildi: N. sativa, siyah\ntohum, diyabet, glikoz seviyesi, lipit ve ins\u00fclin.&nbsp;Derleme makaleleri,\nolgu sunumlar\u0131, sempozyum ve kongrede \u00f6zet, di\u011fer bitkilerle kar\u0131\u015ft\u0131r\u0131lan N. sativa\n\u00e7al\u0131\u015fmalar\u0131 hari\u00e7 tutulmu\u015ftur.&nbsp;Ele\u015ftirel de\u011ferlendirmelere dayanarak,\ndahil edilen makalelerin uygunlu\u011fu de\u011ferlendirildi.<\/p>\n\n\n\n<p><strong>Bulgular:&nbsp;<\/strong>Son olarak 19 uygun makale (2 insan denemesi, 14 hayvan modeli ve 3 in vivo\n\/ in vitro \u00e7al\u0131\u015fma) se\u00e7ildi.&nbsp;N. sativa&#8217;n\u0131n, antioksidan \u00f6zellikleri ve\nins\u00fclin sekresyonu, glikoz emilimi, glukoneogenez ve gen ekspresyonu \u00fczerindeki\netkileri de dahil olmak \u00fczere \u00e7e\u015fitli potansiyel mekanizmalarla hiperglisemi ve\nlipit profili i\u015flev bozuklu\u011funu mod\u00fcle edebilece\u011fini belirtmi\u015flerdir.&nbsp;Baz\u0131\n\u00e7al\u0131\u015fmalar, N. sativa&#8217;n\u0131n \u00e7e\u015fitli tiplerinin (ekstrakt, ya\u011f, toz) etkilerini\nbirbirleriyle kar\u015f\u0131la\u015ft\u0131rd\u0131 ve \u00e7e\u015fitli siyah tohum t\u00fcrleriyle farkl\u0131 \u00f6zellikler\nbildirdiler.<\/p>\n\n\n\n<p><strong>Sonu\u00e7:&nbsp;<\/strong>N. sativa diyabet modellerinde glisemik durumu ve lipit profilini\niyile\u015ftirebilir.&nbsp;Bununla birlikte, N. sativa&#8217;n\u0131n yararl\u0131 etkilerini,\ndiyabet y\u00f6netimi i\u00e7in etkili tipini ve dozaj\u0131n\u0131 ve komplikasyonlar\u0131n\u0131 a\u00e7\u0131kl\u0131\u011fa\nkavu\u015fturmak i\u00e7in daha fazla klinik \u00e7al\u0131\u015fma gereklidir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">21-)Thymoquinone, a Bioactive Component of Nigella\nSativa, Normalizes Insulin Secretion From Pancreatic \u03b2-Cells Under Glucose\nOverload via Regulation of malonyl-CoA<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;10.1152\n\/ ajpendo.00250.2015<\/li><\/ul>\n\n\n\n<p>Timokinon (2-izopropil-5-metilbenzo-1,4-kinon), tip 2\ndiyabetik hastalarda y\u00fcksek kan \u015fekeri seviyeleri de dahil olmak \u00fczere \u00e7e\u015fitli\nsemptomlar\u0131 tedavi etmek i\u00e7in geleneksel t\u0131pta kullan\u0131lan bir bitki olan\nNigella sativa&#8217;n\u0131n \u00f6nemli bir biyoaktif bile\u015fenidir.&nbsp;Y\u00fcksek kan \u015fekerinin\nnormalle\u015ftirilmesi, hem periferik dokular taraf\u0131ndan glikozun at\u0131lmas\u0131na hem de\npankreatik \u03b2 h\u00fccrelerinden glikozla uyar\u0131lan ins\u00fclin sekresyonuna (GSIS) ba\u011fl\u0131d\u0131r.&nbsp;Timokinon\n(TQ) ve Nigella sativa ekstraktlar\u0131n\u0131n (NSE&#8217;ler) GSIS ve GSIS reg\u00fclasyonunda\nyer alan kataplerotik metabolik yolaklar \u00fczerindeki etkilerini ara\u015ft\u0131rmak i\u00e7in\nklonal cells h\u00fccreleri ve kemirgen adac\u0131klar\u0131 kulland\u0131k.&nbsp;TQ ve NSE, kinona\nba\u011f\u0131ml\u0131 bir redoks d\u00f6ng\u00fc mekanizmas\u0131 arac\u0131l\u0131\u011f\u0131yla NAD (P) H \/ NAD (P) (+)\noranlar\u0131n\u0131 d\u00fczenledi.&nbsp;TQ i\u00e7eri\u011fi, NSE ekstraktlar\u0131n\u0131n redoks d\u00f6ng\u00fc\naktivitesinin derecesi ile pozitif korelasyon g\u00f6sterdi,&nbsp;TQ&#8217;nun NSE&#8217;ye\nba\u011fl\u0131 redoks d\u00f6ng\u00fcs\u00fcne arac\u0131l\u0131k eden \u00f6nemli bir bile\u015fen oldu\u011funu\nd\u00fc\u015f\u00fcnd\u00fcrmektedir.&nbsp;Hem akut hem de kronik TQ ve NSE&#8217;ye maruz kalma GSIS&#8217;yi\nartt\u0131rd\u0131 ve TQ ve NSE&#8217;nin ATP \/ ADP oran\u0131n\u0131 art\u0131rma kabiliyeti ile\nili\u015fkilendirildi.&nbsp;Ayr\u0131ca, TQ, cells h\u00fccrelerinin glikoz a\u015f\u0131r\u0131 y\u00fcklenmesine\nkronik maruz kalmas\u0131n\u0131n ard\u0131ndan GSIS bozulmas\u0131n\u0131 iyile\u015ftirmi\u015ftir.&nbsp;Bu\nkoruyucu etki, kronik glikoz a\u015f\u0131r\u0131 y\u00fcklenmesini takiben kronik malonil-CoA\nbirikiminin TQ&#8217;ya ba\u011fl\u0131 normalle\u015fmesi, asetil-CoA karboksilaz (ACC), ya\u011f asidi\nsentaz\u0131 ve ya\u011f asidi ba\u011flay\u0131c\u0131 proteinlerin y\u00fckselmesi ile ili\u015fkiliydi.&nbsp;Bu\nveriler birlikte, TQ&#8217;nun cell-h\u00fccre redoks devresini mod\u00fcle etti\u011fini ve \u03b2-h\u00fccre\nmetabolik yollar\u0131n\u0131n normal ko\u015fullar alt\u0131nda ve hiperglisemi alt\u0131nda glikoz ve\nGSIS&#8217;ye duyarl\u0131l\u0131\u011f\u0131n\u0131 artt\u0131rd\u0131\u011f\u0131n\u0131 g\u00f6stermektedir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">22-)Effects of Nigella Sativa Seeds (Black Cumin) on\nInsulin Secretion and Lipid Profile: A Pilot Study in Healthy Volunteers<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;10.1111\/bcp.13922<\/li><\/ul>\n\n\n\n<p>Siyah kimyon olarak da bilinen Nigella sativa tohumlar\u0131n\u0131n\n(NSS) antidiyabetik ve lipit d\u00fc\u015f\u00fcr\u00fcc\u00fc \u00f6zelliklere sahip oldu\u011fu iddia\nedilmi\u015ftir.&nbsp;Pilot \u00e7al\u0131\u015fmam\u0131z, sa\u011fl\u0131kl\u0131 erkek g\u00f6n\u00fcll\u00fclerde toz NSS&#8217;nin\nins\u00fclin sekresyonu ve lipit profili \u00fczerindeki etkilerini ara\u015ft\u0131rd\u0131.&nbsp;30\nki\u015fide \u00e7ift k\u00f6r, randomize, plasebo kontroll\u00fc 4 haftal\u0131k bir \u00e7al\u0131\u015fma\nger\u00e7ekle\u015ftirdik, a\u011f\u0131zdan NSS tozu (1 g \/ g\u00fcn) veya plasebo (15 ki\u015fi \/ grup)\nald\u0131k.&nbsp;Hiperglisemik klemp tekni\u011fi, ins\u00fclin duyarl\u0131l\u0131\u011f\u0131, kolesterol ve\ntrigliserit serum konsantrasyonlar\u0131 ile belirlenen ins\u00fclin sekresyonu tedaviden\n\u00f6nce ve sonra \u00f6l\u00e7\u00fcld\u00fc.&nbsp;NSS toz uygulamas\u0131 klinik olarak iyi tolere\nedilmi\u015ftir.&nbsp;A\u00e7l\u0131k glisemi ve ins\u00fclinemiyi de\u011fi\u015ftirmedi ve glikoza ba\u011fl\u0131\nins\u00fclin sekresyonu ve ins\u00fclin duyarl\u0131l\u0131\u011f\u0131 \u00fczerinde etkisizdi.&nbsp;Herhangi bir\ntedavi grubunda veya iki tedavi grubu aras\u0131nda tedaviden sonra serum\nlipitlerinde anlaml\u0131 bir de\u011fi\u015fiklik g\u00f6zlenmemi\u015ftir.&nbsp;Bununla birlikte,\nsadece tedavi edilen grupta, tedaviden sonra toplam kolesterol de\u011fi\u015fimi ile\nba\u015flang\u0131\u00e7 \u200b\u200bseviyesi (r = -0.71, P = 0.006, n = 13) ile d\u00fc\u015f\u00fck yo\u011funluklu\nlipoprotein (LDL) kolesterol de\u011fi\u015fimi aras\u0131nda anlaml\u0131 bir ili\u015fki vard\u0131. tedavi\nve ba\u015flang\u0131\u00e7 \u200b\u200bseviyesi (r = -0.74, P = 0.004, n = 13).&nbsp;Y\u00fcksek yo\u011funluklu\nlipoprotein (HDL) kolesterol ve trigliseritler i\u00e7in b\u00f6yle bir korelasyon\nbulunamad\u0131.&nbsp;Bu sonu\u00e7lar glikoz reg\u00fclasyonu \u00fczerinde herhangi bir NSS\netkisini do\u011frulamaz;&nbsp;bununla birlikte, NSS tozunun hiperlipidemik\ndeneklerde lipit konsantrasyonlar\u0131n\u0131 d\u00fc\u015f\u00fcrmede ilgi \u00e7ekici olabilece\u011fini\nd\u00fc\u015f\u00fcnd\u00fcrmektedir. <\/p>\n\n\n\n<h1 class=\"wp-block-heading\">23-)Nigella Sativa Relieves the Altered Insulin\nReceptor Signaling in Streptozotocin-Induced Diabetic Rats Fed With a High-Fat\nDiet<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;10.1155\/2016\/2492107<\/li><\/ul>\n\n\n\n<p>Siyah kimyon (Nigella sativa) &#8220;NS&#8221; veya siyah\ntohumlar, antioksidan, antikarsinojenik, antihipertansif ve antidiyabetik\n\u00f6zellikler gibi bir\u00e7ok farmakolojik aktiviteye sahiptir.&nbsp;Bu \u00e7al\u0131\u015fmada,\ny\u00fcksek ya\u011fl\u0131 bir diyetle beslenen streptozotosin kaynakl\u0131 diyabetik s\u0131\u00e7anlar,\nkan \u015fekeri, lipit profili, oksidatif stres parametreleri ve baz\u0131 ins\u00fclinin gen\nekspresyonu \u00fczerindeki etkisini incelemek i\u00e7in g\u00fcnl\u00fck olarak NS ya\u011f\u0131 (NSO) ile\ntedavi edildi.Bu tedavi ayr\u0131ca baz\u0131 ila\u00e7lar (metformin ve glimepirid) ve\nins\u00fclin resept\u00f6r inhibit\u00f6r\u00fc I-OMe-AG538 ile birle\u015ftirildi.&nbsp;NSO uygulamas\u0131,\nNSO almayan s\u0131\u00e7anlara k\u0131yasla ins\u00fclin resept\u00f6r\u00fcn\u00fcn gen ekspresyonunu \u00f6nemli\n\u00f6l\u00e7\u00fcde ind\u00fckledi.&nbsp;Ayr\u0131ca, ins\u00fclin benzeri b\u00fcy\u00fcme fakt\u00f6r\u00fc-1 ve\nfosfoinositid-3 kinaz\u0131n ekspresyonunu d\u00fczenledi,&nbsp;oysa ADAM-17 ekspresyonu\na\u015fa\u011f\u0131 reg\u00fcle edildi.&nbsp;ADAM-17&#8217;nin ekspresyonu, TIMP-3 i\u00e7eri\u011finin analizi\nile do\u011frulanmaktad\u0131r.&nbsp;Ek olarak, NSO kan \u015fekeri seviyesini, lipit\nprofilinin bile\u015fenlerini, oksidatif stres parametrelerini, serum ins\u00fclin \/\nins\u00fclin resept\u00f6r oran\u0131n\u0131 ve t\u00fcm\u00f6r nekroz fakt\u00f6r\u00fc-\u03b1&#8217;y\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde azaltt\u0131 ve\nNSO&#8217;nun bir antidiyabetik aktiviteye sahip oldu\u011funu do\u011frulad\u0131.&nbsp;Bu nedenle,\ns\u0131\u00e7an modelimizdeki g\u00fcnl\u00fck NSO tedavisi, NSO&#8217;nun diyabet tedavisinde ve ins\u00fclin\nkaynakl\u0131 sinyalin iyile\u015ftirilmesinde bir potansiyele sahip oldu\u011funu\ng\u00f6stermektedir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">24-)Thymoquinone Ameliorates Obesity-Induced\nMetabolic Dysfunction, Improves Reproductive Efficiency Exhibiting a Dose-Organ\nRelationship<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;10.1080\/19396368.2019.1626933<\/li><\/ul>\n\n\n\n<p>Obezitesi olan kad\u0131nlar\u0131n karma\u015f\u0131k bir \u00fcreme ya\u015fam\u0131na sahip\nolma olas\u0131l\u0131\u011f\u0131 daha y\u00fcksektir.&nbsp;\u0130ns\u00fclin direnci ve metabolik disfonksiyon\nobezite ile ili\u015fkilidir.&nbsp;Timokinon (TQ), AMPK aktivat\u00f6r\u00fc olarak kabul\nedilen iyi bilinen bir antioksidand\u0131r.&nbsp;Bu \u00e7al\u0131\u015fman\u0131n amac\u0131, TKY&#8217;nin\ndo\u011furganl\u0131\u011f\u0131 ve laktasyonu iyile\u015ftirme yetene\u011fini ara\u015ft\u0131rmak ve olas\u0131\nmekanizmay\u0131 a\u00e7\u0131kl\u0131\u011fa kavu\u015fturmakt\u0131.&nbsp;Di\u015fi C57BL \/ 6 fareleri, TQ (% 10 pmm)\nve TQ (% 20 pmm) ile takviye edilmi\u015f Y\u00fcksek Ya\u011f Diyetine (HFD) tabi\ntutuldu.&nbsp;Meme ve yumurtal\u0131k \u00f6rnekleri \u00fczerinde histopatolojik inceleme\nyap\u0131ld\u0131.&nbsp;Metabolik ve oksidan durum de\u011ferlendirildi ve qRT-PCR analizi,\nAMPK \/ PGC1a \/ SIRT1 metabolik yol aktivitesini do\u011frulamak i\u00e7in\nyap\u0131ld\u0131.&nbsp;Bu \u00e7al\u0131\u015fma, TQ&#8217;nun yumurtal\u0131k metabolik fonksiyonu \u00fczerindeki doza\nba\u011fl\u0131 bir \u015fekilde olumlu etkilerini bildirmektedir.&nbsp;TQ, d\u00fc\u015f\u00fck dozda meme\nbezi metabolik fonksiyonu \u00fczerindeki olumlu etkilerini g\u00f6stermi\u015ftir.&nbsp;Bu,\nTQ&#8217;nun doza ba\u011fl\u0131 bu etkilerini g\u00f6steren ilk \u00e7al\u0131\u015fmad\u0131r.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">25-)Effects of&nbsp;<em>Nigella Sativa<\/em>&nbsp;on\nType-2 Diabetes Mellitus: A Systematic Review<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;10.3390\/ijerph16244911<\/li><\/ul>\n\n\n\n<p>Diabetes mellitus, t\u00fcm cinsiyet, ya\u015f ve \u0131rktan insanlar\u0131 etkileyen en\nyayg\u0131n metabolik bozukluklardan biridir.&nbsp;\u015eifal\u0131 bitkiler ara\u015ft\u0131rmac\u0131lar taraf\u0131ndan\nb\u00fcy\u00fck ilgi g\u00f6rd\u00fc ve entegre etkileri nedeniyle oral antidiyabetik ila\u00e7lara\nfaydal\u0131 bir adjuvan ajan olarak kabul edildi.&nbsp;<em>Nigella sativa&#8217;n\u0131n<\/em>&nbsp;\u00e7e\u015fitli\nyararl\u0131 etkileri ile ilgili olarak&nbsp;, bu sistematik derleme,&nbsp;<em>Nigella\nsativa&#8217;n\u0131n<\/em>&nbsp;insanlardaki glikoz ve ins\u00fclin profili durumu\n\u00fczerindeki&nbsp;etkileri hakk\u0131nda kapsaml\u0131 bilgi sa\u011flamay\u0131\nama\u00e7lamaktad\u0131r&nbsp;.&nbsp;A\u015fa\u011f\u0131daki anahtar kelimelerle Scopus ve Medline\n\u00fczerinden Ebscohost \u00fczerinden ger\u00e7ekle\u015ftirilen bilgisayarl\u0131 veritaban\u0131\nara\u015ft\u0131rmas\u0131:&nbsp;<em>Nigella Sativa<\/em>VEYA siyah tohum ya\u011f\u0131 VEYA timokinon\nVEYA siyah kimyon VE diyabetes mellitus VEYA hiperglisemi VEYA kan \u015fekeri VEYA\nhemoglobin A1C, ilgili 875 makaleyi iade etmi\u015ftir.&nbsp;Toplam yedi makale daha\nileri de\u011ferlendirme i\u00e7in al\u0131nm\u0131\u015f ve bu incelemeye dahil edilmesi i\u00e7in veri\n\u00e7\u0131karma i\u015flemi yap\u0131lm\u0131\u015ft\u0131r.&nbsp;<em>\u00c7\u00f6rek otu sativa&#8217;n\u0131n<\/em>&nbsp;tedaviden\nsonra a\u00e7l\u0131k kan \u015fekerinde \u00f6nemli bir d\u00fc\u015f\u00fc\u015f, postprandiyal kan glikoz seviyesi 2\nsaat, glisinli hemoglobin ve ins\u00fclin direncinde ve serum ins\u00fclininde bir\nart\u0131\u015fla hiperglisemi ve diyabet kontrol\u00fcn\u00fcn laboratuvar parametrelerini \u00f6nemli\n\u00f6l\u00e7\u00fcde iyile\u015ftirdi\u011fi g\u00f6sterilmi\u015ftir.&nbsp;Sonu\u00e7 olarak, bu bulgular&nbsp;<em>Nigella\nsativa&#8217;n\u0131n<\/em>&nbsp;diyabet kontrol\u00fcnde oral antidiyabetik ila\u00e7lar i\u00e7in bir\nadjuvan olarak kullan\u0131labilece\u011fini d\u00fc\u015f\u00fcnd\u00fcrmektedir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">26-)Black Seed Thymoquinone Improved Insulin\nSecretion, Hepatic Glycogen Storage, and Oxidative Stress in\nStreptozotocin-Induced Diabetic Male Wistar Rats<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;10.1155\/2018\/8104165<\/li><\/ul>\n\n\n\n<p>Diyabetes mellitus, \u00e7e\u015fitli komplikasyonlar\u0131 olan metabolik\nhastal\u0131klardan biridir.&nbsp;<em>\u00c7\u00f6rek otu sativa<\/em>&nbsp;ya\u011f\u0131 (NSO) diyabetik\nkomplikasyonlar\u0131n tedavisinde faydal\u0131 etkilere sahip olabilir.&nbsp;Otuz iki\nolgun erkek Wistar s\u0131\u00e7an\u0131 e\u015fit olarak d\u00f6rt deney grubuna ayr\u0131ld\u0131: kontrol,\nkontrol NSO 2 mL \/ kg, streptozotosin- (STZ-) ile ind\u00fcklenmi\u015f diyabetik ve\ndiyabetik (STZ ile ind\u00fcklenmi\u015f) 30 g\u00fcn boyunca oral NSO ile 2 mg \/ kg ile tedavi\nedildi.A\u00e7l\u0131k kan \u015fekeri (FBG), ins\u00fclin ve lipit profili d\u00fczeyleri\nbelirlendi.&nbsp;Katalaz ve GSH i\u00e7in pankreas ve hepatik dokular\nkullan\u0131ld\u0131.&nbsp;Histopatoloji, hepatik glikojen i\u00e7eri\u011fi, ins\u00fclin\nimm\u00fcnohistokimyas\u0131 ve pankreatik adac\u0131k morfometrisi yap\u0131ld\u0131.&nbsp;NSO 2 mL \/\nkg, FBG&#8217;yi d\u00fc\u015f\u00fcrd\u00fc\u011f\u00fc ve (&nbsp;<em>P<\/em>&nbsp;&lt;0.05) artt\u0131\u011f\u0131 (&nbsp;<em>P<\/em>&lt;0.05)\ndiyabetik s\u0131\u00e7anlarda, diyabetik tedavi edilmemi\u015f hayvanlara g\u00f6re ins\u00fclin\nseviyeleri.&nbsp;Lipid profili&nbsp;, diyabetik gruba g\u00f6re NSO 2 mL \/ kg alan\ndiyabetik s\u0131\u00e7anlarda&nbsp;anlaml\u0131 (&nbsp;<em>P<\/em>&nbsp;&lt;0.5)\niyile\u015fme&nbsp;g\u00f6sterdi&nbsp;.&nbsp;Hem pankreatik hem de hepatik katalaz ve GSH\naktiviteleri&nbsp;, NSO ile tedavi edilen diyabetik grupta diyabetik\nhayvanlardan daha&nbsp;\u00f6nemli (&nbsp;<em>P<\/em>&nbsp;&lt;0.05) bir\nart\u0131\u015f&nbsp;ortaya koydu&nbsp;.&nbsp;NSO, diyabetik grubun histopatolojik\nresmini ve hepatik glikojen i\u00e7eri\u011fini ve ayr\u0131ca (&nbsp;<em>P<\/em>&nbsp;&lt;0.05)\nins\u00fclin imm\u00fcno-reaktif k\u0131s\u0131mlar\u0131n\u0131 ve ortalama pankreatik adac\u0131k\n\u00e7ap\u0131n\u0131&nbsp;artt\u0131rd\u0131&nbsp;.&nbsp;NSO, STZ&#8217;nin neden oldu\u011fu diyabetik erkek\nWistar s\u0131\u00e7anlar\u0131 \u00fczerinde iyile\u015ftirici ve terap\u00f6tik etkiler uygular.