{"id":65,"date":"2020-04-13T11:54:20","date_gmt":"2020-04-13T08:54:20","guid":{"rendered":"https:\/\/blog.drozberk.com\/?p=65"},"modified":"2020-05-09T04:46:27","modified_gmt":"2020-05-09T01:46:27","slug":"calendula-officinalis","status":"publish","type":"post","link":"https:\/\/blog.drozberk.com\/index.php\/2020\/04\/13\/calendula-officinalis\/","title":{"rendered":"AYNISEFA (CALENDULA OFF\u0130C\u0130NAL\u0130S)"},"content":{"rendered":"\n

MAKALE 1-)https:\/\/scihub.bban.top\/10.1007\/s00432-020-03124-x
How to bridge the gap? European medical plants used for treating oral mucositis: on the search for evidence<\/strong>
Oral mukozit, kanser tedavisinin (\u00f6rn. I\u015f\u0131nlanma) veya sistemik (\u00f6rn. Kemoterapi) olmas\u0131 gibi kanser tedavisinin yayg\u0131n, a\u011fr\u0131l\u0131 bir yan etkisidir. Fitoterapi genellikle hastalar taraf\u0131ndan semptomlar\u0131 hafifletmek i\u00e7in kullan\u0131l\u0131r. Bununla birlikte, hangi t\u0131bbi bitkilerin Geleneksel Avrupa T\u0131bb\u0131 (TEM) ile ilgili literat\u00fcr taraf\u0131ndan \u00f6nerildi\u011fi, bunlar\u0131n semptomlar \u00fczerindeki etkileri ve etkinlikleri hakk\u0131nda ciddi bilgi yoktur. Bu nedenle, TEM’de kullan\u0131lan bitkisel bitkilerin geleneksel bilgilerini de\u011ferlendirmek i\u00e7in yeni bir yakla\u015f\u0131m geli\u015ftirdik ve bu bitkilerin etkilerini bildiren \u00e7al\u0131\u015fmalar i\u00e7in \u00e7evrimi\u00e7i veritabanlar\u0131n\u0131 ara\u015ft\u0131rd\u0131k.
Y\u00d6NTEMLER:
\u0130lk ba\u015fta, \u00e7evrimi\u00e7i ara\u015ft\u0131rma tatmin edici say\u0131da \u00e7al\u0131\u015fma vermedi (MESH terimleri: “mukozit” VEYA “stomatit” VE “bitkisel” VEYA “bitkisel ila\u00e7”). Denemeler, \u00e7al\u0131\u015fmay\u0131 y\u00fcr\u00fcten \u00fclke taraf\u0131ndan etiketlendi. Paralel olarak, TEM ile ilgili 14 kitab\u0131 tarayarak oral mukozit tedavisi i\u00e7in \u00f6nerilen 78 bitkinin bir listesini derledik. Daha sonra, en s\u0131k bahsedilen bitkilerden olu\u015fan bir “hit list” olu\u015fturuldu ve Latin bitki adlar\u0131n\u0131 MESH terimi olarak kullanan ikinci bir \u00e7evrimi\u00e7i ara\u015ft\u0131rma i\u00e7in daha fazla kullan\u0131ld\u0131. Her iki \u00e7evrimi\u00e7i arama da analiz i\u00e7in bir araya getirildi.
SONU\u00c7LAR:
Geleneksel bilgi ile TEM taraf\u0131ndan kullan\u0131lan t\u0131bbi bitkileri ara\u015ft\u0131ran denemeler aras\u0131nda bir bo\u015fluk vard\u0131r. Genel olarak, bitkisel ila\u00e7lar oral mukoziti ve \u00f6zellikle di\u015f eti iltihab\u0131n\u0131 hafifletir. Matricaria recutita L., Salvia officinalis L., Calendula officinalis L. ve Thymus spp. L. oral mukozit tedavisi i\u00e7in.
SONU\u00c7:
TEM’de bilinen t\u0131bbi bitkileri ara\u015ft\u0131ran klinik \u00e7al\u0131\u015fmalar nadirdir. Bununla birlikte, ara\u015ft\u0131rma stratejimizi takiben, oral mukozit ve di\u015f eti iltihab\u0131 semptomlar\u0131n\u0131 hafifletmek i\u00e7in iyi kan\u0131tlarla d\u00f6rt bitki tahmin edebiliriz. <\/p>\n\n\n\n


MAKALE 2-)https:\/\/scihub.bban.top\/10.1136\/bmjopen-2019-031876
Efficacy of a topical herbal and mineral formulation (Dynamiclear) for the treatment of herpes simplex labialis in the community setting: study protocol for a randomised, double-blind placebo-controlled trial.<\/strong><\/p>\n\n\n\n

G\u0130R\u0130\u015e:
Herpes simpleks labialis (HSL), oral mukozada yayg\u0131n olarak u\u00e7uk olarak adland\u0131r\u0131lan a\u011fr\u0131l\u0131 lezyonlara neden olabilen yayg\u0131n bir enfeksiyondur. Mevcut biyomedikal tedaviler, atak s\u00fcresini ortalama 0.5 g\u00fcn azaltan topikal asiklovir i\u00e7erir. Bu \u00e7al\u0131\u015fma, tezgah \u00fcst\u00fc topikal tedavinin, HSL epizodlar\u0131n\u0131n s\u00fcresini ve \u015fiddetini azaltmada Dynamiclear’\u0131n etkinli\u011fini ve tolere edilebilirli\u011fini inceleyecektir.
Y\u00d6NTEM VE ANAL\u0130Z:
Bu prospektif, randomize, \u00e7ift-k\u00f6r, plasebo kontroll\u00fc, \u00e7ok merkezli deneme, Avustralya ve Yeni Zelanda’da ba\u015flang\u0131\u00e7tan sonraki 48 saat i\u00e7inde so\u011fuk alg\u0131nl\u0131\u011f\u0131 ile ba\u015fvuran en az 292 yeti\u015fkin kat\u0131l\u0131mc\u0131y\u0131 i\u015fe alacakt\u0131r. Topikal Dynamiclear (aktif) veya plasebo almak i\u00e7in rastgele 2: 1 oran\u0131nda tahsis edilecektir. Dynamiclear’\u0131n aktif bile\u015fenleri Hypericum perforatum , Calendula Officinalis’dir.ve bak\u0131r s\u00fclfat. Aktif veya plasebo i\u00e7in tek bir topikal tedavi, eczane tabanl\u0131 bir ara\u015ft\u0131rmac\u0131 taraf\u0131ndan uygulanacak ve kat\u0131l\u0131mc\u0131lara \u00fclserle\u015fmi\u015f lezyonlardan herpes vir\u00fcs\u00fcn\u00fcn 1 veya 2 varl\u0131\u011f\u0131n\u0131 do\u011frulamak i\u00e7in bir viral swab kiti sa\u011flanacakt\u0131r. Kat\u0131l\u0131mc\u0131lar, g\u00f6rsel bir k\u0131lavuz kullanarak so\u011fuk yara lezyonlar\u0131n\u0131 de\u011ferlendiren ve iyile\u015fene kadar say\u0131sal \u00f6l\u00e7eklerde di\u011fer semptomlar\u0131 kaydeden \u00e7evrimi\u00e7i bir g\u00fcnl\u00fck g\u00fcnl\u00fc\u011f\u00fcn\u00fc tamamlamak i\u00e7in e-posta ve \/ veya SMS yoluyla hat\u0131rlat\u0131c\u0131lar alacaklar. Birincil sonu\u00e7 de\u011fi\u015fkeni, sunumdan normal cilde d\u00f6nmek i\u00e7in g\u00fcn cinsinden (kat\u0131l\u0131mc\u0131 de\u011ferlendirilir) HSL b\u00f6l\u00fcm\u00fcn\u00fcn ortalama s\u00fcresidir. Sekonder sonu\u00e7lar, semptomatik fazda lezyon a\u011fr\u0131s\u0131n\u0131n \u015fiddeti, ka\u015f\u0131nt\u0131, yanma ve kar\u0131ncalanma ve \u00fclserasyona ilerleyen lezyonlar\u0131n oran\u0131n\u0131 i\u00e7erir.<\/p>\n\n\n\n


MAKALE 3-)
Evolution of a diabetic foot wound with the use of calendula: A single-case experimental design.<\/strong><\/p>\n\n\n\n


\u00d6ZET:Yap\u0131lan deney sonucunda tek bir hasta \u00fczerinde g\u00f6zle g\u00f6r\u00fcl\u00fcr bir iyile\u015fme g\u00f6z\u00fckm\u00fc\u015ft\u00fcr.Makalenin i\u00e7erisinde y\u00f6ntemler anlat\u0131lm\u0131\u015f ve g\u00f6rsellerle a\u00e7\u0131klanm\u0131\u015ft\u0131r.Sonu\u00e7 olarak Calendula\u2019n\u0131n etkisi g\u00f6r\u00fclm\u00fc\u015ft\u00fcr fakat bu konu \u00fczerinde yeterince klinik \u00e7al\u0131\u015fma yap\u0131lmas\u0131 gerekmektedir.<\/p>\n\n\n\n


MAKALE 4-)https:\/\/scihub.bban.top\/10.1111\/wrr.12737
A systematic review of Calendula officinalis extract for wound healing.<\/strong><\/p>\n\n\n\n


