\nhttps:\/\/www.liebertpub.com\/doi\/abs\/10.1089\/jmf.2016.0114\n<\/div><\/figure>\n\n\n\n
Bu randomize \u00e7apraz \u00e7al\u0131\u015fma, saf hindistancevizi ya\u011f\u0131n\u0131n\n(VCO) aspir ya\u011f\u0131 (SO) \u00fczerindeki v\u00fccut kompozisyonu ve kardiyovask\u00fcler risk\nfakt\u00f6rleri \u00fczerindeki etkisini kar\u015f\u0131la\u015ft\u0131rm\u0131\u015ft\u0131r. On iki postmenopozal kad\u0131n\n(58.8 \u00b1 3.7 y\u0131l) 28 g\u00fcn boyunca 30 mL VCO veya SO t\u00fcketmi\u015f, 28 g\u00fcn y\u0131kanm\u0131\u015ft\u0131r.\nAntropometri v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131 ve kal\u00e7a ve bel \u00e7evresini i\u00e7eriyordu. Toplam v\u00fccut,\nandroid ve ginoid, ya\u011f k\u00fctlesi ve ya\u011fs\u0131z k\u00fctle i\u00e7in ya\u011f y\u00fczdesi, \u00e7ift enerjili\nX-\u0131\u015f\u0131n\u0131 absorbsiyometrisi kullan\u0131larak \u00f6l\u00e7\u00fcld\u00fc. Kad\u0131nlar \u00e7al\u0131\u015fma s\u0131ras\u0131nda 28\ng\u00fcnl\u00fck g\u0131da kay\u0131tlar\u0131n\u0131 kaydeden tipik diyetlerini s\u00fcrd\u00fcrd\u00fcler. Sonu\u00e7lar, P\n\u2009<0.05 olan SPSS v24 ile analiz edildi . Kar\u015f\u0131la\u015ft\u0131rmalar e\u015fle\u015ftirilmi\u015f t\nolarak bildirilir.Hi\u00e7bir m\u00fcdahale dizisi etkisi g\u00f6zlenmedi\u011finden test. VCO,\ntoplam kolesterol, TC (+18.2 \u00b1 22.8 mg \/ dL), d\u00fc\u015f\u00fck yo\u011funluklu lipoprotein\n(+13.5 \u00b1 16.0 mg \/ dL) ve y\u00fcksek yo\u011funluklu lipoprotein, HDL (+6.6 \u00b1 7.5 mg \/\ndL) \u00f6nemli \u00f6l\u00e7\u00fcde artt\u0131rd\u0131. SO, lipit de\u011ferlerini \u00f6nemli \u00f6l\u00e7\u00fcde de\u011fi\u015ftirmedi.\nTC ve HDL test ya\u011flar\u0131 aras\u0131nda anlaml\u0131 olarak farkl\u0131yd\u0131. TC \/ HDL oran\u0131ndaki\nde\u011fi\u015fim, hem VCO hem de SO’nun n\u00f6tr bir etkisini g\u00f6sterdi. Bir ki\u015finin VCO’ya\nkar\u015f\u0131 olumsuz reaksiyonlar\u0131 ve artm\u0131\u015f inflamasyonu vard\u0131. VCO, IL-1 azalm\u0131\u015ft\u0131r\nptespit edilen her bir ki\u015fi i\u00e7in. VCO ve SO’nun di\u011fer sitokinler \u00fczerindeki\netkisi bireysel olarak de\u011fi\u015fmi\u015ftir. Bu, ABD’de ya\u015fayan Kafkas postmenopozal\nkad\u0131nlarda VCO’nun v\u00fccut kompozisyonu \u00fczerindeki etkisini de\u011ferlendiren ilk\n\u00e7al\u0131\u015fmad\u0131r. Sonu\u00e7lar, diyetlerinde hindistancevizi ya\u011f\u0131 kullanmak isteyen\nbireylerin bunu g\u00fcvenli bir \u015fekilde yapabilece\u011fini d\u00fc\u015f\u00fcnd\u00fcrmektedir, ancak daha\nb\u00fcy\u00fck \u00f6rnek boyutlar\u0131, \u00e7e\u015fitli pop\u00fclasyonlar ve partik\u00fcl boyutu gibi daha\nspesifik klinik belirte\u00e7lerle daha fazla \u00e7al\u0131\u015fma yap\u0131lmas\u0131 gerekmektedir.<\/p>\n\n\n\n
6-)Effects of conjugated linoleic acid on serum\nleptin concentration, body-fat accumulation, and \u03b2-oxidation of fatty acid in\nOLETF rats<\/strong><\/p>\n\n\n\n\nhttps:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11377131\n<\/div><\/figure>\n\n\n\n
Biz bir 4-haftal\u0131k takviyesi etkinli\u011fini ara\u015ft\u0131r\u0131lm\u0131\u015ft\u0131r\nkonjuge linoleik asit olarak (CLA) serbest ya\u011f asidi (FFA) ya da\ntria\u00e7ilgliserol serum \u00fczerinde (TG) , leptin konsantrasyonunun, v\u00fccut ya\u011f\nbirikimi ve mitokondriyal \u03b2-oksidasyon Otsuka Long-Evans Tokushima Ya\u011fl\u0131\n(OLETF) s\u0131\u00e7anlar. TG-CLA ve FFA-CLA gruplar\u0131nda serum leptin konsantrasyonunda\nanlaml\u0131 bir azalma (% 42) ve perirenal, epididimal ve omental \/ visseral-ya\u011f\ndokusunun \u0131slak a\u011f\u0131rl\u0131klar\u0131nda bir azalma OLETF kontrol grubuna g\u00f6re bulundu.\nHer iki CLA takviyesi, g\u0131da al\u0131m\u0131n\u0131n OLETF gruplar\u0131nda benzer olmas\u0131na ra\u011fmen,\nkontrole k\u0131yasla v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131nda% 5.2’lik bir azalma \u00fcretti. Ayr\u0131ca, CLA’n\u0131n\nher iki formu da artt\u0131OLETF kontrol grubuna k\u0131yasla kahverengi adipoz doku,\nperirenal adipoz doku, k\u0131rm\u0131z\u0131gastroknemius kas\u0131ve karaci\u011ferde\nkarnitin-palmitoiltransferaz aktivitesi . TG-CLA ve FFA-CLA ile takviye edilmi\u015f\ndiyetlerle beslenen s\u0131\u00e7anlarda serum esterlenmemi\u015f ya\u011f asidi ve TG\nkonsantrasyonlar\u0131 da azalm\u0131\u015ft\u0131r.<\/p>\n\n\n\n
7-)Conjugated\nlinoleic acid and chromium lower body weight and visceral fat mass in\nhigh-fat-diet-fed mice<\/strong><\/p>\n\n\n\n\nhttps:\/\/link.springer.com\/article\/10.1007\/s11745-006-5117-3\n<\/div><\/figure>\n\n\n\n
