{"id":58,"date":"2020-04-13T11:49:20","date_gmt":"2020-04-13T08:49:20","guid":{"rendered":"https:\/\/blog.drozberk.com\/?p=58"},"modified":"2020-05-09T04:57:22","modified_gmt":"2020-05-09T01:57:22","slug":"helichrysum-italicum","status":"publish","type":"post","link":"https:\/\/blog.drozberk.com\/index.php\/2020\/04\/13\/helichrysum-italicum\/","title":{"rendered":"\u00d6LMEZ \u00c7\u0130\u00c7EK (HEL\u0130CHRYSUM \u0130TAL\u0130CUM)"},"content":{"rendered":"\n

1-)Chemical\ncomposition and antimicrobial activity of essential oil of Helichrysum italicum<\/em> (Roth)\nG. Don fil. (Asteraceae) from Montenegro.<\/h4>\n\n\n\n

DOI:10.1080\/14786419.2018.1538218<\/a><\/p>\n\n\n\n

Karada\u011f Helichrysum italicum<\/em> (Roth) esansiyel\nya\u011f\u0131 \u00fczerine deneysel bir ara\u015ft\u0131rma G. Don fil. (Asteraceae) rapor\nedilmi\u015ftir. U\u00e7ucu ya\u011f, hem s\u0131v\u0131 hem de buhar fazlar\u0131nda analiz\nedildi. S\u0131v\u0131 ya\u011f\u0131n gaz kromatografisi-k\u00fctle spektrometresi analizi,\nseskiterpenlerin \u03b2-<\/em> eudesmene (% 21.65) ve \u03b2-<\/em> bisabolen\n(% 19.90) ile b\u00fcy\u00fck \u00e7o\u011funlu\u011funu g\u00f6sterdi . Monoterpen fraksiyonu\nesas olarak a-pinen (% 16.90) ve neril asetat (% 10.66) ile temsil\nedildi. Head-space tekni\u011fi, a-<\/em> pinen (% 78.76)\nbask\u0131nl\u0131\u011f\u0131 olan monoterpenler ile zenginle\u015ftirilmi\u015f buhar faz\u0131n\u0131 ortaya\n\u00e7\u0131karm\u0131\u015ft\u0131r . U\u00e7ucu ya\u011f metisiline duyarl\u0131 Staphylococcus\naureus<\/em> (ATCC 29213), Escherichia coli’ye<\/em> kar\u015f\u0131 test\nedildi(ATCC 25922), Candida albicans<\/em> (ATCC 14053) ve\nmetisiline diren\u00e7li S. aureus<\/em> , karbapenem diren\u00e7li Klebsiella\npneumoniae<\/em> , karbapenem diren\u00e7li Acinetobacter baumannii<\/em> ve\nkarbapenem diren\u00e7li Pseudomonas aeruginosa’n\u0131n<\/em> klinik\nsu\u015flar\u0131 . C. albicans<\/em> ve karbapenem diren\u00e7li A.\nbaumannii’ye<\/em> kar\u015f\u0131 ilgin\u00e7 fungisidal \/ bakterisidal potens ,%\n5 v \/ v<\/em> konsantrasyonunda ortaya \u00e7\u0131kar\u0131ld\u0131 .<\/strong><\/p>\n\n\n\n

2-)Chemical composition analysis and in vitro<\/em> biological\nactivities of ten essential oils in human skin cells.<\/h4>\n\n\n\n

DOI:10.1016\/j.biopen.2017.04.001<\/a><\/p>\n\n\n\n

Esansiyel ya\u011flar\u0131n insan\ncilt h\u00fccreleri \u00fczerindeki biyolojik etkileri \u00fczerine ara\u015ft\u0131rmalar\nnadirdir. Bu \u00e7al\u0131\u015fmada, \u00f6ncelikle kronik iltihaplanmay\u0131 sim\u00fcle eden\n\u00f6nceden iltihapl\u0131 bir insan dermal fibroblast sisteminde 10 esans ya\u011f\u0131n\u0131n\n(dokuz tek ve bir kar\u0131\u015f\u0131m) biyolojik aktivitelerini\nara\u015ft\u0131rd\u0131k. Enflamasyon, ba\u011f\u0131\u015f\u0131kl\u0131k tepkileri ve doku yeniden modelleme\ni\u015flemleri i\u00e7in kritik protein d\u00fczeylerini \u00f6l\u00e7t\u00fck. Dokuz tek ya\u011f Citrus\nbergamia<\/em> (bergamot), Coriandrum sativum<\/em> (ki\u015fni\u015f), Pelargonium\ngraveolens<\/em> (sardunya), Helichrysum italicum<\/em> ( helichrysum ), Pogostemon cablin<\/em> (pa\u00e7uli), Citrus\naurantium<\/em> (petitgrain),Santalum alb\u00fcm\u00fc<\/em> (sandal\na\u011fac\u0131), Nardostachys jatamansi<\/em> (spikenard) ve Cananga\nodorata<\/em> (ylang ylang). Esansiyel ya\u011f harman\u0131 (ticari ad\u0131\nImmortelle) s\u0131\u011fla, Hawai sandal a\u011fac\u0131, lavanta, m\u00fcr, herdemye\u015fil ve g\u00fcl ya\u011flar\u0131ndan\nolu\u015fur . \u0130ncelenen t\u00fcm ya\u011flar bu h\u00fccrelere kar\u015f\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde\nanti-proliferatifti. Ayr\u0131ca, bergamot, ki\u015fni\u015f ve spikenard esansiyel\nya\u011flar\u0131, iltihaplanma, ba\u011f\u0131\u015f\u0131kl\u0131k tepkileri ve doku yeniden modelleme\ni\u015flemleriyle ilgili protein molek\u00fcllerini \u00f6ncelikle inhibe ederek\nanti-enflamatuar ve yara iyile\u015fme \u00f6zelliklerine sahip olduklar\u0131n\u0131 d\u00fc\u015f\u00fcnd\u00fcrmektedir. Herdemye\u015filve ylang ylang esansiyel ya\u011flar\u0131n\u0131n yan\u0131 s\u0131ra\nImmortelle esas olarak doku yeniden \u015fekillenmesi ile ili\u015fkili proteinleri\ninhibe etti, bu da bir yara iyile\u015ftirici \u00f6zelli\u011fi d\u00fc\u015f\u00fcnd\u00fcrd\u00fc. Veriler, bu\nya\u011flar\u0131 di\u011fer modellerde inceleyen mevcut \u00e7al\u0131\u015fmalar\u0131n sonu\u00e7lar\u0131yla tutarl\u0131d\u0131r\nve incelenen ya\u011flar\u0131n \u00fcmit verici terap\u00f6tik adaylar olabilece\u011fini\nd\u00fc\u015f\u00fcnd\u00fcrmektedir. Biyolojik etki mekanizmalar\u0131 hakk\u0131nda daha fazla\nara\u015ft\u0131rma yap\u0131lmas\u0131 \u00f6nerilir. Bu u\u00e7ucu ya\u011flar\u0131n diferansiyel etkileri,\nfarkl\u0131 mekanizmalar veya yollarla faaliyet g\u00f6sterdiklerini ve daha fazla\nara\u015ft\u0131rmay\u0131 gerektirdi\u011fini g\u00f6stermektedir. Bu ya\u011flar\u0131n kimyasal bile\u015fimi,\ngaz kromatografisi-k\u00fctle spektrometresi kullan\u0131larak analiz edildi.<\/p>\n\n\n\n

3-)Intramolecular\nHydrogen Bonding and Conformational Preferences of Arzanol-An Antioxidant\nAcylphloroglucinol.<\/h4>\n\n\n\n