Yara iyile\u015fmesi i\u00e7in tamamlay\u0131c\u0131 ve alternatif t\u0131bb\u0131n kullan\u0131m\u0131 ana t\u0131bbi uygulamay\u0131 etkilemektedir. Bu sistematik derleme Calendula officinalis’in rol\u00fcn\u00fc de\u011ferlendirir in vivo yara iyile\u015fmesi kontrol\u00fc ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda monoterapi olarak \u00e7i\u00e7ek \u00f6z\u00fc. Aramalar PubMed, EMBASE, Cochrane Kontroll\u00fc \u00c7al\u0131\u015fmalar Merkezi Kay\u0131t Defteri, CINAHL ve Scopus’ta (Nisan 2018’e kadar) 7 hayvan deneyi ve 7 klinik denemeyi i\u00e7eren 14 \u00e7al\u0131\u015fma ile dahil edildi. Akut yara iyile\u015fmesi incelemesinden elde edilen bulgular, ekstrakt ile tedavi edilen test gruplar\u0131nda gran\u00fclasyon dokusu \u00fcretiminin artmas\u0131yla inflamasyon faz\u0131n\u0131n daha h\u0131zl\u0131 \u00e7\u00f6z\u00fclmesini g\u00f6sterdi. Bu bulgular be\u015f hayvan \u00e7al\u0131\u015fmas\u0131nda ve bir randomize klinik \u00e7al\u0131\u015fmada tutarl\u0131yd\u0131. Kronik yara iyile\u015fme \u00e7al\u0131\u015fmalar\u0131 \u00e7e\u015fitlidir. Ven\u00f6z \u00fclserler \u00fczerinde yap\u0131lan iki klinik kontrol \u00e7al\u0131\u015fmas\u0131, kontrollere k\u0131yasla \u00fclser y\u00fczey alan\u0131n\u0131 azaltt\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Bir ba\u015fka randomize klinik \u00e7al\u0131\u015fma, nergis i\u00e7in herhangi bir iyile\u015fme g\u00f6stermedibacak \u00fclseri iyile\u015fmesinde grup. Yan\u0131k iyile\u015fmesi de benzer \u015fekilde kar\u0131\u015f\u0131k sonu\u00e7lar verdi. \u0130ki hayvan \u00e7al\u0131\u015fmas\u0131 , yan\u0131k yaralanmas\u0131ndan \u00f6nce nergis \u00f6z\u00fct\u00fcn\u00fcn uygulanmas\u0131 i\u00e7in profilaktik bir etki g\u00f6stermi\u015ftir . K\u0131smi ila tam kal\u0131nl\u0131kta yan\u0131klardan muzdarip hastalar\u0131n randomize klinik \u00e7al\u0131\u015fmas\u0131, kontrollere k\u0131yasla nergis ekstrakt\u0131n\u0131n topikal uygulamas\u0131 i\u00e7in hi\u00e7bir fayda g\u00f6stermedi . \u0130ki randomize klinik \u00e7al\u0131\u015fma, radyasyon sonras\u0131 dermatiti \u00f6nleme potansiyelini de\u011ferlendirdi, bir \u00e7al\u0131\u015fma trolamine k\u0131yasla iyile\u015fme g\u00f6sterirken, di\u011feri aqua jel kremine k\u0131yasla iyile\u015fme bulamad\u0131. Hayvan \u00e7al\u0131\u015fmalar\u0131, inflamasyon faz\u0131ndan daha iyi iyile\u015fme ve nergiste gran\u00fclasyon dokusu \u00fcretiminin artmas\u0131 i\u00e7in orta d\u00fczeyde kan\u0131t sa\u011flar\u00f6z\u00fct tedavi gruplar\u0131. Bu derleme , geleneksel t\u0131ptaki rol\u00fc ile tutarl\u0131 olarak C. officinalis ekstrakt\u0131n\u0131n yara iyile\u015fmesi i\u00e7in yararl\u0131 etkileri i\u00e7in baz\u0131 kan\u0131tlar tan\u0131mlam\u0131\u015ft\u0131r . Calendula’n\u0131n komplikasyonlar da dahil olmak \u00fczere yara iyile\u015fmesi \u00fczerindeki etkisini de\u011ferlendirmek i\u00e7in daha b\u00fcy\u00fck, iyi tasarlanm\u0131\u015f randomize kontrol \u00e7al\u0131\u015fmalar\u0131na ihtiya\u00e7 vard\u0131r
MAKALE 5-)
https:\/\/scihub.bban.top\/https:\/\/doi.org\/10.4103\/jfmpc.jfmpc_121_17
The impact of calendula ointment on cesarean wound healing: A randomized controlled clinical trial.<\/strong>
Sezaryen en yayg\u0131n cerrahi m\u00fcdahalelerden biridir. Yara komplikasyonlar\u0131 sezaryen sonras\u0131 en s\u0131k g\u00f6r\u00fclen morbiditelerden biridir. Calendula , yara iyile\u015fmesini destekler ve yara iyile\u015fme s\u00fcresini k\u0131saltmada etkili olabilir. Bu merhemin sezaryen yara iyile\u015fmesi \u00fczerindeki etkisi incelenmedi\u011fi i\u00e7in bu bitkinin iyile\u015fmesi ile ilgili s\u0131n\u0131rl\u0131 ara\u015ft\u0131rmalar yap\u0131lm\u0131\u015ft\u0131r. Bu nedenle, bu \u00e7al\u0131\u015fman\u0131n amac\u0131 ilkel kad\u0131nlarda nergis sezaryen yara iyile\u015fmesi \u00fczerindeki etkisini incelemekti .
Y\u00d6NTEM:
Bu klinik \u00e7al\u0131\u015fma, Akbar-Abadi E\u011fitim Hastanesi’ne kabul edilen cerrahi do\u011fum yapan 72 kalifiye primipal\u0131 di\u015fiyi kapsamaktad\u0131r. Bunlar rastgele iki deney grubu ( n = 1) ve kontrol ( n = 2) grubuna ayr\u0131ld\u0131. Deney grubundaki kad\u0131nlarda 12 saatte bir calendula merhemi, kontrol grubunda ise 10 g\u00fcn hastane rutini kullan\u0131ld\u0131. Yara iyile\u015fmesi 3 de\u011ferlendirildi rd , 6 th , 9 thREEDA \u00f6l\u00e7e\u011fi (REEDA, k\u0131zar\u0131kl\u0131k, \u00f6dem, ekimoz, ak\u0131nt\u0131 ve yakla\u015f\u0131kl\u0131k gibi kriterleri olan) k\u0131zar\u0131kl\u0131k, \u00f6dem, ekimoz, ak\u0131nt\u0131 ve yakla\u015f\u0131kl\u0131k anlam\u0131na gelir. Veriler demografik anket ve k\u0131zar\u0131kl\u0131k ile toplanm\u0131\u015f, \u00f6dem veri analizi i\u00e7in Ki-kare testi ve ba\u011f\u0131ms\u0131z T-testi kullan\u0131lm\u0131\u015ft\u0131r.
SONU\u00c7LAR:
\u00c7al\u0131\u015fmaya yetmi\u015f iki kad\u0131n dahil edildi. \u0130la\u00e7 grubunda 36, kontrol grubunda 36 olgu incelendi. \u0130ki gruptaki hastalar\u0131n ya\u015flar\u0131 aras\u0131nda anlaml\u0131 fark yoktu (s\u0131ras\u0131yla 27\/17 \u00b1 4\/72, 28\/97 \u00b1 4\/99 y\u0131l; P = 0\/276). Ayr\u0131ca, incelenen gruplar aras\u0131nda hastalar\u0131n e\u011fitim d\u00fczeyi ve kocalar\u0131, annenin i\u015fi ve ekonomik durum a\u00e7\u0131s\u0131ndan anlaml\u0131 bir fark yoktu.
SONU\u00c7:
Sonu\u00e7lara g\u00f6re, calendula merhem kullan\u0131m\u0131 sezaryen yara iyile\u015fme h\u0131z\u0131n\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde artt\u0131r\u0131r, b\u00f6ylece sezaryen iyile\u015fmesini h\u0131zland\u0131rmak i\u00e7in kullan\u0131labilir.
MAKALE 6-)
https:\/\/scihub.bban.top\/10.1016\/j.yrtph.2018.07.027
Screening of acute and sub-chronic dermal toxicity of Calendula officinalis L essential oil.<\/strong>
\u00c7al\u0131\u015fman\u0131n amac\u0131 akut ve sub-kronik dermal toksisiteyi inceleyerek Calendula esansiyel ya\u011f\u0131n\u0131n g\u00fcvenli\u011fine ula\u015fmakt\u0131r . Calendula esansiyel ya\u011f\u0131n\u0131n dermal toksisiteleri, s\u0131ras\u0131yla 402 ve 411 numaral\u0131 OECD y\u00f6nergelerine g\u00f6re de\u011ferlendirildi. Hayvanlar Calendula officinalis’e maruz b\u0131rak\u0131ld\u0131(CO) akut dermal toksisite i\u00e7in v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131 20 mL \/ kg esansiyel ya\u011f dozu iken, dermal sub-kronik toksisite \u00e7al\u0131\u015fmas\u0131 i\u00e7in s\u0131\u00e7anlar, 90 g\u00fcn boyunca bir hafta. Parametre \u00e7al\u0131\u015fmalar\u0131 aras\u0131nda CNS stim\u00fclasyonu, depresyon, hematolojik parametreler (RBC, WBC, Hb, Lenfosit% vb.), Biyokimyasal parametreler (toplam protein, alb\u00fcmin, toplam bilirubin, ALP, AST, vb.), Ba\u011f\u0131l organ a\u011f\u0131rl\u0131\u011f\u0131, nekropsi ve histopatoloji bulunmaktad\u0131r. Toksisite \u00e7al\u0131\u015fmalar\u0131nda, t\u00fcm hayvanlar hematoloji, kan biyokimyas\u0131, nekroskopik ve histopatolojide herhangi bir de\u011fi\u015fiklik olmadan normal davran\u0131\u015f sergilemi\u015ftir. CO ya\u011f\u0131n\u0131n g\u00f6zlenmeyen etki seviyesi (NOEL) ve g\u00f6zlenmeyen yan etki seviyesi (NOAEL) s\u0131ras\u0131yla 2.5 ve 10 mg \/ kg \/ g\u00fcn idi.50 20 kg \/ kg v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131 de\u011feri. Sonu\u00e7, CO esansiyel ya\u011f\u0131n\u0131n \u00f6nemli bir toksik etki \u00fcretmedi\u011fini g\u00f6stermektedir.
MAKALE 7-) PMID:30000917
CALENDULA OFF\u0130C\u0130NAL\u0130S <\/strong>
Calendula ( Calendula officinalis ) \u00e7i\u00e7ekleri, triterpen glikozitler ve aglikonlar, karotenoidler ve u\u00e7ucu ya\u011flar i\u00e7erir. Calendula \u00fcr\u00fcnlerinin topikal uygulamas\u0131, homeopatik veya farmakolojik preparatlarda hem\u015firelik s\u0131ras\u0131nda a\u011fr\u0131l\u0131 ve \u00e7atlam\u0131\u015f meme u\u00e7lar\u0131n\u0131 tedavi etmek i\u00e7in kullan\u0131lm\u0131\u015ft\u0131r [1] [2] [3]. Kontrols\u00fcz bir vaka serisi, Mimosa tenuiflora ve Calendula officinalis i\u00e7eren bir kremin emzirme s\u0131ras\u0131nda \u00e7atlam\u0131\u015f meme u\u00e7lar\u0131n\u0131 iyile\u015ftirmek i\u00e7in yararl\u0131 oldu\u011funu bulmu\u015ftur ; [5] Bununla birlikte, bir kontrol grubunun olmamas\u0131 ve ba\u015fka bir bile\u015fenin varl\u0131\u011f\u0131, calendula’n\u0131n etkinli\u011fini de\u011ferlendirmeyi imkans\u0131z k\u0131lmaktad\u0131r. Oral nergisEmzirme d\u00f6neminde emzirme ile ilgili spesifik kullan\u0131mlar\u0131 yoktur ve nergislerin oral kullan\u0131m\u0131 hakk\u0131nda bilgi mevcut de\u011fildir . Calendula , baharat veya aroma olarak kullan\u0131ld\u0131\u011f\u0131nda ABD G\u0131da ve \u0130la\u00e7 \u0130daresi taraf\u0131ndan bir g\u0131da olarak “genel olarak g\u00fcvenli” olarak kabul edilir (GRAS). Kas\u0131mpat\u0131, papatyalar ve kadife \u00e7i\u00e7e\u011fi \u00e7apraz reaksiyonlar\u0131 da dahil olmak \u00fczere alerjik reaksiyonlar nadiren g\u00f6r\u00fcl\u00fcr. Diyet takviyeleri, ABD G\u0131da ve \u0130la\u00e7 \u0130daresi taraf\u0131ndan kapsaml\u0131 bir pazarlama \u00f6ncesi onay gerektirmez. \u00dcreticiler g\u00fcvenli\u011fi sa\u011flamaktan sorumludur, ancak kan\u0131tlamalar\u0131 gerekmezdiyet takviyelerinin pazarlanmadan \u00f6nce g\u00fcvenli\u011fi ve etkinli\u011fi. Diyet takviyeleri birden fazla bile\u015fen i\u00e7erebilir ve genellikle etiketli ve ger\u00e7ek bile\u015fenler veya miktarlar\u0131 aras\u0131nda farkl\u0131l\u0131klar bulunur. Bir \u00fcretici bir \u00fcr\u00fcn\u00fcn veya i\u00e7indeki maddelerden kalitesini do\u011frulamak i\u00e7in ba\u011f\u0131ms\u0131z bir \u00f6rg\u00fct anla\u015fma yapabiliriz, ama bu yok de\u011fil , bir \u00fcr\u00fcn\u00fcn g\u00fcvenli\u011fini veya etkinli\u011fini do\u011frular\u0131m. Yukar\u0131daki sorunlar nedeniyle, bir \u00fcr\u00fcndeki klinik test sonu\u00e7lar\u0131 di\u011fer \u00fcr\u00fcnler i\u00e7in ge\u00e7erli olmayabilir. Diyet takviyeleri hakk\u0131nda daha ayr\u0131nt\u0131l\u0131 bilgi:LactMed Web
MAKALE 8-)https:\/\/scihub.bban.top\/10.3390\/antiox4020293
A Review of the Use of Topical Calendula in the Prevention and Treatment of Radiotherapy-Induced Skin Reactions.<\/strong>
Calendula , Calendula Officinalis bitkisinden elde edilen topikal bir ajand\u0131r . \u00c7ok say\u0131da polifenolik antioksidan i\u00e7eren kalendula , radyasyona ba\u011fl\u0131 cilt toksisitesinin tedavisinde ve \u00f6nlenmesinde kullan\u0131m i\u00e7in hem laboratuvarda hem de klinik ortamda \u00e7al\u0131\u015f\u0131lm\u0131\u015ft\u0131r. Calendula’n\u0131n radyasyona ba\u011fl\u0131 cilt toksisitesini \u00f6nlemedeki etki mekanizmas\u0131n\u0131 destekleyen g\u00fc\u00e7l\u00fc kan\u0131tlara ra\u011fmen , klinik \u00e7al\u0131\u015fmalar kar\u0131\u015f\u0131k sonu\u00e7lar g\u00f6stermi\u015ftir.
MAKALE 9-) DOI:10.7860\/JCDR\/2015\/11984.6626
Comparison of Antimicrobial Efficacy of Triclosan- Containing, Herbal and Homeopathy Toothpastes- An Invitro Study.<\/strong>
Antimikrobiyal ajanlar\u0131n kullan\u0131m\u0131, oral hastal\u0131klar\u0131 \u00f6nlemek i\u00e7in \u00f6nemli stratejilerden biridir. Bu ajanlar \u00f6nleyici ve terap\u00f6tik faydalar sa\u011flama yeteneklerinde farkl\u0131l\u0131k g\u00f6sterir.
AMA\u00c7:
Bu invitro \u00e7al\u0131\u015fmas\u0131, farkl\u0131 di\u015f macunlar\u0131n\u0131n \u00e7e\u015fitli oral patojenlere kar\u015f\u0131 antimikrobiyal etkinli\u011fini de\u011ferlendirmek i\u00e7in yap\u0131ld\u0131.
MALZEMELER VE Y\u00d6NTEMLER:
\u00dc\u00e7 gruptaki toplam dokuz di\u015f macunu, Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 25923), Streptococcus mutans (ATCC 0266P) ve Candida albicans’a (Laboratuvar Su\u015fu) kar\u015f\u0131 modifiye agar kuyu dif\u00fczyon y\u00f6ntemi ile antimikrobiyal aktiviteleri a\u00e7\u0131s\u0131ndan test edildi. \u0130statistiksel Analiz Minitab Yaz\u0131l\u0131m\u0131 kullan\u0131larak yap\u0131ld\u0131. 0.05’ten d\u00fc\u015f\u00fck bir p de\u011feri anlaml\u0131 kabul edildi.
SONU\u00c7LAR:
Flor\u00fcr (1000ppm) kombinasyonu ile triklosan bazl\u0131 di\u015f form\u00fclasyonu, test organizmalar\u0131na kar\u015f\u0131 d\u00fc\u015f\u00fck flor\u00fcr konsantrasyonu veya sodyum monoflorofosfat kombinasyonundan daha y\u00fcksek antimikrobiyal aktivite sergiledi. Bitkisel di\u015f macunlar\u0131 aras\u0131nda Neem, Pudina, Long, Babool, Zerde\u00e7al ve Vajradanti i\u00e7eren form\u00fclasyonlar test edilen d\u00f6rt mikroorganizmaya kar\u015f\u0131 \u00f6nemli antimikrobiyal aktivite g\u00f6sterdi (p <0.05). Bununla birlikte, Streptococcus mutans’a kar\u015f\u0131, her \u00fc\u00e7 bitkisel \u00fcr\u00fcn de \u00f6nemli antimikrobiyal aktivite g\u00f6sterdi. Homeo \u00fcr\u00fcnleri test edilen su\u015flar \u00fczerinde en az antimikrobiyal aktivite g\u00f6sterdi. Kreosotum, Plantago major ve calendula ile form\u00fclasyon sadece Streptococcus mutans’a kar\u015f\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde etkiliydi.
SONU\u00c7:
Bu \u00e7al\u0131\u015fmada, aktif bile\u015fenler olarak hem triklosan hem de flor\u00fcr (1000 ppm) i\u00e7eren di\u015f macununun antimikrobiyal aktivitesi, test edilen d\u00f6rt mikrofloraya kar\u015f\u0131 d\u00fc\u015f\u00fck flor\u00fcr konsantrasyonu veya sodyum monoflorofosfat ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda \u00f6nemli bir fark (p <0.05) g\u00f6stermi\u015ftir. Bitkisel gruplardan, birka\u00e7 fitokimyasal i\u00e7eren tek di\u015f temizleme maddesinin, triklosan-flor\u00fcr (1000ppm) form\u00fclasyonu ile \u00f6nemli \u00f6l\u00e7\u00fcde etkili ve kar\u015f\u0131la\u015ft\u0131r\u0131labilir oldu\u011fu bulunmu\u015ftur. B\u00f6ylece, bu bitkisel di\u015f macunu, triklosan bazl\u0131 form\u00fclasyonlara alternatif olarak kullan\u0131labilir. Bununla birlikte, invivo test edilmedik\u00e7e bu sonu\u00e7lar klinik olarak yararl\u0131 olmayabilir.
MAKALE 10-)https:\/\/scihub.bban.top\/10.1155\/2015\/709628
Anti-Aging Potential of Phytoextract Loaded-Pharmaceutical Creams for Human Skin Cell Longetivity.<\/strong><\/p>\n\n\n\n