ABD n\u00fcfusunun yar\u0131s\u0131nda fazlas\u0131 25 kg \/ v\u00fccut kitle indeksine sahip olup\nkilolu veya obez olarak s\u0131n\u0131fland\u0131r\u0131l\u0131r. Obezite s\u0131kl\u0131kla diyabet,\nkardiyovask\u00fcler hastal\u0131klar ve kanser gibi komorbiditelerle ili\u015fkilidir. CLA ve\nkrom, v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131n\u0131 ve ya\u011f k\u00fctlesini azaltan ve hayvan modellerinde bazal\nmetabolik h\u0131z\u0131 artt\u0131ran ba\u015fl\u0131ca diyet takviyeleri olarak ortaya \u00e7\u0131km\u0131\u015ft\u0131r. Bununla\nbirlikte, \u00e7al\u0131\u015fmalar CLA’n\u0131n farelerde ve insanlarda ins\u00fclin direncini\nind\u00fcklerken, Cr’in ins\u00fclin duyarl\u0131l\u0131\u011f\u0131n\u0131 geli\u015ftirdi\u011fini g\u00f6stermektedir. Bu\nnedenle, bu \u00e7al\u0131\u015fmay\u0131 CLA ve Cr’nin Balb \/ c farelerinde v\u00fccut kompozisyonu ve\nins\u00fclin duyarl\u0131l\u0131\u011f\u0131 \u00fczerindeki kombine etkisini incelemek \u00fczere tasarlad\u0131k ( n=\n10 \/ grup) y\u00fcksek ya\u011fl\u0131 diyetle ind\u00fcklenen obezite modeli. CLA tek ba\u015f\u0131na v\u00fccut\na\u011f\u0131rl\u0131\u011f\u0131n\u0131, toplam v\u00fccut ya\u011f k\u00fctlesini ve visseral ya\u011f k\u00fctlesini d\u00fc\u015f\u00fcrd\u00fc,\nbunlar\u0131n sonuncusu CLA ve Cr kombinasyonu ile daha da azald\u0131. Bu etkiye CLA ile\nbeslenen ve CLA + Cr ile beslenen farelerde serum leptin seviyelerinin d\u00fc\u015fmesi\nve CLA + Cr ile beslenen farelerde daha y\u00fcksek enerji t\u00fcketimi (EE) ve oksijen\nt\u00fcketimi (OC) e\u015flik etti. CLA ile serum glikoz, ins\u00fclin, pro-enflamatuar\nsitokinler, t\u00fcm\u00f6r nekroz fakt\u00f6r\u00fc-\u03b1 (TNF-a) ve interl\u00f6kin-6 (IL-6) d\u00fczeyleri,\nCLA ile azal\u0131rken, CLA ile azald\u0131 ve Cr kombinasyon halinde ins\u00fclin ve IL-6\nkonsantrasyonlar\u0131 ve IRI \u00fczerinde \u00f6nemli etkilere sahipti. \u00d6zetle, CLA + Cr,\ny\u00fcksek ya\u011fl\u0131 diyetle beslenen farelerde v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131n\u0131 ve ya\u011f k\u00fctlesini\nazaltt\u0131, bu da azalm\u0131\u015f leptin seviyeleri ve daha y\u00fcksek EE ve OC ile ili\u015fkili\nolabilir.<\/p>\n\n\n\n
8-)Time-dependent effects of safflower oil to\nimprove glycemia, inflammation and blood lipids in obese, post-menopausal women\nwith type 2 diabetes: A randomized, double-masked, crossover study<\/strong><\/p>\n\n\n\n\nhttps:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0261561411000021\n<\/div><\/figure>\n\n\n\n
Arka plan ve ama\u00e7lar<\/p>\n\n\n\n
Tip 2 diyabetli ki\u015filerde diyet ya\u011f kalitesinin metabolik\netkileri iyi anla\u015f\u0131lmam\u0131\u015ft\u0131r. \u00c7al\u0131\u015fman\u0131n amac\u0131 konjuge linoleik asit (CLA) ve\naspir (SAF) ya\u011flar\u0131n\u0131n glisemi , kan lipitleri ve inflamasyon \u00fczerindeki\netkilerini de\u011ferlendirmektir . Test etti\u011fimiz hipotez, diyet ya\u011flar\u0131n\u0131n , diyet\nya\u011flar\u0131yla takviye edilen deneklerde linoleik asit ve CLA izomerlerinin\nbirikmesini takip eden, zamana ba\u011fl\u0131 bir \u015fekilde glisemi, lipitler ve\nenflamatuar belirte\u00e7leri geli\u015ftirmesidir.<\/p>\n\n\n\n
Y\u00f6ntemler<\/p>\n\n\n\n
Menopoz sonras\u0131 elli be\u015f tip 2 diyabetli obez kad\u0131n\nkaydedildi ve 35’i bu randomize, \u00e7ift maskeli \u00e7apraz \u00e7al\u0131\u015fmay\u0131 tamamlad\u0131.\nTedaviler, her biri 16 hafta boyunca g\u00fcnl\u00fck 8 g CLA ve SAF idi. \u00d6nemli bir\netkinin tespit edildi\u011fi en erken s\u00fcreyi belirlemek i\u00e7in \u00f6nceden belirlenmi\u015f\nad\u0131m analizleri ile \u00e7oklu bir test prosed\u00fcr\u00fc kulland\u0131k.<\/p>\n\n\n\n
Sonu\u00e7lar<\/p>\n\n\n\n
CLA \u00f6l\u00e7\u00fclen metabolik parametreleri de\u011fi\u015ftirmedi . SAF\nazalma HbA1c (-0.64 \u00b1 0.18%, p = 0.0007)\nve C-reaktif protein (-13.6 \u00b1 8.2 mg \/ L p \n= 0.0472), artan QUICKI (0.0077 \u00b1 0.0035, p etkisi minimum zamanla = 0.0146) tedaviden 16\nhafta sonra g\u00f6zlenmi\u015ftir. SAF, HDL kolesterol\u00fc (0.12 \u00b1 0.05 mmol \/ L, p = 0.0228), 12. haftada SAF’\u0131n bir etkisini\nsaptamak i\u00e7in minimum s\u00fcreyi artt\u0131rd\u0131. CLA veya SAF ile takviye edilen\nkad\u0131nlar\u0131n serumunda s\u0131ras\u0131yla c9t11-CLA, t10c12-CLA ve linoleik asit art\u0131\u015f\u0131n\u0131\nsaptamak i\u00e7in minimum s\u00fcre d\u00f6rt haftad\u0131r.<\/p>\n\n\n\n
Sonu\u00e7lar<\/p>\n\n\n\n
G\u00fcnl\u00fck 8 g SAF’nin glisemi, iltihap ve kan lipitlerini\niyile\u015ftirdi\u011fi, diyet ya\u011f kalitesindeki k\u00fc\u00e7\u00fck de\u011fi\u015fikliklerin diyabetle ilgili\nkomplikasyonlar i\u00e7in risk fakt\u00f6rlerini iyile\u015ftirmek i\u00e7in diyabet tedavilerini\nart\u0131rabilece\u011fi sonucuna var\u0131yoruz.<\/p>\n\n\n\n
9-)The role of conjugated linoleic acid in\nreducing body fat and preventing holiday weight gain<\/strong><\/p>\n\n\n\n\nhttps:\/\/www.nature.com\/articles\/0803437\n<\/div><\/figure>\n\n\n\n