DOI:10,3390 \/ molecules22081294<\/a><\/p>\n\n\n\n

Arzanol, Helichrysum italicum’dan<\/em> izole edilmi\u015f,\ndo\u011fal olarak olu\u015fan, prenillenmi\u015f asilfloroglusinold\u00fcr.Bu bile\u015fik antioksidan,\nantibiyotik ve antiviral aktiviteler sergilemi\u015ftir. Molek\u00fcl, metilen\nk\u00f6pr\u00fcs\u00fc yoluyla floroglusinol k\u0131sm\u0131na ba\u011fl\u0131 bir a-piron k\u0131sm\u0131\ni\u00e7erir. Birka\u00e7 hidrojen ba\u011f don\u00f6r\u00fc veya al\u0131c\u0131 b\u00f6lgesinin varl\u0131\u011f\u0131\nmolek\u00fcller aras\u0131 hidrojen ba\u011flanma modellerini bask\u0131n stabilize edici fakt\u00f6r\nyapar. M\u00fcmk\u00fcn olan t\u00fcm farkl\u0131 hidrojen ba\u011flama modellerine sahip\nkonformerler, vakumda ve \u00fc\u00e7 \u00e7\u00f6z\u00fcc\u00fc i\u00e7inde tamamen rahat geometri ile HF \/ 6-31G\n(d, p) ve DFT \/ B3LYP \/ 6-31 + G (d, p) seviyelerinde hesaplanm\u0131\u015ft\u0131r. Kloroform,\nasetonitril ve su (bu seviyeler, asilfloroglucinollerle ilgili \u00f6nceki\n\u00e7al\u0131\u015fmalarla kar\u015f\u0131la\u015ft\u0131rmay\u0131 m\u00fcmk\u00fcn k\u0131lmak i\u00e7in se\u00e7ilmi\u015ftir). \u00c7\u00f6zeltideki\nhesaplamalar Polarize Edilebilir S\u00fcreklilik Modeli ile ger\u00e7ekle\u015ftirilmi\u015ftir. Sonu\u00e7lar,\nen d\u00fc\u015f\u00fck enerji uyumlay\u0131c\u0131lar\u0131n\u0131n en y\u00fcksek say\u0131da g\u00fc\u00e7l\u00fc molek\u00fcl i\u00e7i hidrojen\nba\u011f\u0131na sahip oldu\u011funu g\u00f6stermektedir.<\/p>\n\n\n\n

4-)Chemical\nconstituents of Helichrysum<\/em> italicum<\/em> (Roth) G. Don essential oil and their\nantimicrobial activity against Gram-positive and Gram-negative bacteria,\nfilamentous fungi and Candida albicans<\/em>.<\/h4>\n\n\n\n

DOI:10.1016\/j.jsps.2016.11.001<\/a><\/p>\n\n\n\n

Helichrysum italicum<\/em> (Roth) G. Don’\u0131n<\/em> hava\nk\u0131s\u0131mlar\u0131, gaz kromatografisi ve k\u00fctle spektrometresi ile birle\u015ftirilmi\u015f\ngaz kromatografisi ile analiz edilen ve agar taraf\u0131ndan 12 bakteri, iki maya ve\nd\u00f6rt mantar kar\u015f\u0131 antimikrobiyal aktivite a\u00e7\u0131s\u0131ndan test edilen u\u00e7ucu ya\u011flar\u0131\nelde etmek i\u00e7in hidrodistillemeye tabi tutuldu.U\u00e7ucu ya\u011f% 0.44 (h \/ h)\nvermi\u015ftir ve ya\u011f\u0131n% 99.24’\u00fcn\u00fc olu\u015fturan 67 bile\u015fik, y\u00fcksek oranda oksijenlenmi\u015f\nseskiterpen (% 61.42) i\u00e7eri\u011fiyle tan\u0131mlanm\u0131\u015ft\u0131r. En oksijenli seskiterpen\nbile\u015fikleri a-Cedren (% 13.61), a-Curcumene (% 11.41), Sardunil asetat (%\n10.05), Limonen (% 6.07), Nerol (% 5.04), Neril asetat (% 4.91) ve \u03b1- Pinen (%\n3.78). U\u00e7ucu ya\u011f\u0131n antimikrobiyal aktivitesi, \u00fczerinde disk dif\u00fczyon\ny\u00f6ntemi kullan\u0131larak deneye tabi tutuldu.Escherichia coli<\/em> ATCC\n25922, Staphylococcus aureus<\/em> ATCC 6538, Micrococcus\nluteus<\/em> ATCC 4698, Klebsiella pn\u00f6moni<\/em> ATCC 4352, Enterococcus\ncereus<\/em> ATCC 2035, Bacillus cereus<\/em> ATCC 10876, Staphylococcus\nepidermidis<\/em> ATCC 12228, Bacillus subtilis<\/em> ATCC\n9372, Pseudomonas aeruginosa<\/em> ATCC 27853, Enterococcus\nfaecalis<\/em> ATCC 49452, Proteus mirabilis<\/em> ATCC 35659,\nATIA 15313 Listeria monocytogenes<\/em> ve mayalar Candida\nalbicans<\/em> ATCC 10231, Saccharomyces cerevisiae<\/em> ATCC\n9763 ve mantarlar,Fusarium solani<\/em> var. coeruleum<\/em> , Aspergillus\nniger<\/em> , Alternaria alternata<\/em> , Ascochyta\nrabiei<\/em> . H. italicum<\/em> \u00fc\u00e7\nbakteri, d\u0131\u015f\u0131nda test edilen mikroorganizmalar\u0131n geli\u015fimini inhibe E.\nColi<\/em> ATCC 25922, K. pn\u00f6moni<\/em> ATCC 4352 ve L.\nmonocytogenes<\/em> en hassas bakteri oldu\u011fu ATCC 15313. E. cereus\nATCC 2035<\/em> minimum inhibit\u00f6r ve bakteri konsantrasyonlar\u0131 ile 0.79 \u03bcg\nml- 1<\/sup> . Asgari fungistatik ve fungisit\nkonsantrasyonu s\u0131ras\u0131yla 6.325 \u03bcg ml -1<\/sup> ve 12.65\n\u03bcg ml -1<\/sup> ile elde edildi.C. albicans<\/em> ATCC\n10231 ve S. cerevisiae<\/em> ATCC 9763. Bununla birlikte, d\u00f6rt\nmantar, 6.325 \u03bcg ml -1<\/sup> ila 50.6 \u03bcg ml- 1<\/sup> ve\nfungisit minimum konsantrasyonu 50.6 \u03bcg ml- 1<\/sup> aras\u0131nda\ndaha diren\u00e7lidir . Bu antimikrobiyal aktivite, u\u00e7ucu ya\u011f kimyasal\nbile\u015fimine atfedilebilir. Bu nedenle bu \u00e7al\u0131\u015fma , Kuzey Cezayir’den\ntoplanan H. italicum<\/em> (Roth)\nG. Don’un kimyasal bile\u015fimi ve antimikrobiyal \u00f6zellikleri\n\u00fczerine yap\u0131lan \u00e7al\u0131\u015fmadaki ilk ad\u0131m\u0131 temsil etmektedir .<\/p>\n\n\n\n

5-)Phytochemical\nstudy of Helichrysum italicum (Roth) G. Don: Spectroscopic elucidation\nof unusual amino-phlorogucinols and antimicrobial assessment of secondary\nmetabolites from medium-polar extract.<\/h4>\n\n\n\n

DOI:10.1016\/j.phytochem.2016.09.012<\/a><\/p>\n\n\n\n

Helichrysum italicum AC\nolarak adland\u0131r\u0131lan \u00fc\u00e7 ola\u011fand\u0131\u015f\u0131 amino-floroglucinol ile birlikte\nasetofenonlar, tremetrone t\u00fcrevleri, d\u00fc\u015f\u00fck molek\u00fcler a\u011f\u0131rl\u0131kl\u0131 fenoller,\nflavonol glikozitler dahil on yedi bilinen bile\u015fik, Helichrysum italicum (Roth)\nG. Don, a’n\u0131n orta polar ekstrakt\u0131ndan izole edilmi\u015ftir. Akdeniz\nbitki \u00f6rt\u00fcs\u00fc tipik t\u0131bbi bitkisidir. Bile\u015fiklerin yap\u0131lar\u0131, Q-TOF\nHRMS 2<\/sup> analizi ile birlikte COSY, TOCSY, HSQC,\nCIGAR-HMBC, H2BC ve HSQC-TOCSY dahil olmak \u00fczere kapsaml\u0131 2D-NMR spektroskopik\nanalizlere dayan\u0131larak a\u00e7\u0131klanm\u0131\u015ft\u0131r . Yeni bile\u015fiklerin stereo\nyap\u0131lar\u0131 Mosher y\u00f6ntemi ve NOESY deneyi ile a\u00e7\u0131klanm\u0131\u015ft\u0131r. Se\u00e7ilen\nbile\u015fiklerin Staphylococcus epidermidis’e kar\u015f\u0131 antimikrobiyal \u00f6zellikleri\nde\u011ferlendirildi.<\/p>\n\n\n\n

6-)In Vitro Activity of Twenty\nCommercially Available, Plant-Derived Essential Oils against Selected\nDermatophyte Species.<\/h4>\n\n\n\n