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">27-)Nigella Sativa Oil and Chromium Picolinate\nAmeliorate Fructose-Induced Hyperinsulinemia by Enhancing Insulin Signaling and\nSuppressing Insulin-Degrading Enzyme in Male Rats<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;10.1007\/s12011-017-1167-z<\/li><\/ul>\n\n\n\n<p>\u0130n vivo ve in vitro \u00e7al\u0131\u015fmalar, kromun, ins\u00fclin resept\u00f6r\nsinyalini te\u015fvik ederek ins\u00fclin duyarl\u0131l\u0131\u011f\u0131n\u0131 artt\u0131rd\u0131\u011f\u0131n\u0131\ng\u00f6stermi\u015ftir.&nbsp;Bununla birlikte, ins\u00fclin klerensi \u00fczerindeki etkisi hen\u00fcz\ntan\u0131mlanmam\u0131\u015ft\u0131r.&nbsp;Yayg\u0131n olarak kullan\u0131lan bir baharat olan \u00e7\u00f6rek otu,\nantidiyabetik bir aktiviteye sahiptir.&nbsp;Bu nedenle, krom pikolinat\u0131n\nins\u00fcline diren\u00e7li s\u0131\u00e7anlarda ins\u00fclin par\u00e7alay\u0131c\u0131 enzimi (IDE) mod\u00fcle ederek\nins\u00fclin klerensini de\u011fi\u015ftirebilece\u011fini varsayd\u0131k.&nbsp;Ayr\u0131ca Nigella sativa\nya\u011f\u0131n\u0131n ins\u00fclin sinyali ve bozulmas\u0131 \u00fczerindeki etkisini krom pikolinat\na\u00e7\u0131s\u0131ndan de\u011ferlendirdik.&nbsp;Bu hipotezleri de\u011ferlendirmek i\u00e7in, 30 erkek\nWistar albino s\u0131\u00e7an\u0131nda 45 g\u00fcn boyunca y\u00fcksek fruktozlu suyun (HFW,% 20 a \/ h)\noral yoldan verilmesi yoluyla ins\u00fclin direnci ind\u00fcklendi.&nbsp;Bu s\u0131\u00e7anlar daha\nsonra \u00fc\u00e7 gruba ayr\u0131ld\u0131 (n = 10 \/ grup).&nbsp;45 g\u00fcn boyunca HFW (a\u011f \/ hac% 20)\nile birlikte a\u011f\u0131zdan tedavi (kontrol grubu) veya Nigella sativa ya\u011f\u0131 (500 mg \/\nkg bw \/ g\u00fcn) veya krom pikoloinat (200 ug \/ kg bw \/ g\u00fcn) verilmemi\u015ftir.&nbsp;\u00c7\u00f6rek\notu ya\u011f\u0131 veya krom pikolinat HFW ile e\u015fzamanl\u0131 uygulama, v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131n\u0131,\nserum lipitlerini, glukagonu, ins\u00fclin direncini ve hepatik IDE seviyesini\n\u00f6nemli \u00f6l\u00e7\u00fcde azaltt\u0131, ancak mRNA ekspresyonunu ve ins\u00fclin resept\u00f6r\u00fc\nfosforlizyonunu ve ayr\u0131ca y\u00fcksek yo\u011funluklu lipoprotein kolesterol (HDL-C)\nseviyesini artt\u0131rd\u0131. kontrol grubu de\u011ferleriyle kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda ins\u00fclin\nsinyali ve klerensi i\u00e7in mod\u00fclat\u00f6rler olarak potansiyellerini\nd\u00fc\u015f\u00fcnd\u00fcrmektedir.&nbsp;Bununla birlikte, Nigella sativa ya\u011f\u0131, beslenme\netkinli\u011fi oran\u0131nda, krom picolinate&#8217;e g\u00f6re glukagon, ins\u00fclin, ins\u00fclin direnci,\nhepatik IDE seviyesi ve ins\u00fclin resept\u00f6r\u00fc fosforilasyon seviyelerinde daha iyi\nbir geli\u015fme g\u00f6sterdi,&nbsp;daha fazla ins\u00fclin duyarl\u0131la\u015ft\u0131rma kapasitesine\nsahiptir.&nbsp;Verilerimiz, ilk kez, Nigella sativa ya\u011f\u0131 ve krom pikolinat\nmonoterapisinin, hepatik IDE proteinini azaltarak ve ins\u00fclin resept\u00f6r\nsinyalinin aktivasyonunu yaparak fruktoza ba\u011fl\u0131 ins\u00fclin direncini\nazaltabilece\u011fini kan\u0131tlamaktad\u0131r.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">28-)Herbal Treatment of Allergic Rhinitis:\nThe Use of Nigella Sativa<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;10.1016\/j.amjoto.2010.07.019<\/li><\/ul>\n\n\n\n<p><strong>Giri\u015f ve hedefler:&nbsp;<\/strong>Alerjik\nrinit, \u00f6zellikle \u00e7ocuklarda en s\u0131k g\u00f6r\u00fclen kronik ve alerjik\nhastal\u0131kt\u0131r.&nbsp;Bu \u00e7al\u0131\u015fmada, Nigella sativa&#8217;n\u0131n antienflamatuar etkileri ve\nalerjik rinit semptomlar\u0131 olan hastalarda inflamatuar fakt\u00f6rler \u00fczerindeki\netkileri ve klinik \u00e7al\u0131\u015fma \u00fccretleri s\u00fcreci ara\u015ft\u0131r\u0131ld\u0131.<\/p>\n\n\n\n<p>\u00c7al\u0131\u015fma&nbsp;<strong>:&nbsp;<\/strong>Bu\n\u00e7al\u0131\u015fma, tan\u0131mlay\u0131c\u0131 analitik ile prospektif ve \u00e7ift k\u00f6r olarak y\u00fcr\u00fct\u00fclen bir\nklinik \u00e7al\u0131\u015fmad\u0131r.<\/p>\n\n\n\n<p><strong>Gere\u00e7 ve y\u00f6ntem:&nbsp;<\/strong>\u00d6rnekte\nN. sativa ya\u011f\u0131na maruz kalan alerjik rinitli 66 hasta (vaka ve plasebo)\nvard\u0131.&nbsp;Ya\u015f ve cinsiyet gibi bireysel \u00f6zellikler ile burun t\u0131kan\u0131kl\u0131\u011f\u0131,\nburun ak\u0131nt\u0131s\u0131, ka\u015f\u0131nt\u0131l\u0131 burun ve hap\u015f\u0131rma ataklar\u0131 gibi hastal\u0131\u011f\u0131n\n\u00f6zellikleri de\u011ferlendirildi.&nbsp;\u00c7al\u0131\u015fman\u0131n ba\u015flang\u0131c\u0131ndan, yani 0. g\u00fcnden,\n\u00e7al\u0131\u015fman\u0131n sonuna kadar, yani 30. g\u00fcnden itibaren bir g\u00f6zlemci semptomlar\u0131n\n\u015fiddet anketini doldurdu.<\/p>\n\n\n\n<p><strong>\u0130statistiksel analiz:&nbsp;<\/strong>Veriler\nortalama \u00b1 SEM olarak sunuldu.&nbsp;Gruplar aras\u0131 kar\u015f\u0131la\u015ft\u0131rmalar ikili\nStudent t testi kullan\u0131larak yap\u0131ld\u0131.&nbsp;P de\u011ferleri .05 ve .01&#8217;den k\u00fc\u00e7\u00fckse\nfarklar anlaml\u0131 kabul edildi.<\/p>\n\n\n\n<p><strong>Bulgular:&nbsp;<\/strong>Bu\n\u00e7al\u0131\u015fmaya 22 erkek (% 33.3) dahil olmak \u00fczere alerjik rinitli 66 hasta ve ya\u015f\nortalamas\u0131 47.19 y\u0131l olan 44 kad\u0131n (% 66.7) dahil edildi.&nbsp;Tedaviden \u00f6nce\n38 hastada imm\u00fcnoglobulin E toplam\u0131 100&#8217;den fazla bildirilmi\u015ftir.&nbsp;Yedi\nhastada nazal y\u0131kamada imm\u00fcnoglobulin E g\u00f6zlendi ve 59 olguda\n\u00f6l\u00e7\u00fclemedi.&nbsp;\u00c7al\u0131\u015fma pop\u00fclasyonunun sadece% 6.1&#8217;inde nazal mukozal\neozinofil vard\u0131.<\/p>\n\n\n\n<p><strong>Sonu\u00e7:&nbsp;<\/strong>Sonu\u00e7lar\nN. sativa&#8217;n\u0131n ilk 2 hafta (15 g\u00fcn) burun mukozas\u0131nda t\u0131kan\u0131kl\u0131k, burun\nka\u015f\u0131nt\u0131s\u0131, burun ak\u0131nt\u0131s\u0131, hap\u015f\u0131rma ataklar\u0131, konka hipertrofisi ve mukozal\nsolgunlu\u011fun varl\u0131\u011f\u0131n\u0131 azaltabildi\u011fini g\u00f6stermektedir.&nbsp;Mevcut bulgular, N.\nsativa bile\u015fenlerinin antialerjik etkilerinin alerjik rinite atfedilebilece\u011fine\ndair kan\u0131tlarla tutarl\u0131d\u0131r.&nbsp;Ayr\u0131ca, di\u011fer antialerjik ila\u00e7lar\u0131n\netkilerinden ka\u00e7\u0131n\u0131lmas\u0131 gerekti\u011finde alerjik rinit tedavisinde N. sativa\nd\u00fc\u015f\u00fcn\u00fclmelidir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">29-)Effect of Nigella Sativa (Black Seed) on\nSubjective Feeling in Patients With Allergic Diseases<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;10.1002\/ptr.1356<\/li><\/ul>\n\n\n\n<p>\u00c7\u00f6rek otu sativa (siyah tohum) \u00f6nemli bir \u015fifal\u0131\nbitkidir.&nbsp;Bir\u00e7ok Arap, Asya ve Afrika \u00fclkesinde, siyah tohum ya\u011f\u0131, \u00e7e\u015fitli\nalerjiler de dahil olmak \u00fczere \u00e7ok \u00e7e\u015fitli hastal\u0131klar i\u00e7in do\u011fal bir ila\u00e7\nolarak kullan\u0131lmaktad\u0131r.&nbsp;Bitkinin etki mekanizmas\u0131 hala b\u00fcy\u00fck \u00f6l\u00e7\u00fcde\nbilinmemektedir.&nbsp;Alerjilerdeki etkinli\u011fi \u00fczerine \u00e7al\u0131\u015fma verilerinin\nolmamas\u0131 nedeniyle, Nigella sativa&#8217;n\u0131n alerjik hastal\u0131klarda klinik etkinli\u011fi\n\u00fczerine d\u00f6rt \u00e7al\u0131\u015fma sunulmaktad\u0131r.&nbsp;Bu \u00e7al\u0131\u015fmalarda alerjik hastal\u0131\u011f\u0131 olan\ntoplam 152 hasta (alerjik rinit, bron\u015fiyal ast\u0131m, atopik egzama) 40 ila 80 mg \/\nkg \/ g\u00fcn dozunda kaps\u00fcllerde verilen Nigella sativa ya\u011f\u0131 ile tedavi\nedildi.&nbsp;Hastalar \u00f6nceden belirlenmi\u015f bir \u00f6l\u00e7ek kullanarak hedef\nsemptomlar\u0131n \u00f6znel \u015fiddetini puanlad\u0131lar.&nbsp;A\u015fa\u011f\u0131daki laboratuvar\nparametreleri ara\u015ft\u0131r\u0131ld\u0131: IgE, eozinofil say\u0131s\u0131, plazma ve idrarda endojen\nkortizol, ACTH,&nbsp;trigliseritler, toplam kolesterol, LDL ve HDL kolesterol\nve lenfosit alt pop\u00fclasyonlar\u0131.&nbsp;S\u00fcbjektif duygu skoru, d\u00f6rt \u00e7al\u0131\u015fmada da\nsiyah tohum ya\u011f\u0131 ile tedavi s\u00fcresince azald\u0131.&nbsp;Lenfosit alt pop\u00fclasyonlar\u0131,\nendojen kortizol seviyeleri ve ACTH sal\u0131n\u0131m\u0131 de\u011fi\u015fmeden kal\u0131rken, plazma\ntrigliseritlerinde hafif bir azalma ve HDL kolesterol\u00fcnde belirgin bir art\u0131\u015f\nmeydana geldi.&nbsp;Bu nedenle siyah tohum ya\u011f\u0131n\u0131n alerjik hastal\u0131klar\u0131n\ntedavisinde etkili bir yard\u0131mc\u0131 oldu\u011fu kan\u0131tlanm\u0131\u015ft\u0131r.&nbsp;endojen kortizol\nseviyeleri ve ACTH sal\u0131n\u0131m\u0131 de\u011fi\u015fmedi.&nbsp;Bu nedenle siyah tohum ya\u011f\u0131n\u0131n\nalerjik hastal\u0131klar\u0131n tedavisinde etkili bir adjuvan oldu\u011fu kan\u0131tlanm\u0131\u015ft\u0131r.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">30-)Clinical and Experimental Effects of&nbsp;<em>Nigella\nsativa<\/em>&nbsp;and Its Constituents on Respiratory and Allergic Disorders<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>PMCID:&nbsp;PMC6526035<\/li><\/ul>\n\n\n\n<p><strong>Ama\u00e7:&nbsp;<\/strong>Siyah\nkimyon veya&nbsp;<em>Nigella sativa<\/em>&nbsp;(&nbsp;<em>N. sativa<\/em>&nbsp;)\ntohumu, terap\u00f6tik etkileri nedeniyle geleneksel olarak t\u0131bbi bir do\u011fal \u00fcr\u00fcn\nolarak yayg\u0131n olarak kullan\u0131lmaktad\u0131r.&nbsp;Bu derlemede,&nbsp;solunum ve\nalerjik hastal\u0131klar\u0131n tedavisi i\u00e7in iyile\u015ftirici bir ila\u00e7 olarak&nbsp;<em>N.\nsativa&#8217;n\u0131n<\/em>&nbsp;t\u0131bbi \u00f6zellikleri&nbsp;de\u011ferlendirilmi\u015ftir.<\/p>\n\n\n\n<p><strong>Gere\u00e7 ve y\u00f6ntemler:&nbsp;<\/strong>T\u0131bbi\nve t\u0131bbi olmayan veritabanlar\u0131nda (\u00f6rne\u011fin PubMed, Science Direct, Scopus ve\nGoogle Akademik)&nbsp;<em>Nigella sativa<\/em>&nbsp;, siyah tohum, timokinon,\nsolunum, pulmoner, akci\u011fer ve alerjik hastal\u0131klar gibi&nbsp;anahtar\nkelimeler&nbsp;arand\u0131.&nbsp;1993-2018 y\u0131llar\u0131 aras\u0131nda yay\u0131nlanan klinik \u00f6ncesi\n\u00e7al\u0131\u015fmalar ve klinik \u00e7al\u0131\u015fmalar se\u00e7ildi.<\/p>\n\n\n\n<p><strong>Bulgular:&nbsp;<\/strong>Deneysel\nve klinik \u00e7al\u0131\u015fmalarda,&nbsp;<em>N. sativa<\/em>&nbsp;farkl\u0131 ekstraktlar\u0131n\u0131n,\nekstrakt fraksiyonlar\u0131n\u0131n ve bile\u015fenlerinin&nbsp;antioksidan, imm\u00fcnomod\u00fclat\u00f6r,\nantienflamatuar, antihistaminik, antialerjik, antitussif ve bronkodilat\u00f6r\n\u00f6zellikleri&nbsp;g\u00f6sterilmi\u015ftir.&nbsp;Klinik \u00e7al\u0131\u015fmalar ast\u0131ml\u0131 hastalarda\nbitkinin bronkodilat\u00f6r ve \u00f6nleyici \u00f6zelliklerini de g\u00f6stermi\u015ftir.&nbsp;<em>N.\nsativa<\/em>&nbsp;\u00f6z\u00fct\u00fc,&nbsp;k\u00fck\u00fcrt hardal\u0131 maruziyetinin neden oldu\u011fu akci\u011fer\nbozukluklar\u0131 \u00fczerinde \u00f6nleyici bir etki g\u00f6stermi\u015ftir.&nbsp;Bitki ve\nbile\u015fenlerinin \u00e7e\u015fitli alerjik bozukluklar \u00fczerindeki terap\u00f6tik etkileri de\ng\u00f6sterilmi\u015ftir.<\/p>\n\n\n\n<p><strong>Sonu\u00e7:&nbsp;<\/strong>Bu\nnedenle,&nbsp;<em>N. sativa<\/em>&nbsp;ve bile\u015fenleri, alerjik ve obstr\u00fcktif\nakci\u011fer hastal\u0131klar\u0131n\u0131n yan\u0131 s\u0131ra di\u011fer solunum hastal\u0131klar\u0131n\u0131n tedavisinde\netkili ila\u00e7lar olarak d\u00fc\u015f\u00fcn\u00fclebilir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">31-)A Review on the Cosmeceutical and External\nApplications of&nbsp;<em>Nigella sativa<\/em>.<\/h1>\n\n\n\n<p>DOI:10.1155\/2017\/7092514<\/p>\n\n\n\n<p>D\u00fcnya Sa\u011fl\u0131k \u00d6rg\u00fct\u00fc (WHO) taraf\u0131ndan d\u00fcnya n\u00fcfusunun \u00e7o\u011funun\nsa\u011fl\u0131k bak\u0131mlar\u0131 i\u00e7in bitkisel ila\u00e7lara ba\u011fl\u0131 oldu\u011fu tahmin\nedilmektedir.&nbsp;Kara kimyon ve &#8220;Kalonji&#8221; olarak da bilinen&nbsp;<em>Nigella sativa<\/em><em>&nbsp;(N.&nbsp;sativa&nbsp;),<\/em>&nbsp;t\u00fcm d\u00fcnyada tan\u0131nm\u0131\u015f bir\ntohumdur.&nbsp;D\u00fcnya \u00e7ap\u0131nda en yayg\u0131n t\u0131bbi bitkilerden biridir ve sabit\nya\u011f\u0131nda timokinon, timohidrokinon, ditmokinon, timol, nigellisin, karvakrol,\nnigellimin, nigellisin, nigellidin ve alfa-hederin gibi bir\u00e7ok yararl\u0131 kimyasal\nbile\u015fen i\u00e7erir.&nbsp;Bu \u00e7ok say\u0131da \u00f6nemli bile\u015fen nedeniyle v\u00fccudumuzun farkl\u0131\nb\u00f6lgelerini etkiledi\u011fi ve antibakteriyel,&nbsp;antiviral&nbsp;gibi\nbir\u00e7ok farmakolojik etkiye sahip oldu\u011fu bulunmu\u015ftur.( anti-enflamatuar ve yara\niyile\u015ftirici etki ve ayr\u0131ca akne vulgaris, cilt kanseri, pigmentasyon ve bir\u00e7ok\nkozmetik uygulama i\u00e7in).&nbsp;<em>N.&nbsp;sativa<\/em>&nbsp;tohumlar\u0131n\u0131n\nve ya\u011f\u0131n\u0131n&nbsp;folklor kullan\u0131m\u0131na dayanarak,&nbsp;\u00e7e\u015fitli g\u0131da ve ila\u00e7\nsistemlerinde kullan\u0131l\u0131rlar.&nbsp;Bu makalenin amac\u0131&nbsp;, bu konuda daha\nfazla \u00e7al\u0131\u015fmay\u0131 te\u015fvik etmesi beklenen&nbsp;<em>N.&nbsp;sativa&#8217;n\u0131n<\/em>&nbsp;kozmes\u00f6tik\nve d\u0131\u015f uygulamalar\u0131n\u0131n literat\u00fcr\u00fcn\u00fcn ayr\u0131nt\u0131l\u0131 bir incelemesini\nsa\u011flamakt\u0131r&nbsp;.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">32-)SELECTIVE INHIBITION OF HEPATITIS C VIRUS\nREPLICATION BY ALPHA-ZAM, A&nbsp;<em>NIGELLA\nSATIVA<\/em>&nbsp;SEED FORMULATION.<\/h1>\n\n\n\n<p>DOI:10.21010\/ajtcam.v13i6.20<\/p>\n\n\n\n<p>Do\u011frudan etkili antivirallerin (DAA) geli\u015fmesi nedeniyle hepatit C\nvir\u00fcs\u00fc (HCV) enfeksiyonu tedavi edilebilir hale geldi.&nbsp;Bununla birlikte,\nDAA&#8217;lar\u0131n y\u00fcksek maliyeti, HCV enfeksiyonunun tedavisi \u00fczerindeki potansiyel\netkilerini b\u00fcy\u00fck \u00f6l\u00e7\u00fcde engellemi\u015ftir.&nbsp;Sonu\u00e7 olarak, hepatit C d\u00fc\u015f\u00fck ve\norta gelirli \u00fclkelerde kronik olarak enfekte olmu\u015f bireyler aras\u0131nda ciddi\nmorbidite ve mortaliteye neden olmaya devam edecektir.&nbsp;Bu nedenle, bu\n\u00fclkelerdeki hepatit C hastalar\u0131na sunulan daha ucuz ila\u00e7lar\u0131n geli\u015ftirilmesine\nacil ihtiya\u00e7 vard\u0131r.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">MALZEMELER VE Y\u00d6NTEMLER:<\/h4>\n\n\n\n<p><em>Nigella sativa<\/em>&nbsp;tohumundan&nbsp;bir\nyerli bitkisel form\u00fclasyon olan alfa-zam,&nbsp;genotip 1b HCV replikon\nh\u00fccrelerinde anti-HCV aktivitesi ve sitotoksisitesi a\u00e7\u0131s\u0131ndan incelendi.&nbsp;Antiviral&nbsp;sitotoksisite replikon h\u00fccreleri\ni\u00e7inde canl\u0131 h\u00fccre say\u0131s\u0131 ve gliseraldehit-3-fosfat dehidrojenaz RNA sentezi\nile de\u011ferlendirilmi\u015ftir ise aktivitesi, lusiferaz ekspresyonu ve viral RNA\nsentezi ile tespit edildi.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">SONU\u00c7LAR:<\/h4>\n\n\n\n<p>Alfa-zam&#8217;\u0131n HCV replikasyonunun se\u00e7ici bir inhibit\u00f6r\u00fc oldu\u011fu\nbulunmu\u015ftur.&nbsp;Alfa-zam&#8217;\u0131n% 50 etkili seyreltilmesi ve% 50 sitotoksik\nseyreltmesi, subgenomik replikon h\u00fccrelerde LucNeo # 2&#8217;de s\u0131ras\u0131yla 761 ve\n&lt;100 kat olmu\u015ftur.