Ultraviyole radyasyonlara (UVR) maruz kalma, cilt g\u00fcne\u015f yan\u0131\u011f\u0131n\u0131n anahtar kayna\u011f\u0131d\u0131r; zararl\u0131 olu\u015fumlar, reaktif oksijen t\u00fcrleri (ROS) \u00fcreterek ya\u015flanmaya neden olabilir. Cilt, krem gibi \u00e7e\u015fitli farmas\u00f6tik form\u00fclasyonlar kullan\u0131larak ROS’un zararl\u0131 etkilerinden tedavi edilebilir ve korunabilir. Krem, ROS’u s\u00f6nd\u00fcrmek i\u00e7in antioksidanlarla y\u00fcklenerek foto\u011fraf koruyucu etkilere neden olabilir. Dahas\u0131, modern ila\u00e7lar insan hastal\u0131klar\u0131n\u0131n korunmas\u0131 veya tedavisi i\u00e7in etnobotaniklere ba\u011f\u0131ml\u0131d\u0131r. Bu derleme makalesi, fito-ekstraktlarla y\u00fckl\u00fc bitkisel kremler \u00fczerinde yap\u0131lan \u00e7e\u015fitli in vivo antioksidan \u00e7al\u0131\u015fmalar\u0131 \u00f6zetlemektedir. Bu form\u00fclasyonlar cildi UVR’nin zararl\u0131 etkilerine kar\u015f\u0131 korumak i\u00e7in kozmetik olarak kullan\u0131labilir. Dermatolojik kullan\u0131m i\u00e7in krem formunda incelenen botanikler aras\u0131nda Acacia nilotica, Benincasa hispida, Calendula officinalis, Camellia sinensis, Camellia sinensis, Nelumbo nucifera, Capparis decidua, Castanea sativa, Coffea arabica, Crocus sativus, Emblica officinalis Gaertn, Foeniculum vulgare, Hippophae rhamnoides, Lithospermum erythrorhizon, Malus domestica, Matta. basilicum, Oryza sativa, Polygonum eksi, Punica granatum, Silybum marianum, Tagetes erecta Linn., Terminalia chebula, Trigonella foenum-graecum ve Vitis vinifera. Krem form\u00fclasyonlar\u0131n\u0131n g\u00f6zlenen ya\u015flanma kar\u015f\u0131t\u0131 etkileri, birden fazla bile\u015fenin koordinasyon etkisinin bir sonucu olabilir. \u00c7ok say\u0131da botanikten, fenolik asitler ve flavonoidler UVR’nin neden oldu\u011fu hasara kar\u015f\u0131 etkili g\u00f6r\u00fcnmektedir; ancak ya\u015flanma kar\u015f\u0131t\u0131 etkileri i\u00e7in kan\u0131ta dayal\u0131 \u00e7al\u0131\u015fmalara hala ihtiya\u00e7 vard\u0131r.
MAKALE 11-)https:\/\/scihub.bban.top\/10.1155\/2015\/789732
Production of Sterilizing Agents from Calendula officinalis Extracts Optimized by Response Surface Methodology.<\/strong>
Bu \u00e7al\u0131\u015fman\u0131n amac\u0131, Calendula officinalis \u00f6zleri ile elle sterilize eden s\u0131v\u0131 ve \u0131slak mendiller \u00fcretmekti.. Bu bitki, fitokimyasal bile\u015fenleri nedeniyle iyi bilinen antimikrobiyal aktiviteye sahip oldu\u011fundan, ekstraksiyon verimindeki art\u0131\u015f, \u00fcretim s\u00fcrecinin temel k\u0131sm\u0131 olarak se\u00e7ilmi\u015ftir. Maksimum verimi elde etmek i\u00e7in kat\u0131-s\u0131v\u0131 oran\u0131, ekstraksiyon s\u0131cakl\u0131\u011f\u0131 ve zaman parametreleri incelenmi\u015ftir. Optimum ko\u015fullar, s\u0131cakl\u0131k, zaman ve kat\u0131-s\u0131v\u0131 oran\u0131 i\u00e7in s\u0131ras\u0131yla 41 \u00b0 C, 7 saat ve 3,3 g \/ 200 mL yan\u0131t y\u00fczeyi metodolojisi ile belirlenmi\u015ftir. Bu ko\u015fullarda elde edilen verimin y\u00fczde 90 oldu\u011fu bulundu. En y\u00fcksek flavonoid miktarlar\u0131 optimum d\u00fczeyde saptan\u0131rken, en y\u00fcksek triterpen ve saponin bile\u015fenleri farkl\u0131 tasar\u0131m noktalar\u0131nda belirlenmi\u015ftir. Ekstraktlar\u0131n mikrobiyal verimleri, se\u00e7ilen mikroorganizmalar\u0131n b\u00fcy\u00fcmesinin inhibisyonu ile belirlenmi\u015ftir. \u0130nhibisyon parametreleri olarak farkl\u0131 seyreltme h\u0131zlar\u0131 ve etkile\u015fim s\u00fcreleri kullan\u0131lm\u0131\u015ft\u0131r. Kurucular\u0131n hi\u00e7biri de\u011fil, aralar\u0131ndaki simbiyotik ili\u015fki, y\u00fczde 90’l\u0131k en y\u00fcksek inhibisyona ula\u015ft\u0131. Ekstraktlar\u0131n pH de\u011ferleri 5.1 ila 5.4 idi. Sonu\u00e7 olarak,Optimum ko\u015fullarda Calendula officinalis , \u0131slak mendil ve el sterilizasyon s\u0131v\u0131s\u0131 \u00fcretiminde etkili bir \u015fekilde kullan\u0131labilir.
MAKALE 12-) PMID: 25970977
Assessment of the microbial load of some medicinal plants commonly used in Romania<\/p>\n\n\n\n