ABD’de obezite ve a\u015f\u0131r\u0131 kilo insidans\u0131 son yirmi y\u0131lda\n\u00f6nemli \u00f6l\u00e7\u00fcde artm\u0131\u015ft\u0131r ve \u015fu anda yeti\u015fkin n\u00fcfusun% 65’ini etkilemektedir.\nAra\u015ft\u0131rmalar, tatil sezonunda k\u00fc\u00e7\u00fck ama geri d\u00f6n\u00fc\u015f\u00fcms\u00fcz kazan\u00e7lar\u0131n yeti\u015fkinlik\nd\u00f6neminde kilo art\u0131\u015f\u0131na katk\u0131da bulundu\u011funu g\u00f6stermi\u015ftir. Do\u011fal olarak olu\u015fan\nbir diyet ya\u011f asidi olan konjuge linoleik asidin (CLA) kilo al\u0131m\u0131n\u0131 azaltt\u0131\u011f\u0131\nve hayvanlarda ya\u011f k\u00fctlesini \u00f6nemli \u00f6l\u00e7\u00fcde azaltt\u0131\u011f\u0131 bulunmu\u015ftur. \u0130nsanlarda\nyap\u0131lan ara\u015ft\u0131rmalar tutars\u0131z sonu\u00e7lar g\u00f6sterse de, \u00e7al\u0131\u015fmalar\u0131n \u00e7o\u011fu yetersiz\nkalm\u0131\u015ft\u0131r veya \u015fu anda kabul edilen kriterden daha az do\u011fru olan v\u00fccut\nkompozisyonu y\u00f6ntemlerini kullanm\u0131\u015ft\u0131r.<\/p>\n\n\n\n
10-)Dietary gamma-linolenic acid in the form of\nborage oil causes less body fat accumulation accompanying an increase in\nuncoupling protein 1 mRNA level in brown adipose tissue<\/strong><\/p>\n\n\n\n\nhttps:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0305049100002546\n<\/div><\/figure>\n\n\n\n
S\u0131\u00e7anlara,% 2 aspir ya\u011f\u0131 veya linoleik asit bak\u0131m\u0131ndan\nzengin aspir ya\u011f\u0131,% 25 gama (\u03b3) -linolenik asit i\u00e7eren hodan ya\u011f\u0131 veya\nenzimatik olarak haz\u0131rlanan \u03b3-linolenik asit ile zenginle\u015ftirilmi\u015f hodan ya\u011f\u0131\ni\u00e7eren az ya\u011fl\u0131 bir diyet verildi. Enerji al\u0131m\u0131 ve hayvanlar\u0131n b\u00fcy\u00fcmesi gruplar\naras\u0131nda ayn\u0131yd\u0131. Az ya\u011fl\u0131 bir diyetle kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda y\u00fcksek aspir ya\u011f\u0131\ndiyeti, hem epididimal hem de perirenal beyaz adipoz doku a\u011f\u0131rl\u0131klar\u0131nda \u00f6nemli\nart\u0131\u015flara neden oldu. Bununla birlikte, \u03b3-linolenik asit bak\u0131m\u0131ndan zengin\ny\u00fcksek ya\u011fl\u0131 diyetler bunu ba\u015faramad\u0131. D\u00fc\u015f\u00fck ya\u011fl\u0131 bir diyetle\nkar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, t\u00fcm y\u00fcksek ya\u011fl\u0131 diyetler kahverengi ya\u011f dokusunda\nayr\u0131\u015fan protein 1 ve lipoprotein lipaz\u0131n mRNA seviyelerini artt\u0131rd\u0131. Art\u0131\u015f\u0131n\nboyutlar\u0131, \u03b3-linolenik asit bak\u0131m\u0131ndan zengin y\u00fcksek ya\u011fl\u0131 diyetlerle daha\nb\u00fcy\u00fckt\u00fc. Az ya\u011fl\u0131 bir diyetle kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda \u00e7e\u015fitli y\u00fcksek ya\u011fl\u0131\ndiyetler, beyaz ya\u011f dokusunda glikoz ta\u015f\u0131y\u0131c\u0131 4 mRNA’y\u0131 ayn\u0131 seviyelere\nd\u00fc\u015f\u00fcrd\u00fc. Diyet ya\u011f miktar\u0131 ve tipleri epididimal beyaz adipoz dokudaki leptin\nmRNA seviyesini etkilememi\u015ftir. Bununla birlikte, y\u00fcksek aspir ya\u011f\u0131 diyeti,\nancak d\u00fc\u015f\u00fck ya\u011fl\u0131 bir diyete g\u00f6re \u03b3-linolenik asit bak\u0131m\u0131ndan zengin y\u00fcksek\nya\u011fl\u0131 diyetler, perirenal beyaz adipoz doku leptin mRNA d\u00fczeylerini artt\u0131rd\u0131.\nD\u00fc\u015f\u00fck ya\u011fl\u0131 bir diyete g\u00f6re t\u00fcm y\u00fcksek ya\u011fl\u0131 diyetler, hepatik mitokondriyal\nya\u011f asidi oksidasyon h\u0131z\u0131n\u0131 ve ya\u011f asidi oksidasyon enzimi mRNA bolluklar\u0131n\u0131\nayn\u0131 seviyelere y\u00fckseltti. Y\u00fcksek ya\u011fl\u0131 diyetler de peroksizomal yola\u011f\u0131nda bu\nparametreleri artt\u0131rd\u0131 ve art\u0131\u015flar lin-linolenik asit bak\u0131m\u0131ndan zengin y\u00fcksek\nya\u011fl\u0131 diyetlerle daha y\u00fcksekti. Kahverengi ya\u011f dokusu gen ekspresyonunu ve\nperoksizomal ya\u011f asidi oksidasyonunu artt\u0131rmadaki fizyolojik aktivite,\n\u03b3-linolenik asit i\u00e7eri\u011finde farkl\u0131l\u0131k g\u00f6steren iki t\u00fcr hodan ya\u011f\u0131 aras\u0131nda\nbenzerdi. Diyet \u03b3-linolenik asidin kahverengi ya\u011f dokusunda ayr\u0131\u015fan protein\n1’in gen ifadelerindeki art\u0131\u015f yoluyla v\u00fccut ya\u011f birikimini azaltt\u0131\u011f\u0131 \u00f6ne\ns\u00fcr\u00fclm\u00fc\u015ft\u00fcr. Karaci\u011fer peroksizomal ya\u011f asidi oksidasyonundaki bir art\u0131\u015f,\n\u03b3-linolenik asidin v\u00fccut ya\u011f k\u00fctlesini azaltmada fizyolojik aktivitesine de\nkatk\u0131da bulunabilir.<\/p>\n\n\n\n