&nbsp;HCV&#8217;nin se\u00e7ici inhibisyonu, ger\u00e7ek zamanl\u0131 ters\ntranskriptaz polimeraz zincir reaksiyonu kullan\u0131larak LucNeo # 2 ve tam genom HCV\nreplikon h\u00fccreleri NNC # 2&#8217;deki HCV RNA seviyeleri ile de\ndo\u011fruland\u0131.&nbsp;Ayr\u0131ca, Alfa-zam&#8217;\u0131n anti-HCV aktivitesi, interferonun\nind\u00fcklenmesinden kaynaklanmad\u0131.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">SONU\u00c7:<\/h4>\n\n\n\n<p>Alpha-zam, HCV replikasyonunu se\u00e7ici olarak inhibe eder ve bu\nnedenle&nbsp;HCV enfeksiyonuna kar\u015f\u0131&nbsp;yeni bir&nbsp;antiviral&nbsp;ajan&nbsp;i\u00e7in potansiyele\nsahiptir&nbsp;.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">33-)Nigella sativa&nbsp;as an anti-inflammatory agent\nin asthma.<\/h1>\n\n\n\n<p>DOI:10.1186 \/ s13104-018-3858-8<\/p>\n\n\n\n<p>\u00c7\u00f6rek otu sativa&nbsp;(N.&nbsp;sativa&nbsp;), antioksidan, antidiyabetik,\nantikanser,&nbsp;antitussif&nbsp;,\nimm\u00fcnomod\u00fclat\u00f6r, analjezik, antimikrobiyal, antienflamatuar, spazmolitik ve\nbronkodilat\u00f6r&nbsp;i\u00e7eren birka\u00e7 farmakolojik&nbsp;etkiye sahiptir.&nbsp;Bu\n\u00e7al\u0131\u015fman\u0131n amac\u0131,&nbsp;peritoneal Wistar s\u0131\u00e7an mast h\u00fccreleri \u00fczerinde\nanti-inflamasyon olarak&nbsp;N.&nbsp;sativa&nbsp;etanol\n\u00f6z\u00fct\u00fcn\u00fcn&nbsp;etkinli\u011fini \u00f6l\u00e7mektir&nbsp;.&nbsp;Laboratuvar deneyi,&nbsp;mast\nh\u00fccreleri \u00fczerinde bir anti-enflamatuar olarak&nbsp;N.&nbsp;sativa&#8217;n\u0131n&nbsp;etkinli\u011fini ara\u015ft\u0131rmak i\u00e7in\nkullan\u0131ld\u0131&nbsp;.&nbsp;Alt\u0131 grup mast h\u00fccresi, histamin sal\u0131nmas\u0131 i\u00e7in C48 \/ 80\nile uyar\u0131ld\u0131.&nbsp;Grup 1&#8217;de N.&nbsp;sativa\nbulunmazken&nbsp;, grup 2, 3, 4, 5 ve 6&#8217;ya N.&nbsp;sativa&nbsp;verildis\u0131ras\u0131yla 0.1 mg \/ ml, 0.2 mg \/\nml, 0.3 mg \/ ml, 0.4 mg \/ ml ve 0.5 mg \/ ml&#8217;lik\nkonsantrasyonlarla.&nbsp;Histamin konsantrasyonu, y\u00fcksek performansl\u0131 s\u0131v\u0131\nkromatografisi-florometri ile \u00f6l\u00e7\u00fcld\u00fc.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">SONU\u00c7:<\/h4>\n\n\n\n<p>\u00c7al\u0131\u015fma, N.&nbsp;sativa&nbsp;etanol\n\u00f6z\u00fct\u00fcn\u00fcn, peritoneal Wistar s\u0131\u00e7an mast h\u00fccrelerinden konsantrasyonuyla orant\u0131l\u0131\nolarak histamin sal\u0131n\u0131m\u0131n\u0131 etkili bir \u015fekilde inhibe&nbsp;etti\u011fini\ng\u00f6sterdi&nbsp;.&nbsp;N.&nbsp;sativa&nbsp;,\nhistamin sal\u0131n\u0131m\u0131n\u0131 inhibe ederek mast h\u00fccreleri \u00fczerinde bir anti-enflamasyon\nolarak etkilidir ve mast h\u00fccresi \u00fczerinde toksik etkisi yoktur.&nbsp;N.&nbsp;sativa&nbsp;, ast\u0131m tedavisi ve \u00f6nlenmesi i\u00e7in\npotansiyel bir tedavi olarak d\u00fc\u015f\u00fcn\u00fclebilir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">34-)Black Seed&nbsp;<em>(<\/em><em>Nigella Sativa<\/em><em>)<\/em>&nbsp;and its Constituent\nThymoquinone as an Antidote or a Protective Agent Against Natural or Chemical\nToxicities.<\/h1>\n\n\n\n<p>PMCID:PMC5963642<\/p>\n\n\n\n<p><em>Nigella sativa<\/em><em>&nbsp;(N&nbsp;.&nbsp;Sativa&nbsp;),<\/em>&nbsp;Ranunculaceae botanik ailesine ait, d\u00fcnyada\nyayg\u0131n olarak kullan\u0131lan \u015fifal\u0131 bitkidir.&nbsp;Farkl\u0131 hastal\u0131klar\u0131n tedavisinde<em>&nbsp;N.&nbsp;sativa<\/em>&nbsp;tohumlar\u0131 ve ya\u011f\u0131 kullan\u0131lm\u0131\u015ft\u0131r.&nbsp;<em>N.&nbsp;sativa<\/em>&nbsp;\u00fczerinde \u00e7e\u015fitli \u00e7al\u0131\u015fmalar yap\u0131lm\u0131\u015f ve\nfarmakolojik etkilerinin antioksidan, antidiyabetik, antikanser,&nbsp;antitussif&nbsp;, imm\u00fcnomod\u00fclat\u00f6r, analjezik,\nantimikrobiyal, antienflamatuar, spazmolitik ve bronkodilat\u00f6r gibi geni\u015f bir\nyelpazesi olu\u015fturulmu\u015ftur.&nbsp;Bu ayn\u0131 zamanda<em>&nbsp;N.&nbsp;sativa&#8217;n\u0131n<\/em>&nbsp;terap\u00f6tik etkilerinin \u00e7o\u011funun u\u00e7ucu\nya\u011f\u0131n ana biyoaktif bile\u015feni olan timokinonun (TQ) varl\u0131\u011f\u0131ndan\nkaynaklanmaktad\u0131r.&nbsp;\u00c7e\u015fitli kan\u0131tlara g\u00f6re, bu bitkinin ve ana bile\u015feninin\nbeyin, kalp, karaci\u011fer, b\u00f6brek ve akci\u011fer dahil olmak \u00fczere farkl\u0131 dokulardaki\nkoruyucu etkileri,&nbsp;hayvan \u00e7al\u0131\u015fmalar\u0131nda do\u011fal veya kimyasal toksinlere&nbsp;kar\u015f\u0131\nbaz\u0131 toksik&nbsp;ajanlara&nbsp;kar\u015f\u0131\nkan\u0131tlanm\u0131\u015ft\u0131r&nbsp;.&nbsp;Bu derlemede, \u00e7e\u015fitli&nbsp;<em>in vitro<\/em>&nbsp;ve\npanzehir ve koruyucu etkilerini ara\u015ft\u0131rmak bilimsel veri tabanlar\u0131nda ve hayvan\n\u00e7al\u0131\u015fmalar\u0131nda&nbsp;<em>N.&nbsp;Sativa <\/em>ve do\u011fal\nve kimyasal kaynakl\u0131 toksisitelere kar\u015f\u0131 ana bile\u015fenleri\nverilmektedir.&nbsp;\u0130nsan raporlar\u0131 nadir oldu\u011fu i\u00e7in, bu bitkinin insan\nzehirlenmesinde bir antidot veya koruyucu ajan olarak etkinli\u011fini belirlemek\ni\u00e7in daha fazla \u00e7al\u0131\u015fmaya ihtiya\u00e7 vard\u0131r.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">35-)Nigella\nsativa&nbsp;Pretreatment in Guinea Pigs Exposed to Cigarette Smoke\nModulates In Vitro Tracheal Responsiveness.<\/h1>\n\n\n\n<p>DOI:10.5812\/ircmj.10421<\/p>\n\n\n\n<p>Daha \u00f6nceki \u00e7al\u0131\u015fmalarda,&nbsp;Nigella\nsativa&#8217;n\u0131n&nbsp;bronkodilat\u00f6r\u00fc ve&nbsp;antitussif&nbsp;etkileri&nbsp;kobaylarda\ng\u00f6sterilmi\u015ftir.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">AMA\u00c7:<\/h4>\n\n\n\n<p>Bu \u00e7al\u0131\u015fmada, N. hidro ekstresinin etkisi&nbsp;sativa&nbsp;sigara duman\u0131na maruz gine\ndomuzlar\u0131nda trakeal yan\u0131t \u00fczerinde incelendi.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">MALZEMELER VE Y\u00d6NTEMLER:<\/h4>\n\n\n\n<p>\u00dc\u00e7 grup kobay modelinde sadece i\u00e7me suyu (KOAH grubu), C vitamini\ni\u00e7eren i\u00e7me suyu (KOAH + VC grubu) ve N.&nbsp;sativa&nbsp;(KOAH\n+ NS grubu) verildi.&nbsp;Metakolin&#8217;e trakeal yan\u0131tlar, kontrol hayvanlar\u0131nda\n(grup C) maksimum yan\u0131t\u0131n% 50&#8217;sine (EC50 M) ve KOAH&#8217;l\u0131 \u00fc\u00e7 grup kobay grubuna\n(t\u00fcm gruplar i\u00e7in n = 7) neden olan etkili konsantrasyon olarak\n\u00f6l\u00e7\u00fcld\u00fc.&nbsp;10 uM metakolin ile elde edilen kas\u0131lmaya k\u0131yasla% 0.1 ovalb\u00fcmine\ntrakeal yan\u0131tlar da incelendi.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">SONU\u00c7LAR:<\/h4>\n\n\n\n<p>KOAH&#8217;l\u0131 kobaylarda hem metakolin hem de ovalb\u00fcmine trakeal cevap\nverebilirlik kontrollerden anlaml\u0131 derecede y\u00fcksekti (her iki vaka i\u00e7in de P\n&lt;0.001).&nbsp;KOAH + VC ve KOAH + NS gruplar\u0131ndaki trakeal yan\u0131t\u0131n hem\nmetakolin hem de ovalb\u00fcmine kar\u015f\u0131 duyarl\u0131l\u0131\u011f\u0131, KOAH grubuna g\u00f6re anlaml\u0131 olarak\nazalm\u0131\u015ft\u0131r (s\u0131ras\u0131yla P &lt;0.05 ve P &lt;0.001).<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">SONU\u00c7LAR:<\/h4>\n\n\n\n<p>Bu sonu\u00e7lar, N. Sativa ekstresinin \u00f6nleyici bir etkisi\ng\u00f6zlenmi\u015ftir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">36-)The Protective Effect of \u03b1-Hederin, the Active\nConstituent of&nbsp;Nigella sativa, on Lung\nInflammation and Blood Cytokines in Ovalbumin Sensitized Guinea Pigs.<\/h1>\n\n\n\n<p>DOI:10.1002\/ptr.5429<\/p>\n\n\n\n<p>Bu \u00e7al\u0131\u015fmada,&nbsp;Nigella&nbsp;sativa&#8217;n\u0131n\naktif bile\u015feni olan iki farkl\u0131 a-hederin konsantrasyonunun \u00f6nleyici etkisi,\novalbumin duyarl\u0131la\u015ft\u0131r\u0131lm\u0131\u015f kobaylarda akci\u011fer iltihab\u0131 ve kan sitokinleri\n\u00fczerinde incelendi.&nbsp;K\u0131rk sekiz erkek yeti\u015fkin kobay, kontrol (C),\nduyarl\u0131la\u015ft\u0131r\u0131lm\u0131\u015f (S) ve duyarl\u0131la\u015ft\u0131r\u0131lm\u0131\u015f \u00f6n-muamele gruplar\u0131na\nayr\u0131ld\u0131;&nbsp;timokinon (S + TQ), d\u00fc\u015f\u00fck doz (S + LAH) ve y\u00fcksek doz a-hederin\n(S + HAH) ve inhale flutikazon propionat (S + FP) ile.&nbsp;Akci\u011fer\nhistopatolojisi ve IL-4, IFN-y ve IL-17&#8217;nin kan d\u00fczeyleri\nde\u011ferlendirildi.&nbsp;Hassasla\u015ft\u0131r\u0131lm\u0131\u015f hayvanlarla kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, \u00f6n\ntedavi uygulanan gruplarda t\u00fcm patolojik de\u011fi\u015fiklikler \u00f6nemli \u00f6l\u00e7\u00fcde iyile\u015fti\n(p &lt;0.001 ila p &lt;0.05).&nbsp;A-hederin ile \u00f6n i\u015fleme tabi tutulmu\u015f\ngruplardaki bu geli\u015fmeler, S + TQ grubundan daha d\u00fc\u015f\u00fck olan S + LAH ve S + HAH\ngruplar\u0131nda h\u00fccresel infiltrasyon hari\u00e7 S + TQ ve S + FP gruplar\u0131na benzerdi (p\n&lt;0.05).&nbsp;S + HAH gruplar\u0131ndaki kan IL-4 ve IL-17 d\u00fczeyleri, S grubuna\ng\u00f6re anlaml\u0131 bir d\u00fc\u015f\u00fc\u015f g\u00f6sterdi (p &lt;0.&nbsp;05) S + TQ ve S + FP gruplar\u0131na\nbenzerdi.&nbsp;S + LAH ve S + HAH gruplar\u0131nda IFN-level d\u00fczeyi, S + FP\ngrubundan daha y\u00fcksek olan S grubuna (p &lt;0.05) g\u00f6re anlaml\u0131 olarak artt\u0131 (p\n&lt;0.05).&nbsp;S + HAH grubunda kan IL-4, S + LAH grubundan anlaml\u0131 olarak\nd\u00fc\u015f\u00fckt\u00fc (p &lt;0.05).&nbsp;Sonu\u00e7 olarak, \u03b1-hederin akci\u011fer iltihab\u0131n\u0131\nhafifletebilir ve kullan\u0131lan dozajlarda timokinon ve flutikazon gibi sitokin\nde\u011fi\u015fikliklerini iyile\u015ftirebilir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">37-) Effect of the herbal medicines in obesity and\nmetabolic syndrome: A systematic review and meta-analysis of clinical trials<\/h1>\n\n\n\n<p>Obezite, enerji al\u0131m\u0131 ve enerji harcamas\u0131 aras\u0131ndaki\ndengesizlik nedeniyle a\u015f\u0131r\u0131 v\u00fccut ya\u011f\u0131n\u0131n topland\u0131\u011f\u0131 t\u0131bbi bir\ndurumdur.&nbsp;Obezite tedavisi ve y\u00f6netimi i\u00e7in \u00e7e\u015fitli \u00e7al\u0131\u015fmalar\u0131n mevcut\nolmas\u0131na ra\u011fmen,t\u00fcm d\u00fcnyada hala b\u00fcy\u00fck bir sorun olmaya devam\netmektedir.&nbsp;Mevcut sistematik derleme ve meta-analiz, insanda obezite ve\nmetabolik sendromun tedavisinde ve tedavisinde etkili bitkisel ila\u00e7lar\u0131n\netkinli\u011fini, g\u00fcvenli\u011fini ve mekanizmalar\u0131n\u0131 de\u011ferlendirmeyi\nama\u00e7lam\u0131\u015ft\u0131r.&nbsp;Bitkilerden veya bitkilerin b\u00f6l\u00fcmlerinden elde edilen ham\nveya rafine \u00fcr\u00fcnlerin a\u015f\u0131r\u0131 kilolu ve obezite yeti\u015fkinlerde obezite ve\nmetabolik sendrom \u00fczerindeki etkilerini de\u011ferlendirmek i\u00e7in Web of Science,\nScopus, PubMed ve Cochrane veri taban\u0131 arac\u0131l\u0131\u011f\u0131yla ilgili t\u00fcm klinik\nara\u015ft\u0131rmalar\u0131 sistematik olarak ara\u015ft\u0131rd\u0131k.&nbsp;May\u0131s 2019 sonuna kadar\nyap\u0131lan t\u00fcm \u00e7al\u0131\u015fmalar sistematik derlemede ele al\u0131nd\u0131.&nbsp;Veriler iki uzman\ntaraf\u0131ndan ba\u011f\u0131ms\u0131z olarak al\u0131nm\u0131\u015ft\u0131r.&nbsp;Kalite de\u011ferlendirmesi Konsolide\nRaporlama Denemeleri Standartlar\u0131 kontrol listesi kullan\u0131larak\nde\u011ferlendirildi.&nbsp;Ana sonu\u00e7lar antropometrik indeksler ve metabolik sendrom\nbile\u015fenleridir.&nbsp;Bitkisel ila\u00e7lar\u0131n obezite ve metabolik sendrom \u00fczerindeki\nhavuzlanm\u0131\u015f etkisi standart ortalama fark (SMD) ve% 95 g\u00fcven aral\u0131\u011f\u0131 (CI)\nolarak sunuldu.&nbsp;Toplam 279 ilgili klinik \u00e7al\u0131\u015fma dahil\nedilmi\u015ftir.&nbsp;Ye\u015fil \u00e7ay i\u00e7eren bitkiler, Phaseolus vulgaris, Garcinia\ncambogia,&nbsp;Bitkisel ila\u00e7lar\u0131n obezite ve metabolik sendrom \u00fczerindeki\nhavuzlanm\u0131\u015f etkisi standart ortalama fark (SMD) ve% 95 g\u00fcven aral\u0131\u011f\u0131 (CI)\nolarak sunuldu.&nbsp;Toplam 279 ilgili klinik \u00e7al\u0131\u015fma dahil edilmi\u015ftir. Obezite\nve metabolik sendromdaki bitkilerin klinik etkinli\u011fini kesin olarak belirlemek\ni\u00e7in y\u00fcksek kaliteli \u00e7al\u0131\u015fmalara hala ihtiya\u00e7 vard\u0131r.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">38-) The cardiovascular actions of the\nvolatile oil of the black seed (Nigella\nsativa) in rats: elucidation of the mechanism of action.<\/h1>\n\n\n\n<p>DOI:10.1016\/0306-3623(93)90359-6<\/p>\n\n\n\n<p>Siyah tohumun (&nbsp;Nigella sativa&nbsp;)\nu\u00e7ucu ya\u011f\u0131n\u0131n (UY) etkileri) arteryel kan bas\u0131nc\u0131 ve \u00fcretan ile anestezi\nuygulanm\u0131\u015f s\u0131\u00e7anlar\u0131n kalbi \u00fczerinde ara\u015ft\u0131r\u0131ld\u0131 ve etkileri kurucu timokinon\n(TQ) ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131.S\u0131\u00e7anlara doz aral\u0131\u011f\u0131nda (4-32 mikrolitre kg.-1) veya\nTQ (0.2-1.6 mg kg-1) intraven\u00f6z.UY uygulamas\u0131, arteriyel kan bas\u0131nc\u0131n\u0131 ve kalp\nh\u0131z\u0131n\u0131 doza ba\u011fl\u0131 bir \u015fekilde azaltt\u0131.&nbsp;UY\u2019nIn etkileri, hayvanlar\u0131n\nsiproheptadin, hekzametonyum atropin ve omurilik iltihab\u0131 ile \u00f6nemli \u00f6l\u00e7\u00fcde\nantagonize edildi.Hayvanlar\u0131n reserpin ile (2 g\u00fcn boyunca 5 mg kg-1 g\u00fcn-1)\ntedavisi, 4 ve 8 mikrolitre UY kg-1 ile ind\u00fcklenen kardiyovask\u00fcler depresan\netkileri \u00f6nemli \u00f6l\u00e7\u00fcde antagonize etti, ancak daha b\u00fcy\u00fck dozlar taraf\u0131ndan\nind\u00fcklenenler de\u011fil.&nbsp;5. TKY&nbsp;ind\u00fcklenen kardiyovask\u00fcler depresan\netkiler atropin ve siproheptadin taraf\u0131ndan \u00f6nemli \u00f6l\u00e7\u00fcde antagonize edildi,\nancak reserpin taraf\u0131ndan antagonize edilmedi.&nbsp;6. Sonu\u00e7lar, UY ile\nind\u00fcklenen kardiyovask\u00fcler depresan etkilere temel olarak hem\n5-hidroksitriptaminerjik hem de muskarinik mekanizmalar\u0131 i\u00e7eren dolayl\u0131 ve\ndo\u011frudan mekanizmalar arac\u0131l\u0131\u011f\u0131yla arac\u0131l\u0131k etti\u011fini g\u00f6stermi\u015ftir.&nbsp;Do\u011frudan\nmekanizmalar, UY&#8217;de TQ&#8217;nun varl\u0131\u011f\u0131ndan kaynaklanabilir. UY, merkezi olarak\netkili bir antihipertansif ajan olma potansiyeline sahip gibi g\u00f6r\u00fcn\u00fcyordu.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">39-) Biogenic platinum nanoparticles using black\ncumin seed and their potential usage as&nbsp;antimicrobial&nbsp;and\nanticancer agent.<\/h1>\n\n\n\n<p>DOI:10.1016\/j.jpba.2019.112961<\/p>\n\n\n\n<p>Burada biyojenik platin nanopartik\u00fcller (Pt NP&#8217;ler), siyah\nkimyon tohumu (&nbsp;Nigella sativa&nbsp;)\nkullan\u0131larak sentezlendiL.) indirgeyici ajan olarak ekstrakt edindi.&nbsp;Siyah\nkimyon tohumu \u00f6z\u00fct\u00fc ile sentezlenen biyojenik platin nanopartik\u00fcller,\nTransmisyon Elektron Mikroskopisi (TEM), UV-vis spektrofotometre, X-\u0131\u015f\u0131n\u0131\nk\u0131r\u0131n\u0131m\u0131 (XRD), X-\u0131\u015f\u0131n\u0131 fotoelektron spektroskopisi (XPS) ile ayr\u0131nt\u0131l\u0131 olarak\nkarakterize edildi.&nbsp;TEM analizine g\u00f6re, Pt nanopar\u00e7ac\u0131klar\u0131n\u0131n k\u00fcresel\n\u015fekilleri ve boyutlar\u0131 1-6 nm aras\u0131ndad\u0131r.&nbsp;Ayr\u0131ca, biyojenik Pt NP&#8217;leri\nMDA-MB-231 meme ve HeLa serviks kanser hatlar\u0131 \u00fczerindeki sitotoksisite etkisi\nve gram-pozitif ve negatif bakterilerin se\u00e7ilmi\u015f su\u015flar\u0131na kar\u015f\u0131 antibakteriyel\netkileri a\u00e7\u0131s\u0131ndan de\u011ferlendirildi.&nbsp;Sitotoksisite ve bakteriyel testler,\nbiyojenik Pt nanopartik\u00fcllerinin etkinli\u011fini g\u00f6sterdi.