AMA\u00c7:
Bu \u00e7al\u0131\u015fma , yayg\u0131n olarak t\u0131bbi \u00e7ay olarak kullan\u0131lan baz\u0131 t\u0131bbi bitkilerin (Matricaria chamomilla, Achillea millefolium, Ocimum basilicum, Calendula officinalis , Tilia cordata, Hypericum perforatum) mikrobiyal y\u00fck\u00fcn\u00fc de\u011ferlendirmeyi ama\u00e7lamaktad\u0131r .
MATERYAL VE METODLAR:
Yerel pazardan ve Galati \u0130l\u00e7esi’nin spontan floras\u0131ndan toplanan toplam 24 numune, toplam mikrop say\u0131s\u0131, koliform bakteri i\u00e7eri\u011fi, maya ve k\u00fcfler ve spesifik patojenik bakterilerin varl\u0131\u011f\u0131 a\u00e7\u0131s\u0131ndan analiz edildi. (Escherichia coli, Bacillus cereus, Coagulase-pozitif Staphylococcus, Salmonella spp.).
SONU\u00c7LAR:
Toplam mikrop, maya ve k\u00fcf say\u0131s\u0131 i\u00e7in elde edilen de\u011ferler, kullan\u0131mdan \u00f6nce s\u0131cak suyun ilave edildi\u011fi bitki \u00fcr\u00fcnleri i\u00e7in Avrupa Farmakopesi taraf\u0131ndan belirlenen s\u0131n\u0131rlara uygun olmu\u015ftur. Spesifik patojenik bakterilerde, \u00f6rneklerin% 41.66’s\u0131nda E. coli varl\u0131\u011f\u0131, \u00f6rneklerin% 16.66’s\u0131nda Coagulase pozitif Staphylococcus varl\u0131\u011f\u0131 ve \u00f6rneklerin% 33.33’\u00fcnde Bacillus cereus varl\u0131\u011f\u0131 do\u011frulanm\u0131\u015ft\u0131r. Salmonella spp. b\u00fct\u00fcn numunelerde yoktu.
SONU\u00c7LAR:
\u00c7al\u0131\u015fma, analiz edilen t\u0131bbi bitkilerin belirli bir mikrobiyal y\u00fck\u00fcn\u00fc vurgulayarak, \u00fcretimin t\u00fcm a\u015famalar\u0131nda kalite kontrol\u00fcn \u00f6nemini vurgulamaktad\u0131r.
MAKALE 13-)https:\/\/scihub.bban.top\/10.1016\/j.ejps.2015.01.016
Development of lamellar gel phase emulsion containing marigold oil (Calendula officinalis) as a potential modern wound dressing<\/strong>.<\/p>\n\n\n\n

Yara tedavileri i\u00e7in uygun terap\u00f6tikler, doku onar\u0131m\u0131n\u0131n patofizyolojisini inceleyerek elde edilebilir. Burada Calendula officinalis i\u00e7eren lamellar jel faz (LGP) em\u00fclsiyonlar\u0131n\u0131n form\u00fclasyonlar\u0131n\u0131 geli\u015ftiriyoruz. S\u0131\u00e7anlarda deneysel yara iyile\u015fmesinde stabilitelerini ve aktivitelerini de\u011ferlendiren ya\u011f. LGP em\u00fclsiyonlar\u0131, iyi miktarda anizotropik yap\u0131ya ve stabiliteye sahip olan en iyi LGP em\u00fclsiyonunu se\u00e7mek i\u00e7in bir faz \u00fc\u00e7l\u00fc diyagram\u0131 temel al\u0131narak geli\u015ftirilmi\u015f ve de\u011ferlendirilmi\u015ftir. Se\u00e7ilen LGP form\u00fclasyonu, farkl\u0131 s\u0131cakl\u0131klarda i\u00e7sel ve h\u0131zland\u0131r\u0131lm\u0131\u015f fiziksel stabiliteye g\u00f6re analiz edildi. Ek olarak, yara iyile\u015ftirici s\u0131\u00e7anlar \u00fczerinde bir model olarak in vitro ve in vivo \u00e7al\u0131\u015fmalar yap\u0131lm\u0131\u015ft\u0131r. LGP em\u00fclsiyonu (% 15.0 marigold ya\u011f\u0131; kar\u0131\u015f\u0131m y\u00fczey aktif cisimlerinin% 10.0’u ve% 75.0 saf su [a\u011f \/ a\u011f]), form\u00fclasyonun yara ile daha uzun s\u00fcre temas etmesini \u00f6neren iyi stabilite ve y\u00fcksek viskozite g\u00f6stermi\u015ftir. Kadife \u00e7i\u00e7e\u011fi ya\u011f\u0131nda sitotoksik aktivite (50-1000 \u03bcg \/ mL) g\u00f6zlenmedi. Yara iyile\u015ftirme s\u0131\u00e7an modelinde, LGP (15 mg \/ mL), kontrole k\u0131yasla en az 2 ve 7. g\u00fcnlerde yaraya l\u00f6kosit al\u0131m\u0131nda bir art\u0131\u015f g\u00f6sterdi, ancak 14 ve 21 g\u00fcn sonra l\u00f6kosit al\u0131m\u0131n\u0131 azaltt\u0131. Ek olarak, 2 ve 7. g\u00fcnlerde LGP em\u00fclsiyonunda kollajen \u00fcretimi azalt\u0131lm\u0131\u015f ve yaran\u0131n kendisinin yeniden epitelizasyon s\u00fcreci daha da h\u0131zland\u0131r\u0131lm\u0131\u015ft\u0131r. Mevcut \u00e7al\u0131\u015fmada kullan\u0131lan metodoloji, yara iyile\u015fme s\u00fcrecini geli\u015ftirebilen stabil bir LGP em\u00fclsiyonu i\u00e7eren CO i\u00e7in potansiyel olarak yararl\u0131 bir form\u00fclasyon \u00fcretmi\u015ftir.
MAKALE 14-)https:\/\/scihub.bban.top\/10.1002\/ptr.5293
PI3K-mediated proliferation of fibroblasts by Calendula officinalis tincture: implication in wound healing<\/strong><\/p>\n\n\n\n

Asteraceae ailesinin bir \u00fcyesi olan calendula officinalis , \u00e7i\u00e7ekli bir bitkidir ve antibakteriyel, antifungal, antiviral, antienflamatuar, antikanser ve yara iyile\u015fme aktivitesi i\u00e7in kullan\u0131lm\u0131\u015ft\u0131r. C. officinalis tent\u00fcr\u00fcn\u00fcn yara iyile\u015fmesi \u00fczerindeki etki \u015fekli tam olarak anla\u015f\u0131lamam\u0131\u015ft\u0131r. Burada C. officinalis tent\u00fcr\u00fcn\u00fcn (CDOT) h\u00fccre canl\u0131l\u0131\u011f\u0131 ve yara kapanmas\u0131 \u00fczerindeki rol\u00fcn\u00fc ara\u015ft\u0131rd\u0131k . C. officinalistent\u00fcr, fibroblastlar\u0131n hem proliferasyonunu hem de g\u00f6\u00e7\u00fcn\u00fc PI3K’ya ba\u011f\u0131ml\u0131 bir yolda istatistiksel olarak anlaml\u0131 bir \u015fekilde uyard\u0131. CDOT tedavisinden sonra FAK (Tyr 397) ve Akt’\u0131n (Ser 473) fosforilasyonundaki art\u0131\u015f tespit edildi. PI3K yolunun wortmannin ve LY294002 taraf\u0131ndan inhibisyonu, hem h\u00fccre proliferasyonunu hem de h\u00fccre g\u00f6\u00e7\u00fcn\u00fc azaltt\u0131. HPLC-ESI MS, CDOT’un ana bile\u015fikleri olarak flavonol glikozitlerin varl\u0131\u011f\u0131n\u0131 ortaya koydu. Sonu\u00e7 olarak, sonu\u00e7lar\u0131m\u0131z CDOT’un PI3K’ye ba\u011f\u0131ml\u0131 bir yoldaki fibroblast\u0131n proliferasyonunu ve migrasyonunu uyararak yara iyile\u015fmesini g\u00fc\u00e7lendirdi\u011fini ve tan\u0131mlanan bile\u015fiklerin yara iyile\u015fme aktivitesinden sorumlu olaca\u011f\u0131n\u0131 g\u00f6stermi\u015ftir.
MAKALE 15-)PMID: 26946571<\/strong>
The influence of selected plants on the tobacco smoking-induced effects in the oral cavity–review.
T\u00fct\u00fcn i\u00e7mek, oral mukozadaki bir\u00e7ok patolojik lezyonun su\u00e7lusudur. Bu literat\u00fcr derlemesinde t\u00fct\u00fcn kaynakl\u0131 mukozal patolojiler i\u00e7in \u00e7e\u015fitli terap\u00f6tik se\u00e7eneklere odakland\u0131k. Aloe vera, Papatya, Curcuma longa ve Calendula’n\u0131n bir\u00e7ok aktif bile\u015feni g\u00fc\u00e7l\u00fc antienflamatuar ve rejeneratif aktivite g\u00f6sterir, bu da bitki kaynakl\u0131 ila\u00e7lar\u0131 geleneksel farmas\u00f6tikler i\u00e7in makul bir se\u00e7enek haline getirir.<\/p>\n\n\n\n