11-)Protective effect of dietary long-chain n<\/em>-3\npolyunsaturated fatty acids on bone loss in gonad-intact middle-aged male rats<\/strong><\/p>\n\n\n\n\nhttps:\/\/www.cambridge.org\/core\/journals\/british-journal-of-nutrition\/article\/protective-effect-of-dietary-longchain-n3-polyunsaturated-fatty-acids-on-bone-loss-in-gonadintact-middleaged-male-rats\/FAAEE08F9637F78EDB0FC2655D136600\n<\/div><\/figure>\n\n\n\n
Bu \u00e7al\u0131\u015fma, uzun zincirli (LC) n- 3 PUFA i\u00e7eren bir ya\u011f\nkar\u0131\u015f\u0131m\u0131n\u0131n gonad ile bozulmam\u0131\u015f orta ya\u015fl\u0131 erkek s\u0131\u00e7anlarda (12 ayl\u0131k, n 28)\nkemik mineral yo\u011funlu\u011fu (BMD) ve kemik metabolizmas\u0131 \u00fczerindeki etkisini\nde\u011ferlendirmi\u015ftir . Ba\u015flang\u0131\u00e7taki KMY’yi belirlemek i\u00e7in diyet m\u00fcdahalesinin 0.\ng\u00fcn\u00fcnde yedi s\u0131\u00e7an \u00f6ld\u00fcr\u00fcld\u00fc. Geri kalan s\u0131\u00e7anlara (grup ba\u015f\u0131na yedi) a\u015fa\u011f\u0131daki\ndiyet lipit tedavilerinden biri (g \/ kg diyet) ile bir diyet verildi: 167g\naspir ya\u011f\u0131 + 33g menhaden ya\u011f\u0131 (N6 + N3 diyeti, kontrol), 200g aspir ya\u011f\u0131 (N6\ndiyeti, neredeyse LC n -3 PUFA yok) veya 190g menhaden ya\u011f\u0131 + 10g m\u0131s\u0131r ya\u011f\u0131\n(N3 diyeti, LC n a\u00e7\u0131s\u0131ndan zengin-3 PUFA). 20 hafta sonra, t\u00fcm diyet tedavi\ngruplar\u0131 ba\u015flang\u0131\u00e7 \u200b\u200breferans\u0131na k\u0131yasla daha d\u00fc\u015f\u00fck bir KMY’ye sahipti. Bununla\nbirlikte, N3 diyetiyle beslenen s\u0131\u00e7anlar, N6 ile beslenen ve N6 + N3 diyetini\nkontrol edenlere k\u0131yasla en y\u00fcksek kemik mineral i\u00e7eri\u011fine ve kortikal +\nsubkortikal BMD’ye sahipti. Kontrol (N6 + N3) grubu ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda,\ns\u0131\u00e7anlar N3 diyet, serum b\u00fcy\u00fcme ins\u00fclin benzeri fakt\u00f6r\u00fc-I, paratiroid hormonu,\n1, 25- (OH) i\u00e7in daha y\u00fcksek de\u011ferlere sahip beslenen 2 D vitamini 3 ve kemi\u011fe\nspesifik alkali fosfataz aktivitesi ancak daha d\u00fc\u015f\u00fck kemik NO \u00fcretimi ve idrar\nCa, N6 diyeti ile beslenen s\u0131\u00e7anlar y\u00fcksek kemik, prostaglandin E \u00fcretimi ve\nserum piridinolin vard\u0131. Bu bulgular LC n’nin koruyucu etkisini g\u00f6stermektedir.<\/p>\n\n\n\n
12-)Protective actions of soy isoflavones and n-3\nPUFAs on bone mass in ovariectomized rats<\/strong><\/p>\n\n\n\n\nhttps:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0955286305001166\n<\/div><\/figure>\n\n\n\n
Di\u015fi s\u0131\u00e7anlarda ovariektomi (OVX), endojen \u00f6strojen\nkonsantrasyonlar\u0131nda belirgin bir d\u00fc\u015f\u00fc\u015fe neden olur ve kemik kayb\u0131n\u0131 art\u0131ran ve\nosteopeni geli\u015fme riskini art\u0131ran kemik yeniden \u015fekillenme anormalliklerini\nind\u00fckler. Bu ara\u015ft\u0131rma, iki d\u00fczey soya izoflavon (IFs), eser (\u2212IF) ve y\u00fcksek (+\nIF) (s\u0131ras\u0131yla 0.03 ve 3.43 mg \/ g protein) ve iki d\u00fczey n-3 \u00e7oklu doymam\u0131\u015f ya\u011f\nasidinin (s\u0131ras\u0131yla PUFA’lar) 2 ayl\u0131k cinsel olgunla\u015fan OVX Sprague \u2013 Dawley\ns\u0131\u00e7anlar\u0131nda kemik korunumu \u00fczerinedir. T\u00fcm diyet tedavileri, aspir ya\u011f\u0131 (N6)\nveya aspir ya\u011f\u0131 ve menhaden ya\u011f\u0131 (N3) kar\u0131\u015f\u0131m\u0131ndan 110.4 g \/ kg ya\u011f sa\u011flad\u0131.\nOVX s\u0131\u00e7anlar\u0131 rasgele N6 \u2212 IF, N6 + IF, N3 \u2212 IF ve N3 + IF gruplar\u0131na atand\u0131.\nOVX ve sahte s\u0131\u00e7anlara 12 haftal\u0131k beslenme sonras\u0131nda \u00f6tenazi uyguland\u0131.\nS\u0131ral\u0131 femoral ve tibial in vivo kemik mineral yo\u011funlu\u011fu ve kemik mineral\ni\u00e7eri\u011fi (BMC) \u00f6l\u00e7\u00fcmleri i\u00e7in veriler her 4 haftada bir belirlendi. Arka mineral\nverileri, + IF ile ilgili pozitif bir kemik mineral koruyucu etkiye do\u011fru bir\ne\u011filim g\u00f6sterdi. OVX s\u0131\u00e7anlar\u0131 aras\u0131nda, N3 + IF diyetiyle beslenenler, tibial\nBMC i\u00e7in \u00f6nemli \u00f6l\u00e7\u00fcde daha y\u00fcksek bir de\u011fere sahipti. Serum piridinolin \u00e7apraz\nba\u011flant\u0131lar\u0131n\u0131n konsantrasyonu N3 + IF grubunda \u00f6nemli \u00f6l\u00e7\u00fcde d\u00fc\u015f\u00fckt\u00fc. Bu\nbulgular, soya IF’lerinin ve n-3 PUFA’lar\u0131n OVX s\u0131\u00e7anlar\u0131nda kemik mineral\nazalmas\u0131n\u0131 azaltmak i\u00e7in tamamlay\u0131c\u0131 bir etkisini g\u00f6sterir. Serum piridinolin\n\u00e7apraz ba\u011flant\u0131lar\u0131n\u0131n konsantrasyonu N3 + IF grubunda \u00f6nemli \u00f6l\u00e7\u00fcde d\u00fc\u015f\u00fckt\u00fc.\nBu bulgular, soya IF’lerinin ve n-3 PUFA’lar\u0131n OVX s\u0131\u00e7anlar\u0131nda kemik mineral\nazalmas\u0131n\u0131 azaltmak i\u00e7in tamamlay\u0131c\u0131 bir etkisini g\u00f6sterir. Serum piridinolin\n\u00e7apraz ba\u011flant\u0131lar\u0131n\u0131n konsantrasyonu N3 + IF grubunda \u00f6nemli \u00f6l\u00e7\u00fcde d\u00fc\u015f\u00fckt\u00fc.\nBu bulgular, soya IF’lerinin ve n-3 PUFA’lar\u0131n OVX s\u0131\u00e7anlar\u0131nda kemik mineral\nazalmas\u0131n\u0131 azaltmak i\u00e7in tamamlay\u0131c\u0131 bir etkisini g\u00f6sterir.<\/p>\n\n\n\n