PMID:26434145<\/p>\n\n\n\n

Boswellia sacra, Citrus\nbergamia, C. limon, C. medica, Cinnamomum zeylanicum, Eucalyptus globulus,\nFoeniculum vulgare, Helichrysum italicum’dan elde\nedilen yirmi kimyasal olarak tan\u0131mlanm\u0131\u015f u\u00e7ucu ya\u011f\u0131n (EO) in vitro aktivitesi,\nIllicium verum, Litsea cubeba, Mentha spicata, Myrtus communis, Ocimum\nbasilicum, Origanum majorana, O. vulgare, Pelargonium graveolens, Rosmarinus\nofficinalis, Santalum alb\u00fcm\u00fc, Satureja montana ve Thymus serpyllum, Microsporum\nmentoztontik mentoztontik Teneke mentozlar\u0131 , T. erinacei, T. terrestre ve\nMicrosporum gypseum, insanlarda zoonotik ve \/ veya \u00e7evresel dermatofitozlar\u0131n\nana etken maddeleri. Bu t\u00fcr EO’larda y\u00fcksek miktarlarda bulunan tek ana\nbile\u015fenler de test edildi. Farkl\u0131 dermatofit t\u00fcrleri duyarl\u0131l\u0131kta dikkate\nde\u011fer farkl\u0131l\u0131klar g\u00f6stermi\u015ftir. Genel olarak, daha etkili EO’lar T.\nserpyllum (MIC aral\u0131\u011f\u0131% 0.025 -% 0.25), O. vulgare (MIC aral\u0131\u011f\u0131% 0.025 -% 0.5)\nve L. cubeba (MIC aral\u0131\u011f\u0131% 0.025 -% -1.5) idi. F. vulgare, M gypseum ve T\nterrestre gibi jeofilik t\u00fcrlere kar\u015f\u0131 \u0131l\u0131ml\u0131 bir etkinlik\ng\u00f6stermi\u015ftir. Test edilen tek ana bile\u015fenler aras\u0131nda neral en aktifti\n(MIC ve MFC de\u011ferleri 5% 0.25). Mevcut \u00e7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131, baz\u0131 tahlil\nedilmi\u015f EO’lar\u0131n in vivo kullan\u0131m\u0131 i\u00e7in umut verici g\u00f6r\u00fcnmektedir.<\/p>\n\n\n\n

7-)Biochemical\ncharacterization of Helichrysum italicum (Roth) G.Don subsp. italicum (Asteraceae) from Montenegro:\nphytochemical screening, chemotaxonomy, and antioxidant properties.<\/h4>\n\n\n\n

DOI:10.1002 \/ cbdv.201400174<\/a><\/p>\n\n\n\n

Kimyasal bile\u015fimi ve bir\nu\u00e7ucu bitki ya\u011f\u0131 ve \u00d6lmez EtOH \u00f6z\u00fc (antioksidan \u00f6zellikleri Helichrysum italicum (Roth) G.Don subsp. \u0130talicumKarada\u011f’da toplanan Asteraceae)\nde\u011ferlendirildi. U\u00e7ucu ya\u011f GC \/ MS analizi ile karakterize edildi ve EtOH\nekstrakt\u0131ndaki toplam fenoliklerin ve flavonoidlerin i\u00e7eri\u011fi Folin\uf8ffCiocalteu\nreaktifi kullan\u0131larak belirlendi. Hem esans ya\u011f\u0131n\u0131n hem de EtOH\nekstrakt\u0131n\u0131n serbest radikal s\u00fcp\u00fcrme kapasitesi (RSC),\n2,2-difenil-1-pikrilhidrazil (DPPH) y\u00f6ntemi ile de\u011ferlendirildi. Ayr\u0131ca,\nhidroksil radikali ((.) OH) \u00fcretiminin, \u00f6l\u00fcms\u00fcz\u00fcn EtOH \u00f6z\u00fc ile inhibisyonu\nburada ilk kez de\u011ferlendirildi. Neril asetat (% 28.2) ve p-curcumene (%\n18.8) esansiyel ya\u011fdaki ana bile\u015fiklerdi, bunu neril propionat (% 9.1) ve\nar-curcumene (% 8.3) izledi. \u0130ncelenen ve ilave 16 se\u00e7ilmi\u015f Helichrysum italicum ya\u011flar\u0131n\u0131n kimyasal\nbile\u015fimiLiterat\u00fcrde tan\u0131mlanan taksonlar ana bile\u015fen (PCA) ve k\u00fcme (CA)\nanalizleri kullan\u0131larak kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131. \u0130statistiksel analizlerin\nsonu\u00e7lar\u0131, u\u00e7ucu ya\u011flar\u0131n en az d\u00f6rt farkl\u0131 ana ve \u00fc\u00e7 subkimotipinin ortaya\n\u00e7\u0131kmas\u0131n\u0131 ima etti. Antioksidan \u00f6zellikleri g\u00f6z \u00f6n\u00fcne al\u0131nd\u0131\u011f\u0131nda,\n\u00f6l\u00fcms\u00fcz\u00fcn EtOH \u00f6z\u00fct\u00fc, propil gallat ve quercetin ile benzer bir potansiyel\nsergilerken, esansiyel ya\u011f nispeten zay\u0131f DPPH (.) Temizleme kapasitesi\nsergilemi\u015ftir.<\/p>\n\n\n\n

8-)Helichrysum italicum: from traditional use to scientific data.<\/h4>\n\n\n\n

DOI:10.1016\/j.jep.2013.11.005<\/a><\/p>\n\n\n\n

ETNOFARMAKOLOJ\u0130K \u0130L\u0130\u015eK\u0130:<\/h4>\n\n\n\n

Helichrysum italicum (Roth) G. Don fil. (Asteraceae ailesi) t\u0131bbi\n\u00f6zellikleri i\u00e7in uzun s\u00fcredir kullan\u0131lmaktad\u0131r ve g\u00fcn\u00fcm\u00fczde bile Akdeniz\n\u00fclkelerinin geleneksel t\u0131bb\u0131nda \u00f6nemli bir rol oynamaya devam etmektedir. Bu\ngeleneksel bilgiye dayanarak, farkl\u0131 farmakolojik aktiviteleri aktif\nara\u015ft\u0131rman\u0131n oda\u011f\u0131 olmu\u015ftur. Bu derleme, Helichrysum italicum’un farmakolojik\naktivitelerinin yan\u0131 s\u0131ra geleneksel kullan\u0131mlar\u0131, toksisitesi, ila\u00e7\netkile\u015fimleri ve g\u00fcvenli\u011fi hakk\u0131ndaki mevcut bilgi durumu hakk\u0131nda genel\nbir bak\u0131\u015f sunmay\u0131 ama\u00e7lamaktad\u0131r .<\/p>\n\n\n\n

MALZEMELER VE Y\u00d6NTEMLER:<\/h4>\n\n\n\n

\u0130lgili verilerin\nse\u00e7imi anahtar kelimeler “kullanarak bir arama yoluyla yap\u0131ld\u0131\u011f\u0131 Herdemye\u015fil \u0131talicum ” ve “H. \u0131talicum ” “DOI Yay\u0131n Dizin” de,\n“Google Scholar”, “ISI Web of Knowledge”,\n“PubMed”, “ScienceDirect “ve” Wiley Online K\u00fct\u00fcphanesi\n“. Yerli ve yabanc\u0131 kitaplarda ve di\u011fer kaynaklarda elde edilen\nbilgiler de dahil edilmi\u015ftir.<\/p>\n\n\n\n

SONU\u00c7LAR:<\/h4>\n\n\n\n

Helichrysum italicum’un Avrupa \u00fclkelerinde, \u00f6zellikle \u0130talya, \u0130spanya,\nPortekiz ve Bosna-Hersek’in geleneksel kullan\u0131m\u0131 hakk\u0131nda raporlar\nbulunmaktad\u0131r . Bu \u00fclkelerde, \u00e7i\u00e7ekleri ve yapraklar\u0131 alerji, so\u011fuk\nalg\u0131nl\u0131\u011f\u0131, \u00f6ks\u00fcr\u00fck, cilt, karaci\u011fer ve safra kesesi bozukluklar\u0131, iltihaplanma,\nenfeksiyonlar ve uykusuzluk gibi sa\u011fl\u0131k bozukluklar\u0131n\u0131n tedavisinde en \u00e7ok\nkullan\u0131lan par\u00e7alard\u0131r. Helichrysum italicum’un geleneksel\nkullan\u0131mlar\u0131ndan baz\u0131lar\u0131n\u0131 do\u011frulamak ve \u00f6zleri ve izole edilmi\u015f\nbile\u015fikleri i\u00e7in di\u011fer potansiyel uygulamalar\u0131 vurgulamak i\u00e7in, son y\u0131llarda\n\u00e7e\u015fitli bilimsel \u00e7al\u0131\u015fmalar yap\u0131lm\u0131\u015ft\u0131r. Helichrysum italicum’u tan\u0131mlayan\nin vitro \u00e7al\u0131\u015fmalarbir antimikrobiyal ve anti-enflamatuar ajan\nolarak. Flavonoidleri ve terpenler bakterilere (\u00f6rn. Staphylococcus\naureus), asetofenonlar\u0131na, floroglucinollere ve terpenoidlere kar\u015f\u0131 Candida\nalbicans’a kar\u015f\u0131 antifungal etki g\u00f6sterdi ve flavonoidleri ve floroglucinolleri\nHSV ve HIV’i inhibe etti. Helichrysum italicum asetofenonlar,\nflavonoidler ve floroglucinoller, ara\u015fidonik asit metabolizmas\u0131n\u0131n ve di\u011fer\npro-enflamatuar arac\u0131lar\u0131n farkl\u0131 yollar\u0131nda inhibe edici etki\ng\u00f6stermi\u015ftir. Helichrysum italicum Hakk\u0131ndain\nvivo aktivitede, vurgu, hem hayvanlarda hem de insanlarda g\u00f6sterilen\nflavonoidlerinin anti-eritemat\u00f6z ve foto-koruyucu aktivitelerine ve hayvan\nmodellerinde g\u00f6r\u00fcld\u00fc\u011f\u00fc gibi flavonoidler, asetofenonlar ve floroglucinollerin\nsergiledi\u011fi anti-enflamatuar \u00f6zelliklere gider. G\u00fcvenlik ve yan etkileri\nile ilgili olarak, Helichrysum italicum \u00f6nemli\nd\u00fczeyde sitotoksisite veya genotoksisite sergilemese de, flavonoidlerinden\nbirinin baz\u0131 CYP izoformlar\u0131n\u0131 inhibe etti\u011fi ve ekstraktlar\u0131na alerjik bir\nreaksiyon oldu\u011fu bildirilmelidir.<\/p>\n\n\n\n