MAKALE 16-)PMID:PMC4228529
Shampoo-clay heals diaper rash faster than calendula officinalis<\/strong>
Bebek bezi d\u00f6k\u00fcnt\u00fcs\u00fc bebeklik ve \u00e7ocukluk \u00e7a\u011f\u0131n\u0131n en s\u0131k g\u00f6r\u00fclen cilt bozukluklar\u0131ndan biridir. Baz\u0131 \u00e7al\u0131\u015fmalar, \u015fampuan-kilin kronik dermatiti tedavi etmede etkili oldu\u011funu g\u00f6stermi\u015ftir. Daha sonra, bebek bezi d\u00f6k\u00fcnt\u00fcs\u00fcnde etkili olabilece\u011fi varsay\u0131lmaktad\u0131r; ancak bu konuda yay\u0131nlanm\u0131\u015f herhangi bir \u00e7al\u0131\u015fma bulunmam\u0131\u015ft\u0131r.
AMA\u00c7:
Bu \u00e7al\u0131\u015fma, \u00e7ocuk bezi d\u00f6k\u00fcnt\u00fcs\u00fcn\u00fc iyile\u015ftirmek i\u00e7in \u015eampuan-kil (SC) ve Calendula officinalis (CO) etkilerini kar\u015f\u0131la\u015ft\u0131rmay\u0131 ama\u00e7lam\u0131\u015ft\u0131r .
HASTALAR VE Y\u00d6NTEMLER:
Humeyni \u015fehrinde sa\u011fl\u0131k merkezlerine veya \u00e7ocuk kliniklerine sevk edilen ve \u00e7ocuk bezi d\u00f6k\u00fcnt\u00fcs\u00fc te\u015fhisi konmu\u015f 60 ayaktan bebek \u00fczerinde randomize, \u00e7ift k\u00f6r, paralel kontroll\u00fc, a\u015fa\u011f\u0131l\u0131k olmayan bir \u00e7al\u0131\u015fma yap\u0131lm\u0131\u015ft\u0131r. Hastalar, bire bir tahsis oran\u0131 kullan\u0131larak SC grubu (n = 30) ve CO grubu (n = 30) olmak \u00fczere rastgele iki tedavi grubuna ayr\u0131ld\u0131. \u00dc\u00e7 g\u00fcn i\u00e7inde tam iyile\u015fme oran\u0131 birincil sonu\u00e7tu. Veriler bir kontrol listesi kullan\u0131larak toplanm\u0131\u015f ve t-testi, Ki-kare ve Fisher kesin testleri ve risk oran\u0131 kullan\u0131larak analiz edilmi\u015ftir.
SONU\u00c7LAR:
Toplamda, SC grubundaki lezyonlar\u0131n% 93.3’\u00fc ilk 6 saatte iyile\u015firken, bu oran CO grubunda% 40 idi (P <0.001). \u0130lk 6 saatte iyile\u015fme i\u00e7in iyile\u015fme oran\u0131 SC grubunda 7 kat daha fazlayd\u0131. Ek olarak, SC grubundaki bebeklerin% 90’\u0131 ve CO grubundaki% 36.7’si ilk 3 g\u00fcnde tamamen d\u00fczeldi (P <0.001).
SONU\u00c7LAR:
SC bebek bezi d\u00f6k\u00fcnt\u00fclerini iyile\u015ftirmede etkiliydi ve ayr\u0131ca CO’ya k\u0131yasla daha h\u0131zl\u0131 etkileri oldu.
MAKALE 17-) https:\/\/scihub.bban.top\/10.1002\/ptr.5236
Extracts from Calendula officinalis offer in vitro protection against H2 O2 induced oxidative stress cell killing of human skin cells.<\/strong>
Calendula officinalis \u00e7i\u00e7ek ba\u015f ekstraktlar\u0131n\u0131n in vitro g\u00fcvenli\u011fi ve antioksidan potansiyeli ara\u015ft\u0131r\u0131ld\u0131. Farkl\u0131 konsantrasyonlarda (0.125, 0.5, 1.0, 2.0 ve% 5.0 (h \/ h)) Calendula \u00f6z\u00fctlerinin in vitro insan deri h\u00fccreleri HaCaT \u00fczerindeki etkisi ara\u015ft\u0131r\u0131ld\u0131. % 1.0 (h \/ h) (0.88 mg kuru a\u011f\u0131rl\u0131k \/ mL) veya daha d\u00fc\u015f\u00fck dozlarda toksisite g\u00f6r\u00fclmemi\u015ftir. H\u00fccreler ayr\u0131ca 1 saat boyunca oksidatif bir hakarete (hidrojen peroksit H202) maruz b\u0131rak\u0131lmadan \u00f6nce 4, 24 veya 48 saat boyunca Calendula ekstraktlar\u0131na maruz b\u0131rak\u0131ld\u0131. MTT sitotoksisite deneyi kullan\u0131larak, iki ba\u011f\u0131ms\u0131z C. officinalis ekstrakt\u0131n\u0131n insan deri h\u00fccreleri kullan\u0131larak in vitro olarak ind\u00fcklenen oksidatif strese kar\u015f\u0131 zamana ba\u011fl\u0131 ve konsantrasyona ba\u011fl\u0131 H2O2 korumas\u0131 sa\u011flad\u0131\u011f\u0131 g\u00f6zlenmi\u015ftir . \u0130le \u00f6n ink\u00fcbasyon24 ve 48 saat boyunca nergis ekstraktlar\u0131, oksidatif tehdidin ard\u0131ndan ekstrakts\u0131z pop\u00fclasyona g\u00f6re s\u0131ras\u0131yla% 20 ve% 40
artt\u0131. Calendula ekstraktlar\u0131n\u0131n antioksidan potansiyeli, tamamlay\u0131c\u0131 bir kimyasal teknik olan DPPH (\u25cf) deneyi kullan\u0131larak do\u011frulanm\u0131\u015ft\u0131r. Calendula ekstreleri serbest radikal temizleme kabiliyetleri sergiledi. Bu \u00e7al\u0131\u015fma, Calendula \u00e7i\u00e7ek \u00f6zlerinin, bir insan cilt h\u00fccre k\u00fclt\u00fcr\u00fc modelinde oksidatif strese kar\u015f\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde koruma sa\u011flayan biyoaktif ve serbest radikal s\u00fcp\u00fcr\u00fcc\u00fc bile\u015fikler i\u00e7erdi\u011fini g\u00f6stermektedir.
MAKALE 17-) https:\/\/scihub.bban.top\/10.1002\/ar.23057
Effect of Calendula officinalis cream on achilles tendon healing.<\/strong>
Son y\u0131llarda, bilim toplulu\u011fu bitki ekstreleri \u00fczerinde ara\u015ft\u0131rma yaparak, farkl\u0131 t\u0131p alanlar\u0131nda kullan\u0131labilecek farmakolojik aktivitelere sahip bile\u015fikler aramaktad\u0131r. Calendula officinalis L.’nin cilt yan\u0131klar\u0131n\u0131 tedavi etmek i\u00e7in kullan\u0131ld\u0131\u011f\u0131nda antioksidan, antienflamatuar, antibakteriyel ve yara iyile\u015ftirici \u00f6zelliklere sahip oldu\u011fu bilinmektedir. Bu nedenle, bu \u00e7al\u0131\u015fman\u0131n amac\u0131, C. officinalis’in A\u015fil tendonu iyile\u015fmesinin ilk a\u015famas\u0131 \u00fczerindeki etkilerini analiz etmektir . Wistar fareleri \u00fc\u00e7 gruba ayr\u0131lm\u0131\u015ft\u0131r: Calendula (Cal) S\u0131\u00e7anlar bir nakledilmi\u015f tendonu C topikal uygulamalar ile muamele edildi officinalis krem ve daha sonra yaralanmadan 7 g\u00fcn sonra \u00f6tenazi; Kontrol (C) s\u0131\u00e7anlar\u0131, transeksiyondan sonra sadece ara\u00e7 ile muamele edildi; ve Tenotomi i\u00e7ermeyen Normal (N) s\u0131\u00e7anlar. Cal grubunda C grubuna g\u00f6re daha y\u00fcksek hidroksiprolin (toplam kollajen g\u00f6stergesi) ve kollajen\u00f6z olmayan protein konsantrasyonlar\u0131 g\u00f6zlenmi\u015ftir. Zimografi, C ve Cal gruplar\u0131 aras\u0131nda metaloproteinaz-2 ve metaloproteinaz-9 izoformlar\u0131n\u0131n miktar\u0131 aras\u0131nda bir fark g\u00f6stermemi\u015ftir. Polarizasyon mikroskopi g\u00f6r\u00fcnt\u00fcleri analizi, Cal grubunun C grubuna k\u0131yasla biraz daha y\u00fcksek \u00e7ift k\u0131r\u0131lma sergiledi\u011fini g\u00f6stermi\u015ftir. Tol\u00fcidin mavisi ile boyanm\u0131\u015f tendon b\u00f6l\u00fcmlerinde, kesilen gruplar N grubuna k\u0131yasla daha y\u00fcksek metakromasi g\u00f6stermi\u015ftir. Kondroitin-6-s\u00fclfat i\u00e7in imm\u00fcnositokimya analizi C ve Cal gruplar\u0131 aras\u0131nda fark g\u00f6stermedi. Sonu\u00e7 olarak,Tendon transeksiyonu sonras\u0131 officinalis , iyile\u015fmenin ilk a\u015famas\u0131nda kollajen ve kollajen\u00f6z olmayan proteinlerin konsantrasyonlar\u0131n\u0131 ve kolajen organizasyonunu artt\u0131r\u0131r.
MAKALE 17-)
https:\/\/scihub.bban.top\/10.1080\/03601234.2014.896673
Antibacterial activity against Clostridium genus and antiradical activity of the essential oils from different origin.<\/strong><\/p>\n\n\n\n