13-)Bone-Protecting Effect of Safflower Seeds in\nOvariectomized Rats.<\/strong><\/p>\n\n\n\nAspir (Carthamus tinctorius L.) tohumlar\u0131 uzun zamand\u0131r\nKore’de kemik olu\u015fumunu te\u015fvik etmek ve osteoporozu \u00f6nlemek i\u00e7in klinik olarak\nkullan\u0131lmaktad\u0131r. Bununla birlikte, yararl\u0131 etki bilimsel olarak\nde\u011ferlendirilmemi\u015ftir. Bu nedenle, biz bu \u00e7al\u0131\u015fmada fito\u00f6strojen a\u00e7\u0131s\u0131ndan\nzengin aspir tohumlar\u0131n\u0131n yumurtal\u0131klar\u0131 al\u0131nm\u0131\u015f s\u0131\u00e7anlarda kemik kayb\u0131n\u0131 azalt\u0131p\nazaltmad\u0131\u011f\u0131n\u0131 ara\u015ft\u0131rd\u0131k. Di\u015fi Sprague-Dawley s\u0131\u00e7anlar\u0131na bilateral\novariektomi veya sahte cerrahi uyguland\u0131. Ameliyattan bir hafta sonra,\nyumurtal\u0131klar\u0131 al\u0131nm\u0131\u015f s\u0131\u00e7anlara ya\u011fs\u0131z aspir tohumlar\u0131 i\u00e7eren bir diyet\nverildi veya 4 hafta boyunca 17b-estradiol (E2) enjekte edildi. Beklendi\u011fi\ngibi, ovariektomi proksimal tibian\u0131n trabek\u00fcler kemik k\u00fctlesinde, kemik ili\u011fi\nya\u011f\u0131n\u0131n birikmesinde ve uterus atrofisinde dramatik bir azalmaya neden\noldu. E2 tedavisi kemik kayb\u0131n\u0131n yan\u0131 s\u0131ra kemik ili\u011fi ya\u011flanmas\u0131n\u0131 neredeyse\ntamamen \u00f6nledi, taramal\u0131 elektron mikroskopisi ve histomorfometri ile\nincelenmi\u015ftir. Aspir tohumlar\u0131 ovariektomiye ba\u011fl\u0131 kemik kayb\u0131n\u0131 k\u0131smen\nazaltm\u0131\u015f ve kemik ili\u011fi ya\u011flanmas\u0131n\u0131 hafif\u00e7e azaltm\u0131\u015ft\u0131r. Aspir tohumlar\u0131,\nE2’nin aksine, \u00e7ok zay\u0131f uterotrofik etki yapt\u0131. Altta yatan mekanizmalar\u0131\na\u00e7\u0131klamak amac\u0131yla, aspir tohumlar\u0131ndan ekstrakte edilen polifenolik\nbile\u015fiklerin osteoblast benzeri h\u00fccrelerin proliferasyonu \u00fczerindeki etkisi de\nin vitro olarak de\u011ferlendirildi. Kar\u0131\u015f\u0131k polifenolik bile\u015fikler, E2 ve\ngenistein kadar g\u00fc\u00e7l\u00fc bir \u015fekilde doza ba\u011fl\u0131 bir \u015fekilde (5-100 mg \/ ml) ROS 17\n\/ 2.8 osteoblast benzeri h\u00fccrelerin b\u00fcy\u00fcmesini uyarm\u0131\u015ft\u0131r. Mevcut veriler,\naspir tohumlar\u0131n\u0131n uterus \u00fczerinde \u00f6nemli bir etkisi olmaks\u0131z\u0131n \u00f6strojen\neksikli\u011finin neden oldu\u011fu kemik kayb\u0131 \u00fczerinde koruyucu bir etkiye sahip\noldu\u011funa dair ilk do\u011frudan in vivo kan\u0131t sa\u011flar. Aspir tohumlar\u0131n\u0131n\nfaydal\u0131 etkisi arac\u0131l\u0131k edilebilir.<\/p>\n\n\n\n
14-)Diet-Induced Thermogenesis Is Lower in Rats Fed a\nLard Diet Than in Those Fed a High Oleic Acid Safflower Oil Diet, a Safflower\nOil Diet or a Linseed Oil Diet<\/strong><\/p>\n\n\n\n\nhttps:\/\/academic.oup.com\/jn\/article-abstract\/125\/4\/920\/4730585\n<\/div><\/figure>\n\n\n\n
Bu \u00e7al\u0131\u015fman\u0131n amac\u0131, ya\u011f asidi bile\u015fiminde farkl\u0131l\u0131k\ng\u00f6steren diyet ya\u011flar\u0131n\u0131n diyetle ind\u00fcklenen termojenez, kahverengi ya\u011f\ndokusunda sempatik aktivite ve s\u0131\u00e7anlarda v\u00fccut ya\u011f birikimi \u00fczerindeki\netkilerini incelemektir. S\u0131\u00e7anlar, domuz ya\u011f\u0131, y\u00fcksek oleik asit aspir ya\u011f\u0131,\naspir ya\u011f\u0131 veya keten tohumu ya\u011f\u0131 esas al\u0131narak izojenerjik bir diyet i\u00e7in 12\nhafta boyunca beslendi ve kahverengi adipoz dokuda norepinefrin devir oranlar\u0131\ntahmin edildi. Yemekten sonra t\u00fcm v\u00fccut oksijen t\u00fcketimi, diyetle beslenen termojenezin\ndomuz ya\u011f\u0131 diyetiyle beslenen s\u0131\u00e7anlarda di\u011fer diyetlerle beslenenlerden daha\nd\u00fc\u015f\u00fck oldu\u011funu g\u00f6sterdi. \u0130nterskapular kahverengi adipoz dokudaki norepinefrin\ndevir h\u0131z\u0131 da domuz ya\u011f\u0131 diyet grubunda di\u011fer diyet gruplar\u0131na g\u00f6re anlaml\u0131\nolarak daha d\u00fc\u015f\u00fckt\u00fc. Karkas ya\u011f i\u00e7eri\u011fi domuz ya\u011f\u0131 diyet grubunda di\u011fer diyet\ngruplar\u0131na g\u00f6re anlaml\u0131 derecede y\u00fcksekken, kar\u0131n ya\u011f dokusu a\u011f\u0131rl\u0131klar\u0131 t\u00fcm\ndiyet gruplar\u0131nda ayn\u0131d\u0131r. Bu sonu\u00e7lar, doymam\u0131\u015f ya\u011f asitleri bak\u0131m\u0131ndan zengin\nhayvansal ya\u011flar\u0131n al\u0131m\u0131n\u0131n, tekli doymam\u0131\u015f veya \u00e7oklu doymam\u0131\u015f ya\u011f asitleri\nbak\u0131m\u0131ndan zengin bitkisel ya\u011flar\u0131n al\u0131m\u0131yla kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, kahverengi\nya\u011f dokusunda sempatik aktivitenin azalmas\u0131yla diyet kaynakl\u0131 termojenezi\nazaltt\u0131\u011f\u0131n\u0131 ve bu da tan\u0131t\u0131mla sonu\u00e7land\u0131\u011f\u0131n\u0131 d\u00fc\u015f\u00fcnd\u00fcrmektedir. <\/p>\n\n\n\n