SONU\u00c7LAR:<\/h4>\n\n\n\n

Helichrysum italicum , umut verici farmakolojik aktiviteleri olan t\u0131bbi\nbir bitkidir. Bununla birlikte, geleneksel olarak iddia edilen uygulamalar\u0131n\u0131n\n\u00e7o\u011fu hen\u00fcz bilimsel olarak kan\u0131tlanmam\u0131\u015ft\u0131r. Bu verileri daha da\ndo\u011frulamak ve Helichrysum italicum’u \u00e7e\u015fitli\nhastal\u0131klar\u0131n tedavisinde \u00f6nemli bir ara\u00e7 olarak tan\u0131tmak i\u00e7in klinik\n\u00e7al\u0131\u015fmalara ihtiya\u00e7 vard\u0131r .<\/p>\n\n\n\n

9-)Antimicrobial phenolics and unusual glycerides from Helichrysum italicum subsp.\nmicrophyllum.<\/h4>\n\n\n\n

DOI:10.1021\/np3007149<\/a><\/p>\n\n\n\n

Helichrysum italicum subsp.’den\nheterodimerik floroglusinil piron arzanol (la) i\u00e7in b\u00fcy\u00fck \u00f6l\u00e7ekli bir izolasyon\nkampanyas\u0131 s\u0131ras\u0131nda mikrofilum, birka\u00e7 yeni fenolik ve santinol (5a-c,\n6-8) ad\u0131 verilen al\u0131\u015f\u0131lmad\u0131k bir lipit s\u0131n\u0131f\u0131 karakterize\nedilmi\u015ftir. Santinoller, dallanm\u0131\u015f asil- veya keto-asil zincirlerinin\nvarl\u0131\u011f\u0131 ile karakterize edilen ve \u015fimdiye kadar bildirilmemi\u015f bir bitki\nlipitleri s\u0131n\u0131f\u0131n\u0131 temsil eden anteloylenmi\u015f gliseritlerdir. Arzanol\u00fcn\nve kumarit, benzofuran, piron ve heterodimerik floroglucinol i\u00e7eren bir\ndizi Helichrysum fenolikinin\nantibakteriyel aktivitesi de\u011ferlendirildi, bu da sadece heterodimerlerin\n\u00e7ok ilaca diren\u00e7li Staphylococcus aureus izolatlar\u0131na kar\u015f\u0131 g\u00fc\u00e7l\u00fc\nantibakteriyel etki g\u00f6sterdi\u011fini g\u00f6sterdi. Bu g\u00f6zlemler, topikal\nkullan\u0131m\u0131nHelichrysum , Akdeniz b\u00f6lgesinin\ngeleneksel t\u0131bb\u0131nda s\u0131k\u0131 bir \u015fekilde kurulmu\u015f bir uygulama olan yara enfeksiyonlar\u0131n\u0131\n\u00f6nlemek i\u00e7in \u00f6zler<\/p>\n\n\n\n

10-)Arzanol, a prenylated heterodimeric phloroglucinyl pyrone,\ninhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in\nvivo.<\/h4>\n\n\n\n

DOI:10.1016\/j.bcp.2010.09.025<\/a><\/p>\n\n\n\n

T h\u00fccrelerinde in vitro\nHIV-1 replikasyonunu inhibe etme kapasitesine ve monositlerde pro-enflamatuar\nsitokinlerin sal\u0131nmas\u0131na ba\u011fl\u0131 olarak, prenillenmi\u015f heterodimerik floroglucinil\na-pirone arzanol, Helichrysum italicum’dan ana\nanti-enflamatuar ve anti-viral bile\u015fen olarak tan\u0131mland\u0131. Arzanol\u00fcn\npro-enflamatuar eikosanoidlerin biyosentezi \u00fczerindeki aktivitesini ara\u015ft\u0131rd\u0131k,\nanti-enflamatuar etkinli\u011fini in vitro ve in vivo de\u011ferlendirdik. Arzanol,\nn\u00f6trofillerdeki 5-lipoksijenaz (EC 7.13.11.34) aktivitesini ve ilgili l\u00f6kotrien\nolu\u015fumunun yan\u0131 s\u0131ra siklooksijenaz (COX) -1 (EC 1.14.99.1) aktivitesini ve\nCOX-2’den t\u00fcretilen prostaglandin (PG) olu\u015fumunu inhibe etti. E (2) in vitro\n(IC (50) = 2.3-9\u03bcM). Ayr\u0131nt\u0131l\u0131 \u00e7al\u0131\u015fmalar, arzanol\u00fcn \u00f6ncelikle COX-2\nyerine mikrozomal PGE (2) sentaz (mPGES) -1 (EC 5.3.99.3, IC (50) = 0.4\u03bcM)\ninhibe etti\u011fini ortaya koymu\u015ftur. Asl\u0131nda arzanol, lipopolisakkarit ile\nuyar\u0131lm\u0131\u015f insan monositlerinde ve insan tam kan\u0131nda COX-2 \/ mPGES-1 arac\u0131l\u0131 PGE\n(2) biyosentezini engelleyebilir, ancak e\u015f zamanl\u0131 COX-2’den t\u00fcretilmi\u015f\ntromboksan B (2) veya 6’n\u0131n biyosentezini engelleyemez. -keto PGF (la), ve\nCOX-2 veya mPGES-1 proteininin ifadesi etkilenmemi\u015ftir. Arzanol,\ns\u0131\u00e7anlarda karagenan kaynakl\u0131 pl\u00f6rezi iltihaplanma tepkisini g\u00fc\u00e7l\u00fc bir \u015fekilde\nbast\u0131rd\u0131 (3.6 mg \/ kg, ip), plevral eks\u00fcdalarda \u00f6nemli \u00f6l\u00e7\u00fcde azalt\u0131lm\u0131\u015f PGE\n(2) seviyeleri ile. Birlikte ele al\u0131nd\u0131\u011f\u0131nda, verilerimiz arzanol\u00fcn PGE\n(2) gibi pro-enflamatuar lipit arac\u0131lar\u0131n\u0131n in vitro ve in vivo biyosentezini\ng\u00fc\u00e7l\u00fc bir \u015fekilde inhibe etti\u011fini ve H’nin anti-enflamatuar aktivitesi i\u00e7in\nmekanik bir gerek\u00e7e sa\u011flad\u0131\u011f\u0131n\u0131 g\u00f6stermektedir.italicum ve\nbu yeni anti-enflamatuar lead’in klinik \u00f6ncesi de\u011ferlendirilmesi i\u00e7in bir\ngerek\u00e7e.<\/p>\n\n\n\n

11-)Arzanol, an anti-inflammatory and\nanti-HIV-1 phloroglucinol alpha-Pyrone from Helichrysum italicum ssp. microphyllum.<\/h4>\n\n\n\n