Bu \u00e7al\u0131\u015fmada 15 esans ya\u011f\u0131n\u0131n antimikrobiyal ve antiradikal aktiviteleri ara\u015ft\u0131r\u0131ld\u0131. Antimikrobiyal aktiviteler, DPPH radikal aktiviteleri \u00fczerindeki temizleme etkilerini test ederek u\u00e7ucu ya\u011flar\u0131n Clostridium cinsine ve antioksidan \u00f6zelliklerine kar\u015f\u0131 agar disk dif\u00fczyonu ve et suyu mikrodil\u00fcsyon y\u00f6ntemleri kullan\u0131larak belirlenmi\u015ftir. Clostridium butyricum, Clostridium hystoliticum, Clostridium intestinale, Clostridium perfringens ve Clostridium ramosum’un antibakteriyel aktivitesini belirledik. Lavandula angustifolia, Carum carvi, Pinus montana, Mentha piperita, Foeniculum vulgare Mill., Pinus sylvestris, Satureia montana, Origanum vulgare L. (2 \u00f6rnek), Pimpinella anisum, Rosmarinus officinalis L., Salvia’n\u0131n orijinal ticari esansiyel ya\u011f \u00f6rneklerini elde ettik. officinalisSlovakya’da ( Calendula) \u00fcretilen L. Rausch ve Thymus vulgaris L., Abies alba Mill., Chamomilla recutita L.Nova Lubovna, Slovakya). Disk dif\u00fczyon y\u00f6nteminin sonu\u00e7lar\u0131, test edilen t\u00fcm mikroorganizma su\u015flar\u0131na kar\u015f\u0131 \u00e7ok y\u00fcksek u\u00e7ucu ya\u011f aktivitesi g\u00f6sterdi. C. butyricum’a kar\u015f\u0131 en iyi antimikrobiyal aktivite Pimpinella anisum’da, C. hystoliticum’a kar\u015f\u0131 Pinus sylvestris’de, C. intestinale’ye kar\u015f\u0131 Satureia hortensis L.’de, C. perfringens’e kar\u015f\u0131 Origanum vulgare L.’de ve C’ye kar\u015f\u0131 bulundu. ramosum Pinus sylvestris’de bulundu. Et suyu mikrodil\u00fcsyon tahlilinin sonu\u00e7lar\u0131, u\u00e7ucu ya\u011flar\u0131n hi\u00e7birinin C. hystoliticum’a kar\u015f\u0131 aktif olmad\u0131\u011f\u0131n\u0131 g\u00f6sterdi. C. butyricum’a kar\u015f\u0131 en iyi antimikrobiyal aktivite Abies alba Mill’de, C. intestinale’ye kar\u015f\u0131 Abies alba Mill’de, C. perfringens’e kar\u015f\u0131 Satureia montana ve C. ramosum’a kar\u015f\u0131 Abius alba ve Carum carvi’de bulundu . Antioksidan DPPH radikal s\u00fcp\u00fcrme aktivitesi, ya\u011f numunelerinin \u00e7e\u015fitli \u00e7\u00f6zeltilerinde (50 \u03bcL.mL (-1) -0.39 \u03bcL.mL (-1)) ve en y\u00fcksek konsantrasyonda (50 \u03bcL.mL (-1) en iyi s\u00fcp\u00fcrme etkisinde belirlenmi\u015ftir. ) g\u00f6zlemlendi. Antioksidan \u00f6zellikler, \u00f6zellikle bitki t\u00fcrlerinde farkl\u0131yd\u0131. 30 dakika sonra en y\u00fcksek inhibisyon% ‘si. reaksiyon, Origanum vulgare (% 93), Satureia montana (% 90.66) ve Lavandula augustifolia’da (% 90.22) g\u00f6zlendi.
MAKALE 18-) DOI:10.4103\/0972-124X.124491
Evaluation of Calendula officinalis as an anti-plaque and anti-gingivitis agent<\/strong>
ARKA FON:
Genellikle pot kadife \u00e7i\u00e7e\u011fi olarak bilinen Calendula officinalis (C. officinalis ), m\u00fckemmel antimikrobiyal, yara iyile\u015fmesi ve antienflamatuar aktiviteye sahip t\u0131bbi bir bitkidir.
AMA\u00c7:
C. officinalis’in dental plak ve di\u015f eti iltihab\u0131n\u0131n azalt\u0131lmas\u0131ndaki etkinli\u011fini de\u011ferlendirmek
SONU\u00c7:Bu \u00e7al\u0131\u015fman\u0131n s\u0131n\u0131rlar\u0131 dahilinde, calendula a\u011f\u0131z gargaras\u0131n\u0131n di\u015f plakas\u0131n\u0131 ve \u00f6l\u00e7eklenmeye yard\u0131mc\u0131 di\u015f eti iltihab\u0131n\u0131 azaltmada etkili oldu\u011fu sonucuna var\u0131labilir
MAKALE 19-) https:\/\/scihub.bban.top\/10.1007\/s12088-012-0329-0
Essential oils and herbal extracts as antimicrobial agents in cosmetic emulsion.<\/p>\n\n\n\n

Kozmetik end\u00fcstrisi, koruyucular\u0131n kullan\u0131m\u0131n\u0131 s\u0131n\u0131rlamak ve koruyucular\u0131n bitki k\u00f6kenli hammaddelerle de\u011fi\u015ftirildi\u011fi koruyucu i\u00e7ermeyen veya kendi kendini koruyan kozmetik \u00fcr\u00fcnleri geli\u015ftirmek isteyen t\u00fcketicilerin ihtiya\u00e7lar\u0131na uyum sa\u011flar. \u00c7al\u0131\u015fman\u0131n amac\u0131, ekstraktlar\u0131n antimikrobiyal aktivitesinin kar\u015f\u0131la\u015ft\u0131r\u0131lmas\u0131yd\u0131 (Matricaria chamomilla, Aloe vera, Calendula officinalis) ve metilparaben ile u\u00e7ucu ya\u011flar (Lavandulla officinallis, Melaleuca alternifolia, Cinnamomum zeylanicum). Ekstraktlar (% 2.5), u\u00e7ucu ya\u011flar (% 2.5) ve metilparaben (% 0.4) Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 29213, Candida albicans ATCC 14053’e kar\u015f\u0131 test edildi. U\u00e7ucu ya\u011flar test edilen mikroorganizmaya kar\u015f\u0131 daha y\u00fcksek inhibit\u00f6r aktivite g\u00f6sterdi. ekstraktlardan ve metilparabenden daha fazlad\u0131r. Test edilen mikroorganizma su\u015funa ba\u011fl\u0131 olarak, test edilen t\u00fcm ekstraktlar ve u\u00e7ucu ya\u011flar, antimikrobiyal aktivite s\u0131ras\u0131yla metilparabenden 0.8-1.7 ve 1-3.5 kat daha g\u00fc\u00e7l\u00fcd\u00fcr. Bu, test edilen ekstraktlar\u0131n ve u\u00e7ucu ya\u011flar\u0131n metilparabenin kullan\u0131m\u0131n\u0131n yerini alabilece\u011fini ve ayn\u0131 zamanda kozmetiklerin kullan\u0131m\u0131 ve depolanmas\u0131 alt\u0131nda mikrobiyolojik safl\u0131k garantisi verdi\u011fini g\u00f6stermektedir.
MAKALE 20-)https:\/\/scihub.bban.top\/10.1016\/s0254-6272(13)60047-3
Antiglycation and antioxidation properties of Juglans regia and Calendula officinalis: possible role in reducing diabetic complications and slowing down ageing.<\/strong><\/p>\n\n\n\n

AMA\u00c7:
Proteinlerin enzimatik olmayan glikasyonu ve oksidasyonu nedeniyle v\u00fccutta geli\u015fmi\u015f glikasyon son \u00fcr\u00fcnlerinin (AGE’ler) birikmesi ya\u015flanma ve diyabetes mellitus ile ili\u015fkilidir. Bu \u00e7al\u0131\u015fmada iki t\u0131bbi bitkinin antiglisizasyon ve antioksidasyon potansiyelini ara\u015ft\u0131rmak istedik: Juglans regia ve Calendula officinalis
SONU\u00c7:J. regia ve C. officinalis , Maillard reaksiyonunu inhibe etti ve in vitro oksidasyonu \u00f6nledi. Bu nedenle, bu bitkilerin \u00f6zleri, kronik diyabetik komplikasyonlar\u0131 azaltmada ve ya\u015flanmay\u0131 yava\u015flatmada terap\u00f6tik kullan\u0131mlara sahip olabilir.
MAKALE 21-)DOI: 10.2174\/1389201019666180226151910
Characterization of Biologically Active Substances from Calendula officinalis<\/strong><\/p>\n\n\n\n