15-)Conjugated Linoleic Acid Supplementation Does Not\nReduce Visceral Adipose Tissue in Middle-Aged Men Engaged in a\nResistance-Training Program<\/strong><\/p>\n\n\n\n\nhttps:\/\/jissn.biomedcentral.com\/articles\/10.1186\/1550-2783-3-2-28\n<\/div><\/figure>\n\n\n\n
Konjuge linoleik asit (CLA) takviyesi, hayvanlarda v\u00fccut\nya\u011f\u0131n\u0131 azaltmada ikna edici etkiler g\u00f6stermi\u015ftir; yine de insan \u00e7al\u0131\u015fma\nsonu\u00e7lar\u0131 bir \u015fekilde sonu\u00e7suz kalm\u0131\u015ft\u0131r. Bu \u00e7al\u0131\u015fman\u0131n amac\u0131, bir ticari\npaketin yakla\u015f\u0131k uzunlu\u011fu olan d\u00f6rt haftal\u0131k CLA takviyesinin diren\u00e7 e\u011fitimi\nalm\u0131\u015f orta ya\u015fl\u0131 erkeklerde visseral ya\u011f dokusunda pozitif bir de\u011fi\u015fikli\u011fe\nneden olup olamayaca\u011f\u0131n\u0131 belirlemektir. \u015eu anda diren\u00e7 e\u011fitimine kat\u0131lan 30\na\u015f\u0131r\u0131 kilolu ve orta derecede obez fakat ba\u015fka t\u00fcrl\u00fc sa\u011fl\u0131kl\u0131 erkek denekler\n(35 ila 55 ya\u015f aras\u0131) \u00e7ift k\u00f6r, plasebo kontroll\u00fc bir yakla\u015f\u0131mla rastgele\nolarak CLA ve plasebo gruplar\u0131na ayr\u0131lm\u0131\u015ft\u0131r. \u00c7al\u0131\u015fma 12 hafta s\u00fcrd\u00fc ve d\u00f6rt\nhaftal\u0131k \u00fc\u00e7 d\u00f6nemden olu\u015fuyordu. \u0130lk d\u00f6rt hafta boyunca (al\u0131\u015ft\u0131rma d\u00f6nemi) her\nbir hastaya plasebo (4 g aspir ya\u011f\u0131) verildi. \u00d6n\u00fcm\u00fczdeki d\u00f6rt hafta boyunca (ek\ns\u00fcre), plasebo grubu plasebo almaya devam ederken, CLA grubu 3.2 g \/ g\u00fcn CLA\nald\u0131. Son d\u00f6rt hafta boyunca (t\u00fckenme d\u00f6nemi) t\u00fcm denekler plasebo ald\u0131.\nBilgisayarl\u0131 tomografi (BT) taramalar\u0131, 4, 8 ve 12. haftalarda viseral ya\u011f\ndokusunu (KDV) \u00f6l\u00e7mek i\u00e7in kullan\u0131ld\u0131. \u00c7al\u0131\u015fma s\u0131ras\u0131nda CLA grubunda KDV kesit\nalan\u0131nda anlaml\u0131 bir azalma saptanmad\u0131. Aksine, KDV’nin 23.12 cm’lik kesit\nalan\u0131nda \u00f6nemli bir azalmaTakviye d\u00f6neminde 2 , salg\u0131 d\u00f6neminde hafifletilen\nplasebo grubunda \u00f6l\u00e7\u00fcld\u00fc. Sonu\u00e7lar\u0131m\u0131z d\u00f6rt hafta boyunca 3.2 g \/ g\u00fcn CLA\ntakviyesinin \u015fu anda bir diren\u00e7 e\u011fitimi program\u0131na kat\u0131lan orta ya\u015fl\u0131\nerkeklerde KDV’deki d\u00fc\u015f\u00fc\u015fleri desteklemedi\u011fini g\u00f6stermektedir.<\/p>\n\n\n\n
16-)Conjugated linoleic acid and phytosterols counteract\nobesity induced by high-fat diet<\/strong><\/p>\n\n\n\n\nhttps:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0963996912005467\n<\/div><\/figure>\n\n\n\n
Bu \u00e7al\u0131\u015fma, sa\u011fl\u0131kl\u0131 s\u0131\u00e7anlarda tokluk hormonlar\u0131, g\u0131da\nal\u0131m\u0131, kilo kayb\u0131 ve periferik glikoz intolerans\u0131 ve ins\u00fclin direnci \u00fczerindeki\netkilerini do\u011frulamak i\u00e7in diyet konjuge linoleik asit (CLA) ve fitosterol\ntakviyesinin etkilerini ve bunlar\u0131n y\u00fcksek ya\u011fl\u0131 diyete eklendi\u011fini\nde\u011ferlendirmeyi ama\u00e7lamaktad\u0131r. . Yirmi bir g\u00fcnl\u00fck erkek sa\u011fl\u0131kl\u0131 Sprague \u2013\nDawley s\u0131\u00e7anlar\u0131 be\u015f gruba ayr\u0131ld\u0131 ( n \n= 5): Standart grup (P), Standart\nY\u00fcksek Ya\u011f grubu (HF) ve % 2 ile diyetle beslenen \u00fc\u00e7 y\u00fcksek ya\u011fl\u0131 grup CLA\n(HC),% 2 fitosterol (HP) ve % 2 CLA art\u0131% 2 fitosterol (HS) ilave edildi.\nStandart diyet,% 12 protein ve% 4 bitkisel ya\u011f i\u00e7eren AIN-93G idi; y\u00fcksek ya\u011fl\u0131\ndiyet % 12 protein ve % 35 ya\u011f (% 4 bitkisel ya\u011f ve% 31 hayvansal ya\u011f)\ni\u00e7eriyordu. Takviye alan gruplar, HF grubuna k\u0131yasla retroperitoneal ve\nepididimal ya\u011f dokusunda anlaml\u0131 bir azalma g\u00f6sterdi ( p < \n0.05). Bununla birlikte, her iki grupta da ins\u00fclin direnci ve glukozda\nbir iyile\u015fme g\u00f6r\u00fclmedi ( p < 0.05). Leptin sadece CLA alan gruplarda\nazald\u0131 ( p < 0.05). Takviye edilen t\u00fcm gruplar diyet\nt\u00fcketiminde bir azalma g\u00f6sterdi, ancak takviyeleri alan gruplar HF grubuna\nk\u0131yasla kilo kayb\u0131 g\u00f6sterdi ( p <\n0.05). Takviyeleri tek ba\u015f\u0131na veya kombinasyon halinde alan hayvanlar ya\u011f\nk\u00fctlesini azaltt\u0131 ve etki HS grubunda kuvvetlendirildi, ancak grelin,\nadiponektin ins\u00fclin ve glikoz direncinde bir geli\u015fme olmad\u0131. Takviyeler tek\nba\u015f\u0131na veya kombinasyon halinde g\u0131da al\u0131m\u0131n\u0131n azalt\u0131lmas\u0131n\u0131 ve ayr\u0131ca deney\nhayvanlar\u0131nda kilo kayb\u0131n\u0131 desteklemi\u015ftir.<\/p>\n\n\n\n