DOI:10.1021\/np060581r<\/a><\/p>\n\n\n\n


\nHelichrysum italicum’un bir aseton \u00f6z\u00fct\u00fcssp. microphyllum,\ng\u00fc\u00e7l\u00fc bir NF-kappaB inhibit\u00f6r\u00fc olarak floroglusinol alfa-piron arzanol\u00fc (la)\nverdi. Arzanol, yap\u0131s\u0131 revize edilmesi gereken homoarenol (2a) ile\nayn\u0131d\u0131r. Arzanol\u00fcn floroglusinol tipi yap\u0131s\u0131 ve homoarenol\u00fcn baz kaynakl\u0131\nfragmantasyon \u00fcr\u00fcn\u00fcn\u00fcn 1,2,4-trihidroksifenil tipi yap\u0131s\u0131, aromatik\nk\u0131s\u0131m. Bu bulgulara dayanarak, klinik olarak faydal\u0131 antibiyotik\narenarinin ana bile\u015feni olan arenol\u00fcn yap\u0131s\u0131, biyojenetik t\u00fcrevi \u00fczerinde uzun\nzamand\u0131r devam eden bir bulmacay\u0131 \u00e7\u00f6zerek 2b’den 1b’ye revize\nedilmelidir. Bir alfa-piron (mikropiron, 7), monoterpen rac-E-omega-oleoiloksilinalol\n(10), bilinen d\u00f6rt tremeton (9a-d), ve dimerik piron helipiron (8) da elde\nedilmi\u015ftir. Arzanol, T h\u00fccrelerinde HIV-1 replikasyonunu ve LPS ile\nuyar\u0131lan primer monositlerde pro-enflamatuar sitokinlerin sal\u0131nmas\u0131n\u0131 inhibe\netti ve yeni bir bitki t\u00fcrevi antienflamatuar ve antiviral kemotip olarak\nara\u015ft\u0131rmaya de\u011fer.<\/p>\n\n\n\n

12-)Influence of environmental factors\non composition of volatile constituents and biological activity of Helichrysum italicum (Roth)\nDon (Asteraceae). <\/h4>\n\n\n\n

DOI:10.1080\/1478641042000261969<\/a><\/p>\n\n\n\n

Calabria ve Sardunya’da\n(\u0130talya) yeti\u015fen Helichrysum italicum (Roth)\nDon’un biyolojik \u00e7e\u015fitlili\u011fi bildirildi. Bu t\u00fcr, kimyasal\nbelirte\u00e7lerin (alfa-terpinolen, trans-kariof\u0131len ve neril asetat) GC ve GC-MS\nile saptanmas\u0131, izole edilmesi ve kantitatif de\u011ferlendirmesi ile karakterize\nedilmi\u015ftir. Metanolik H. italicum’un antioksidan aktivitesiDPPH ve\nbeta-karoten a\u011fartma testi kullan\u0131larak elde edilen ekstraktlar, Calabrian\n\u00f6rneklerinin Sardinya’dan daha aktif oldu\u011funu g\u00f6sterdi. T\u00fcm ekstraktlar\u0131n\nantibakteriyel aktivitesi, Gram pozitif bakteriler \u00fczerinde \u00f6zellikle\nMicrococcus luteus \u00fczerinde en iyi performans\u0131 g\u00f6sterdi. Ayr\u0131ca, t\u00fcm\nekstraktlar\u0131n antifungal aktivitesi, \u00f6zellikle fitopatojen mantar Pythium\nultimum \u00fczerinde \u00f6nemli sonu\u00e7lar ortaya koyan test edildi. Genel olarak,\nantifungal aktivite ile ilgili olarak, Sardunya’dan elde edilen ekstraktlar\nCalabria’dan daha aktiftir. Fitokimyasal analiz ve biyolojik aktivite\nverileri, bu bitki matrislerinin beslenme, kozmetik ve farmas\u00f6tik alanlar\u0131nda\nolas\u0131 bir kullan\u0131m\u0131n\u0131 \u00f6nerdi.<\/p>\n\n\n\n

13-)Evaluation of antiherpesvirus-1 and\ngenotoxic activities of Helichrysum italicum extract.<\/h4>\n\n\n\n

PMID:12585233<\/p>\n\n\n\n

Helichrysum italicum’un (Compositae) \u00e7i\u00e7ekli \u00fcstlerinden dietil eter ekstrakt\u0131n\u0131n\nantiherpes vir\u00fcs\u00fc-1 ve genotoksik aktiviteleri ara\u015ft\u0131r\u0131ld\u0131. Ekstrakt\n400 ila 100 mikrog \/ ml aras\u0131ndaki konsantrasyonlarda \u00f6nemli antiviral aktivite\ng\u00f6sterdi. Bu aktivite ekstrakt\u0131n sitotoksik etkisine ba\u011fl\u0131 de\u011fildi \u00e7\u00fcnk\u00fc\nVero h\u00fccreleri daha y\u00fcksek konsantrasyonda (800 mikrog \/ ml) sitotoksik\netkilerin g\u00f6stergesi olan de\u011fi\u015fen morfoloji veya b\u00fcy\u00fcme \u00f6zellikleri\nsergiledi. Ayr\u0131ca H. italicum ekstrakt\u0131\n2000 mikrog \/ diske kadar konsantrasyonlarda DNA’ya zarar veren aktivite\ng\u00f6stermemi\u015ftir.<\/p>\n\n\n\n

14-)Chemical composition, plant genetic\ndifferences, and antifungal activity of the essential oil of Helichrysum italicum G.\nDon ssp. microphyllum (Willd) Nym.<\/h4>\n\n\n\n

DOI:10,1021 \/ jf025940c<\/a><\/p>\n\n\n\n

Sardunyal\u0131 c\u00fcce k\u00f6ri bitkisinin u\u00e7ucu ya\u011f\u0131n\u0131n kimyasal bile\u015fimi [ Helichrysum italicum G. Don\nssp. microphyllum (Willd) Nym] incelendi. Genetik analiz iki\nkemotipin varl\u0131\u011f\u0131n\u0131 ortaya koydu; morfolojik ve kimyasal farkl\u0131l\u0131klar iki\nkemotipin (A ve B) varl\u0131\u011f\u0131n\u0131 do\u011frulad\u0131. Maksimum verimler, \u00e7i\u00e7ekli \u00fcst\nk\u0131s\u0131mlar ve g\u00f6vdeler i\u00e7in s\u0131ras\u0131yla% 0.18 ve% 0.04 (h \/ h) idi. Nerol ve\nesterleri (asetat ve propionat), limonen ve linalool konsantrasyonlar\u0131, hem\n\u00e7i\u00e7eklenme hem de saplarda \u00e7i\u00e7eklenme a\u015famas\u0131nda en y\u00fcksek de\u011ferlerine\nula\u015f\u0131r. DOI:<\/p>\n\n\n\n

15-)Anti-inflammatory and antioxidant\nproperties of Helichrysum italicum.<\/h4>\n\n\n\n

DOI:10,1211 \/ 0022357021778600<\/a><\/p>\n\n\n\n

Helichrysum italicum’un hava k\u0131sm\u0131n\u0131n anti-enflamatuar ve antioksidan\naktiviteleriekstraktlar \u00e7e\u015fitli in-vivo ve in-vitro deneysel modellerde\nolu\u015fturulmu\u015ftur. Fare kula\u011f\u0131nda 12-O-tetradekanoilphorbol 13-asetat (TPA)\nve etil fenilpropiolat taraf\u0131ndan ind\u00fcklenen akut \u00f6demlerde, TPA’n\u0131n tekrar\ntekrar uygulanmas\u0131yla ind\u00fcklenen kronik enflamasyonda serotonin ve fosfolipaz\nA2 (PLA2) ile elde edilen sonu\u00e7lar fare kula\u011f\u0131nda ve koyun k\u0131rm\u0131z\u0131 kan\nh\u00fccrelerinin neden oldu\u011fu gecikmi\u015f tip a\u015f\u0131r\u0131 duyarl\u0131l\u0131k \u00fczerinde, bahsedilen\nanti-enflamatuar aktivitenin, kortikoid benzeri bir mekanizma yoluyla ifade\nedilen bile\u015fiklerin etkilerinden kaynakland\u0131\u011f\u0131n\u0131 d\u00fc\u015f\u00fcnd\u00fcrmektedir. Ek\nolarak, ekstraktlar\u0131n antioksidan aktivitesi, bu enzimatik ve enzimatik olmayan\nlipit peroksidasyonunu inhibe etti\u011fi ve serbest radikal s\u00fcp\u00fcr\u00fcc\u00fc \u00f6zelliklere\nsahip oldu\u011fu i\u00e7in bu anti-enflamatuar aktivitede rol oynamaktad\u0131r. Sonu\u00e7\nolarak anti-inflamatuar aktivite g\u00f6zlendi.Helichrysum italicum ,\nenflamatuar enzim inhibisyonu, serbest radikal s\u00fcp\u00fcr\u00fcc\u00fc aktivite ve kortikoid\nbenzeri etkiler dahil olmak \u00fczere \u00e7oklu etkilerle a\u00e7\u0131klanabilir.<\/p>\n\n\n\n