&nbsp;Doza ba\u011fl\u0131\ntoksisite etkileri MDA-MB-231 meme ve HeLa serviks kanser hatlar\u0131nda\ng\u00f6sterilmi\u015ftir (s\u0131ras\u0131yla IC50: 36.86 \u03bcg \/ mL ve 19.83 \u03bcg \/ mL).&nbsp;Ek\nolarak,&nbsp;Pt NP&#8217;leri, 100 ve 500 ug \/ ml konsantrasyonlarda gram-pozitif ve\ngram-negatif bakterilere kar\u015f\u0131 y\u00fcksek b\u00f6lge \u00e7aplar\u0131 g\u00f6sterdi.&nbsp;Bu sonu\u00e7lar,\nila\u00e7 end\u00fcstrisinin potansiyel bir antibakteriyel ve antikanser ajan olarak\ngeli\u015fmesine katk\u0131da bulunur.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">40-) Vegetable butters and oils in skin wound\nhealing: Scientific evidence for new opportunities in dermatology<\/h1>\n\n\n\n<p>DOI:10.1002\/ptr.6524<\/p>\n\n\n\n<p>Bitkisel ya\u011f ve ya\u011f kullan\u0131m\u0131, antimikrobiyal,\nantienflamatuar ve antioksidatif aktiviteleri yoluyla yara iyile\u015fme s\u00fcrecinin\na\u015famalar\u0131 \u00fczerinde etkili bir etkiye sahip olduklar\u0131 ve h\u00fccre \u00e7o\u011falmas\u0131n\u0131\nte\u015fvik ederek cilt yaralar\u0131n\u0131n tedavisinde umut verici sonu\u00e7lar g\u00f6sterir.\nkolajen sentezi, dermal rekonstr\u00fcksiyonun uyar\u0131lmas\u0131 ve cildin lipit bariyer\nfonksiyonunun onar\u0131lmas\u0131.&nbsp;Bu makalede, argan (Argania spinosa), avokado\n(Persea americana), siyah kimyon (&nbsp;Nigella sativa&nbsp;)\nin vitro ve in vivo \u00e7al\u0131\u015fmalar\u0131), kalophyllum (Calophyllum inophyllum),\nhindistancevizi (Cocos nucifera), k\u0131z\u0131lc\u0131k (Vaccinium macrocarpon), \u00fcz\u00fcm (Vitis\nvinifera), ye\u015fil kahve (Coffea arabica), lentisk (Pistacia lentiscus), keten\ntohumu (Linum usitatissimum), lucuma (Pouteria) , mango (Mangifera indica),\nzeytin (Olea europaea), nar (Punica granatum), kabak (Cucurbita pepo), kolza\ntohumu (Brassica napus), deniz topalak (Hippophae rhamnoides) ve ay\u00e7i\u00e7e\u011fi\n(Helianthus annuus) ya\u011flar\u0131 incelendi.&nbsp;Bir\u00e7ok durumda, bitkisel ya\u011flar\u0131n\nkontrol olarak kullan\u0131lan sentetik yara iyile\u015ftirici bile\u015fiklerden daha etkili\noldu\u011fu kan\u0131tlanm\u0131\u015ft\u0131r.&nbsp;Bitkisel ya\u011flar\u0131n ya\u011f asidi bile\u015fenlerinin, yara\niyile\u015ftirme i\u015fleminde, \u00f6zellikle linoleik asit gibi \u00e7oklu doymam\u0131\u015f ya\u011f\nasitlerinde \u00f6nemli bir rol oynad\u0131\u011f\u0131 varsay\u0131lmaktad\u0131r.&nbsp;Kan\u0131tlar, linoleik \/\noleik asit oran\u0131 daha y\u00fcksek olan ya\u011flar\u0131n lipit bariyeri onar\u0131m\u0131 i\u00e7in daha\netkili oldu\u011funu g\u00f6stermektedir.&nbsp;Bununla birlikte, bitkisel ya\u011flar\u0131n cilt\n\u00fczerindeki etkileri hakk\u0131nda bilgi edinmek i\u00e7in derinlemesine \u00e7al\u0131\u015fmalara\nihtiya\u00e7 vard\u0131r.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">41-) Bioactive Compounds of&nbsp;<em>Nigella Sativa<\/em>&nbsp;Essential Oil as\nAntibacterial&nbsp;Agents&nbsp;against&nbsp;<em>Chlamydia\nTrachomatis<\/em>&nbsp;D.<\/h1>\n\n\n\n<p>DOI:10.3390\/microorganisms7090370<\/p>\n\n\n\n<p>Zorlu h\u00fccre i\u00e7i bakterilerin neden oldu\u011fu \u00fcrogenital sistem\nenfeksiyonu&nbsp;<em>Chlamydia trachomatis<\/em>&nbsp;D (&nbsp;<em>Ctr<\/em>&nbsp;D) cinsel\nyolla bula\u015fan hastal\u0131klar\u0131n \u00f6nde gelen nedenidir.&nbsp;<em>Nigella\nsativa<\/em>&nbsp;esansiyel ya\u011f\u0131 (EO)&nbsp;geni\u015f bir&nbsp;antimikrobiyal&nbsp;spektruma sahiptir.&nbsp;Bu\n\u00e7al\u0131\u015fman\u0131n amac\u0131&nbsp;<em>N.&nbsp;sativa<\/em>&nbsp;EO&#8217;nun&nbsp;biyoaktif\nbile\u015fiklerinin (p-cymene, timokinon, karvakrol ve timol)&nbsp;<em>Ctr<\/em>&nbsp;D&#8217;ye&nbsp;kar\u015f\u0131&nbsp;antimikrobiyal&nbsp;aktivitesini&nbsp;de\u011ferlendirmekti.&nbsp;Bile\u015fiklerin&nbsp;sitotoksik\netkileri MTT deneyi ile belirlendi.&nbsp;Bile\u015fiklerin anti-klamidyal\naktivitesini \u00f6l\u00e7mek i\u00e7in HeLa h\u00fccreleri&nbsp;<em>Ctr<\/em>&nbsp;D veya&nbsp;<em>Ctr<\/em>&nbsp;ile\nenfekte edildiD daha \u00f6nce bile\u015fiklerle i\u015flemden ge\u00e7irildi.&nbsp;Enfeksiy\u00f6z&nbsp;<em>Ctr<\/em>&nbsp;D&#8217;&nbsp;nin\ntitresi,&nbsp;dolayl\u0131 imm\u00fcnofloresan deneyi ile belirlendi.&nbsp;Bile\u015fiklerin\nminimum \u00f6nleyici konsantrasyonlar\u0131, do\u011frudan kantitatif PCR ile\nde\u011ferlendirildi.&nbsp;Bile\u015fiklerin hi\u00e7biri, test edilen konsantrasyonlarda HeLa\nh\u00fccreleri \u00fczerinde sitotoksik bir etki g\u00f6stermedi.&nbsp;\u0130mm\u00fcnofloresan testine\ng\u00f6re, t\u00fcm bile\u015fikler&nbsp;<em>Ctr<\/em>&nbsp;D&#8217;&nbsp;nin b\u00fcy\u00fcmesini \u00f6nemli \u00f6l\u00e7\u00fcde\ninhibe etti&nbsp;. Kantitatif PCR, anti-klamidyal aktivite uygulayan minimum\nkonsantrasyonun, timokinon ve p-cymene durumunda 3.12 uM oldu\u011funu, karvakrol ve\ntimol, 6.25 uM idi.&nbsp;Bu nedenle&nbsp;<em>N.&nbsp;sativa<\/em>&nbsp;EO&#8217;nun&nbsp;biyoaktif\nbile\u015fiklerinin&nbsp;etkili&nbsp;antimikrobiyal&nbsp;olarak\nkullan\u0131labilece\u011fi&nbsp;sonucuna var\u0131labilir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">42-) Development of Novel Topical Cosmeceutical\nFormulations from&nbsp;<em>Nigella sativa<\/em>&nbsp;L.\nwith&nbsp;Antimicrobial&nbsp;Activity\nagainst Acne-Causing Microorganisms.<\/h1>\n\n\n\n<p>DOI:10.1155\/2019\/5985207<\/p>\n\n\n\n<p>Akne vulgaris, derideki ya\u011f folik\u00fcllerinin iltihab\u0131 nedeniyle\nolu\u015fur.&nbsp;<em>Propionibacterium acnes<\/em>&nbsp;,&nbsp;<em>Staphylococcus\naureus<\/em>&nbsp;ve&nbsp;<em>Staphylococcus epidermidis<\/em>&nbsp;gibi baz\u0131\nbakteri t\u00fcrlerinin aktivitesi ile tetiklenir&nbsp;.&nbsp;Bu mikroorganizmalar\ntaraf\u0131ndan antibiyotik direncinin elde edilmesi ve mevcut tedavi rejimleriyle\nili\u015fkili olumsuz etkiler&nbsp;, akne vulgaris i\u00e7in&nbsp;yeni terap\u00f6tik&nbsp;ajanlar\u0131n kullan\u0131lmas\u0131n\u0131&nbsp;gerektirir&nbsp;.&nbsp;Bu\nnedenle, bu \u00e7al\u0131\u015fma&nbsp;<em>Nigella sativa<\/em>&nbsp;L.&nbsp;tohumlar\u0131ndan\nyeni jel form\u00fclasyonlar\u0131 geli\u015ftirmek&nbsp;ve baz\u0131 akneye neden olan bakteri\nt\u00fcrlerine kar\u015f\u0131 antibakteriyel potansiyeli de\u011ferlendirmek i\u00e7in\nyap\u0131lm\u0131\u015ft\u0131r.&nbsp;Tohum ekstrelerinin antibakteriyel aktivitesi\nba\u015flang\u0131\u00e7ta&nbsp;<em>S. aureus&#8217;a<\/em>&nbsp;kar\u015f\u0131 taranm\u0131\u015ft\u0131r.Daha sonra&nbsp;\u00fc\u00e7\nfarkl\u0131 konsantrasyonda&nbsp;<em>N.&nbsp;sativa<\/em>&nbsp;tohumlar\u0131n\u0131n\netil asetat ekstrakt\u0131n\u0131 i\u00e7eren topikal jeller form\u00fcle edildi&nbsp;.&nbsp;Bu\ntopikal form\u00fclasyonlar&nbsp;antimikrobiyal&nbsp;aktivite\n\u00e7al\u0131\u015fmalar\u0131na&nbsp;tabi&nbsp;tutulurken stabilite 30 g\u00fcnl\u00fck bir s\u00fcre boyunca\nde\u011ferlendirildi.&nbsp;\u00dc\u00e7 form\u00fclasyonun t\u00fcm\u00fc&nbsp;, tohum ekstrakt\u0131n\u0131n% 15&#8217;ini\ni\u00e7eren form\u00fclasyondaki en y\u00fcksek antibakteriyel aktiviteye\nsahip&nbsp;olan&nbsp;<em>S. aureus<\/em>&nbsp;ve&nbsp;<em>P. acnes&#8217;in<\/em>&nbsp;b\u00fcy\u00fcmesini\ninhibe&nbsp;<em>edebilmi\u015ftir<\/em>&nbsp;.&nbsp;Bu form\u00fclasyonun&nbsp;<em>S.\naureus&#8217;a<\/em>&nbsp;kar\u015f\u0131 antibakteriyel g\u00fcc\u00fcpozitif kontrol olarak kullan\u0131lan\nticari sentetik \u00fcr\u00fcn\u00fc a\u015ft\u0131.&nbsp;Ayr\u0131ca, renk, koku, homojenlik,\ny\u0131kanabilirlik, k\u0131vam ve pH&#8217;da herhangi bir de\u011fi\u015fiklik g\u00f6zlenmezken,\nantibakteriyel etki de depolama s\u00fcresi boyunca korunmu\u015ftur.&nbsp;Etil asetat\nekstresi geli\u015ftirilen topikal jel form\u00fclasyonlar\u0131nda g\u00fc\u00e7l\u00fc bir anti bakteriyel\naktivite&nbsp;<em>N&nbsp;sativa<\/em>&nbsp;mevcut\nantiakne alternatif olarak kullan\u0131lmas\u0131 uygun g\u00f6r\u00fclm\u00fc\u015ft\u00fct.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">43-) PROTECTIVE EFFECT OF&nbsp;<em>NIGELLA SATIVA<\/em>&nbsp;OIL\nON MYOCARDIUM IN STREPTOZOTOCIN-INDUCED DIABETIC RATS.<\/h1>\n\n\n\n<p>DOI:10.4183\/aeb.2019.289<\/p>\n\n\n\n<p><br>\nStreptozotosin kaynakl\u0131 diyabetik s\u0131\u00e7anlarda&nbsp;<em>Nigella sativa<\/em>&nbsp;ya\u011f\u0131n\u0131n\n(NSO) miyokard \u00fczerindeki&nbsp;koruyucu etkisini de\u011ferlendirmek&nbsp;.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">MALZEMELER VE Y\u00d6NTEMLER:<\/h4>\n\n\n\n<p>Otuz iki 7-8 haftal\u0131k di\u015fi Wistar albino s\u0131\u00e7anlar\u0131 (300-350 g)\ne\u015fit olarak 4 gruba ayr\u0131ld\u0131: diyabetik tedavi edilmemi\u015f hayvanlar (kontrol),\ndiabetes mellitus (DM), NSO ve DM + NSO gruplar\u0131.&nbsp;Diyabetin ind\u00fcksiyonu\ni\u00e7in, DM ve DM + NSO gruplar\u0131ndaki s\u0131\u00e7anlara tek bir intraperitoneal doz olarak\n45 mg \/ kg streptozotosin uyguland\u0131.&nbsp;NSO (400 mg \/ kg), 21 g\u00fcn boyunca\ng\u00fcnde bir kez intragastrik kateter yoluyla oral yoldan\nuyguland\u0131.&nbsp;Miyokard\u0131n formalinle fikse edilmi\u015f, parafine g\u00f6m\u00fclm\u00fc\u015f doku\nkesitleri histopatolojik ve imm\u00fcnohistokimyasal olarak de\u011ferlendirildi.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">SONU\u00c7LAR:<\/h4>\n\n\n\n<p>Kontrol, NSO ve DM + NSO gruplar\u0131na k\u0131yasla, DM grubundaki\ns\u0131\u00e7anlardan gelen miyokardiyal doku \u00f6rnekleri anlaml\u0131 derecede daha y\u00fcksek\nmiyozit, hiyalin dejenerasyonu ve Zenker nekrozuna sahipti.&nbsp;Ayr\u0131ca, Bcl-2\nekspresyonlar\u0131 kontrol, NSO ve DM + NSO gruplar\u0131nda DM grubuna g\u00f6re anlaml\u0131\nolarak daha y\u00fcksekti.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">SONU\u00c7:<\/h4>\n\n\n\n<p>NSO, b\u00fcy\u00fck olas\u0131l\u0131kla apoptozu bask\u0131layarak, streptozotosin\nkaynakl\u0131 diyabetik s\u0131\u00e7anlar\u0131n miyokard\u0131 \u00fczerinde koruyucu bir etkiye sahiptir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">44-) The anti-inflammatory, analgesic and\nantipyretic activity of Nigella sativa.<\/h1>\n\n\n\n<p>DOI:10.1016\/s0378-8741(01)00216-1<\/p>\n\n\n\n<p><br>\nNigella sativa&#8217;n\u0131n (N. sativa) sulu ekstresi, hayvan modellerindeki\nanti-enflamatuar, analjezik ve antipiretik aktiviteler i\u00e7in\nara\u015ft\u0131r\u0131ld\u0131.&nbsp;Ekstrakt\u0131n Carrageenan kaynakl\u0131 pen\u00e7e \u00f6demi \u00fczerindeki\n\u00f6nleyici etkileri ile g\u00f6sterilen bir anti-enflamatuar etkisi\nvard\u0131r.&nbsp;Ayr\u0131ca analjezik etkiyi g\u00f6steren farelerde s\u0131cak plaka reaksiyon\ns\u00fcresinde \u00f6nemli bir art\u0131\u015f \u00fcretti.&nbsp;Bununla birlikte, N. sativa ham\ns\u00fcspansiyonunun maya ile ind\u00fcklenen pireksi \u00fczerinde bir etkisi\nolmam\u0131\u015ft\u0131r.&nbsp;Bu nedenle bu \u00e7al\u0131\u015fma, halk t\u0131bb\u0131nda hem analjezik hem de\nanti-enflamatuar ajan olarak kullan\u0131m\u0131n\u0131 desteklemektedir ve etki mekanizmas\u0131n\u0131\nayd\u0131nlatmak i\u00e7in daha fazla ara\u015ft\u0131rma yap\u0131lmas\u0131n\u0131 gerektirmektedir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">45-) Efficacy and tolerability of a fixed\ncombination of peppermint oil and&nbsp;caraway oil&nbsp;in\npatients suffering from functional dyspepsia.<\/h1>\n\n\n\n<p>DOI:10.1046\/j.1365-2036.2000.00873.x<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">AMA\u00c7:<\/h4>\n\n\n\n<p>Fonksiyonel dispepsi olan hastalarda&nbsp;90 mg nane ya\u011f\u0131 ve 50\nmg&nbsp;kimyon ya\u011f\u0131&nbsp;(PCC; Enteroplant)&nbsp;sabit\nbir kombinasyonunu i\u00e7eren enterik kapl\u0131 kaps\u00fcllerin etkinli\u011fini ve\ng\u00fcvenilirli\u011fini de\u011ferlendirmek&nbsp;.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Y\u00d6NTEMLER:<\/h4>\n\n\n\n<p>Toplam 96 hastaya 28 g\u00fcn boyunca g\u00fcnde iki kez PCC veya plasebo\nverildi.&nbsp;Birincil etkililik de\u011fi\u015fkenleri, (i) a\u011fr\u0131 yo\u011funlu\u011funda ve (ii) 1\nve 29. g\u00fcnler aras\u0131nda bas\u0131n\u00e7, a\u011f\u0131rl\u0131k ve dolgunluk hissindeki birey i\u00e7i\nde\u011fi\u015fim ve ara\u015ft\u0131rmac\u0131lar\u0131n (iii) k\u00fcresel iyile\u015fme derecesi (Klinik Global\n\u0130zlenimler [CGI]) idi. Madde 2) 29. g\u00fcnde. Alfa = 0.05 genel tip I hatas\u0131\nhipotezlerin \u00f6nceden s\u0131ralanmas\u0131yla kontrol edildi.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">SONU\u00c7LAR:<\/h4>\n\n\n\n<p>T\u00fcm hastalar etkinlik ve g\u00fcvenlilik a\u00e7\u0131s\u0131ndan\nde\u011ferlendirildi.&nbsp;29. g\u00fcnde PCC grubunda ba\u015flang\u0131\u00e7ta ortalama a\u011fr\u0131\nyo\u011funlu\u011fu% 40, plasebo grubunda% 22 azalm\u0131\u015ft\u0131r.&nbsp;Bas\u0131n\u00e7, a\u011f\u0131rl\u0131k ve\ndolgunluk a\u00e7\u0131s\u0131ndan PCC i\u00e7in% 43, plasebo i\u00e7in% 22 azalma\ng\u00f6zlenmi\u015ftir.&nbsp;CGI madde 2&#8217;de hastalar\u0131n% 67&#8217;si (PCC) ve hastalar\u0131n% 21&#8217;i\n(plasebo) \u00e7ok fazla veya \u00e7ok geli\u015fmi\u015f olarak tan\u0131mlanm\u0131\u015ft\u0131r.&nbsp;\u00dc\u00e7 hedef\nparametrenin hepsinde, PCC&#8217;nin plaseboya g\u00f6re \u00fcst\u00fcnl\u00fc\u011f\u00fc istatistiksel olarak\nanlaml\u0131yd\u0131.&nbsp;Alt\u0131 hasta (PCC: 5; plasebo: 1), ara\u015ft\u0131rmayla ilgisi olmayan\nveya ara\u015ft\u0131r\u0131lan hastal\u0131\u011f\u0131n \u015fiddetlenmesine atfedilebilen olumsuz olaylar\nbildirmi\u015ftir.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">SONU\u00c7:<\/h4>\n\n\n\n<p>Bu sonu\u00e7lar, fonksiyonel dispepsi tedavisinde PCC&#8217;nin iyi tolere\nedilebilirli\u011fini ve olumlu risk-yarar oran\u0131n\u0131 g\u00f6stermektedir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">46-) Antinociceptive effects of&nbsp;Nigella sativa oil&nbsp;and its major component,\nthymoquinone, in mice.<\/h1>\n\n\n\n<p>DOI:10.1016\/s0014-2999(00)00340-x<\/p>\n\n\n\n<p>Nigella sativa ya\u011f\u0131n\u0131n&nbsp;antinosiseptif\netkileri ve ana bile\u015feni olan timokinon farelerde incelendi.&nbsp;N. sativa\nya\u011f\u0131 (50-400 mg \/ kg) po uygulamas\u0131, s\u0131cak plaka testinde, kuyruk k\u0131st\u0131rma\ntestinde, asetik asite ba\u011fl\u0131 k\u0131vranma testinde ve formalin testinin erken\nevresindeki nosiseptif cevab\u0131 doza ba\u011fl\u0131 olarak bast\u0131rd\u0131.&nbsp;Nalokson enjekte\nedilen sc (1 mg \/ kg) formalin testinin erken evresinde N. sativa ya\u011f\u0131 ve\ntimokinon ile ind\u00fcklenen antinosisepeksiyonu \u00f6nemli \u00f6l\u00e7\u00fcde bloke\netti.&nbsp;Ayr\u0131ca, nalokson (10 mikrogram \/ fare), mu (1) -opioid resept\u00f6r\nantagonisti, naloksononazin (1-5 mikrogram \/ fare) icv enjeksiyonu,&nbsp;veya\nkappa-opioid resept\u00f6r antagonisti, nor-binaltorfimin (1-5 mikrogram \/ fare),\nformalin testinin ge\u00e7 faz\u0131nda de\u011fil, erken fazda timokinon ile ind\u00fcklenen\nantinosikepsi \u00f6nemli \u00f6l\u00e7\u00fcde tersine \u00e7evirirken, delta-opioid resept\u00f6r\nantagonisti, naltrindol ( 1-5 ng \/ fare, icv), her iki faz \u00fczerinde de etkisi\nolmam\u0131\u015ft\u0131r.&nbsp;Morfinin antinosiseptif etkisi, timokinon ve N. sativa ya\u011fa\ntoleransl\u0131 farelerde \u00f6nemli \u00f6l\u00e7\u00fcde azald\u0131, ancak tam tersi de\u011fildi.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">47-) Antimicrobial activity of the volatile oil of\nNigella sativa Linneaus seeds.