17-)<\/strong> High Dose trans<\/em>-10,cis<\/em>-12\nCLA Increases Lean Body Mass in Hamsters, but Elevates Levels of Plasma Lipids\nand Liver Enzyme Biomarkers<\/strong><\/p>\n\n\n\n\nhttps:\/\/link.springer.com\/article\/10.1007\/s11745-011-3616-3\n<\/div><\/figure>\n\n\n\n
Bu \u00e7al\u0131\u015fma , ham bile\u015fimlerde dereceli c 9, t 11 ve t 10, c\n12 CLA izomer dozlar\u0131n\u0131n, hamsterlardaki v\u00fccut kompozisyonu, enerji t\u00fcketimi,\nhepatik ve serum lipit karaci\u011fer biyobelirte\u00e7leri \u00fczerindeki etkisini\nincelemi\u015ftir . Hayvanlar ( n = 105),\nyedi tedavilere randomize edildi (kontrol, 1, 2, 3% , c 9, t 11; 1, 2, 3,% t\n10, C 12), 28 g\u00fcn i\u00e7in. 28 g\u00fcn tedavi% 1-3 sonra t 10, c al\u00e7alt\u0131lm\u0131\u015f 12 (\ns , kontrol grubuna k\u0131yasla <0.05),\nv\u00fccut ya\u011f k\u00fctlesi. % 1\u20133 t 10, c 12 ve% 3 c 9, t11 beslenen grup, di\u011fer gruplara g\u00f6re daha y\u00fcksek ( p <0.05)\nya\u011fs\u0131z k\u00fctle g\u00f6sterdi. Bu% 3 ile beslenen hayvanlarda plazma toplam kolesterol\nve non-HDL-kolesterol seviyelerinde olumsuz de\u011fi\u015fiklikler g\u00f6zlenmi\u015ftir t , 10 C\n12 CLA izomerleri. % 2,% 3 t 10, c12 gruplar\u0131nda y\u00fcksek ( p <0.05) ALT seviyeleri g\u00f6r\u00fclm\u00fc\u015ft\u00fcr. Mevcut\nveriler, bir diyet% 2’den daha fazla zenginle\u015ftirilmi\u015f d\u00fc\u015f\u00fcnd\u00fcrmektedir t , 10\nc karaci\u011fer ar\u0131za ve pozlar plazma lipid profilleri \u00fczerinde olumsuz\nde\u011fi\u015fiklikler yol 12. % 1 t 10, c12 CLA \nv\u00fccut ya\u011f k\u00fctlesini d\u00fc\u015f\u00fcrd\u00fc ( p <0.05) ve ya\u011fs\u0131z v\u00fccut k\u00fctlesini artt\u0131rd\u0131 ( p\n<0.05). c 9, t 11 CLA, t 10, c 12 CLA’dan daha az etkili etkiye sahiptir .\nCLA’n\u0131n enerji ve lipit metabolizmas\u0131 \u00fczerindeki etkilerinin hamster modelinde\nforma ve doza ba\u011fl\u0131 oldu\u011fu sonucuna vard\u0131k.<\/p>\n\n\n\n
18-)<\/strong> <\/strong>CLA\nDoes Not Impair Endothelial Function and Decreases Body Weight as Compared with\nSafflower Oil in Overweight and Obese Male Subjects<\/strong><\/p>\n\n\n\n\nhttps:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/07315724.2011.10719940\n<\/div><\/figure>\n\n\n\n
Ama\u00e7: Konjuge linoleik asit (CLA), hayvan modellerinde ve\ninsanlarda kardiyovask\u00fcler sa\u011fl\u0131kla ili\u015fkili \u00e7ok \u00e7e\u015fitli faydal\u0131 biyolojik\netkiler g\u00f6stermi\u015ftir. \u0130nsan \u00e7al\u0131\u015fmalar\u0131n\u0131n \u00e7o\u011funda referans olarak zeytinya\u011f\u0131\nkullan\u0131lm\u0131\u015ft\u0131r. Bu \u00e7al\u0131\u015fma, a\u015f\u0131r\u0131 kilolu ve obez erkeklerde aspir ya\u011f\u0131 ile\nkar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda CLA’n\u0131n endotelyal fonksiyon ve kardiyovask\u00fcler risk\nbelirte\u00e7leri \u00fczerindeki etkisini de\u011ferlendirmi\u015ftir. Ek tan\u0131mlay\u0131c\u0131 kontrol i\u00e7in\n\u0131s\u0131tmal\u0131 aspir ya\u011f\u0131 ve zeytinya\u011f\u0131 verildi.<\/p>\n\n\n\n
Y\u00f6ntem: 4 haftal\u0131k \u00e7ift k\u00f6r bir \u00e7al\u0131\u015fma seksen be\u015f kilolu\nerkek (ya\u015f 45-68 ya\u015f, v\u00fccut k\u00fctle indeksi 25-35 kg \/ 2 ) 4.5 g \/ g\u00fcn, CLA\nizomer kar\u0131\u015f\u0131m\u0131, aspir ya\u011f\u0131, \u0131s\u0131t\u0131lm\u0131\u015f aspir ya\u011f\u0131 ya da zeytin ya\u011f\u0131 i\u00e7inde\nalmak \u00fczere randomize edildi. Endotel fonksiyonu, a\u00e7l\u0131k ve postprandiyal\ndurumda periferik arteriyel tonometri (PAT) indeksi belirlemesi ile\nde\u011ferlendirildi (yani, ya\u011f ve s\u00fckroz bak\u0131m\u0131ndan zengin bir \u00f6\u011f\u00fcn t\u00fcketilmesinden\n4 saat sonra).<\/p>\n\n\n\n
Bulgular: Aspir ya\u011f\u0131 t\u00fcketimi ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda CLA\na\u00e7l\u0131k veya postprandiyal PAT indeksini bozmad\u0131, ancak v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131n\u0131 azaltt\u0131.\nAspir ya\u011f\u0131 ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda CLA toplam, d\u00fc\u015f\u00fck yo\u011funluklu lipoprotein\n(LDL) veya y\u00fcksek yo\u011funluklu lipoprotein (HDL) kolesterol\u00fcn\u00fc de\u011fi\u015ftirmedi.<\/p>\n\n\n\n
Sonu\u00e7: CLA endotel fonksiyonunu etkilememi\u015ftir. Metabolik\nsendrom ve oksidatif stres ile ili\u015fkili di\u011fer parametreler de\u011fi\u015ftirilmedi veya\nbiraz iyile\u015fti. Sonu\u00e7lar CLA’n\u0131n kardiyovask\u00fcler riski artt\u0131rmad\u0131\u011f\u0131n\u0131\ng\u00f6stermektedir. Artan F 2 Bu ba\u011flamda -isoprostane konsantrasyonlar\u0131 oksidatif\nstres art\u0131\u015f g\u00f6stermektedir olmayabilir.<\/p>\n\n\n\n