16-)Effects of Helichrysum italicum extract\non growth and enzymatic activity of Staphylococcus aureus.<\/h4>\n\n\n\n

DOI:10.1016 \/ s0924-8579 (01) 00.336-3<\/a><\/p>\n\n\n\n

Helichrysum italicum G. Don (Compositae) Akdeniz b\u00f6lgelerinin kuru, kumlu ve ta\u015fl\u0131\nalanlar\u0131nda yayg\u0131n olarak bulunan bir \u00e7al\u0131d\u0131r. Bu bitki, anti-enflamatuar,\nanti-alerjik ve antimikrobiyal aktivitesi ile bilinir. Bu \u00e7al\u0131\u015fman\u0131n amac\u0131,\ndietil eter ekstrakt\u0131n\u0131n Staphylococcus aureus (ATCC 6538P, MRSA ve MSSA\nizolatlar\u0131) b\u00fcy\u00fcmesi \u00fczerindeki etkisini ve vir\u00fclans fakt\u00f6rleri olarak kabul\nedilen baz\u0131 enzimler \u00fczerindeki minimum inhibit\u00f6r konsantrasyonlar\u0131n\n(subMIC’ler) etkisini de\u011ferlendirmektir. Sonu\u00e7lar, H. italicum ekstrakt\u0131n\u0131n S. aureus su\u015flar\u0131 \u00fczerinde\nhem b\u00fcy\u00fcmelerini hem de koag\u00fclaz, DNAz, termon\u00fckleaz ve lipaz gibi baz\u0131\nenzimleri azaltan inhibit\u00f6r bir etkiye sahip oldu\u011funu\ng\u00f6stermektedir . Herdemye\u015fil italicum \u00f6z,\nyeni bir antimikrobiyal ajan, insan derisi ve dokular\u0131 i\u00e7in daha az toksik\nolabilir, daha fazla \u00e7al\u0131\u015fmaya lay\u0131k olabilir.<\/p>\n\n\n\n

17-)Arzanol, a\npotent mPGES-1 inhibitor: novel anti-inflammatory agent.<\/h4>\n\n\n\n

DOI:10.1155\/2013\/986429<\/a><\/p>\n\n\n\n

Arzanol, bir Akdeniz\nbitkisi Helichrysum italicum’dan izole\nedilmi\u015f yeni bir floroglucinol a-pironudur(Roth) Don ssp. Asteraceae\nfamilyas\u0131na ait mikrofilum. Arzanol’\u00fcn \u00e7e\u015fitli farmakolojik aktivitelere\nsahip oldu\u011fu bildirilmi\u015ftir. Bununla birlikte, anti-enflamatuar, anti-HIV\nve antioksidan aktiviteler biraz ayr\u0131nt\u0131l\u0131 olarak incelenmi\u015ftir. Arzanol\u00fcn\nenflamatuar transkripsiyon fakt\u00f6r\u00fc NF \u03baB aktivasyonunu, T h\u00fccrelerinde HIV\nreplikasyonunu, IL-1 \u03b2, IL-6, IL-8 ve TNF-a’n\u0131n sal\u0131n\u0131m\u0131n\u0131 ve potansiyel olarak\nmPGES-1 enzimini inhibe ederek PGE\u2082’nin biyosentezini inhibe etti\u011fi\nbildirilmi\u015ftir. . Arzanol\u00fcn etki mekanizmalar\u0131n\u0131n \u00e7e\u015fitlili\u011fi, otoimm\u00fcn\nhastal\u0131klar ve kanser gibi bu enflamatuar arac\u0131lar\u0131 i\u00e7eren hastal\u0131\u011f\u0131n\ntedavisinde faydal\u0131 olabilir. Bu derleme arzanol\u00fcn kimyas\u0131, yap\u0131-aktivite\nili\u015fkisi ve farmakolojik aktiviteleri hakk\u0131nda kapsaml\u0131 bilgiler sunmaktad\u0131r.<\/p>\n\n\n\n

18-)Chemical and biological studies on\ntwo Helichrysum species of Greek origin.<\/h4>\n\n\n\n

DOI:10.1055\/s-2006-957914<\/a><\/p>\n\n\n\n


\nHelichrysum amorginum ve H. italicum’un hava\nk\u0131s\u0131mlar\u0131ndan elde edilen u\u00e7ucu ya\u011flar\u0131n kimyasal bile\u015fimi GC ve GC \/ MS\nile analiz edildi. \u0130ki ya\u011f\u0131n s\u0131ras\u0131yla% 89.98’ini ve% 82.06’s\u0131n\u0131 temsil\neden yirmi be\u015f bile\u015fenden, ana bile\u015fenler sarduniol, sardunil asetat, neril\nasetat ve nerolidol idi. Ayr\u0131ca, ya\u011flar\u0131n test edilen alt\u0131 Gram (+\/-)\nbakteriye kar\u015f\u0131 kesin antibakteriyel aktivite sergiledi\u011fi bulunmu\u015ftur.<\/p>\n\n\n\n

19-)Helichrysum italicum<\/em> (Roth)\nG. Don: Taxonomy, biological activity, biochemical and genetic diversity<\/h4>\n\n\n\n
https:\/\/doi.org\/10.1016\/j.indcrop.2019.111487<\/a><\/h6>\n\n\n\n

Helichrysum italicum<\/em> (Roth) G. Don,\nAsteraceae familyas\u0131ndan \u00e7ok y\u0131ll\u0131k bir termofilustur. \u00c7ok y\u00f6nl\u00fc biyolojik\nfaaliyetler ve uygulamalar nedeniyle, Helichrysum italicum<\/em> bilimsel\nara\u015ft\u0131rma ve kullan\u0131m\u0131na olan ilgi son birka\u00e7 on y\u0131lda\nartm\u0131\u015ft\u0131r. Sonu\u00e7 olarak, artan end\u00fcstriyel talep nedeniyle, ekimi \u00e7iftli\u011fi\nDo\u011fu Avrupa Akdeniz \u00fclkelerinde b\u00fcy\u00fck bir geni\u015fleme ya\u015fad\u0131. Bu derleme\nmakalesinin amac\u0131 Helichrysum italicum hakk\u0131ndaki<\/em> mevcut\nverileri sunmakt\u0131.bilgideki bo\u015fluklar\u0131 ve gelecekteki potansiyel ara\u015ft\u0131rmalar\nve konuya katk\u0131lar i\u00e7in a\u00e7\u0131kl\u0131klar\u0131 belirlemek. Scopus veri taban\u0131n\u0131n\nincelemesi yap\u0131ld\u0131 ve 1990’dan 2019’daki en son yay\u0131nlara kadar yap\u0131lan\nbilimsel \u00e7al\u0131\u015fmalar \u00f6zetlendi. Makale son g\u00f6zden ge\u00e7irilmi\u015f taksonomiyi,\nmorfolojik \u00f6zellikleri, co\u011frafi da\u011f\u0131l\u0131m\u0131, kullan\u0131mlar\u0131, kimyasal \u00e7e\u015fitlili\u011fi,\nbiyolojik aktiviteyi (antimikrobiyal, antiviral, antioksidan, antienflamatuar,\nkovucu ve b\u00f6cek \u00f6ld\u00fcr\u00fcc\u00fc aktivite) ve genetik \u00e7e\u015fitlili\u011fi i\u00e7erir. Ek\nolarak, di\u011fer baz\u0131 potansiyel kullan\u0131mlar da a\u00e7\u0131klanmaktad\u0131r. Mevcut\nbilimsel verilerin \u00e7o\u011fu u\u00e7ucu ya\u011f\u0131n kimyasal bile\u015fimine odaklanm\u0131\u015ft\u0131r,\nancak Helichrysum italicum’un<\/em> yeti\u015ftirme y\u00f6netimi hakk\u0131nda \u00e7ok\naz \u015fey bilinmektedir.ekim gereksinimleri, fide \u00fcretimi, bitki yo\u011funlu\u011fu,\ng\u00fcbreleme ve beslenme gereksinimleri, hasat, hastal\u0131klar, b\u00f6cekler ve yabanc\u0131\not kontrol\u00fc i\u00e7erir. Helichrysum italicum<\/em> hakk\u0131nda genetik\nbilgi de azd\u0131r, ancak Helichrysum italicum’un<\/em> gelecek\nyeti\u015ftirme programlar\u0131 ve yeni \u00e7e\u015fitlerin se\u00e7imi i\u00e7in\ngereklidir .<\/p>\n\n\n\n