<\/h1>\n\n\n\n<p>DOI:10.1128\/aac.6.2.225<\/p>\n\n\n\n<p><br>\nNigella sativa Linneaus tohumlar\u0131n\u0131n u\u00e7ucu ya\u011f\u0131n\u0131n antimikrobiyal\naktivitesi incelenmi\u015ftir.&nbsp;Antimikrobiyal prensip izole edildi,\ntimohidrokinon olarak tan\u0131mland\u0131 ve gram-pozitif bakteri ve mayalara kar\u015f\u0131\naktif oldu\u011fu bulundu.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">48-) Pharmacological and toxicological properties\nof Nigella sativa.<\/h1>\n\n\n\n<p>DOI:10.1002\/ptr.1309<\/p>\n\n\n\n<p>\u00c7\u00f6rek otu tohumlar\u0131 (Ranunculaceae), yayg\u0131n olarak siyah\ntohum veya siyah kimyon olarak bilinir, t\u00fcm d\u00fcnyada halk (bitkisel) t\u0131pta\nast\u0131m, ishal ve dislipidemi i\u00e7eren bir dizi hastal\u0131\u011f\u0131n ve durumun tedavisi ve\n\u00f6nlenmesi i\u00e7in kullan\u0131l\u0131r.&nbsp;Bu makale, N. sativa ve bile\u015fenlerinin\nfarmakolojik ve toksikolojik \u00f6zelliklerinin ana raporlar\u0131n\u0131 g\u00f6zden\nge\u00e7irmektedir.&nbsp;Tohumlar hem sabit hem de u\u00e7ucu ya\u011flar, proteinler, alkaloidler\nve saponin i\u00e7erir.&nbsp;Tohumlar\u0131n biyolojik aktivitesinin \u00e7o\u011funun, u\u00e7ucu ya\u011f\u0131n\nana bile\u015feni olan fakat ayn\u0131 zamanda ya\u011fda bulunan timokinondan kaynakland\u0131\u011f\u0131\ng\u00f6sterilmi\u015ftir.&nbsp;Tohumlar\u0131n ham ekstrelerinin (ve aktif bile\u015fenlerinin bir\nk\u0131sm\u0131n\u0131n, \u00f6r.&nbsp;u\u00e7ucu ya\u011f ve timokinon), nefrotoksisiteye ve hastal\u0131k veya\nkimyasallar\u0131n neden oldu\u011fu hepatotoksisiteye kar\u015f\u0131 korumay\u0131\ni\u00e7erir.&nbsp;Tohumlar \/ ya\u011f, antienflamatuar, analjezik, antipiretik,\nantimikrobiyal ve antineoplastik aktiviteye sahiptir.&nbsp;Ya\u011f kan bas\u0131nc\u0131n\u0131\nd\u00fc\u015f\u00fcr\u00fcr ve solunumu art\u0131r\u0131r.&nbsp;S\u0131\u00e7anlar\u0131n tohum ekstrakt\u0131 ile 12 haftaya\nkadar tedavi edilmesinin hemogramda hem paketlenmi\u015f h\u00fccre hacminde (PCV) hem de\nhemoglobin (Hb) bir art\u0131\u015f ve kolesterol, trigliseritlerin plazma\nkonsantrasyonlar\u0131nda bir azalma i\u00e7eren de\u011fi\u015fiklikleri ind\u00fckledi\u011fi\nbildirilmi\u015ftir.Tohumlar \u00e7ok d\u00fc\u015f\u00fck derecede toksisite ile karakterize\nedilir.&nbsp;Topikal kullan\u0131m\u0131 takiben iki ki\u015fide iki kontakt dermatit vakas\u0131\nbildirilmi\u015ftir.&nbsp;Tohum \u00f6z\u00fct\u00fcn\u00fcn veya ya\u011f\u0131n\u0131n verilmesinin, karaci\u011fer veya\nb\u00f6brek fonksiyonlar\u0131 \u00fczerinde \u00f6nemli olumsuz etkiler yaratmad\u0131\u011f\u0131\ng\u00f6sterilmi\u015ftir.&nbsp;Tohumlar\u0131n ve timokinonun kullan\u0131m\u0131n\u0131n yararl\u0131 etkilerinin\nsitoprotektif ve antioksidan etkileri ve baz\u0131 iltihap arac\u0131lar\u0131 \u00fczerindeki\netkileri ile ili\u015fkili olabilece\u011fi anla\u015f\u0131lmaktad\u0131r<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">49-) Effects of intraduodenal application of\npeppermint oil (WS(R) 1340) and&nbsp;caraway oil&nbsp;(WS(R)\n1520) on gastroduodenal motility in healthy volunteers.<\/h1>\n\n\n\n<p>DOI:10.1002\/ptr.1089<\/p>\n\n\n\n<p>Sabit nane ya\u011f\u0131 \/&nbsp;kimyon ya\u011f\u0131&nbsp;kombinasyonu\n(\u00f6rn. Enteroplant\u00ae)&nbsp;i\u00e7eren enterik kapl\u0131 preparatlar&nbsp;fonksiyonel\ndispepsi hastalar\u0131nda yayg\u0131n olarak kullan\u0131lmaktad\u0131r.&nbsp;Enteroplant\u00ae (90 mg\nnane ya\u011f\u0131 (WS (R) 1340), 50 mg&nbsp;kimyon ya\u011f\u0131&nbsp;)\naktif bile\u015fenlerinin ayr\u0131 bir intraduodenal uygulamas\u0131n\u0131n etkisi(WS (R) 1520)\nkaps\u00fcl ba\u015f\u0131na) ve gastroduodenal motilite \u00fczerindeki Enteroplant\u00ae\nform\u00fclasyonunda (kaps\u00fcl ba\u015f\u0131na doz) bulunan hidrofobik fazl\u0131 galenik yard\u0131mc\u0131\nmateryalin sa\u011fl\u0131kl\u0131 g\u00f6n\u00fcll\u00fclerde sabit manometri ile \u00e7al\u0131\u015f\u0131lm\u0131\u015ft\u0131r.&nbsp;Deney\nd\u00fczene\u011finin talep etti\u011fi ta\u015f\u0131y\u0131c\u0131 da kontrol g\u00f6revi g\u00f6rd\u00fc.&nbsp;Sonu\u00e7lar \u015funu\ng\u00f6sterdi: (1) g\u00f6\u00e7 eden motor kompleksinin (MMC) faz III s\u0131ras\u0131nda, kas\u0131lmalar\u0131n\ns\u0131kl\u0131\u011f\u0131 ve s\u00fcresi, WS (R) 1340 i\u00e7in duodenumda \u00f6nemli bir azalma\ng\u00f6sterdi;&nbsp;(2) WS (R) 1520, MMC&#8217;nin faz I ve II s\u0131ras\u0131nda duodenumdaki\nkas\u0131lma genliklerini \u00f6nemli \u00f6l\u00e7\u00fcde azaltt\u0131;&nbsp;(3) gastrik korpus ve\nduodenumda WS (R) 1340 ve mide antrumunda WS (R) 1520 i\u00e7in azalm\u0131\u015f de\u011ferler\ne\u011filimleri g\u00f6r\u00fclm\u00fc\u015ft\u00fcr;&nbsp;(4) gastrik korpusta, kas\u0131lma s\u00fcresi, MMC&#8217;nin I ve\nII a\u015famalar\u0131nda WS @ 1340 uygulanmas\u0131ndan sonra \u00f6nemli \u00f6l\u00e7\u00fcde azald\u0131;&nbsp;(5)\nWS (R) 1520, MMC&#8217;nin III. Faz\u0131 s\u0131ras\u0131nda kas\u0131lma genliklerini ve mide\nkorpusundaki kas\u0131lma s\u00fcresini \u00f6nemli \u00f6l\u00e7\u00fcde azaltt\u0131;&nbsp;(6) hidrofobik faz\ni\u00e7in duodenumda kas\u0131lma s\u00fcresinde ve gastrik korpusta kas\u0131lma s\u0131kl\u0131\u011f\u0131nda orta\nderecede ancak anlaml\u0131 bir azalma g\u00f6r\u00fclm\u00fc\u015ft\u00fcr.&nbsp;\u00c7al\u0131\u015fma s\u0131ras\u0131nda hi\u00e7bir\nyan etki g\u00f6zlenmemi\u015ftir.&nbsp;Sonu\u00e7 olarak, hem WS (R) 1340 hem de WS (15)\n1520&#8217;nin Enteroplant\u00ae&#8217;\u0131n etkinli\u011fine katk\u0131da bulundu\u011fu g\u00f6sterilebilir.&nbsp;D\u00fcz\nkas gev\u015femesi i\u00e7in mide ve duodenumda lokal olarak hareket ederler.<\/p>\n\n\n\n<p><strong>50-)Effect of\npeppermint oil and&nbsp;caraway oil&nbsp;on\ngastrointestinal motility in healthy volunteers: a pharmacodynamic study using\nsimultaneous determination of gastric and gall-bladder emptying and orocaecal\ntransit time<\/strong>.<\/p>\n\n\n\n<p>&nbsp;DOI:10,1046\n\/ j.1365-2036.2003.01421.x<\/p>\n\n\n\n<p>Her ne kadar nane ya\u011f\u0131 ve&nbsp;kimyon ya\u011f\u0131&nbsp;,\nbitkisel ila\u00e7larda abdominal rahats\u0131zl\u0131k ve a\u011fr\u0131 i\u00e7in s\u0131kl\u0131kla kullan\u0131lsa da,\ngastrointestinal sistem \u00fczerindeki etkilerine dair farmakolojik bilgiler\nzay\u0131ft\u0131r.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Y\u00d6NTEMLER:<\/h4>\n\n\n\n<p>Plasebo, 10 mg sisaprid ve 10 mg ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda&nbsp;90\nmg nane ya\u011f\u0131 (WS 1340) ve 50 mg&nbsp;kimyon\nya\u011f\u0131n\u0131n&nbsp;(WS 1520) mide ve safra kesesinin motilitesi ve oroka\u00e7ekal\nge\u00e7i\u015f s\u00fcresi \u00fczerindeki farmakodinamik etkileri n-butilskopolamin, 12 sa\u011fl\u0131kl\u0131\ng\u00f6n\u00fcll\u00fcde incelendi.&nbsp;\u00c7al\u0131\u015fma lakuloz H2 nefes testi kullan\u0131larak\noroka\u00e7ekal ge\u00e7i\u015f s\u00fcresinin de\u011ferlendirilmesi ile birlikte gastrik ve safra\nkesesi bo\u015falmas\u0131n\u0131n e\u015f zamanl\u0131 ultrasonik olarak belirlenmesini\ni\u00e7ermi\u015ftir.&nbsp;Bu y\u00f6ntemlerin kombinasyonu, bir ki\u015fide ayn\u0131 anda \u00fc\u00e7\ngastrointestinal organ\u0131n incelenmesine izin verir.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">SONU\u00c7LAR:<\/h4>\n\n\n\n<p>Antral doldurma s\u00fcresi, plasebo, nane ya\u011f\u0131,&nbsp;kimyon ya\u011f\u0131&nbsp;ve sisaprid ile\nkar\u015f\u0131la\u015ft\u0131r\u0131labilirken, n-butilskopolamin ile anlaml\u0131 derecede k\u0131salt\u0131lm\u0131\u015ft\u0131r\n(P = 0.04, iki tarafl\u0131 \u00e7iftli t-testi).&nbsp;Gastrik bo\u015falma s\u00fcresi plasebo,\nnane ya\u011f\u0131,&nbsp;kimyon ya\u011f\u0131&nbsp;ve\nsisaprid&nbsp;aras\u0131nda \u00f6nemli \u00f6l\u00e7\u00fcde farkl\u0131l\u0131k g\u00f6stermedi&nbsp;, ancak\nn-butilskopolamin ile \u00f6nemli \u00f6l\u00e7\u00fcde uzat\u0131ld\u0131 (P = 0.04, iki tarafl\u0131 \u00e7iftli\nt-testi).&nbsp;Safra kesesi bo\u015falmas\u0131n\u0131n tamamen inhibisyonuna hem ya\u011flar hem\nde n-butilskopolamin neden olmu\u015ftur.&nbsp;Cisaprid, plaseboya k\u0131yasla safra\nkesesi bo\u015falmas\u0131n\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde k\u0131saltt\u0131 (P = 0.02, iki tarafl\u0131 i\u015faretli\ns\u0131ralama testi).&nbsp;Oroka\u00e7ekal ge\u00e7i\u015f s\u00fcresi, nane ya\u011f\u0131 (P = 0.004) ve\nn-butilskopolamin (P = 0.002) ile \u00f6nemli \u00f6l\u00e7\u00fcde uzat\u0131ld\u0131, fakat&nbsp;kimyon ya\u011f\u0131 ile&nbsp;\u00f6nemli \u00f6l\u00e7\u00fcde uzat\u0131lmad\u0131.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">SONU\u00c7LAR:<\/h4>\n\n\n\n<p>Nane ya\u011f\u0131 ve&nbsp;kimyon ya\u011f\u0131&nbsp;safra\nkesesi \u00fczerinde rahatlat\u0131c\u0131 bir etki g\u00f6sterir ve ilki ince ba\u011f\u0131rsak ge\u00e7i\u015fini\nyava\u015flat\u0131r.&nbsp;Daha ileri \u00e7al\u0131\u015fmalar, her iki ya\u011f\u0131n maksimum kas\u0131lma\nuyar\u0131c\u0131s\u0131 \u00fczerindeki safra kesesi ve motilite bozukluklar\u0131 olan hastalarda\netkilerini ara\u015ft\u0131rmal\u0131d\u0131r.<\/p>\n\n\n\n<p><strong>51-) The\nprotective effect of Nigella sativa extract on lung inflammation and oxidative\nstress induced by lipopolysaccharide in rats<\/strong><\/p>\n\n\n\n<p>DOI:10.1142 \/ S0192415X03001399<\/p>\n\n\n\n<p>Enflamasyon\ns\u0131ras\u0131nda oksidatif stres, enflamasyonu art\u0131rabilir ve dokuya zarar verebilir.\nNigella sativa L. (NS), antioksidan ve antienflamatuar aktiviteler dahil olmak\n\u00fczere bir\u00e7ok farmakolojik \u00f6zellik g\u00f6sterdi.<\/p>\n\n\n\n<p>\u00c7ALI\u015eMANIN\nAMACI:Bu \u00e7al\u0131\u015fmada, s\u0131\u00e7anlarda NS&#8217;nin akci\u011fer iltihab\u0131 ve lipopolisakkarit\n(LPS) taraf\u0131ndan ind\u00fcklenen oksidatif stres \u00fczerindeki \u00f6nleyici etkisi\nara\u015ft\u0131r\u0131lm\u0131\u015ft\u0131r.<\/p>\n\n\n\n<p>MALZEMELER\nVE Y\u00d6NTEMLER:Erkek s\u0131\u00e7anlar a\u015fa\u011f\u0131dakilere atand\u0131: Kontrol, LPS (1 mg \/ kg, ip),\nLPS + NS (100, 200, 400 mg \/ kg, ip), (grup ba\u015f\u0131na 10). Kontrol grubunun\ns\u0131\u00e7anlar\u0131na LPS yerine salin (1 ml \/ kg) intra-peritoneal (ip) enjekte edildi.\nLPS 14 g\u00fcn boyunca salin i\u00e7inde \u00e7\u00f6z\u00fcld\u00fc ve ip enjekte edildi. NS ekstraktlar\u0131yla\ntedavi, LPS uygulamas\u0131ndan iki g\u00fcn \u00f6nce ba\u015flam\u0131\u015f ve LPS uygulamas\u0131 s\u0131ras\u0131nda\ntedaviye devam edilmi\u015ftir. BALO ve akci\u011fer histopatolojisinde beyaz kan\nh\u00fccreleri (WBC), total ve diferansiyel, ayr\u0131ca bronkoalveolar s\u0131v\u0131 (BALF) ve\nserumdaki oksidatif stres indeksi, TGF-\u03b21, IFN-\u03b3, PGE 2 ve IL-4 d\u00fczeyleri\nincelendi.<\/p>\n\n\n\n<p>SONU\u00c7LAR:LPS\nuygulamas\u0131ndan toplam l\u00f6kosit, eozinofiller, n\u00f6trofiller, bazofiller ve\nmonositler say\u0131mlar\u0131 olarak BALF&#8217;de oksidatif stres belirte\u00e7leri ve serum gibi,\nTGF-p1, IFN-y, PGE artan 2 , BAL s\u0131v\u0131s\u0131nda ve patolojik de\u011fi\u015fiklikler, IL-4\nseviyeleri akci\u011fer dokusunun. Bu etkilerin t\u00fcm\u00fc, dozla ba\u011f\u0131ml\u0131 olarak NS\nekstrakt\u0131 tedavisi ile azalt\u0131lm\u0131\u015ft\u0131r.<\/p>\n\n\n\n<p>SONU\u00c7:Bu\nsonu\u00e7lar NS ekstrakt\u0131n\u0131n akci\u011fer iltihab\u0131 ve oksidatif stres \u00fczerindeki\nkoruyucu etkilerinin yan\u0131 s\u0131ra LPS dozuna ba\u011fl\u0131 olarak ortaya \u00e7\u0131kan akci\u011fer\npatolojisi \u00fczerindeki etkisini \u00f6nerdi.<\/p>\n\n\n\n<p><strong>52-)Probiotics\nand Nigella sativa extract supplementation improved behavioral and electrophysiological\neffects of PTZ-induced chemical kindling in rats<\/strong><\/p>\n\n\n\n<p>G\u0130R\u0130\u015e:Epilepsi,\nbili\u015f \u00fczerinde olumsuz etkileri olan en yayg\u0131n n\u00f6rolojik bir hastal\u0131kt\u0131r. Bu\n\u00e7al\u0131\u015fmada Nigella sativa (NS) ve probiyotiklerin pentilentetrazol (PTZ) \u00e7\u0131rpma\nepilepsi modelinde n\u00f6bet aktivitesi, bili\u015fsel performans ve sinaptik plastisite\n\u00fczerindeki koruyucu etkisini ara\u015ft\u0131rd\u0131k .<\/p>\n\n\n\n<p>Y\u00d6NTEMLER:Y\u00fcz\nk\u0131rk d\u00f6rt s\u0131\u00e7an 2 deneye b\u00f6l\u00fcnd\u00fc: Deney 1&#8217;de hayvanlar a\u015fa\u011f\u0131daki gibi\ngrupland\u0131r\u0131ld\u0131 ve tedavi edildi: 1) kontrol (PTZ + salin), 2) NS tedavisi, 3)\nprobiyotik tedavi ve 4) NS ve probiyotik tedavisi. Tedaviden alt\u0131 hafta sonra\nPTZ yakma i\u015flemi ger\u00e7ekle\u015ftirildi ve yakma i\u015fleminden 48 saat sonra Morris su\nlabirent (MWM) testinde \u00f6l\u00e7\u00fcld\u00fc. Deney 2&#8217;deki hayvanlar deney 1 ile ayn\u0131\ntedaviyi ald\u0131: kontrol grubu olmayan gruplarda kontrol hayvanlar\u0131\nprobiyotikler, NS ve probiyotikler + NS ile tedavi edildi. Tedaviden alt\u0131 hafta\nsonra PTZ yakma i\u015flemi ger\u00e7ekle\u015ftirildi ve yakma i\u015fleminden 48 saat sonra\nhipokampusun dentat girus alan\u0131ndan alan potansiyelleri kaydedildi; sinaptik\niletim ve uzun s\u00fcreli kuvvetlendirme (LTP) \u00f6l\u00e7\u00fcld\u00fc.<\/p>\n\n\n\n<p>SONU\u00c7LAR:Sonu\u00e7lar\nprobiyotik ve NS takviyesinin \u00e7\u0131ra geli\u015fimini \u00f6nemli \u00f6l\u00e7\u00fcde azaltt\u0131\u011f\u0131n\u0131,\nb\u00f6ylece PTZ + NS + probiyotikteki hayvanlar\u0131n tam \u00e7\u0131ra g\u00f6stermedi\u011fini g\u00f6sterdi.\nMWM testinde, tutu\u015fmu\u015f gruptaki ka\u00e7\u0131\u015f gecikmesi ve hareket yolu kontrol\ngrubundan anlaml\u0131 derecede y\u00fcksekti. PTZ + NS + probiyotiklerde, bu\nparametreler PTZ + salin grubundan anlaml\u0131 olarak daha d\u00fc\u015f\u00fckt\u00fc. Probiyotik ve\nNS takviyesi eklemek, PTZ + salin grubuna k\u0131yasla pop\u00fclasyon art\u0131\u015f\u0131 (PS)\n-LTP&#8217;yi \u00f6nemli \u00f6l\u00e7\u00fcde azaltt\u0131.<\/p>\n\n\n\n<p>SONU\u00c7:Probiyotik\nve NS takviyesi, tutulmu\u015f s\u0131\u00e7anlarda n\u00f6bet, n\u00f6bet kaynakl\u0131 bili\u015fsel bozukluk ve\nhipokampal LTP&#8217;ye kar\u015f\u0131 bir miktar korumaya sahiptir.<\/p>\n\n\n\n<p><strong>53-)Antiproliferative\nand apoptotic effects of proteins from black seeds (Nigella sativa) on human\nbreast MCF-7 cancer cell line<\/strong><\/p>\n\n\n\n<p>DOI:10.1186\/s12906-019-2804-1\n<\/p>\n\n\n\n<p>ARKA\nFON:Ranunculaceae ailesinin bir \u00fcyesi olan Nigella sativa (NS) yayg\u0131n olarak\nsiyah tohum veya kalonji olarak bilinir. \u00d6zellikle kanser ba\u015fta olmak \u00fczere\n\u00e7e\u015fitli hastal\u0131klarda terap\u00f6tik rol\u00fc i\u00e7in iyi \u00e7al\u0131\u015f\u0131lm\u0131\u015ft\u0131r. Literat\u00fcr NS\ntohumundan biyoaktif bile\u015fiklerle doludur. Bununla birlikte, proteinlerin\nfarmakolojik aktivitesi hakk\u0131nda daha az \u00e7al\u0131\u015fma bildirilmi\u015ftir. Mevcut\n\u00e7al\u0131\u015fma, MCF-7 h\u00fccre dizisi \u00fczerindeki NS tohum proteinlerinin antikanser\n\u00f6zelli\u011fini de\u011ferlendirmek i\u00e7in tasarlanm\u0131\u015ft\u0131r.<\/p>\n\n\n\n<p>Y\u00d6NTEMLER:NS\ntohum ekstresi fosfat tamponlu tuzlu su (PBS) i\u00e7inde haz\u0131rland\u0131 ve proteinler%\n80 amonyum s\u00fclfat kullan\u0131larak \u00e7\u00f6kt\u00fcr\u00fcld\u00fc. Ham tohum proteinleri jel filtrasyon\nkromatografisi kullan\u0131larak k\u0131smen safla\u015ft\u0131r\u0131ld\u0131 ve pikler SDS-PAGE ile\n\u00e7\u00f6z\u00fcld\u00fc. MTT analizi, MCF-7 h\u00fccre dizisi \u00fczerindeki sitotoksik etkileri\na\u00e7\u0131s\u0131ndan ham proteinleri ve pikleri taramak i\u00e7in kullan\u0131ld\u0131. Aktif Zirveler\n(P1 ve P4), ger\u00e7ek zamanl\u0131 ters transkripsiyon PCR ile apoptoz ile ili\u015fkili\ngenlerin ekspresyonunun mod\u00fcle edilmesindeki rolleri i\u00e7in de incelenmi\u015ftir.