19-)<\/strong> Dietary conjugated linoleic acid increases\nendurance capacity and fat oxidation in mice during exercise<\/strong><\/p>\n\n\n\n\nhttps:\/\/link.springer.com\/article\/10.1007\/s11745-005-1381-5\n<\/div><\/figure>\n\n\n\n
CLA’n\u0131n yutulmas\u0131 \u03b2-oksidasyonu aktive eder ve kemirgenlerde\nv\u00fccut ya\u011f kayb\u0131na neden olur. Farelerde egzersiz s\u0131ras\u0131nda diyet CLA’n\u0131n\ndayan\u0131kl\u0131l\u0131k kapasitesi ve enerji metabolizmas\u0131 \u00fczerindeki etkilerini\nara\u015ft\u0131rd\u0131k. Be\u015f haftal\u0131k erkek BALB \/ c farelerine,% 1.0 linoleik asit i\u00e7eren\nbir kontrol diyetine veya 1 hafta s\u00fcreyle e\u015fde\u011fer miktarda linoleik asidin\nyerini alan% 0.5 CLA i\u00e7eren bir diyet verildi. Yorgunlu\u011fa kadar olan maksimum\ny\u00fczme s\u00fcresi CLA ile beslenen grupta kontrol grubuna g\u00f6re anlaml\u0131 olarak daha\ny\u00fcksekti. Ko\u015fu band\u0131 \u00e7al\u0131\u015fmas\u0131 s\u0131ras\u0131nda, solunum de\u011fi\u015fim oran\u0131 CLA ile\nbeslenen grupta \u00f6nemli \u00f6l\u00e7\u00fcde d\u00fc\u015f\u00fckt\u00fc, ancak oksijen t\u00fcketimi gruplar aras\u0131nda\n\u00f6nemli \u00f6l\u00e7\u00fcde farkl\u0131l\u0131k g\u00f6stermedi, bu da FA’n\u0131n CLA ile beslenen farelerde bir\nenerji substrat\u0131 olarak daha fazla katk\u0131da bulundu\u011funu d\u00fc\u015f\u00fcnd\u00fcrd\u00fc. Kas\nlipoprotein lipaz aktivitesi CLA ile beslenen grupta kontrol grubuna g\u00f6re\nanlaml\u0131 olarak daha y\u00fcksekti.<\/p>\n\n\n\n
20-)<\/strong> Defatted safflower seed extract inhibits\nadipogenesis in 3T3-L1 preadipocytes and improves lipid profiles in\nC57BL\/6J ob\/ob<\/em> mice fed a high-fat diet<\/strong><\/p>\n\n\n\n\nhttps:\/\/www.sciencedirect.com\/science\/article\/pii\/S0271531716302263\n<\/div><\/figure>\n\n\n\n
Bu \u00e7al\u0131\u015fmada, s\u00f6z konusu ya\u011f\u0131 al\u0131nm\u0131\u015f hipotezi aspir\na\u00e7\u0131s\u0131ndan zengin oldu\u011fu bilinen tohum polifenoller etkileyebilir. Adipogenesis\nve obezite ile ili\u015fkili bozukluklar ve bu nedenle anti-adipojenik ve\nhipolipidemik ya\u011fdan ar\u0131nd\u0131r\u0131lm\u0131\u015f aspir etanol ekstresi etkileri ( Cathamus\ntinctorius L.) tohumlar\u0131 (CSE) hem k\u00fclt\u00fcrlenmi\u015f 3T3-L1 preadipositlerinde hem\nde y\u00fcksek ya\u011fl\u0131 bir diyetle beslenen C57BL \/ 6J ob \/ ob farelerinde ara\u015ft\u0131r\u0131ld\u0131\n. CSE , 3T3-L1 preadipositlerin adiposit farkl\u0131la\u015fmas\u0131n\u0131 inhibe etti ve\nadipojenik transkripsiyon fakt\u00f6rleri, SREBP1c’nin ekspresyonunun azald\u0131. Alt\u0131\nhaftal\u0131k obez ( ob \/ ob ) farelere y\u00fcksek ya\u011fl\u0131 bir diyet verildi ve 6 hafta\nboyunca oral gavaj yoluyla CSE (50 veya 100 mg \/ kg \/ g\u00fcn) ile tedavi edildi.\nCSE ile tedavi edilen gruplardaki v\u00fccut ya\u011f k\u00fctlesi (epididimal ve perirenal\nbeyaz adipoz dokular\u0131), y\u00fcksek ya\u011fl\u0131 diyet kontrol (HFD) grubundan \u00f6nemli\n\u00f6l\u00e7\u00fcde daha d\u00fc\u015f\u00fck iken, ortalama g\u00fcnl\u00fck g\u0131da al\u0131m\u0131 gruplar aras\u0131nda \u00f6nemli\n\u00f6l\u00e7\u00fcde farkl\u0131 de\u011fildi. Plazma ve hepatik trigliserit d\u00fczeyleri ve plazma d\u00fc\u015f\u00fck\nyo\u011funluklu lipoprotein kolesterol d\u00fczeyi de \u00d6AM gruplar\u0131nda HFD grubuna g\u00f6re\nanlaml\u0131 derecede d\u00fc\u015f\u00fckt\u00fc. Bu sonu\u00e7lar, v\u00fccut ya\u011f k\u00fctlesini azaltan ve lipit\nprofillerini iyile\u015ftiren \u00d6AM’ninplazma ve karaci\u011ferde, obezite ve hiperlipidemi\ndahil ili\u015fkili metabolik bozukluklar i\u00e7in potansiyel bir tedavi se\u00e7ene\u011fini\ntemsil eder .<\/p>\n","protected":false},"excerpt":{"rendered":"
Carthamus tinctorius di\u011fer bir ad\u0131yla Aspir , Papatyagiller familyas\u0131ndan \u00e7ok dall\u0131 yap\u0131da otsu bir bitkidir.Aspir ya\u011f\u0131 Carthamus tinctorius bitkisinin tohumlar\u0131ndan elde edilir.Ya\u011f\u0131n i\u00e7eri\u011finde doymu\u015f ve doymam\u0131\u015f ya\u011f asitleri y\u00fcksek oranda bulunur.Oleik ya\u011f asidi i\u00e7eren aspir ya\u011f\u0131 di\u011ferlerine g\u00f6re daha y\u00fcksek oranda doymam\u0131\u015f ya\u011f i\u00e7ermektedir.\u0130\u00e7eri\u011finde en y\u00fcksek oranda bulunan konjuge linoleik asit (CLA) , v\u00fccutta bulunan […]<\/p>\n","protected":false},"author":1,"featured_media":172,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-71","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-literatur"],"yoast_head":"\n
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