ARKA FON:
Bu \u00e7al\u0131\u015fman\u0131n amac\u0131, Calendula officinalis’in \u00e7i\u00e7ek ve yapraklar\u0131ndan elde edilen su ve organik ekstraktlar\u0131, inf\u00fczyonlar\u0131 ve tent\u00fcrleri biyolojik aktiviteleri ve bile\u015fimleri a\u00e7\u0131s\u0131ndan kar\u015f\u0131la\u015ft\u0131rmakt\u0131. \u00c7al\u0131\u015fman\u0131n amac\u0131, yapraklar\u0131n ve g\u00f6vdelerin ger\u00e7ekten at\u0131k olup olmad\u0131\u011f\u0131n\u0131 veya kullan\u0131labilecek ilgin\u00e7 maddeler i\u00e7erip i\u00e7ermediklerini ara\u015ft\u0131rmakt\u0131. Antimikrobiyal, antifungal, antioksidan ve antienflamatuar aktiviteler incelendi. Daha sonra, kolajenaz\u0131 inhibe etme yetene\u011fi de incelenmi\u015ftir. Sitotoksisite, memeli h\u00fccre dizilerindeki t\u00fcm numuneler i\u00e7in test edilmi\u015ftir.
Y\u00d6NTEMLER:
Ekstraktlar\u0131n, inf\u00fczyonlar\u0131n ve tent\u00fcrlerin bile\u015fimini belirlemek i\u00e7in fitokimyasal analiz (biyolojik olarak aktif bile\u015fik gruplar\u0131n\u0131n saptanmas\u0131 i\u00e7in renk reaksiyonlar\u0131 k\u00fcmesi) ger\u00e7ekle\u015ftirildi ve \u00e7i\u00e7ek ve yapraklardan al\u0131nan numunelerin ayn\u0131 biyolojik olarak aktif madde gruplar\u0131n\u0131 (proteinler ve amino asitler, indirgen \u015fekerler, flavonoidler, saponinler, fenolikler, terpenoidler, steroidler, glikozitler). Test edilen \u00f6rneklerin antimikrobiyal aktivitesi kan\u0131tland\u0131; burada en hassas bakteri Micrococcus luteus ve en hassas maya Geotrichum candidum idi.
SONU\u00c7LAR:
Anti-kolajenaz aktivitesi \u00e7al\u0131\u015fmas\u0131, kolajenaz\u0131n enzimatik reaksiyonunun test edilen t\u00fcm numunelerden etkilendi\u011fini ve etkilerinin konsantrasyona ba\u011fl\u0131 oldu\u011funu g\u00f6stermi\u015ftir. HEK 293T ve HepG2 h\u00fccre soylar\u0131nda su ve metanol ekstraktlar\u0131n\u0131n sitotoksisitesi g\u00f6zlenmi\u015ftir.
SONU\u00c7:
HepG2 h\u00fccreleri, HEK 293T h\u00fccrelerinden daha hassast\u0131. RAW 264.7 h\u00fccre hatt\u0131 kullan\u0131larak, t\u00fcm numunelerin antienflamatuar aktivitesi g\u00f6zlendi. Yapraklar\u0131n tent\u00fcr\u00fc en etkili olan\u0131yd\u0131.
MAKALE 22-) DOI:10.4103\/japtr.JAPTR_305_17
The effect of Calendula officinalis versus metronidazole on bacterial vaginosis in women: A double-blind randomized controlled trial
<\/strong>Bakteriyel vajinoz (BV) \u00fcreme \u00e7a\u011f\u0131ndaki kad\u0131nlar aras\u0131nda yayg\u0131n bir hastal\u0131kt\u0131r. Bu \u00e7al\u0131\u015fma , \u00fcreme \u00e7a\u011f\u0131ndaki kad\u0131nlar aras\u0131nda Calendula officinalis \u00f6z\u00fc bazl\u0131 krem ve metronidazol\u00fcn BV \u00fczerindeki etkisini kar\u015f\u0131la\u015ft\u0131rmay\u0131 ama\u00e7lam\u0131\u015ft\u0131r . Bu \u00e7al\u0131\u015fmada BV ile \u00fcreme \u00e7a\u011f\u0131ndaki 80 kad\u0131n rastgele C. officinalis ( n = 40) veya metronidazole ( n = 40) atand\u0131 . BV te\u015fhisi, 4 Amsel kriterinden en az 3’\u00fcn\u00fcn (pH> 4.5, beyaz\u0131ms\u0131 gri veya ince homojen ak\u0131nt\u0131,% 10 KOH ilave edildi\u011finde bal\u0131k kokusunun sal\u0131nmas\u0131 ve mikroskopik incelemede ipucu h\u00fccrelerinin saptanmas\u0131) kar\u015f\u0131land\u0131\u011f\u0131nda do\u011fruland\u0131. Her grup i\u00e7in ya C. officinalis metanol ekstresiveya 1 hafta s\u00fcreyle intravajinal olarak metronidazol vajinal krem (5 g) kullan\u0131ld\u0131 ve t\u00fcm belirti ve semptomlar tedavinin tamamlanmas\u0131ndan 1 hafta sonra de\u011ferlendirildi. M\u00fcdahale \u00f6ncesinde iki grup vajinal yanma, koku, diz\u00fcri ve dispar\u00fcni a\u00e7\u0131s\u0131ndan anlaml\u0131 farkl\u0131l\u0131k g\u00f6stermedi, ancak ka\u015f\u0131nt\u0131 C. officinalis grubunda metronidazol grubuna g\u00f6re (% 22.5’e kar\u015f\u0131l\u0131k% 2.5, P = 0.01). M\u00fcdahaleden bir hafta sonra, her iki gruptaki t\u00fcm kad\u0131nlar vajinal ka\u015f\u0131nt\u0131 ve yanma hissi, koku, diz\u00fcri ve dispar\u00fcni dahil semptomlardan yoksundu. Her iki gruptaki kad\u0131nlar\u0131n hi\u00e7birinde C. officinalis veya metronidazol\u00fcn herhangi bir yan etkisi olmad\u0131 . C. officinalisherhangi bir yan etkisi olmaks\u0131z\u0131n \u00fcreme \u00e7a\u011f\u0131ndaki kad\u0131nlarda BV tedavisinde etkiliydi. Bu bitki, sentetik ila\u00e7lar\u0131n potansiyel yan etkilerinden rahats\u0131z olan \u00fcreme \u00e7a\u011f\u0131ndaki kad\u0131nlar i\u00e7in \u00f6nerilebilir.
MAKALE 23-)
https:\/\/scihub.bban.top\/10.1080\/03630242.2016.1263272
Comparing the effects of Calendula officinalis and clotrimazole on vaginal Candidiasis: A randomized controlled trial.<\/strong>
Bu \u00fc\u00e7l\u00fc-k\u00f6r \u00e7al\u0131\u015fma, Calendula officinalis vajinal kremin vajinal Kandidiyaz (birincil sonu\u00e7) ve cinsel i\u015flev (ikincil sonu\u00e7) tedavisi \u00fczerindeki etkilerini incelemi\u015ftir . Vajinal Kandidiyazisli (n = 150) 18-45 ya\u015flar\u0131ndaki evli kad\u0131nlar Nisan-Ekim 2014 aras\u0131nda i\u015fe al\u0131nm\u0131\u015f ve her gece yedi gece boyunca 5 g vajinal krem kullan\u0131larak Calendula ve Klotrimazol gruplar\u0131na randomize edilmi\u015ftir . Klinik ve laboratuvar de\u011ferlendirmeleri m\u00fcdahaleden 10-15 ve 30-35 g\u00fcn sonra ger\u00e7ekle\u015ftirilmi\u015f ve kad\u0131n cinsel i\u015flev indeksi 30-35 g\u00fcnde de\u011ferlendirilmi\u015ftir. Alt\u0131 kad\u0131n takipten \u00e7\u0131kt\u0131. Calendula’daki Kandidiyazis i\u00e7in negatif test s\u0131kl\u0131\u011f\u0131 birinci grupta anlaml\u0131 olarak daha d\u00fc\u015f\u00fck (% 49’a kar\u015f\u0131% 74; oran oran\u0131 (OR) 0.32;% 95 g\u00fcven aral\u0131\u011f\u0131 (CI) 0.16-0.67), ikincisinde (% 77’ye kar\u015f\u0131% 34; OR 3.1; 95 % CI 1.5-6.2) klotrimazol grubuna k\u0131yasla takip. \u00c7o\u011fu belirti ve semptom s\u0131kl\u0131\u011f\u0131 ilk takipte iki grupta hemen hemen e\u015fitti, ancak ikinci takipte Calendula grubunda anlaml\u0131 olarak daha d\u00fc\u015f\u00fckt\u00fc . Cinsel i\u015flev her iki grupta da neredeyse e\u015fit derecede anlaml\u0131 iyile\u015fme g\u00f6sterdi. Calendula vajinal kreminin, vajinal Kandidiyaz tedavisinde etkili oldu\u011fu ve klotrimazole k\u0131yasla gecikmi\u015f ancak daha uzun s\u00fcreli bir etkisi oldu\u011fu g\u00f6r\u00fclmektedir.
MAKALE 24-)
https:\/\/scihub.bban.top\/10.1016\/j.jep.2016.12.006
In vitro studies to evaluate the wound healing properties of Calendula officinalis extracts.<\/strong>
\u00c7ALI\u015eMANIN AMACI:
Bu \u00e7al\u0131\u015fman\u0131n amac\u0131, halihaz\u0131rda piyasada kullan\u0131lan bitki ila\u00e7lar\u0131n\u0131 yans\u0131tabilen Calendula ekstraktlar\u0131n\u0131n yara iyile\u015ftirici etkilerinin molek\u00fcler mekanizmas\u0131n\u0131 analiz etmekti
Calendula \u00e7i\u00e7eklerinden elde edilen n-heksanik ve etanolik \u00f6z\u00fctler, insan \u00f6l\u00fcms\u00fczle\u015ftirilmi\u015f keratinositlerde transkripsiyon fakt\u00f6r\u00fc NF -activB’yi aktive ederek ve hem transkripsiyonel hem de protein seviyesinde kemokin IL-8 miktar\u0131n\u0131 art\u0131rarak enflamatuar faz\u0131 etkiler. Yeni doku olu\u015fturma faz\u0131 s\u0131ras\u0131nda keratinositlerin migrasyonu \u00e7izilme tahlilinde sadece \u00e7ok az etkilendi. Bununla birlikte, etanolik ekstrakt in vitro kolajenaz aktivitesini inhibe etti\u011fi ve insan dermal fibroblastlar\u0131n\u0131n s\u00fcpernatan\u0131ndaki kolajen miktar\u0131n\u0131 artt\u0131rd\u0131\u011f\u0131 i\u00e7in gran\u00fclasyon dokusunun etkilendi\u011fi varsay\u0131labilir.
Sonu\u00e7lar\u0131m\u0131z, geleneksel t\u0131bbi bitki Calendula officinalis’in yara iyile\u015ftirici \u00f6zelliklerinin daha iyi anla\u015f\u0131lmas\u0131na katk\u0131da bulunur . Bununla birlikte, bilinen etkilerden hangisinin bu etkilerden sorumlu oldu\u011funu de\u011ferlendirmek i\u00e7in daha fazla \u00e7al\u0131\u015fmaya ihtiya\u00e7 vard\u0131r. Triterpenler sadece marjinal bir rol oynamaktad\u0131r, ancak karoten ve ksantofil t\u00fcrevleri gelecekteki \u00e7al\u0131\u015fmalarda daha fazla dikkat \u00e7ekmelidi.
MAKALE 25-)
https:\/\/scihub.bban.top\/10.12968\/jowc.2016.25.12.732
Therapeutic effectiveness of a Calendula officinalis extract in venous leg ulcer healing.<\/strong><\/p>\n\n\n\n