\nProtein tan\u0131mlama i\u00e7in proteinler sindirildi, ayr\u0131ld\u0131 ve LC-MS \/ MS ile analiz\nedildi. Veri analizi \u00e7evrimi\u00e7i Mascot, ExPASy ProtParam ve UniProt Bilgi Taban\u0131\n(UniProtKB) gen ontolojisi (GO) biyoinformatik ara\u00e7lar\u0131 kullan\u0131larak yap\u0131ld\u0131.<\/p>\n\n\n\n<p>SONU\u00c7LAR:Jel\nfiltrasyon kromatografisi, tohum proteinlerini yedi tepe noktas\u0131na ay\u0131rd\u0131 ve\nSDS-PAGE profili, \u00e7oklu protein bantlar\u0131n\u0131n varl\u0131\u011f\u0131n\u0131 ortaya \u00e7\u0131kard\u0131. T\u00fcm test\nnumuneleri aras\u0131nda, P1 ve P4 Yat\u0131r\u0131m Ortam\u0131 sergileyen, MCF-7 h\u00fccreleri\n\u00fczerinde etkili doza ba\u011fl\u0131 inhibit\u00f6r etkisini tasvir 50 , s\u0131ras\u0131yla 14.25 \u00b1\n0.84 ve 8.05 \u00b1 0.22 ug \/ ml, de\u011ferlerini. Gen ekspresyon analizi apoptozu olas\u0131\nbir h\u00fccre \u00f6ld\u00fcrme mekanizmas\u0131 olarak g\u00f6sterdi. P1 ve P4&#8217;te s\u0131ras\u0131yla toplam 11\nve 24 protein tan\u0131mland\u0131. Tan\u0131mlanan proteinlerin \u00e7o\u011funlu\u011fu sitozolde bulunur,\nbiyolojik metabolik s\u00fcre\u00e7lerle ili\u015fkilidir ve molek\u00fcler fonksiyonlar\u0131 ba\u011flanma\nve katalizdir. Hidropatiklik de\u011ferleri \u00e7o\u011funlukla hidrofilik aral\u0131ktayd\u0131.<\/p>\n\n\n\n<p>SONU\u00c7:Bulgular\u0131m\u0131z,\nNS tohum proteinlerinin kanser i\u00e7in potansiyel bir terap\u00f6tik ajan oldu\u011funu\ng\u00f6stermektedir. Bildi\u011fimiz kadar\u0131yla, NS tohum proteinlerinin antikanser\n\u00f6zelli\u011fini bildiren ilk \u00e7al\u0131\u015fmad\u0131r.<strong><\/strong><\/p>\n\n\n\n<p><strong>54-)Effects\nof Nigella sativa on endothelial dysfunction in diabetes mellitus: A review<\/strong><\/p>\n\n\n\n<p>ETNOFARMAKOLOJ\u0130K\n\u0130L\u0130\u015eK\u0130:Endotel disfonksiyonu, adezyon molek\u00fcllerinin yukar\u0131 reg\u00fclasyonu, artm\u0131\u015f\nkemokin sekresyonu ve l\u00f6kosit yap\u0131\u015fmas\u0131, artm\u0131\u015f h\u00fccre ge\u00e7irgenli\u011fi, artm\u0131\u015f\nd\u00fc\u015f\u00fck yo\u011funluklu lipoprotein oksidasyonu, sitokin detayland\u0131rmas\u0131, artm\u0131\u015f h\u00fccre\nge\u00e7irgenli\u011fi, artm\u0131\u015f d\u00fc\u015f\u00fck yo\u011funluklu lipoprotein oksidasyonu, trombosit\naktivasyonu ve vask\u00fcler d\u00fcz kas h\u00fccresi g\u00f6\u00e7\u00fc ve proliferasyonu. Nigella sativa\n, baz\u0131 \u00fclkelerde \u00e7e\u015fitli t\u0131bbi ama\u00e7lar i\u00e7in kullan\u0131lan t\u0131bbi bitkilerdendir.\n\u00c7\u00f6rek otu tohumu geleneksel t\u0131pta diyabet tedavisi i\u00e7in yayg\u0131n olarak\nkullan\u0131lmaktad\u0131r.<\/p>\n\n\n\n<p>DE\u011eERLEND\u0130RMEN\u0130N\nAMACI:Bu derleme makalesinde, Nigella sativa&#8217;n\u0131n endotelyal disfonksiyon\n\u00fczerindeki terap\u00f6tik etkileri \u00f6zetlenmi\u015ftir .<\/p>\n\n\n\n<p>Y\u00d6NTEMLER:PubMed,\nWeb of Science, Google Akademik, Scopus ve Iran Medex gibi veritabanlar\u0131\ndikkate al\u0131nd\u0131. Arama terimleri &#8221; \u00c7\u00f6rek otu&#8221; veya &#8220;endotel&#8221;\nve &#8220;Diyabet&#8221;, &#8220;endotel disfonksiyonu&#8221;,\n&#8220;Timokinon&#8221; ve &#8220;anti-inflamatuar etki&#8221; idi.<\/p>\n\n\n\n<p>SONU\u00c7LAR:Bu\nderleme, Nigella sativa ve Thymoquinone&#8217;un diyabetin neden oldu\u011fu endotelyal\ndisfonksiyon \u00fczerinde koruyucu bir etkiye sahip oldu\u011funu g\u00f6stermektedir . Bu,\nenflamatuar ve apoptotik belirte\u00e7lerin azalt\u0131lmas\u0131, hiperglisemi, hiperlipidemi\nve antioksidan fonksiyonunun iyile\u015ftirilmesi, trombosit agregasyonunun inhibe\nedilmesi ve endotel disfonksiyonunda yer alan eNOS, VCAM-1 ve LOX-1 genlerinin\nekspresyonunun d\u00fczenlenmesi gibi \u00e7e\u015fitli mekanizmalarla yap\u0131l\u0131r. Timokinon\nayr\u0131ca anti-inflamasyon etkisine yol a\u00e7an MCP-1, interl\u00f6kin-1F, TNF-a, NF-cyB\nve Cox-2 gibi baz\u0131 sitokinlerin ekspresyonunu ve salg\u0131lanmas\u0131n\u0131 azalt\u0131r.<\/p>\n\n\n\n<p>SONU\u00c7:Thymoquinone,\nana fenol-terpen bulunan \u00e7\u00f6rek otu ; anti-diyabetik, anti-enflamatuar ve\nantioksidan aktivite gibi baz\u0131 \u00f6nemli \u00f6zelliklere sahiptir. Bu nedenle, Nigella\nsativa endotelyal disfonksiyonu iyile\u015ftirebilir.<\/p>\n\n\n\n<p><strong>55-)<\/strong><strong>Extra Virgin Olive Oil and&nbsp;<em>Nigella sativa<\/em>&nbsp;Oil\nProduced in Central Italy: A Comparison of the Nutrigenomic Effects of Two\nMediterranean Oils in a Low-Grade Inflammation Model.<\/strong><\/p>\n\n\n\n<p>\u00d6ZET-S\u0131zma\nzeytinya\u011f\u0131 (EVO) ya\u011f\u0131 ve Nigella sativa (NG) ya\u011f\u0131, t\u00fcketimi insan sa\u011fl\u0131\u011f\u0131\n\u00fczerinde yararl\u0131 etkileri ile ili\u015fkili olan iyi bilinen iki Akdeniz g\u0131das\u0131d\u0131r.\nBu \u00e7al\u0131\u015fma, insan makrofajlar\u0131n\u0131n (THP-1 h\u00fccreleri) d\u00fc\u015f\u00fck dereceli\ninflamasyonunun in vitro bir modelinde iki y\u00fcksek kaliteli EVO ve NG ya\u011f\u0131n\u0131n\nnutrigenomik \u00f6zelliklerini ara\u015ft\u0131rmaktad\u0131r. Ama\u00e7, bu sa\u011fl\u0131kl\u0131 g\u0131dalar\u0131n\nantioksidan ve epigenetik mekanizmalar yoluyla inflamasyonu mod\u00fcle edip edemeyece\u011fini\nde\u011ferlendirmekti. THP-1 h\u00fccreleri, hem lipopolisakkaritlere (LPS) ba\u011fl\u0131\nenflamasyon ve ya\u011flara birlikte maruz kald\u0131\u011f\u0131nda, hem EVO hem de NG ya\u011flar\u0131,\nanti-enflamatuar aktivite g\u00f6sterdi. Her iki ya\u011f da normal DNMT 3 A ve HDAC 1\nekspresyon seviyelerini geri y\u00fckleyebildi (ancak DNMT de\u011fil3 B ), bunlar\nenflamatuar ko\u015fullar alt\u0131nda de\u011fi\u015ftirildi. Dahas\u0131, EVO ya\u011f\u0131 TET2&#8217;deki art\u0131\u015f\u0131\n\u00f6nleyebildiiltihapl\u0131 h\u00fccrelerde \u00f6l\u00e7\u00fclen global DNA metilasyonunu ifade eder ve\nazalt\u0131r. Antioksidan \u00f6zelliklerinden \u00f6t\u00fcr\u00fc, EVO ya\u011f\u0131, aksine, iltihaplanma\nmevcudiyetinde azalt\u0131lm\u0131\u015f olan normal membran ak\u0131\u015fkanl\u0131k seviyelerinin\niyile\u015ftirilmesinde \u00f6zellikle etkili olmu\u015ftur. Sonu\u00e7 olarak, bu veriler, bu\nAkdeniz ya\u011flar\u0131n\u0131n d\u00fc\u015f\u00fck dereceli iltihaplanma ve metabolik sendromun\n\u00f6nlenmesinde \u00f6nemli bir rol oynayabilece\u011fi hipotezini desteklemektedir. Bununla\nbirlikte, NS ya\u011f\u0131 proenflamatuar sitokinlerin kontrol\u00fcnde daha etkili gibi\ng\u00f6r\u00fcnmektedir, oysa EVO ya\u011f\u0131 redoks dengesizli\u011fine kar\u015f\u0131 daha iyi yard\u0131mc\u0131\nolmaktad\u0131r. Yerel \u00fcr\u00fcnlerin nutrigenomik \u00f6zelliklerini ayd\u0131nlatan daha ileri\n\u00e7al\u0131\u015fmalar, b\u00f6lgesel olarak y\u00fcksek kaliteli g\u0131dalar\u0131n \u00fcretiminin ve t\u00fcketiminin\nte\u015fvik edilmesine yard\u0131mc\u0131 olabilir ve bu da n\u00fcfusun sa\u011fl\u0131\u011f\u0131 korumas\u0131na ve\ngeli\u015ftirmesine yard\u0131mc\u0131 olabilir.<\/p>\n\n\n\n<p><strong>56-)<\/strong><strong>In Vitro Investigation of the Antibacterial Activity of&nbsp;<em>Nigella sativa<\/em>&nbsp;Oil on Some of the Most\nCommonly Isolated Bacteria in Otitis Media and Externa<\/strong><\/p>\n\n\n\n<p>10.5152\n\/ eurasianjmed.2019.18386<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">AMA\u00c7:Bu \u00e7al\u0131\u015fma,&nbsp;<em>Nigella sativa<\/em>&nbsp;(NS)\ntohumu ya\u011f\u0131n\u0131n orta ve d\u0131\u015f kula\u011f\u0131n en s\u0131k izole bula\u015f\u0131c\u0131 bakterilerine\nkar\u015f\u0131&nbsp;antibakteriyel etkinli\u011fini de\u011ferlendirmeyi ama\u00e7lam\u0131\u015ft\u0131r&nbsp;.<\/h1>\n\n\n\n<h4 class=\"wp-block-heading\">MALZEMELER VE Y\u00d6NTEMLER:NS ya\u011f\u0131n\u0131n in vitro antibakteriyel aktivitesi,\n34 klinik&nbsp;Streptococcus pneumoniae&nbsp;izolat\u0131na, 32 klinik&nbsp;Moraxella catarrhalis&nbsp;izolat\u0131na, 32 klinik&nbsp;Haemophilus influenzae&nbsp;izolat\u0131na ve 32 klinik&nbsp;Pseudomonas aeruginosa&nbsp;izolat\u0131na kar\u015f\u0131\nde\u011ferlendirildi&nbsp;.&nbsp;Staphylococcus aureus&nbsp;,&nbsp;Escherichia coli&nbsp;ve&nbsp;P. aeruginosaayr\u0131ca NS ya\u011f\u0131na duyarl\u0131l\u0131klar\u0131 a\u00e7\u0131s\u0131ndan da\nde\u011ferlendirildi.&nbsp;NS ya\u011f\u0131n\u0131n minimum inhibit\u00f6r konsantrasyonu (MIC), bir et\nsuyu seyreltme tekni\u011fi ile belirlendi.&nbsp;256 ug \/ mL ila 0.25 \u03bcg \/ mL\naras\u0131nda de\u011fi\u015fen mikroplaka kuyular\u0131nda nihai bir NS ya\u011f\u0131 konsantrasyonu elde\netmek i\u00e7in bir Mueller Hinton-F et suyunda seri \u00e7\u00f6zeltiler\nhaz\u0131rlanm\u0131\u015ft\u0131r.&nbsp;Her bir bakteri su\u015fu i\u00e7in b\u00fcy\u00fcme kontrol oyuklar\u0131 ve ortam\u0131\nkullan\u0131ld\u0131 ve mikroplakalar, 35 \u00b0 C&#8217;de 24 saat s\u00fcreyle ink\u00fcbe\nedildi.&nbsp;G\u00f6r\u00fcn\u00fcr b\u00fcy\u00fcmesi olmayan ve NS ya\u011f\u0131n\u0131n en d\u00fc\u015f\u00fck konsantrasyonuna\nsahip olan kuyucuklar\u0131n MIC g\u00f6sterdi\u011fi kabul edildi.<\/h4>\n\n\n\n<h4 class=\"wp-block-heading\">SONU\u00c7LAR:Bu\n\u00e7al\u0131\u015fmada, NS ya\u011f\u0131 ile yukar\u0131da belirtilen bakteri su\u015flar\u0131na kar\u015f\u0131 etkili\noldu\u011fu bilinen \u00e7e\u015fitli antibiyotikler aras\u0131nda bir kar\u015f\u0131la\u015ft\u0131rma\nyap\u0131lm\u0131\u015ft\u0131r.&nbsp;NS&#8217;nin&nbsp;H. influenzae, M. catarrhalis&nbsp;ve&nbsp;S. pneumoniae&#8217;ye&nbsp;kar\u015f\u0131\nbakterisidal aktiviteye sahip oldu\u011fu g\u00f6sterilmi\u015ftir&nbsp;.&nbsp;Bununla\nbirlikte,&nbsp;NS&#8217;nin&nbsp;hi\u00e7bir konsantrasyonda&nbsp;P. aeruginosa&#8217;ya&nbsp;kar\u015f\u0131\netkili olmad\u0131\u011f\u0131 bulunmu\u015ftur&nbsp;.<\/h4>\n\n\n\n<h4 class=\"wp-block-heading\">SONU\u00c7:Bu\nlaboratuvar tabanl\u0131 \u00e7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131, kulak rahats\u0131zl\u0131klar\u0131nda alternatif\nbir tedavi olarak NS ya\u011f\u0131 kullan\u0131m\u0131n\u0131 desteklemektedir.&nbsp;Bununla birlikte,\nNS ya\u011f\u0131n\u0131n kulak enfeksiyonu olan hastalarda antibakteriyel etkinli\u011fini\nde\u011ferlendirmek i\u00e7in klinik \u00e7al\u0131\u015fmalar yapmak gereklidir.<\/h4>\n\n\n\n<p><strong>57-)Antifungal\npotency of&nbsp;Nigella sativa&nbsp;seeds extract\nagainst Rhizopus stolonifer and their effect of immunomodulatory against\naflatoxin-fed mice.<\/strong><\/p>\n\n\n\n<p>PMID 31680082<\/p>\n\n\n\n<p>Bu \u00e7al\u0131\u015fmada,&nbsp;Nigella sativa&nbsp;tohumu\n\u00f6z\u00fct\u00fcn\u00fcn&nbsp;antifungal g\u00fcc\u00fc&nbsp;ve N.&nbsp;sativa&#8217;n\u0131n&nbsp;imm\u00fcnomod\u00fclat\u00f6r\u00fcn\u00fcn&nbsp;aflatoksin\nile beslenen farelere kar\u015f\u0131&nbsp;etkisi a\u00e7\u0131klanmaktad\u0131r&nbsp;.&nbsp;N.&nbsp;sativa&#8217;n\u0131n&nbsp;sulu ekstrakt\u0131n\u0131n antifungal etkinli\u011fi\ni\u00e7in disk dif\u00fczyon y\u00f6ntemi kullan\u0131lm\u0131\u015ft\u0131r&nbsp;.&nbsp;Hayvan deneylerinde,\nlenfoid h\u00fccre say\u0131s\u0131, PEC&#8217;nin toplam ve diferansiyel say\u0131lar\u0131, PEC&#8217;nin\nfagositik aktivitesi ve plak olu\u015fumunun saptanmas\u0131 belirlenmi\u015ftir.&nbsp;E-rozet\nolu\u015fturan h\u00fccreler (RFC), T-h\u00fccresi mitogenez deney h\u00fccreleri, ALT ve AST\ntespit edildi.&nbsp;N.&nbsp;sativa&#8217;n\u0131n&nbsp;sulu\n\u00f6z\u00fc&nbsp;(% 50), R. stolonifera izolatlar\u0131n\u0131n \u00e7o\u011fu ile y\u00fcksek inhibisyon\nb\u00f6lgesi sergiledi. Sonu\u00e7lar, farelerin N.&nbsp;sativa&nbsp;kullan\u0131larak\ntedavi edildi\u011fini g\u00f6sterdi.0.50 g doz ile timus ve PLN&#8217;den h\u00fccre say\u0131s\u0131nda\nbelirgin art\u0131\u015f ve 0.40 ve 0.50 g dozlarla makrofajlar\u0131n mutlak say\u0131s\u0131 ve\nkar\u015f\u0131la\u015ft\u0131rmal\u0131 oran\u0131 g\u00f6stermi\u015ftir.&nbsp;60 dakikada 0.50 g doz ile PEC\ntoplay\u0131c\u0131 aktivitesinde kademeli olarak art\u0131\u015f olur.&nbsp;Serum ALT d\u00fczeyi, bir\nkontrol grubuna k\u0131yasla 0.50 g doz ile \u00f6nemli \u00f6l\u00e7\u00fcde azalt\u0131lm\u0131\u015ft\u0131r.&nbsp;Bu\nsonu\u00e7lar N.&nbsp;sativa&#8217;n\u0131n&nbsp;biyolojik\ntepkinin \u00fcmit verici&nbsp;oldu\u011funu g\u00f6sterdi&nbsp;.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">58-)AgNPs from&nbsp;Nigella sativa&nbsp;Control Breast Cancer: An In\nVitro Study.<\/h1>\n\n\n\n<h1 class=\"wp-block-heading\">10.1615 \/\nJEnvironPatholToxicolOncol.2019027318<\/h1>\n\n\n\n<h1 class=\"wp-block-heading\">Mevcut \u00e7al\u0131\u015fmam\u0131zda,&nbsp;Nigella&nbsp;sativa&#8217;n\u0131n ya\u011fl\u0131 tohum ekstrakt\u0131ndan g\u00fcm\u00fc\u015f nanopartik\u00fclleri\n(AgNP&#8217;ler) sentezledik.&nbsp;Tohum ekstrakt\u0131, indirgeyici ajan olarak i\u015flev\ng\u00f6rebilen ve metal iyonlar\u0131n\u0131 metal nanopar\u00e7ac\u0131klara d\u00f6n\u00fc\u015ft\u00fcrebilen fenoller,\nterpenoidler ve flavonoidler dahil fitokimyasal bile\u015fikler\ni\u00e7erir.&nbsp;Sentezlenmi\u015f AgNP&#8217;lerin olu\u015fumu, UV-g\u00f6r\u00fclebilir spektroskopi,\nFourier d\u00f6n\u00fc\u015f\u00fcm\u00fc k\u0131z\u0131l \u00f6tesi spektroskopisi (FT-IR), taray\u0131c\u0131 elektron\nmikroskopisi (SEM) ve X-\u0131\u015f\u0131nlar\u0131n\u0131n enerji da\u011f\u0131l\u0131m analizi (EDX) kullan\u0131larak\nkarakterize edildi.&nbsp;N-AgNP&#8217;lerin insan meme kanseri (MCF-7) h\u00fccrelerine\nkar\u015f\u0131 etkinli\u011fi test edilmi\u015ftir.&nbsp;Sentezlenen AgNP&#8217;ler, MCF-7 h\u00fccrelerine\nkar\u015f\u0131 doza ba\u011fl\u0131 sitotoksisite (1-200 ug \/ mL) g\u00f6sterdi.&nbsp;H\u00fccrelerin\nmorfolojik de\u011fi\u015fiklikleri de parlak alan g\u00f6r\u00fcnt\u00fcleri olarak ortaya\n\u00e7\u0131kt\u0131.&nbsp;Sentezlenmi\u015f AgNP&#8217;lerin tedavisi, MCF-7 h\u00fccrelerinde Bax ve Bcl-2\n(apoptotik proteinler) ve COX-2&#8217;nin (enflamatuar mark\u00f6r) ekspresyonunu\nde\u011fi\u015ftirdi.&nbsp;Bildi\u011fimiz kadar\u0131yla,Nigella sativa&nbsp;, MCF-7 h\u00fccrelerinde apoptozu ind\u00fckleyebilir.<\/h1>\n\n\n\n<h1 class=\"wp-block-heading\">59-)Effective Medicinal Plants in\nthe Treatment of the Cyclic Mastalgia (Breast Pain): A Review.<\/h1>\n\n\n\n<h1 class=\"wp-block-heading\">10.3831 \/\nKPI.2019.22.017<\/h1>\n\n\n\n<p>Mastalji, kad\u0131nlar\u0131n do\u011furganl\u0131k d\u00f6neminde en s\u0131k g\u00f6r\u00fclen benign\nmeme bozuklu\u011fudur.&nbsp;Mastaljiyi tedavi etmek i\u00e7in \u015fimdiye kadar \u00e7ok \u00e7e\u015fitli\ndo\u011fal veya tamamlay\u0131c\u0131 ila\u00e7lar kullan\u0131lmaktad\u0131r.&nbsp;S\u0131hhi organizasyonlar,\nkan\u0131tlara dayal\u0131 alternatif tedavi i\u00e7in uygun karar\u0131 vermek i\u00e7in kad\u0131nlara\nyard\u0131mc\u0131 olmak i\u00e7in eksiksiz ve uygun ayr\u0131nt\u0131lara ihtiya\u00e7 duyarlar.&nbsp;Bu\n\u00e7al\u0131\u015fman\u0131n amac\u0131 mastalji ile ilgili t\u0131bbi bitki bazl\u0131 tedavileri tan\u0131tmak ve\nbu bozuklukla ilgili klinik \u00e7al\u0131\u015fmalar\u0131 \u00f6zetlemektir.