20-)Evaluation\nof the antioxidant and cytotoxic activity of arzanol, a prenylated \u03b1-pyrone\u2013phloroglucinol\netherodimer from Helichrysum italicum<\/em> subsp.microphyllum<\/em><\/h4>\n\n\n\n

https:\/\/doi.org\/10.1016\/j.cbi.2006.11.006<\/a><\/p>\n\n\n\n

Helichrysum italicum<\/em> G.\nDon (Compositae) Akdeniz b\u00f6lgelerinin kuru, kumlu ve ta\u015fl\u0131 alanlar\u0131nda yayg\u0131n\nolarak bulunan bir \u00e7al\u0131d\u0131r. Bu bitki, anti-enflamatuar, anti-alerjik ve\nantimikrobiyal aktivitesi ile bilinir. Bu \u00e7al\u0131\u015fman\u0131n amac\u0131, dietil eter\nekstrakt\u0131n\u0131n Staphylococcus aureus<\/em> (ATCC 6538P, MRSA ve\nMSSA izolatlar\u0131) b\u00fcy\u00fcmesi \u00fczerindeki etkisini ve vir\u00fclans fakt\u00f6rleri\nolarak kabul edilen baz\u0131 enzimler \u00fczerindeki minimum inhibit\u00f6r konsantrasyonlar\u0131n\n(subMIC’ler) etkisini de\u011ferlendirmektir. Sonu\u00e7lar, H. italicum<\/em> ekstrakt\u0131n\u0131n S.\naureus<\/em> su\u015flar\u0131 \u00fczerinde hem b\u00fcy\u00fcmelerini hem de koag\u00fclaz,\nDNAz, termon\u00fckleaz ve lipaz gibi baz\u0131 enzimleri azaltan inhibit\u00f6r bir\netkiye sahip oldu\u011funu g\u00f6stermektedir . Helichrysum ye\u015fil\nitalicum<\/em> \u00f6z, yeni bir antimikrobiyal ajan, insan derisi ve dokular\u0131\ni\u00e7in daha az toksik olabilir, daha fazla \u00e7al\u0131\u015fmaya lay\u0131k olabilir.<\/p>\n\n\n\n

21-)166 Helichrysum italicum<\/em> essential\noil prevents skin lipids peroxidation caused by pollution and UV<\/h4>\n\n\n\n
https:\/\/doi.org\/10.1016\/j.jid.2017.07.476<\/a><\/h6>\n\n\n\n

D\u0131\u015f sald\u0131r\u0131lara kar\u015f\u0131 ilk kalkan\nderidir. Ultraviyole (UV) ve kirlili\u011fe kronik maruziyet, lipidlerden, DNA\nve protein hasar\u0131ndan sorumlu olan oksidatif strese neden olur ve bu da\niltihaplanma, akne ve erken cilt ya\u015flanmas\u0131na neden olur. Bu \u00e7al\u0131\u015fman\u0131n\namac\u0131 Helichrysum italicum’un<\/em> antioksidan \u00f6zelliklerini\nde\u011ferlendirmekti.(u\u00e7ucu ya\u011f (HIEO). 104 811.5 \u03bcmol Trolox e\u015fde\u011feri \/ 100g\nde\u011feri. ORAC testinde elde edilen, HIEO’nun peroksit radikalini emme\nkabiliyetinin g\u00fc\u00e7l\u00fc oldu\u011funu g\u00f6stermi\u015ftir. Konjuge dien y\u00f6nteminde\nlipozomlar\u0131n hidroksil radikali taraf\u0131ndan bozunmas\u0131ndan korunmas\u0131nda da etkili\nolmu\u015ftur (% 0.1’de% -73.6 bozunma). Cilt y\u00fczeyinin ana antioksidan\u0131 olan\nlipofilik E vitamini (Vit E) kandan ya\u011f bezleri yoluyla ta\u015f\u0131n\u0131r. T\u00fckenmesi\nartan sebum peroksidasyonu ile ili\u015fkilidir. Daha ozon alt\u0131nda skualen\noksidasyon \u00f6nlenir basitle\u015ftirilmi\u015f sebum modeli,% 0.1 ve% 1 HIEO olarak\nskualen kullan\u0131larak (O 3<\/sub> :% 19.7 ve% 32 koruma) ayn\u0131\nkonsantrasyonlarda (% 18.6 ve% 26.9) de vitamin E daha. Tekli oksijen\nalt\u0131nda ( 1<\/sup> O 2<\/sub>HIEO ve Vit E de\u011ferleri%\n0.1 (% 22 ve% 26.7 koruma) ile kar\u015f\u0131la\u015ft\u0131r\u0131labilirken, daha y\u00fcksek\nkonsantrasyonda (% 1’de% 42.1) sadece HIEO etkinli\u011fi artm\u0131\u015ft\u0131r. HIEO ve\nVit E i\u00e7eren bir kozmetik \u00fcr\u00fcn\u00fc, form\u00fcl O alt\u0131nda daha y\u00fcksek bir koruma\ng\u00f6sterdi 3<\/sub> (29.9%) ve 1<\/sup> O 2<\/sub> ,\niki bile\u015fik aras\u0131nda bir sinerji g\u00f6stermektedir (% 59.1) maruz\nkalma. Kentsel alanda ya\u015fayan 51 g\u00f6n\u00fcll\u00fc, form\u00fcl\u00fc 2 ay boyunca g\u00fcnde iki\nkez y\u00fcze uygulad\u0131. Al\u0131ndaki Sebum 0. G\u00fcn (D0), D28 ve D56’da\ntopland\u0131. D0 D28 aras\u0131nda skualen monoperoxide (SQOOH)%<\/sup> 28\nazalm\u0131\u015ft\u0131r *<\/sup> Vit E% *<\/sup> ( *<\/sup>p\n<0.0001). D56’da, bu de\u011ferler stabilize olma e\u011filimi g\u00f6stererek cilt\nantioksidan dengesinin geri y\u00fcklendi\u011fini g\u00f6sterir. Birlikte ele\nal\u0131nd\u0131\u011f\u0131nda, bu sonu\u00e7lar Helichrysum italicum<\/em> esansiyel\nya\u011f\u0131n\u0131n cildi kirlili\u011fe ve UV kaynakl\u0131 oksidatif strese kar\u015f\u0131\nkoruyabilece\u011fini d\u00fc\u015f\u00fcnd\u00fcrmektedir . Radikal s\u00fcp\u00fcr\u00fcc\u00fc \u00f6zellikleri\nVit E’yi tamamlay\u0131c\u0131 gibi g\u00f6z\u00fckmektedir. Kombinasyonlar\u0131 cildi tek ba\u015f\u0131na Vit E\nkonsantrasyonunu artt\u0131rmaktan daha iyi koruyabilir.<\/p>\n\n\n\n

22-)Antibacterial, antifungal and\nantiviral bioactivities of selected Helichrysum<\/em> species<\/h4>\n\n\n\n
https:\/\/doi.org\/10.1016\/j.sajb.2018.09.009<\/a><\/h6>\n\n\n\n