AMA\u00c7: \u0130yile\u015fmeyen ven\u00f6z bacak \u00fclserlerinin (VLU’lar) hastalar\u0131n ya\u015fam kalitesi \u00fczerinde \u00f6nemli bir etkisi vard\u0131r ve sa\u011fl\u0131k bak\u0131m sistemlerindeki harcamalar\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131r\u0131r. Bu \u00e7al\u0131\u015fman\u0131n amac\u0131 VL’lerin tedavisinde Calendula officinalis \u00f6z\u00fct\u00fc olan Plenusdermax’\u0131n klinik etkinli\u011fini de\u011ferlendirmektir .Bulgular\u0131m\u0131z Calendula officinalis \u00f6z\u00fct\u00fcn\u00fcn VLU’lar i\u00e7in etkili bir tedavi oldu\u011funu g\u00f6stermektedi.
MAKALE 26-) https:\/\/scihub.bban.top\/10.1007\/s11130-016-0596-8
Biological Activities of Asteraceae (Achillea millefolium and Calendula officinalis) and Lamiaceae (Melissa officinalis and Origanum majorana) Plant Extracts.<\/strong>
Asteraceae (Achillea millefolium ve Calendula officinalis ) ve Lamiaceae (Melissa officinalis)ve Origanum majorana) ekstreleri iki ard\u0131\u015f\u0131k ekstraksiyon i\u015flemi uygulanarak elde edildi.(Karbondioksit ile s\u00fcperkritik s\u0131v\u0131 ekstraksiyonu, ard\u0131ndan ye\u015fil \u00e7\u00f6z\u00fcc\u00fcler (etanol ve etanol: su 50:50) kullan\u0131larak ultrasonik destekli ekstraksiyon). Ekstraktlar, fenolik bile\u015fiklerin toplam i\u00e7eri\u011fi ve flavonoidlerin i\u00e7eri\u011fi a\u00e7\u0131s\u0131ndan analiz edildi; s\u00fcperkritik ekstraktlar\u0131n u\u00e7ucu ya\u011f bile\u015fimi gaz kromatografisiyle analiz edildi ve antioksidan kapasite ve h\u00fccre toksisitesi belirlendi. Lamiaceae bitki \u00f6zleri, Asteraceae \u00f6zlerinden daha y\u00fcksek fenolik (ve flavonoidler) i\u00e7eri\u011fi sundu. \u0130ncelenen t\u00fcrlerden ba\u011f\u0131ms\u0131z olarak, s\u00fcperkritik ekstraktlar en d\u00fc\u015f\u00fck antioksidan aktiviteyi ve etanol\u00fc sundu: Origanum majorana> Melissa officinalis s\u0131ras\u0131n\u0131 takiben en b\u00fcy\u00fck su ekstraktlar\u0131 sunuldu.\u2248 Achillea millefolium> Calendula officinalis . Bununla birlikte, h\u00fccre toksisitesi \u00fczerindeki etkisi ile ilgili olarak, Asteraceae (\u00f6zellikle Achillea millefolium) s\u00fcperkritik \u00f6zler, bir antioksidan ajan olarak daha az aktif olmas\u0131na ra\u011fmen, \u00f6nemli \u00f6l\u00e7\u00fcde daha etkilidir. Bu sonu\u00e7lar, h\u00fccre canl\u0131l\u0131\u011f\u0131 \u00fczerindeki etkinin, ekstraktlar\u0131n antioksidan aktivitesi ile ili\u015fkili olmad\u0131\u011f\u0131n\u0131 g\u00f6stermektedir.
MAKALE 27-) https:\/\/scihub.bban.top\/10.1002\/ptr.5678
The Water Fraction of Calendula officinalis Hydroethanol Extract Stimulates In Vitro and In Vivo Proliferation of Dermal Fibroblasts in Wound Healing.<\/strong>
Yara iyile\u015fmesinden sorumlu olan Calendula officinalis’in aktif fraksiyonu ve \/ veya bile\u015fikleri hen\u00fcz bilinmemektedir. Bu \u00e7al\u0131\u015fmada C. officinalis’in molek\u00fcler hedefini incelendi.Hidroetanol \u00f6z\u00fct\u00fc (CEE) ve bunun birincil fraksiyonu (hidroetanol \u00f6z\u00fct\u00fcn\u00fcn su fraksiyonu, WCEE) birincil insan dermal fibroblastlar\u0131 (HDF) \u00fczerinde. In vivo olarak, CEE veya WCEE, BALB \/ c farelerinin eksizyonel yaralar\u0131na topikal olarak uyguland\u0131 ve yara kas\u0131lma oran\u0131 ve imm\u00fcnohistolojik \u00e7al\u0131\u015fmalar yap\u0131ld\u0131. CEE ve sadece WCEE’nin HDF h\u00fccrelerinin \u00e7o\u011falmas\u0131n\u0131 ve g\u00f6\u00e7\u00fcn\u00fc \u00f6nemli \u00f6l\u00e7\u00fcde uyard\u0131\u011f\u0131n\u0131 bulduk. Ayr\u0131ca ba\u011f dokusu b\u00fcy\u00fcme fakt\u00f6r\u00fc (CTGF) ve \u03b1-d\u00fcz kas aktinin (\u03b1-SMA) ekspresyonunu in vitro olarak d\u00fczenlerler. \u0130n vivo olarak, CEE veya WCEE ile tedavi edilen fare gruplar\u0131, plasebo kontrol grubuna k\u0131yasla daha h\u0131zl\u0131 yara iyile\u015fmesi ve artan CTGF ve a-SMA ekspresyonu g\u00f6sterdi. Yara onar\u0131m\u0131n\u0131n gran\u00fclasyon faz\u0131 s\u0131ras\u0131nda her iki proteinin ekspresyonunun artmas\u0131 C. officinalis’in potansiyel rol\u00fcn\u00fc g\u00f6sterdi.Ek olarak, aktif su fraksiyonunun HPLC-ESI MS analizi, rutin ve kuersetin-3-O-glukozit olmak \u00fczere iki ana bile\u015fi\u011fin varl\u0131\u011f\u0131n\u0131 ortaya \u00e7\u0131karm\u0131\u015ft\u0131r. B\u00f6ylece, sonu\u00e7lar\u0131m\u0131z C. officinalis’in CTGF ve a-SMA ekspresyonunu uyararak yara iyile\u015fmesini g\u00fc\u00e7lendirdi\u011fini ve ayr\u0131ca aktif bile\u015fikler belirledi\u011fimizi g\u00f6sterdi.
MAKALE 28-) https:\/\/scihub.bban.top\/10.1016\/j.ctcp.2015.12.001
Evaluation of the efficacy of a polyherbal mouthwash containing Zingiber officinale, Rosmarinus officinalis and Calendula officinalis extracts in patients with gingivitis: A randomized double-blind placebo-controlled trial.<\/strong>
Di\u015f eti iltihab\u0131, mikrobiyal enfeksiyon ve m\u00fcteakip inflamasyondan kaynaklanan olduk\u00e7a yayg\u0131n bir periodontal hastal\u0131kt\u0131r. Di\u015f eti iltihab\u0131 olan ki\u015filerde bitkisel preparatlar\u0131n etkinli\u011fi baz\u0131 \u00f6nceki \u00e7al\u0131\u015fmalarda bildirilmi\u015ftir.
AMA\u00c7:
Di\u015f eti iltihab\u0131 olan ki\u015filerde klorheksidin ve plasebo gargaralarla kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda Zingiber officinale, Rosmarinus officinalis ve Calendula officinalis (% 5 \/ h) hidroalkolik \u00f6z\u00fctleri i\u00e7eren poliherbal a\u011f\u0131z gargaras\u0131n\u0131n etkinli\u011fini ara\u015ft\u0131rmak .
Y\u00d6NTEMLER:
Bu randomize \u00e7ift k\u00f6r plasebo kontroll\u00fc ara\u015ft\u0131rmaya 60 hasta kat\u0131lm\u0131\u015f ve rasgele poliherbal gargaraya (n = 20), klorheksidin gargaraya (n = 20) veya plasebo gargaraya (n = 20) atanm\u0131\u015ft\u0131r. Kat\u0131l\u0131mc\u0131lara a\u011f\u0131z y\u0131kama suyunu g\u00fcnde iki kez (kahvalt\u0131 ve ak\u015fam yeme\u011finden sonra) 30 hafta boyunca iki haftal\u0131k bir s\u00fcre boyunca kullanmalar\u0131 s\u00f6ylendi. Di\u015feti ve plak indeksleri, \u00e7al\u0131\u015fman\u0131n ba\u015flang\u0131\u00e7, 7. ve 14. g\u00fcnlerinde MGI, GBI ve MQH skalalar\u0131 kullan\u0131larak de\u011ferlendirildi.
SONU\u00c7LAR:
Hem poliherbal hem de klorheksidin gargara gruplar\u0131nda ba\u015flang\u0131\u00e7tan denemenin sonuna kadar de\u011ferlendirilen t\u00fcm etkinlik \u00f6l\u00e7\u00fclerinde \u00f6nemli geli\u015fmeler olmu\u015ftur; \u00f6rne\u011fin MGI, GBI ve MQH skorlar\u0131; ancak plasebo grubunda skorlar istatistiksel olarak de\u011fi\u015fmedi. Tedavi gruplar\u0131ndaki MGI, BGI ve MQH skorlar\u0131, \u00e7al\u0131\u015fman\u0131n 7. ve 14. g\u00fcnlerinde kontrol grubuna g\u00f6re anlaml\u0131 olarak d\u00fc\u015f\u00fckt\u00fc. Bununla birlikte, \u00e7al\u0131\u015fman\u0131n 7. g\u00fcn\u00fcnde veya 14. g\u00fcn\u00fcnde, poliherbal ve klorheksidin gruplar\u0131 aras\u0131nda anlaml\u0131 bir fark yoktu. Poliherbal gargara g\u00fcvenlidir ve \u00e7al\u0131\u015fma s\u0131ras\u0131nda advers reaksiyon bildirilmemi\u015ftir.
SONU\u00c7:
Di\u015f eti iltihab\u0131n\u0131n tedavisinde Z. officinale, R. officinalis ve C. officinalis (% 5) hidroalkolik \u00f6z\u00fctleri i\u00e7eren poliherbal gargara etkili olmu\u015ftur ve etkinli\u011fi klorheksidin gargara ile kar\u015f\u0131la\u015ft\u0131r\u0131labilir d\u00fczeydedir.<\/p>\n","protected":false},"excerpt":{"rendered":"

MAKALE 1-)https:\/\/scihub.bban.top\/10.1007\/s00432-020-03124-x How to bridge the gap? European medical plants used for treating oral mucositis: on the search for evidence Oral mukozit, kanser tedavisinin (\u00f6rn. I\u015f\u0131nlanma) veya sistemik (\u00f6rn. Kemoterapi) olmas\u0131 gibi kanser tedavisinin yayg\u0131n, a\u011fr\u0131l\u0131 bir yan etkisidir. Fitoterapi genellikle hastalar taraf\u0131ndan semptomlar\u0131 hafifletmek i\u00e7in kullan\u0131l\u0131r. Bununla birlikte, hangi t\u0131bbi bitkilerin Geleneksel Avrupa T\u0131bb\u0131 […]<\/p>\n","protected":false},"author":1,"featured_media":180,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-65","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-literatur"],"yoast_head":"\nAYNISEFA (CALENDULA OFF\u0130C\u0130NAL\u0130S) - Dr. \u00d6zberk Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blog.drozberk.com\/index.php\/2020\/04\/13\/calendula-officinalis\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"AYNISEFA (CALENDULA OFF\u0130C\u0130NAL\u0130S) - Dr. \u00d6zberk Blog\" \/>\n<meta property=\"og:description\" content=\"MAKALE 1-)https:\/\/scihub.bban.top\/10.1007\/s00432-020-03124-x How to bridge the gap? European medical plants used for treating oral mucositis: on the search for evidence Oral mukozit, kanser tedavisinin (\u00f6rn. I\u015f\u0131nlanma) veya sistemik (\u00f6rn. Kemoterapi) olmas\u0131 gibi kanser tedavisinin yayg\u0131n, a\u011fr\u0131l\u0131 bir yan etkisidir. Fitoterapi genellikle hastalar taraf\u0131ndan semptomlar\u0131 hafifletmek i\u00e7in kullan\u0131l\u0131r. 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