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Y\u00d6NTEM:Makaleler,\nulusal ve uluslararas\u0131 veritabanlar\u0131nda SID, \u0130ran Medex, Magiran, PubMed,\nScopus, siklik a\u011fr\u0131, meme, tedavi, terap\u00f6tikler, terapi, klinik ara\u015ft\u0131rma,\nbitkisel, ila\u00e7, mastalji ve olas\u0131 t\u00fcm terimler i\u00e7eren anahtar kelimeler\nkar\u0131\u015f\u0131m\u0131 kullan\u0131larak sa\u011fland\u0131. Fars\u00e7a ve \u0130ngilizce dillerinde Medline, Science\ndirect ve Cochrane k\u00fct\u00fcphanesi.&nbsp;Mastaljinin 2018 Kas\u0131m&#8217;a kadar bitkisel\ntedavisi ile ilgili t\u00fcm kesitsel ve derleme makaleleri incelendi.<\/h4>\n\n\n\n<h4 class=\"wp-block-heading\">SONU\u00c7LAR:Mevcut\nt\u00fcm makalelerin (45 olgu) 19 makalesi ve (1987 olgu) hakk\u0131nda \u00f6rneklem\nb\u00fcy\u00fckl\u00fc\u011f\u00fc \u00e7al\u0131\u015fmam\u0131za dahil edildi.&nbsp;Makaleler klinik\ndeneylerdi.&nbsp;Sonu\u00e7lar mastaljinin&nbsp;Nigella sativa&nbsp;,\nVitex agnus-castus, kurkumin, Hypericum perforatum, Citrus sinensis, bu\u011fday\ntohumu ve Ginkgo biloba&nbsp;taraf\u0131ndan iyile\u015ftirilebilece\u011fini g\u00f6sterdi&nbsp;.<\/h4>\n\n\n\n<h4 class=\"wp-block-heading\">SONU\u00c7:Antienflamatuar\nve analjezik \u00f6zelliklere sahip antioksidan bile\u015fiklere sahip de\u011ferlendirilmi\u015f\nt\u0131bbi bitkilerin \u00e7o\u011fu, mastaljinin tedavisinde iyile\u015ftirici etkiler\ng\u00f6stermi\u015ftir.&nbsp;Bu nedenle, \u015fifal\u0131 bitkiler mastaljinin tedavisinde\nd\u00fc\u015f\u00fcn\u00fclebilir;&nbsp;ancak, olas\u0131 yan etkileri hakk\u0131nda daha fazla ayr\u0131nt\u0131 elde\netmek i\u00e7in daha fazla ara\u015ft\u0131rmaya ihtiya\u00e7 vard\u0131r<\/h4>\n\n\n\n<h1 class=\"wp-block-heading\">&nbsp;<\/h1>\n\n\n\n<h1 class=\"wp-block-heading\">60-)Protective Effects of Thymoquinon on\nPulmonary Disorders in Experimental Studies&nbsp;<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>PMCID:&nbsp;PMC6534803<\/li><\/ul>\n\n\n\n<p>Hayati organ olarak akci\u011fer, akci\u011fer hastal\u0131klar\u0131n\u0131n\npatogenezinde potansiyel nedenler olan iltihaplanma ve oksidatif strese neden\nolabilen bir\u00e7ok zararl\u0131 ajana maruz kal\u0131r.&nbsp;Genellikle siyah tohum olarak\ntan\u0131t\u0131lan&nbsp;<em>\u00e7\u00f6rek otu,<\/em>&nbsp;\u00e7e\u015fitli hastal\u0131klar\u0131n tedavisi i\u00e7in\nd\u00fc\u015f\u00fcn\u00fclm\u00fc\u015ft\u00fcr ve en \u00e7ok ara\u015ft\u0131r\u0131lan bitkilerden biridir.&nbsp;Timokinon (TQ),\nantioksidan, antienflamatuar ve anti-neoplastik \u00f6zelliklere i\u015faret edilen siyah\ntohumun u\u00e7ucu ya\u011f\u0131n\u0131n (% 54) ana bile\u015fenidir.&nbsp;Her ikisi de \u00e7e\u015fitli\nhastal\u0131klar i\u00e7in terap\u00f6tik bir ajan olarak TQ etkisi incelemek i\u00e7in in vitro ve\nin vivo \u00e7al\u0131\u015fmalar yap\u0131ld\u0131s.&nbsp;Bu kapsaml\u0131 derlemede, TKY&#8217;nin inflamatuar\nakci\u011fer hastal\u0131klar\u0131, akci\u011fer fibrozu, ast\u0131m ve akci\u011fer kanseri gibi akci\u011fer\nhastal\u0131klar\u0131 \u00fczerindeki etkinli\u011fi ile ilgili son \u00e7al\u0131\u015fmalar\u0131\n\u00f6zetledik.&nbsp;Anti-enflamatuar, antioksidan, anti-astmatik ve anti-t\u00fcm\u00f6r\naktiviteli TQ&#8217;nun akci\u011fer bozukluklar\u0131na kar\u015f\u0131 terap\u00f6tik etkiler\nsa\u011flayabilece\u011fi sonucuna var\u0131lm\u0131\u015ft\u0131r.&nbsp;Bununla birlikte, insan \u00e7al\u0131\u015fmalar\u0131\ni\u00e7in farmas\u00f6tik bir preparat olarak TQ \u00fcretmek i\u00e7in daha fazla ara\u015ft\u0131rmaya\nihtiya\u00e7 vard\u0131r.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">61-)A New Agent for Treatment of Acute Respiratory Distress Syndrome:\nThymoquinone. An Experimental Study in a Rat Model<\/h1>\n\n\n\n<ul class=\"wp-block-list\"><li>DOI:&nbsp;10.1016\/j.ejcts.2005.04.012<\/li><\/ul>\n\n\n\n<p><strong>Ama\u00e7:&nbsp;<\/strong>Akut solunum s\u0131k\u0131nt\u0131s\u0131\nsendromu (ARDS) ve akut akci\u011fer hasar\u0131 (ALI) torasik cerrahi ve kritik bak\u0131m\nt\u0131bb\u0131nda \u00f6nemli klinik problemlerdir.&nbsp;Tedavi y\u00f6ntemlerinin \u00e7o\u011fu hala\ndestekleyicidir.&nbsp;Timokinonun antienflamatuar, spazmolitik, bronkodilat\u00f6r\nve antibakteriyel etkileri vard\u0131r.&nbsp;S\u0131\u00e7an modelinde ALI \/ ARDS \u00fczerindeki\netkilerini inceledik.<\/p>\n\n\n\n<p><strong>Y\u00f6ntemler:&nbsp;<\/strong>ALI \/ ARDS, 40 Sprague-Dawley\nerkek s\u0131\u00e7an\u0131nda (a\u011f\u0131rl\u0131k olarak 200-250 g) insan mide suyunun intratrakeal\ndam\u0131t\u0131lmas\u0131yla (pH 1.2) geli\u015ftirilmi\u015ftir.&nbsp;S\u0131\u00e7anlar 3 saat boyunca mekanik\nventilat\u00f6r ile tedavi edildi.&nbsp;Be\u015f grup vard\u0131: Kontrol grubu (n =\n11);&nbsp;Steroid grubu (n = 10);&nbsp;Etanol grubu (n = 5);&nbsp;Timokinon\ngrubu (n = 9) ve Timokinon + Steroid grubu (n = 5).&nbsp;Birinci gruba mide\nsuyu d\u0131\u015f\u0131nda a\u015f\u0131lama yap\u0131lmad\u0131.&nbsp;Timokinon 6 mg \/ kg dozunda,\nmetilprednizolon 10 mg \/ kg dozunda, etanol 0.75 ml \/ kg intraperitonal yoldan\n(IP) verildi.&nbsp;Kan gaz\u0131 analizi ve uygunluk \u00f6l\u00e7\u00fcm\u00fc yap\u0131ld\u0131.&nbsp;\u00dc\u00e7\u00fcnc\u00fc\nsaatin sonunda s\u0131\u00e7anlar feda edildi ve akci\u011ferleri histopatolojik inceleme i\u00e7in\neksize edildi.<\/p>\n\n\n\n<p><strong>Bulgular:&nbsp;<\/strong>Timokinon grubunda arteriyel\noksijenin inspire edilen oksijen fraksiyonuna oran\u0131 (PO2 \/ FiO2) di\u011fer gruplara\ng\u00f6re anlaml\u0131 olarak daha iyi idi (P = 0.000-0.043).&nbsp;Statik uyum \u00f6l\u00e7\u00fcmleri,\ntimokinon ve timokinon + steroid gruplar\u0131nda daha y\u00fcksek de\u011ferler ortaya\nkoydu.&nbsp;Histopatolojik incelemeler etkilenen akci\u011fer dokusunun grup 2 ve\n4&#8217;te daha d\u00fc\u015f\u00fck oldu\u011funu g\u00f6sterdi.<\/p>\n\n\n\n<p><strong>Sonu\u00e7lar:&nbsp;<\/strong>Bu \u00e7al\u0131\u015fma, timokinonun ve\nsteroidlerin akci\u011fer dokusunu insan mide suyunun (pH 1.2) histopatolojik olarak\ntehlikeli etkilerinden korurken, oksijenasyonu geli\u015ftirdi\u011fini ortaya koydu.<\/p>\n\n\n\n<p><strong>g<\/strong><\/p>\n\n\n\n<h1 class=\"wp-block-heading\">62-)The\neffect of&nbsp;<em>Nigella sativa<\/em>&nbsp;alone, and in combination\nwith dexamethasone, on tracheal muscle responsiveness and lung inflammation in\nsulfur mustard exposed guinea pigs<\/h1>\n\n\n\n<p>https:\/\/doi.org\/10.1016\/j.jep.2011.07.030<em><br>\nNigella sativa<\/em>&nbsp;L.&#8217;nin&nbsp;hem\nsistemik hem de lokal u\u00e7ucu ya\u011f uygulamalar\u0131n\u0131n antienflamatuar\naktivitesi&nbsp;g\u00f6sterilmi\u015ftir.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">\u00c7al\u0131\u015fman\u0131n amac\u0131<\/h3>\n\n\n\n<p>Bu nedenle,&nbsp;<em>Nigella sativa&#8217;n\u0131n<\/em>&nbsp;k\u00fck\u00fcrt\nhardal\u0131 (SM) maruz kalan kobaylarda trakeal cevap&nbsp;<em>verebilirlik<\/em>&nbsp;(TR) ve\nakci\u011fer iltihab\u0131 \u00fczerindeki etkisi incelendi.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Sonu\u00e7lar<\/h3>\n\n\n\n<p>Bu sonu\u00e7lar,&nbsp;<em>Nigella sativa&#8217;n\u0131n SM&#8217;ye<\/em>&nbsp;maruz\nkalan kobaylar\u0131n TR ve akci\u011fer iltihab\u0131 \u00fczerinde&nbsp;\u00f6nleyici bir etkisini\ng\u00f6stermi\u015ftir&nbsp;.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">63-)Protective Effects of&nbsp;<em>Nigella sativa<\/em>&nbsp;Oil\nin Hyperoxia-Induced Lung Injury<\/h1>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/doi.org\/10.1016\/j.arbr.2012.11.003\n<\/div><\/figure>\n\n\n\n<p>Oksijen kaynakl\u0131 akci\u011fer hasar\u0131n\u0131n premat\u00fcre\nbebeklerde bronkopulmoner displazi geli\u015fimine yol a\u00e7t\u0131\u011f\u0131na\ninan\u0131lmaktad\u0131r.&nbsp;<em>Nigella\nsativa<\/em>&nbsp;ya\u011f\u0131n\u0131n (NSO) hiperoksiye ba\u011fl\u0131 akci\u011fer hasar\u0131 olan\ns\u0131\u00e7anlar \u00fczerindeki&nbsp;yararl\u0131 etkilerini de\u011ferlendirdik&nbsp;.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Y\u00f6ntemler<\/h3>\n\n\n\n<p>Otuz yenido\u011fan Sprague-Dawley s\u0131\u00e7anlar\u0131,\nrasgele hiperoksiye (% 95 O olarak 3 gruba ayr\u0131ld\u0131&nbsp;<sub>2<\/sub>&nbsp;),\nhiperoksi + NSO ve kontrol (% 21 O&nbsp;<sub>2<\/sub>&nbsp;).&nbsp;Hiperoksi +\nNSO grubundaki yavrulara&nbsp;&nbsp;, \u00e7al\u0131\u015fma s\u00fcresi boyunca\ng\u00fcnl\u00fck&nbsp;4&nbsp;ml \/ kg&#8217;l\u0131k&nbsp;bir dozda intraperitoneal NSO\nverildi&nbsp;.&nbsp;Histopatolojik, imm\u00fcnokimyasal ve biyokimyasal\nde\u011ferlendirmeler (s\u00fcperoksit dismutaz [SOD], glutatyon peroksidaz [GSH-Px],\nmalonaldehid [MDA] ve miyeloperoksidaz [MPO]) yap\u0131ld\u0131.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Sonu\u00e7lar<\/h3>\n\n\n\n<p>Histopatolojik ve imm\u00fcnokimyasal\nde\u011ferlendirmede, hiperoksi + NOS grubunda akci\u011fer hasar\u0131n\u0131n \u015fiddeti anlaml\u0131\nderecede d\u00fc\u015f\u00fckt\u00fc (&nbsp;<em>P<\/em>&nbsp;&lt;.05).&nbsp;Doku\nGSH-Px ve SOD seviyeleri \u00f6nemli \u00f6l\u00e7\u00fcde korundu ve MDA, MPO d\u00fczeyleri hiperoksi\n+ NSO grubunda anlaml\u0131 olarak daha d\u00fc\u015f\u00fckt\u00fc (&nbsp;<em>P<\/em>&nbsp;&lt;.05).<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Sonu\u00e7<\/h3>\n\n\n\n<p>NSO, hiperoksiye ba\u011fl\u0131 akci\u011fer hasar\u0131n\u0131n\n\u015fiddetini \u00f6nemli \u00f6l\u00e7\u00fcde azaltt\u0131.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">64-)Effects of&nbsp;<em>Nigella sativa<\/em>&nbsp;seed\nextract on ameliorating lung tissue damage in rats after experimental pulmonary\naspirations<\/h1>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/doi.org\/10.1016\/j.acthis.2008.10.008\n<\/div><\/figure>\n\n\n\n<p><br>\nMide i\u00e7eri\u011finin aspirasyonu&nbsp;ciddi akci\u011fer hasar\u0131na neden olabilir, ancak\npulmoner hasar mekanizmalar\u0131 hala net de\u011fildir ve pulmoner hasar\u0131n iyile\u015fme\ny\u00f6ntemleri \u00e7ok az ara\u015ft\u0131r\u0131lm\u0131\u015ft\u0131r.&nbsp;\u00c7\u00f6rek otu&nbsp;tohumu (NS), belirli\nsa\u011fl\u0131k yararlar\u0131 ve Bu \u00e7al\u0131\u015fman\u0131n amac\u0131 i\u00e7in g\u00f6sterilmi\u015ftir.S\u0131\u00e7anlar rastgele\nalt\u0131 deney grubundan birine (&nbsp;grup ba\u015f\u0131na&nbsp;<em>n&nbsp;<\/em>= 7)&nbsp;ayr\u0131ld\u0131&nbsp;: (1) salin\nkontrol\u00fc, (2) salin + NS ile tedavi edildi, (3)&nbsp;Pulmocare&nbsp;(uzmanpulmoner\nhastalara verilen&nbsp;besin takviyesi&nbsp;), (4) Pulmocare + NS ile tedavi\nedilmi\u015f, (5)&nbsp;hidroklorik asit&nbsp;, (6) hidroklorik asit + NS ile tedavi\nedilmi\u015ftir.&nbsp;Salin, Pulmocare ve hidroklorik asit, akci\u011ferlere 2&nbsp;ml \/\nkg&#8217;l\u0131kbir hacimde enjekte edildi.&nbsp;Farelere g\u00fcnl\u00fck oral dozlarda NS u\u00e7ucu\nya\u011f verildi (400&nbsp;mg \/ kg v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131), materyallerin pulmoner\naspirasyonundan hemen sonra 7 g\u00fcn boyunca intragastrik ent\u00fcbasyon yoluyla\nuyguland\u0131.&nbsp;7 g\u00fcn sonra, s\u0131\u00e7anlar feda edildi ve histopatolojik inceleme\ni\u00e7in her iki akci\u011ferden doku \u00f6rnekleri al\u0131nd\u0131.&nbsp;Bug\u00fcne kadar, materyallerin\npulmoner aspirasyonundan sonra NS tedavisinin akci\u011fer hasar\u0131na kar\u015f\u0131 korunma\npotansiyelini ara\u015ft\u0131ran benzer bir \u00e7al\u0131\u015fma rapor edilmemi\u015ftir.&nbsp;\u00c7al\u0131\u015fmam\u0131z\nNS tedavisi \u00f6nemli \u00f6l\u00e7\u00fcde (indirgeyici iltihapl\u0131 akci\u011fer tepkileri inhibe\netti\u011fini g\u00f6stermi\u015ftir.&nbsp;Verilerimiz,&nbsp;NS tedavisinden sonra farkl\u0131\npulmoner aspirasyon modellerinin akci\u011fer dokusunda&nbsp;ind\u00fcklenebilir nitrik\noksit sentaz&nbsp;(iNOS)&nbsp;aktivitesinde \u00f6nemli bir azalma&nbsp;ve&nbsp;s\u00fcrfaktan\nprotein D&#8217;&nbsp;de&nbsp;bir art\u0131\u015f oldu\u011funu\ng\u00f6stermektedir&nbsp;.&nbsp;Sonu\u00e7lar\u0131m\u0131za dayanarak, NS tedavisinin akci\u011fer\nhasar\u0131nda faydal\u0131 olabilece\u011fi ve potansiyel klinik kullan\u0131ma sahip olabilece\u011fi\nsonucuna vard\u0131k.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">65-)Natural therapeutic approach\nof&nbsp;<em>Nigella sativa<\/em>&nbsp;(Black seed) fixed oil in\nmanagement of Sinusitis<\/h1>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/doi.org\/10.1016\/j.imr.2018.01.005\n<\/div><\/figure>\n\n\n\n<p>Sin\u00fczit&nbsp;, sin\u00fcslerin hava dolu\nbo\u015fluklar\u0131n\u0131n iltihaplanmas\u0131 ve enfeksiyonlar\u0131 ile ili\u015fkilidir.&nbsp;Bu\n\u00e7al\u0131\u015fman\u0131n amac\u0131,&nbsp;<em>Nigella\nsativa<\/em>&nbsp;tohumu sabit ya\u011f\u0131n\u0131n sin\u00fczit\ntedavisinde&nbsp;potansiyel etkinli\u011fini de\u011ferlendirmektir&nbsp;.&nbsp;Bilgiler\neri\u015filebilir uluslararas\u0131 veritabanlar\u0131ndan, geleneksel kitaplardan, elektronik\nkaynaklardan ve yay\u0131nlanmam\u0131\u015f verilerden al\u0131nm\u0131\u015ft\u0131r.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Sonu\u00e7lar<\/h3>\n\n\n\n<p><em>N. sativa&nbsp;<\/em>tohumu sabit ya\u011f\u0131\n\u00fczerinde yap\u0131lan&nbsp;ara\u015ft\u0131rmalar\u0131n sonu\u00e7lar\u0131&nbsp;, anti-inflamatuar,\nantioksidan,&nbsp;antihistaminik&nbsp;, imm\u00fcn mod\u00fclat\u00f6r,&nbsp;antimikrobiyal&nbsp;ve&nbsp;analjezik\netkileri&nbsp;ile sin\u00fczit tedavisinde terap\u00f6tik potansiyelini\ng\u00f6stermi\u015ftir&nbsp;.&nbsp;<em>N.\nsativa&nbsp;<\/em>tohumu sabit ya\u011f\u0131&nbsp;kullan\u0131m\u0131&nbsp;sin\u00fcslerin\nve&nbsp;solunum yollar\u0131n\u0131n&nbsp;iltihaplanmas\u0131n\u0131&nbsp;, mikrobiyal\nenfeksiyonlar\u0131&nbsp;inhibe edebilir&nbsp;ve son olarak coryza, burun\nt\u0131kan\u0131kl\u0131\u011f\u0131, ba\u015f a\u011fr\u0131s\u0131, boyun a\u011fr\u0131s\u0131,&nbsp;kulak a\u011fr\u0131s\u0131&nbsp;ve&nbsp;di\u015f&nbsp;a\u011fr\u0131s\u0131&nbsp;gibi\nsin\u00fczit klinik semptomlar\u0131ndan muzdarip hastalara yard\u0131mc\u0131\nolabilir&nbsp;.&nbsp;Gelecekte sin\u00fczitli hastalarda etkinli\u011fini de\u011ferlendirmek\ni\u00e7in klinik \u00e7al\u0131\u015fmalara ihtiya\u00e7 vard\u0131r.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">66-)Ameliorating effects of&nbsp;<em>Nigella sativa<\/em>&nbsp;oil\non aggravation of inflammation, oxidative stress and cytotoxicity induced by\nsmokeless tobacco extract in an allergic asthma model in Wistar rats<\/h1>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/doi.org\/10.1016\/j.aller.2018.02.005\n<\/div><\/figure>\n\n\n\n<p>Dumans\u0131z\nt\u00fct\u00fcn (ST) maruziyetinin&nbsp;Ovalbumin&nbsp;(Ova) ile duyarl\u0131la\u015ft\u0131r\u0131lm\u0131\u015f\ns\u0131\u00e7anlara veya ast\u0131ml\u0131 hastalara g\u00f6re kar\u015f\u0131la\u015ft\u0131r\u0131lmas\u0131 literat\u00fcrde \u00e7ok az\n\u00e7al\u0131\u015f\u0131lm\u0131\u015ft\u0131r.&nbsp;Bu nedenle, bu \u00e7al\u0131\u015fma, inflamasyonun \u015fiddetlenmesini,\nast\u0131m\u0131n alevlenmesini,&nbsp;oksidatif stresi&nbsp;ve ST&#8217;nin neden oldu\u011fu\nsitotoksisiteyi&nbsp;ara\u015ft\u0131rmay\u0131 ama\u00e7lamaktad\u0131r<\/p>\n\n\n\n<p>Verilerimiz,\nalerjene ve ST&#8217;ye ayn\u0131 anda \u015fiddetli maruz kalman\u0131n&nbsp;, daha \u00f6nce\nduyarl\u0131la\u015fm\u0131\u015f s\u0131\u00e7anlarda&nbsp;hava yolu inflamasyonunu&nbsp;ve oksidatif\nstresi&nbsp;artt\u0131rd\u0131\u011f\u0131n\u0131 kan\u0131tlam\u0131\u015ft\u0131r&nbsp;.