Helichrysum<\/em> t\u00fcrleri \u00e7e\u015fitli\nt\u0131bbi durumlar\u0131 tedavi etmek i\u00e7in yayg\u0131n olarak kullan\u0131lmaktad\u0131r. Bu\n\u00e7al\u0131\u015fmada,H. araxinum<\/em>Takht gibi Helichrysum <\/em>t\u00fcr\u00fcnden elde\nedilen 14 ekstrakt. ex KIRP.,H. armenium<\/em>DC,H. arenarium<\/em>,H.\npallasii<\/em>,H. Stoechas<\/em>,H. sanguineum<\/em>veH. graveolens<\/em>kendi\ni\u00e7in taranm\u0131\u015ft\u0131r. (Asteraceae)in vitro<\/em>anti-bakteriyel, anti-mantar, ve\nantiviral etkinlikleri ara\u015ft\u0131r\u0131lm\u0131\u015ft\u0131r. Antibakteriyel ve antifungal\naktiviteler, Gram negatifin standart ve izole su\u015flar\u0131na (E. coli<\/em>,P.\naeruginosa<\/em>,P. mirabilis) kar\u015f\u0131 de\u011ferlendirildi.<\/em><\/a>, K. pneumoniae<\/em> , A. baumanni<\/em> )\nve Gram pozitif ( S. aureus, E. faecalis<\/em> ) bakterilerin yan\u0131\ns\u0131ra mikrodil\u00fcsyon y\u00f6ntemi ile mantarlar ( Candida albicans<\/a><\/em> , C.\nparapsilosis<\/em> ) da ara\u015ft\u0131r\u0131ld\u0131. Klinik ve Laboratuvar\nStandartlar\u0131 Enstit\u00fcs\u00fc’ne (CLSI; eski ad\u0131yla NCCLS) g\u00f6re duyarl\u0131l\u0131k testi\nyapt\u0131k. \u0130nsan patojenleri olarak Helichrysum’un <\/em>su\nve etanol ekstraktlar\u0131n\u0131n antiviral de\u011ferlendirmesi i\u00e7in hem Herpes\nsimpleks<\/em> vir\u00fcs\u00fc Tip-1 ( HSV <\/em>-1), bir DNA vir\u00fcs\u00fc<\/a> ve bir RNA vir\u00fcs\u00fc<\/a> Parainfluenza-<\/em> 3 vir\u00fcs\u00fc ( PI <\/em>-3) kullan\u0131ld\u0131. T\u00fcm\nekstraktlar Gram pozitif bakterilere<\/a> (16\nila 64 \u03bcg \/ mL aras\u0131nda) kar\u015f\u0131 Gram negatif (8-64 \u03bcg \/ mL) ‘den daha g\u00fc\u00e7l\u00fc\nantibakteriyel aktivite g\u00f6sterirken 8 \u03bcg \/ mL konsantrasyonda \u00f6nemli\nantifungal aktivite g\u00f6stermi\u015ftir. Ekstraktlar\u0131n antifungal aktivitelerinin\nrutin klinik kullan\u0131mda antifungal ajanlara yak\u0131n oldu\u011fu\nbulunmu\u015ftur. \u00d6zellikle, t\u00fcm etanolik ekstraktlar\u0131n 8 ug \/ mL MIC\nde\u011feri ile S. aureus’a <\/em>kar\u015f\u0131 daha iyi inhibisyon g\u00f6sterdi\u011fi\nbulunmu\u015ftur . Bu arada, etanolik ekstreler , H. arenarium<\/em> ve H.\narmenium<\/em> DC \u00f6nemli antiviral hem de kar\u015f\u0131 aktivite g\u00f6sterdi HSV<\/em> 1\nve PI<\/em>3; sitopatik etki olmadan, s\u0131ras\u0131yla 2-32 ve 4-64 \u03bcg \/\nmL aral\u0131\u011f\u0131nda. T\u00fcm aktiviteler toksik olmayan konsantrasyonlarda\nde\u011ferlendirildi. Helichrysum arenarium<\/em> ve H.\narmenium<\/em> DC, biyoaktivite a\u00e7\u0131s\u0131ndan test edilen ekstreler aras\u0131nda en\ndikkat \u00e7ekici t\u00fcrler olarak bulunmu\u015ftur.<\/p>\n\n\n\n

23-)Compositions, antioxidant and\nantimicrobial activities of Helichrysum<\/em> (Asteraceae) species\ncollected from Turkey<\/h4>\n\n\n\n

https:\/\/doi.org\/10.1016\/j.foodchem.2009.06.003<\/a><\/p>\n\n\n\n

16 Helichrysum<\/em> t\u00fcr\u00fcn\u00fcn metanolik\n\u00f6zleri, in vitro<\/em> antioksidan, radikal s\u00fcp\u00fcr\u00fcc\u00fc ve\nantimikrobiyal aktiviteleri a\u00e7\u0131s\u0131ndan ara\u015ft\u0131r\u0131ld\u0131 . T\u00fcm\nekstreler g\u00fc\u00e7l\u00fc antioksidan ve radikal s\u00fcp\u00fcr\u00fcc\u00fc aktivite\ng\u00f6stermi\u015ftir. 194.64  mg \/ g kuru ekstrakt\u0131n askorbik asit\ne\u015fde\u011ferleri (AAE) olarak en y\u00fcksek toplam antioksidan kapasitesi ,\nfosfomolybdenum testinde Helichrysum noeanum<\/em> i\u00e7in elde\nedildi . En y\u00fcksek IC 50<\/sub> de\u011feri\n(7.95  ug \/ ml) ekstresi i\u00e7in g\u00f6zlenmi\u015ftir Helichrysum\nStoechas<\/em> subsp. barellieri<\/em> DPPH\nanalizinde. Ekstraktlar\u0131n toplam fenolik i\u00e7eri\u011fi 66.74 ila 160.63 aras\u0131nda\nde\u011fi\u015fmektedir. mg gallik asit e\u015fde\u011ferleri (GAE) \/ g kuru\nekstrakt. Ekstraktlarda bulunan ana bile\u015fen, klorojenik asit, ard\u0131ndan\napigenin-7-glukozit ve apigenin olarak HPLC analizi ile tan\u0131mland\u0131. T\u00fcm\nekstreler, agar dif\u00fczyon y\u00f6nteminde 13 bakteri ve iki maya i\u00e7eren\nmikroorganizmalara kar\u015f\u0131 \u00f6nemli antimikrobiyal aktivite g\u00f6stermi\u015ftir.<\/p>\n\n\n\n

24-)A\nnew acetophenone derivative from flowers of Helichrysum italicum<\/em> (Roth)\nDon ssp. italicum<\/em><\/h4>\n\n\n\n

https:\/\/doi.org\/10.1016\/j.fitote.2014.09.019<\/a><\/p>\n\n\n\n

Gnaphaliol 9-0-<\/em> propanoat\n( 1<\/strong> ) adl\u0131 yeni bir asetofenon\nt\u00fcrevi , Helichrysum italicum<\/em> ssp. italicum<\/em> \u00e7i\u00e7ekleri\nile birlikte bilinen be\u015f asetofenon 12-asetoksiremeton ( 2<\/strong> ),\n13- (2-metilpropanoiloksi) toksol ( 3<\/strong> ),\n[2,3-dihidro-2- [1- (hidroksimetil) etenil] -5-benzofuranil] – etanon ( 4<\/strong> ),\n1- [2- [1 – [(asetiloksi) metil] etenil] -2,3-dihidro-3-hidroksi-5-benzofuranil]\n-etanon ( 5<\/strong> ) ve gnaphaliol ( 6<\/strong> ). Bile\u015fiklerin\nyap\u0131lar\u0131 1<\/strong> – 6<\/strong> 1D- da\ndahil olmak \u00fczere geni\u015f bir spektroskopik y\u00f6ntemler ile ayd\u0131nlat\u0131lm\u0131\u015ft\u0131r ((1<\/sup> ,\nH’dir ve 13<\/sup> \u00b0 C) ve DQF-COSY 2D-NMR (, HSQC, HMBC, TOCSY\nve ROESY) deneyleri yan\u0131 s\u0131ra ESIMS analizi). \u0130zole edilen bile\u015fikler,\nsitotoksisiteleri, anti-enflamatuar ve antioksidan \u00f6zellikleri a\u00e7\u0131s\u0131ndan\nara\u015ft\u0131r\u0131ld\u0131. \u0130nsan kolonik epitel h\u00fccreleri \u00fczerindeki biyolojik\nanalizler, bile\u015fik 2’nin<\/strong> reaktif oksijen t\u00fcrlerinin\n(ROS) \u00fcretimini azaltan antioksidan etkilere sahip oldu\u011funu g\u00f6sterdi.<\/p>\n","protected":false},"excerpt":{"rendered":"

1-)Chemical composition and antimicrobial activity of essential oil of Helichrysum italicum (Roth) G. Don fil. (Asteraceae) from Montenegro. DOI:10.1080\/14786419.2018.1538218 Karada\u011f Helichrysum italicum (Roth) esansiyel ya\u011f\u0131 \u00fczerine deneysel bir ara\u015ft\u0131rma G. Don fil. (Asteraceae) rapor edilmi\u015ftir. U\u00e7ucu ya\u011f, hem s\u0131v\u0131 hem de buhar fazlar\u0131nda analiz edildi. S\u0131v\u0131 ya\u011f\u0131n gaz kromatografisi-k\u00fctle spektrometresi analizi, seskiterpenlerin \u03b2- eudesmene (% 21.65) ve \u03b2- bisabolen (% 19.90) ile b\u00fcy\u00fck \u00e7o\u011funlu\u011funu g\u00f6sterdi . Monoterpen fraksiyonu esas olarak a-pinen (% 16.90) […]<\/p>\n","protected":false},"author":1,"featured_media":185,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-58","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-literatur"],"yoast_head":"\n\u00d6LMEZ \u00c7\u0130\u00c7EK (HEL\u0130CHRYSUM \u0130TAL\u0130CUM) - Dr. \u00d6zberk Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blog.drozberk.com\/index.php\/2020\/04\/13\/helichrysum-italicum\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00d6LMEZ \u00c7\u0130\u00c7EK (HEL\u0130CHRYSUM \u0130TAL\u0130CUM) - Dr. \u00d6zberk Blog\" \/>\n<meta property=\"og:description\" content=\"1-)Chemical composition and antimicrobial activity of essential oil of Helichrysum italicum (Roth) G. Don fil. (Asteraceae) from Montenegro. DOI:10.1080\/14786419.2018.1538218 Karada\u011f Helichrysum italicum (Roth) esansiyel ya\u011f\u0131 \u00fczerine deneysel bir ara\u015ft\u0131rma G. 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