&nbsp;Ayr\u0131ca oral NSO tedavisinin\nast\u0131m i\u00e7in umut verici bir tedavi olabilece\u011fini d\u00fc\u015f\u00fcnd\u00fcrmektedir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">67-)Oral&nbsp;<em>Nigella sativa<\/em>&nbsp;oil\nameliorates ovalbumin-induced bronchial asthma in mice<\/h1>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/doi.org\/10.1016\/j.intimp.2012.06.023\n<\/div><\/figure>\n\n\n\n<p><em>Nigella\nsativa<\/em>&nbsp;ya\u011f\u0131\n(NSO) halk hekimli\u011finde bron\u015fiyal ast\u0131m da dahil olmak \u00fczere bir\u00e7ok hastal\u0131\u011f\u0131n\ntedavisi olarak kullan\u0131lmaktad\u0131r.&nbsp;Bron\u015fiyal ast\u0131m\u0131n fare modelinde NSO&#8217;nun\nast\u0131m benzeri fenotipler \u00fczerindeki olas\u0131 mod\u00fcle edici etkilerini\nara\u015ft\u0131rd\u0131k.&nbsp;BALB \/ c fareleri&nbsp;,&nbsp;&nbsp;0. ve 12. g\u00fcnlerde1mg&nbsp;\u015fap&nbsp;ile&nbsp;50&nbsp;ug&nbsp;ovalb\u00fcmin&nbsp;(OVA)&nbsp;&nbsp;intraperitoneal\nenjeksiyonlar\u0131&nbsp;ile aktif olarak duyarl\u0131 hale getirildi&nbsp;. 22. g\u00fcnden\nitibaren steril fizyolojik tuzlu su i\u00e7inde OVA&#8217;ya (% 1 (w \/ v)) maruz\nb\u0131rak\u0131ld\u0131. ) 30dakika boyunca, her 4. g\u00fcnde \u00fc\u00e7 kez.&nbsp;Negatif kontrol\nhayvanlar\u0131 da benzer \u015fekilde saline maruz b\u0131rak\u0131ld\u0131.&nbsp;NSO,0. g\u00fcnden 30. g\u00fcne\nkadar31g\u00fcnboyunca oral yoldan uyguland\u0131. Duyarl\u0131l\u0131k ve tehdit g\u00fcn\u00fcnde NSO&#8217;ya 30\nverildi.Hava yolu fonksiyonu say\u0131s\u0131,&nbsp;enflamatuar h\u00fccrelerin&nbsp;i\u00e7inde&nbsp;bronkoalveolar\nlavaj s\u0131v\u0131s\u0131&nbsp;(BALF) seviyelerinde&nbsp;interl\u00f6kin&nbsp;(IL) -4,\nIL-5,&nbsp;IL-13,&nbsp;ve&nbsp;interferon&nbsp;(IFN), -\u03b3 BALF&#8217;de, toplam serum\nseviyelerinin&nbsp;IgE&nbsp;, OVA-spesifik IgE,&nbsp;IgG1&nbsp;ve&nbsp;IgG2a&nbsp;ve\nakci\u011fer dokular\u0131n\u0131n histopatolojik incelemesi ara\u015ft\u0131r\u0131ld\u0131.&nbsp;NSO ile oral\ntedavi,&nbsp;hava yolu a\u015f\u0131r\u0131 duyarl\u0131l\u0131\u011f\u0131nda&nbsp;, toplam&nbsp;l\u00f6kosit&nbsp;say\u0131s\u0131nda&nbsp;,\nmakrofajlarda ve&nbsp;eozinofillerde&nbsp;belirgin bir azalma g\u00f6stermi\u015ftir.,\nBALF&#8217;deki IL-4, IL-5 ve IL-13 seviyeleri, toplam IgE, OVA&#8217;ya \u00f6zg\u00fc IgE ve\nIgG1&#8217;in serum seviyeleri ve IFN-\u03b3&#8217;nin BALF d\u00fczeyindeki ve OVA&#8217;ya \u00f6zg\u00fc IgG2a&#8217;n\u0131n\nserum d\u00fczeyindeki \u00f6nemli art\u0131\u015f yerel&nbsp;Th1 \/ Th2 dengesinin&nbsp;restorasyonu&nbsp;.&nbsp;Ayr\u0131ca,\ng\u00f6r\u00fcnt\u00fcler neredeyse normal oldu\u011fu i\u00e7in akci\u011ferlerin histopatolojik\nde\u011fi\u015fikliklerini \u00f6nemli \u00f6l\u00e7\u00fcde ortadan kald\u0131rd\u0131.&nbsp;Bu sonu\u00e7lar oral NSO ile\ntedavinin insanlarda bron\u015fiyal ast\u0131m i\u00e7in umut verici bir tedavi olabilece\u011fini\nd\u00fc\u015f\u00fcnd\u00fcrmektedir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">68-)Anti-inflammatory, antioxidant, and immunomodulatory aspects\nof&nbsp;<em>Nigella\nsativa<\/em>&nbsp;for its preventive and bronchodilatory\neffects on obstructive respiratory diseases: A review of basic and clinical\nevidence<\/h1>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/doi.org\/10.1016\/j.jff.2015.06.032\n<\/div><\/figure>\n\n\n\n<p><em>\u00c7\u00f6rek\notu <\/em>&nbsp;(&nbsp;<em>N. sativa<\/em>&nbsp;) en \u00e7ok\nkullan\u0131lan \u015fifal\u0131 bitkilerden biridir.&nbsp;Eski zamanlardan beri farkl\u0131\nhastal\u0131klar i\u00e7in g\u0131da katk\u0131 maddesi, koruyucu ve bitkisel bir ila\u00e7 olarak kullan\u0131lm\u0131\u015ft\u0131r.&nbsp;Geleneksel\nt\u0131pta,&nbsp;<em>N. sativa<\/em>&nbsp;i\u00e7in\nsolunum, gastrointestinal, ba\u011f\u0131\u015f\u0131kl\u0131k ve sinir sistemi ile ilgili bir\u00e7ok\nhastal\u0131\u011f\u0131n tedavisi ve \u00f6nlenmesi gibi bir\u00e7ok \u015fa\u015f\u0131rt\u0131c\u0131 etkiden\nbahsedilmi\u015ftir&nbsp;.&nbsp;Son otuz y\u0131lda, bu t\u00fcr halk \u00f6zelliklerini\ndo\u011frulamak, bitki kaynakl\u0131 do\u011fal maddeleri tan\u0131mlamak ve v\u00fccuttaki etki\nmekanizmalar\u0131n\u0131 anlamak i\u00e7in \u00e7ok say\u0131da ara\u015ft\u0131rma yap\u0131lm\u0131\u015ft\u0131r.&nbsp;<em>N. sativa<\/em>antioksidan\nenzimlerin (katalaz, glutatyon peroksidaz ve glutatyon-S-transferaz) etkisini\nartt\u0131r\u0131r ve serbest radikal temizleyici g\u00f6revi g\u00f6r\u00fcr.&nbsp;Bir anti-kanser\najan\u0131 olarak, p53, p73, PTEN, STAT3, PPAR-g, kaspazlar\u0131n aktivasyonu ve ROS\n\u00fcretimi dahil olmak \u00fczere molek\u00fcler hedefler \u00fczerindeki mod\u00fcle edici aktivitesi\ng\u00f6sterilmi\u015ftir.&nbsp;Bir anti-enflamatuar ve imm\u00fcnomod\u00fclat\u00f6r ajan olarak, Th1 \/\nTh2 oran\u0131n\u0131 dengeler ve T h\u00fccresi ve do\u011fal \u00f6ld\u00fcr\u00fcc\u00fc h\u00fccre arac\u0131l\u0131 imm\u00fcn\ntepkisini g\u00fc\u00e7lendirirken, enflamatuar mediat\u00f6rleri, l\u00f6kotrienleri,\nprostaglandinleri ve B h\u00fccresi arac\u0131l\u0131 ba\u011f\u0131\u015f\u0131kl\u0131k tepkisini bast\u0131r\u0131r.&nbsp;<em>N. sativa&#8217;n\u0131n<\/em>&nbsp;temel\nve klinik bulgular\u0131 hakk\u0131ndaki bilimsel ara\u015ft\u0131rmalar\u0131n literat\u00fcr ve deneysel\nverilerini g\u00f6zden ge\u00e7irmeyi ama\u00e7lad\u0131k.Ve bile\u015fenlerini engelleyici solunum yolu\nhastal\u0131klar\u0131 \u00fczerinde \u00f6nleyici (antienflamatuar, antioksidan ve\nimm\u00fcnomod\u00fclat\u00f6r) ve hafifletici (bronkodilat\u00f6r) etkiler.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">69-)Preclinical and clinical effects of&nbsp;<em>Nigella sativa<\/em>&nbsp;and\nits constituent, thymoquinone: A review<\/h1>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/doi.org\/10.1016\/j.jep.2016.06.061\n<\/div><\/figure>\n\n\n\n<p><em>\u00c7\u00f6rek otu<\/em>&nbsp;(&nbsp;<em>N. sativa<\/em>&nbsp;)&nbsp;<em>L<\/em>&nbsp;.&nbsp;(Ranunculaceae),\n\u00e7\u00f6rek otu olarak bilinir, zengin bir tarihsel ge\u00e7mi\u015fe sahip bir bitkisel ila\u00e7\nolarak kullan\u0131lm\u0131\u015ft\u0131r.&nbsp;Geleneksel ve klinik olarak \u00e7e\u015fitli hastal\u0131klar\u0131n\ntedavisinde kullan\u0131lm\u0131\u015ft\u0131r.&nbsp;Bir\u00e7ok inceleme bu de\u011ferli bitkiyi ara\u015ft\u0131rd\u0131,\nancak hi\u00e7biri klinik etkilerine odaklanmad\u0131.&nbsp;Bu nedenle, bu derlemenin\namac\u0131,&nbsp;<em>N. sativa<\/em>&nbsp;ve\nbaz\u0131 bile\u015fenleri hakk\u0131nda&nbsp;kapsaml\u0131 bir klinik \u00e7al\u0131\u015fma raporu\nsunmakt\u0131r&nbsp;.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Malzemeler ve y\u00f6ntemler<\/h3>\n\n\n\n<p>1979-2015 y\u0131llar\u0131 aras\u0131nda yay\u0131nlanan&nbsp;<em>N. sativa<\/em>&nbsp;ve ana\nbile\u015feni olan timokinonun&nbsp;klinik etkileri \u00fczerine yap\u0131lan\n\u00e7al\u0131\u015fmalar&nbsp;\u00e7e\u015fitli veri tabanlar\u0131 kullan\u0131larak ara\u015ft\u0131r\u0131lm\u0131\u015ft\u0131r.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">sonu\u00e7lar ve tart\u0131\u015fma<\/h3>\n\n\n\n<p>Son otuz y\u0131l boyunca, birka\u00e7 in vivo ve in\nvitro hayvan \u00e7al\u0131\u015fmas\u0131, antioksidan, antibakteriyel, antiproliferatif,\nproapoptotik, antienflamatuar ve antiepileptik \u00f6zellikleri ve aterojenez,\nendotel disfonksiyonundaki iyile\u015fme dahil olmak \u00fczere bitkinin farmakolojik\n\u00f6zelliklerini ortaya koydu.Klinik \u00e7al\u0131\u015fmalar, mikrop \u00f6ld\u00fcr\u00fcc\u00fc, antioksidan,\nanti-enflamatuar, anti-t\u00fcm\u00f6r ve anti-diyabetik \u00f6zellikleri hem de metabolik\nsendrom \u00fczerinde tedavi edici etkiler, ve mide-ba\u011f\u0131rsak n\u00f6ronal,\nkardiyovask\u00fcler, solunum, bo\u015falt\u0131m ve \u00fcreme bozukluklar\u0131 olarak bulundu.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Sonu\u00e7<\/h3>\n\n\n\n<p><em>N. sativa<\/em>&nbsp;tohumu tozu, ya\u011f\u0131, \u00f6zleri\n(sulu, etanolik ve metanolik) ve timokinon&nbsp;\u00fczerinde kapsaml\u0131 temel ve\nklinik \u00e7al\u0131\u015fmalar,&nbsp;\u00e7ok \u00e7e\u015fitli g\u00fcvenli dozlarda farkl\u0131 bozukluklar\n\u00fczerinde de\u011ferli terap\u00f6tik etkiler g\u00f6stermi\u015ftir.&nbsp;Bununla birlikte, g\u00f6zden\nge\u00e7irilmi\u015f klinik \u00e7al\u0131\u015fmalarda baz\u0131 kar\u0131\u015ft\u0131r\u0131c\u0131 fakt\u00f6rler vard\u0131 ve bunlardan\nbaz\u0131lar\u0131 bitkinin fitokimyasal bile\u015fimi hakk\u0131nda veri sundu.&nbsp;Bu nedenle,&nbsp;bitkinin\nucuz bir potansiyel biyolojik adjuvan tedavi olarak kullan\u0131lmas\u0131 i\u00e7in&nbsp;<em>N. sativa<\/em>&nbsp;takviyesi&nbsp;ile\ndaha standart bir klinik deney&nbsp;gereklidir.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">70-)Immunomodulatory and anti-inflammatory action of&nbsp;<em>Nigella sativa<\/em>&nbsp;and\nthymoquinone: A comprehensive review<\/h1>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/doi.org\/10.1016\/j.intimp.2015.06.023\n<\/div><\/figure>\n\n\n\n<p>Bir\u00e7ok&nbsp;bitkisel\n\u00fcr\u00fcn&nbsp;\u015fimdi \u00e7e\u015fitli bula\u015f\u0131c\u0131 ve bula\u015f\u0131c\u0131 olmayan durumlar\u0131 tedavi etmek\ni\u00e7in ila\u00e7 olarak kullan\u0131lmaktad\u0131r.&nbsp;Do\u011fu d\u00fcnyas\u0131nda bitki ve do\u011fal\n\u00fcr\u00fcnlerin kullan\u0131m\u0131 \u00e7ok daha belirgin olmas\u0131na ra\u011fmen, Bat\u0131 k\u00fclt\u00fcrlerinde\nkullan\u0131m\u0131 s\u00fcrekli artmaktad\u0131r.&nbsp;Baz\u0131 bitkilerin imm\u00fcnomod\u00fclat\u00f6r etkileri\nkapsaml\u0131 bir \u015fekilde ara\u015ft\u0131r\u0131lm\u0131\u015f olsa da, bir\u00e7ok bitkinin ve \u00e7e\u015fitli\nbaharatlar\u0131n olas\u0131 imm\u00fcnomod\u00fclat\u00f6r etkileri ile ilgili ara\u015ft\u0131rmalar nispeten\nazd\u0131r.&nbsp;Burada,&nbsp;siyah tohum veya siyah kimyon olarak da bilinen&nbsp;<em>Nigella sativa&#8217;n\u0131n<\/em>&nbsp;imm\u00fcnomod\u00fclat\u00f6r\nve antienflamatuar \u00f6zellikleri&nbsp;ve ana aktif maddesi&nbsp;timokinon&nbsp;(TQ)&nbsp;hakk\u0131nda\nkapsaml\u0131 bir inceleme sunuyoruz&nbsp;.&nbsp;Bu derleme makalesi,&nbsp;<em>in vitro<\/em>&nbsp;ve&nbsp;<em>in vivo&nbsp;<\/em>analizlere\nodaklanmaktad\u0131r<em>N.\nsativa&nbsp;<\/em>ve TQ&#8217;nun inflamasyonu, h\u00fccresel ve humoral&nbsp;adaptif\nimm\u00fcn yan\u0131tlar\u0131&nbsp;ve Th1 \/ Th2 paradigmas\u0131n\u0131&nbsp;mod\u00fcle&nbsp;etme\nkabiliyeti ile ilgili olarak bildirilen deneysel\nbulgular&nbsp;.&nbsp;Bildirilen&nbsp;<em>N.\nsativa&#8217;n\u0131n&nbsp;<\/em>do\u011fal \u00f6ld\u00fcr\u00fcc\u00fc (NK) h\u00fccrelerin kanser h\u00fccrelerine\nkar\u015f\u0131 sitotoksik aktivitesini artt\u0131rma&nbsp;kabiliyeti&nbsp;de\nvurgulanmaktad\u0131r.&nbsp;Bu t\u00fcr ba\u011f\u0131\u015f\u0131kl\u0131k ve alt\u0131nda yatan molek\u00fcler ve h\u00fccresel\nmekanizmalar&nbsp;, anti-inflamatuar etkilere&nbsp;ve&nbsp;<em>N. sativa&nbsp;<\/em>ve TQ\nvurgulan\u0131r.&nbsp;Ayr\u0131ca,&nbsp;<em>N.\nsativa<\/em>&nbsp;ve TQ&#8217;nun&nbsp;imm\u00fcno-d\u00fczenleyici i\u015flevlerinde\nyer&nbsp;alan&nbsp;sinyal iletim&nbsp;yollar\u0131n\u0131n&nbsp;alt\u0131\n\u00e7izilmi\u015ftir.&nbsp;Deneysel kan\u0131tlar&nbsp;<em>N.\nsativa&#8217;n\u0131n <\/em>Ekstraktlar ve TQ potansiyel olarak, farkl\u0131 tipte\nalerji,&nbsp;otoimm\u00fcnite&nbsp;ve kanser&nbsp;dahil olmak \u00fczere \u00e7e\u015fitli\nenfeksiy\u00f6z ve enfeksiy\u00f6z olmayan hastal\u0131klarda yer alan ba\u011f\u0131\u015f\u0131kl\u0131k\nreaksiyonlar\u0131n\u0131n d\u00fczenlenmesine y\u00f6nelik etkili terap\u00f6tik ajanlar\u0131n\ngeli\u015ftirilmesinde kullan\u0131labilir&nbsp;.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">71-)Anti-inflammatory effect of thymoquinone in a mouse model of\nallergic lung inflammation<\/h1>\n\n\n\n<figure class=\"wp-block-embed\"><div class=\"wp-block-embed__wrapper\">\nhttps:\/\/doi.org\/10.1016\/j.intimp.2006.02.004\n<\/div><\/figure>\n\n\n\n<p>Thymoquinone&nbsp;(TQ),\nelde edilen u\u00e7ucu ya\u011f ana aktif kurucu&nbsp;<em>otu\nN. sativa&nbsp;<\/em>&#8216;nin tohumlar\u0131, bron\u015fiyal ast\u0131m ve enflamasyon ile\nilgili bir anti-inflamatuar ve imm\u00fcn uyar\u0131c\u0131 etkiye sahip oldu\u011fu rapor\nedilmi\u015ftir.&nbsp;Bununla birlikte, bu etkilerin alt\u0131nda yatan fakt\u00f6rler ve\nmekanizmalar hakk\u0131nda \u00e7ok az \u015fey bilinmektedir.&nbsp;Bu \u00e7al\u0131\u015fmada,&nbsp;alerjik\nast\u0131m\u0131n fare modelinde&nbsp;TQ&#8217;nun&nbsp;hava yolu inflamasyonu&nbsp;\u00fczerindeki\netkisini inceledik&nbsp;.&nbsp;Ovalb\u00fcmin&nbsp;(OVA) duyarl\u0131la\u015ft\u0131r\u0131lm\u0131\u015f\nfarelerin&nbsp;hava yolu tehdidinden \u00f6nce&nbsp;intraperitoneal&nbsp;TQ&nbsp;enjeksiyonu&nbsp;,&nbsp;akci\u011fer\neozinofili&nbsp;ve OVA antijeni ile hava yolu tehdidinden sonra g\u00f6zlenen y\u00fcksek\nTh2 sitokinlerinde&nbsp;belirgin bir azalmayla sonu\u00e7land\u0131&nbsp;;&nbsp;her ikisi\nde in vivo,&nbsp;bronkoalveoler lavajda(BAL) s\u0131v\u0131s\u0131 ve in vitro olarak akci\u011fer\nh\u00fccrelerinin OVA ile uyar\u0131lmas\u0131n\u0131n ard\u0131ndan ger\u00e7ekle\u015fti.&nbsp;TQ ayr\u0131ca OVA&#8217;ya\n\u00f6zg\u00fc&nbsp;IgE ve IgG1&#8217;in&nbsp;serum d\u00fczeylerini de d\u00fc\u015f\u00fcrd\u00fc&nbsp;.&nbsp;Akci\u011fer\ndokusunun histolojik incelemesi, TQ&#8217;nun alerjene ba\u011fl\u0131 akci\u011fer&nbsp;eozinofilik&nbsp;inflamasyonu\nve mukus \u00fcreten goblet h\u00fccrelerini \u00f6nemli \u00f6l\u00e7\u00fcde inhibe etti\u011fini\ng\u00f6sterdi&nbsp;.&nbsp;TQ, IL-4, IL-5 ve&nbsp;IL-13&#8217;\u00fcn&nbsp;inhibe edilmesinde\n\u00f6nemli bir etki&nbsp;ve BAL s\u0131v\u0131s\u0131nda IFN-y \u00fcretiminin ind\u00fcklenmesinde bir\nmiktar etki&nbsp;g\u00f6sterse de,&nbsp;k\u00fclt\u00fcrl\u00fc akci\u011fer taraf\u0131ndan IL-4&#8217;\u00fcn&nbsp;in\nvitro \u00fcretimi&nbsp;\u00fczerinde hafif bir etki g\u00f6stermi\u015fyit.&nbsp;Bu veriler,\nTQ&#8217;nun&nbsp;Th2 sitokinlerini inhibe ederek&nbsp;alerjik hava yolu inflamasyonunu&nbsp;hafifletti\u011fini&nbsp;ve\nsolunum yollar\u0131na&nbsp;eozinofil&nbsp;s\u0131zmas\u0131;&nbsp;b\u00f6ylece&nbsp;akci\u011ferdeki alerjik\nyan\u0131t&nbsp;s\u0131ras\u0131nda potansiyel anti-enflamatuar rol\u00fcn\u00fc g\u00f6sterir.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>1-) Thymoquinone and Its Therapeutic Potentials DOI:&nbsp;10.1016\/j.phrs.2015.03.011 Bitkisel ila\u00e7 son y\u0131llarda b\u00fcy\u00fck ilgi g\u00f6rd\u00fc ve giderek artan \u015fekilde kimyasal ila\u00e7lara alternatif olarak kullan\u0131lmaktad\u0131r.&nbsp;Birka\u00e7 kan\u0131t hatt\u0131, \u015fifal\u0131 bitkilerin \u00e7ok \u00e7e\u015fitli hastal\u0131klar\u0131n \u00f6nlenmesi ve iyile\u015ftirilmesindeki olumlu etkisini desteklemektedir.&nbsp;Timokinon (TQ), Nigella sativa tohumlar\u0131n\u0131n u\u00e7ucu ya\u011f\u0131n\u0131n en bol bile\u015fenidir ve N sativa&#8217;n\u0131n \u00e7o\u011fu \u00f6zelli\u011fi esas olarak TQ&#8217;ya atfedilir.&nbsp;Anti-oksidan, anti-enflamatuar, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":203,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[8],"class_list":["post-37","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-literatur","tag-nigella-sativa"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u00c7\u00d6REK OTU (N\u0130GELLA SAT\u0130VA) - Dr. \u00d6zberk Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blog.drozberk.com\/index.php\/2020\/04\/02\/nigella-sativa\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c7\u00d6REK OTU (N\u0130GELLA SAT\u0130VA) 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